LOCUS       NM_001191924            4496 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Rattus norvegicus nemo like kinase (Nlk), mRNA.
ACCESSION   NM_001191924 XM_573152
VERSION     NM_001191924.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4496)
  AUTHORS   Yan,X., Liu,J., Wu,H., Liu,Y., Zheng,S., Zhang,C. and Yang,C.
  TITLE     Impact of miR-208 and its Target Gene Nemo-Like Kinase on the
            Protective Effect of Ginsenoside Rb1 in Hypoxia/Ischemia Injuried
            Cardiomyocytes
  JOURNAL   Cell Physiol Biochem 39 (3), 1187-1195 (2016)
   PUBMED   27577116
  REMARK    GeneRIF: The results showed that NLK was a direct target of
            mir-208.
REFERENCE   2  (bases 1 to 4496)
  AUTHORS   Huang,Y., Yang,Y., He,Y., Huang,C., Meng,X. and Li,J.
  TITLE     MicroRNA-208a Potentiates Angiotensin II-triggered Cardiac
            Myoblasts Apoptosis via Inhibiting Nemo-like Kinase (NLK)
  JOURNAL   Curr Pharm Des 22 (31), 4868-4875 (2016)
   PUBMED   26861724
  REMARK    GeneRIF: miR-208a can promote Ang II-induced cardiomyocyte
            apoptosis via negatively regulating NLK expression, and inhibition
            of miR-208a may provide a novel therapeutic target for
            cardiomyocyte apoptosis
REFERENCE   3  (bases 1 to 4496)
  AUTHORS   Zhang,Z.Y., Li,S.Z., Zhang,H.H., Wu,Q.R., Gong,J., Liang,T.,
            Gao,L., Xing,N.N., Liu,W.B., Du,R.L. and Zhang,X.D.
  TITLE     Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates
            the interleukin-1beta-stimulated C/EBP signaling pathway
  JOURNAL   Mol Cell Biol 35 (5), 778-788 (2015)
   PUBMED   25512613
REFERENCE   4  (bases 1 to 4496)
  AUTHORS   Xu,D., Zhao,W., Pan,G., Qian,M., Zhu,X., Liu,W., Cai,G. and Cui,Z.
  TITLE     Expression of Nemo-like kinase after spinal cord injury in rats
  JOURNAL   J Mol Neurosci 52 (3), 410-418 (2014)
   PUBMED   24395089
REFERENCE   5  (bases 1 to 4496)
  AUTHORS   Chen,G., Feng,D., Zhang,L., Dang,B., Liu,H. and Wang,Z.
  TITLE     Expression of Nemo-like kinase (NLK) in the brain in a rat
            experimental subarachnoid hemorrhage model
  JOURNAL   Cell Biochem Biophys 66 (3), 671-680 (2013)
   PUBMED   23325309
  REMARK    GeneRIF: NLK is decreasingly expressed in an opposite time-course
            to the development of cerebral vasospasm (CVS) and SAH-induced
            brain injury
            Erratum:[Cell Biochem Biophys. 2024 Sep 27. doi:
            10.1007/s12013-024-01523-2. PMID: 39331357]
REFERENCE   6  (bases 1 to 4496)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Comparative genomics on nemo-like kinase gene
  JOURNAL   Int J Oncol 26 (6), 1715-1719 (2005)
   PUBMED   15870890
  REMARK    GeneRIF: Nlk2 gene and Nlkp pseudogene were predicted as
            retrotransposed Nlk homologs within the rat genome. Nlk2 gene
            encoded a 480-aa Nlk2 protein with partial deletion within the
            kinase domain, which was predicted as the dominant negative Nlk
            homolog.
REFERENCE   7  (bases 1 to 4496)
  AUTHORS   Kanei-Ishii,C., Ninomiya-Tsuji,J., Tanikawa,J., Nomura,T.,
            Ishitani,T., Kishida,S., Kokura,K., Kurahashi,T.,
            Ichikawa-Iwata,E., Kim,Y., Matsumoto,K. and Ishii,S.
  TITLE     Wnt-1 signal induces phosphorylation and degradation of c-Myb
            protein via TAK1, HIPK2, and NLK
  JOURNAL   Genes Dev 18 (7), 816-829 (2004)
   PUBMED   15082531
REFERENCE   8  (bases 1 to 4496)
  AUTHORS   Ohkawara,B., Shirakabe,K., Hyodo-Miura,J., Matsuo,R., Ueno,N.,
            Matsumoto,K. and Shibuya,H.
  TITLE     Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm
            induction
  JOURNAL   Genes Dev 18 (4), 381-386 (2004)
   PUBMED   15004007
REFERENCE   9  (bases 1 to 4496)
  AUTHORS   Yasuda,J., Yokoo,H., Yamada,T., Kitabayashi,I., Sekiya,T. and
            Ichikawa,H.
  TITLE     Nemo-like kinase suppresses a wide range of transcription factors,
            including nuclear factor-kappaB
  JOURNAL   Cancer Sci 95 (1), 52-57 (2004)
   PUBMED   14720327
REFERENCE   10 (bases 1 to 4496)
  AUTHORS   Brott,B.K., Pinsky,B.A. and Erikson,R.L.
  TITLE     Nlk is a murine protein kinase related to Erk/MAP kinases and
            localized in the nucleus
  JOURNAL   Proc Natl Acad Sci U S A 95 (3), 963-968 (1998)
   PUBMED   9448268
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 3, 2022 this sequence version replaced NM_001191924.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.44248.1,
                                           SRR26643289.28715.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1622              JAXUCZ010000010.1  64087267-64088888   c
            1623-1752           JAXUCZ010000010.1  64021843-64021972   c
            1753-1808           JAXUCZ010000010.1  64012233-64012288   c
            1809-1915           JAXUCZ010000010.1  63988002-63988108   c
            1916-2001           JAXUCZ010000010.1  63986451-63986536   c
            2002-2211           JAXUCZ010000010.1  63982976-63983185   c
            2212-2313           JAXUCZ010000010.1  63979954-63980055   c
            2314-2400           JAXUCZ010000010.1  63972873-63972959   c
            2401-2599           JAXUCZ010000010.1  63970457-63970655   c
            2600-2693           JAXUCZ010000010.1  63969704-63969797   c
            2694-4496           JAXUCZ010000010.1  63965432-63967234   c
FEATURES             Location/Qualifiers
     source          1..4496
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..4496
                     /gene="Nlk"
                     /gene_synonym="RGD1561602"
                     /note="nemo like kinase"
                     /db_xref="GeneID:497961"
                     /db_xref="RGD:1561602"
     exon            1..1622
                     /gene="Nlk"
                     /gene_synonym="RGD1561602"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1752
                     /gene="Nlk"
                     /gene_synonym="RGD1561602"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1808
                     /gene="Nlk"
                     /gene_synonym="RGD1561602"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1915
                     /gene="Nlk"
                     /gene_synonym="RGD1561602"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2001
                     /gene="Nlk"
                     /gene_synonym="RGD1561602"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2211
                     /gene="Nlk"
                     /gene_synonym="RGD1561602"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2313
                     /gene="Nlk"
                     /gene_synonym="RGD1561602"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2400
                     /gene="Nlk"
                     /gene_synonym="RGD1561602"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2599
                     /gene="Nlk"
                     /gene_synonym="RGD1561602"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2693
                     /gene="Nlk"
                     /gene_synonym="RGD1561602"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..4496
                     /gene="Nlk"
                     /gene_synonym="RGD1561602"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tatccggctt tgctagggga ggtgagtccg gccgcggcgg caccggcggc tgagaaggcg
       61 gcggctgaag agaaagcggt cacggcggct gtggagaaag caaccgtggg cacggaagcc
      121 gggtgggggg gaggggggga gacggagcag ccttgagccc tgcaggggcc gtcgcgcggg
      181 ggacccaccc gctctccccc ccaaccctcc tcagcacaag cagccggcgg cggcgggggc
      241 aggagtcagc ctgcttccga ccgtcccccg cccgcttccc ggggctccta ttctttggcc
      301 ccgggaccct aacctcctcc ggggcggttc cctgtgtctg ggcgtccgag tgctgcccac
      361 cgctctttca ttccctccct gcaccttctt cccttcactt ttgccggggt tctctctctc
      421 ctcttctgtc ctgcctgtcg cctcctcgcc tcactctctt cctccagcct ccttccctgg
      481 ctcattctgc ccaggaaagt ttggtacatc tccccaaacc ccctcagtcg ggtcaaccag
      541 actcggagta gggggagatg taggaaggcc tgagagttcg aggggaggga agctagacgc
      601 tggtttccct gataatttcc cctcatcttt tttgatttag agtggttgga tttttttttt
      661 tttaattgtg tttttgagga ggtgggaggt gtttagaaaa ggatgtggga atggaagggg
      721 tagatgagtc aaccctctta caagattcca agggtggcgt cttaccagat ctttttcgtg
      781 tgtggagttc agggggtcgg gaggtttggc ctttattccc acattcaaag ttggaacctc
      841 ccccccatta agaatggagt tttagtatcc acttgtagca ggaatcctgg ggggaagggg
      901 cccttttccc tttttctttt cctttttttt tttcttctta ttttatgttc ttaactttta
      961 ttttgacaac ccacaccctt ccacactctc acccaaaaat cgaacaccca agatcctcca
     1021 acttgtctgg attgactgat gaagacataa agccagttcc gctctatgtt ttttgaggtg
     1081 gagtgagtgg tttttcttca ttttttaaat ggccaaatga cagcttgacc cagtttgctt
     1141 tccaatcaaa gggcattttt ttgaatgtct ctttgtggca cacgagccaa cgcaaaaatg
     1201 atggcggctt acaatggcgg tacatctgca gcagcagcag gtcaccacca ccaccatcac
     1261 caccaccttc cacaccttcc tcctcctcac cttcaccacc accaccaccc tcaacaccac
     1321 cttcatccgg ggtcggctgc tgctgtacac cctgtacagc agcatacgtc ttcggcagct
     1381 gcggcagccg cagcggcagc tgcggccgca gccatgttaa accctgggca acaacagcca
     1441 tatttcccat caccggcacc tggtcaggct cctgggccag ctgcagcagc cccagctcag
     1501 gtacaggctg ctgcagctgc tacagttaag gcgcaccatc atcagcactc gcatcatccg
     1561 caacagcagc tggacattga gccggataga cctattggat atggagcctt tggtgttgtc
     1621 tggtcagtaa cagatccaag agatggaaag agagtagcac tcaaaaagat gcccaacgtc
     1681 ttccagaatc tggtctcttg caaaagagtc ttccgggaat tgaagatgtt gtgttttttt
     1741 aaacatgata atgtactctc tgcccttgac atactccagc ctccacacat tgactatttt
     1801 gaagaaatat atgttgtcac agaattgatg cagagtgatc tacataaaat tatcgtctct
     1861 cctcagccac tcagctcaga tcatgtcaaa gtttttcttt atcagatttt gcgaggtttg
     1921 aaatatctcc attcagctgg cattttacat cgcgacatta agccggggaa tctccttgtg
     1981 aacagcaact gtgttctaaa gatttgtgat tttggattgg ccagagtgga agaattggat
     2041 gaatcccgtc acatgactca ggaagttgtt actcagtatt accgggctcc ggagatcctc
     2101 atgggcagcc gccattacag caatgctatt gacatctggt ctgtggggtg catctttgca
     2161 gagctgctgg gccgaaggat actgtttcag gcgcagagtc ccattcagca gttggatttg
     2221 atcacagatc tgttgggcac gccatcactg gaagcgatga ggacagcttg tgaaggtgct
     2281 aaggcacaca tactcagggg tcctcacaaa cagccatctc tccctgtact ctacaccctt
     2341 tccagccagg ccacacatga agccgttcac ctgctttgca gaatgttggt ctttgatcca
     2401 tcaaaaagaa tatccgctaa ggatgcctta gcccacccct acctagatga agggcggctg
     2461 agataccata catgtatgtg taagtgctgc ttttccacct cgacgggaag agtctacacc
     2521 agtgactttg agcctgtcac caaccccaaa tttgatgaca cctttgagaa gaacctcagc
     2581 tctgtccgac aagttaaaga aattatccac cagttcattt tggaacagca gaaaggaaac
     2641 agagtacctc tctgcattaa cccgcagtct gctgccttta agagctttat cagttccacc
     2701 gtcgctcagc cgtctgagat gccaccgtct cctctggtgt gggagtgact gtggaaggca
     2761 ctgtactact gaagatgtaa tgtagctttc actggagtct ggggtttgca attctggagg
     2821 gttaatcatg cttgtactgt aattttacta atgaagtttt aaattaacaa ccactacttg
     2881 tatgatatga ataatattta gaaatgttac tagactttta atcttgtaaa gtggttgtgc
     2941 ttttagaaga aaaaaactat tttacccaga gttgcacatg gttaaagaat tcagtgcagc
     3001 tgttgtggct cacctcagaa caaacgaaaa ttgaaccaaa tttgggcatt tggggtttat
     3061 gtttttattt tattattaat attttttaat gaagtaagat tgttcacatg tatacactca
     3121 cacagaggac agtcatacat tttgatattt gagccattcc taaagattaa gggttttcta
     3181 aaactaaaga atctagaaag tttgccagtg accaatcatg gagccacgtg agctgattgt
     3241 ggctgcgcct gggggatggg aggggagggg ccacctaatg atcaggccct gtaactggct
     3301 tctcattaga gccatgctgg tgacgtgtgc tgtctcacct ccaatgctgt gcgtagagag
     3361 aatgagtatg tgactaggag agactaaccc tctgtttccc ttacccggta taaatatata
     3421 tatatatata tatttaatct atttttatta gaagtttttc tgctctttct tacataaaaa
     3481 aaaaaaaaag agagacccaa gcatgcatct ttcctgtgta aataattcat ttctgggcta
     3541 atttcagaag aatcccagca ctgctgtata actggcttgc acattctagg tctgtgaaat
     3601 tctgtgagac ttttcctgca ctggacagtg aaaaataaga aataaaagac aaaaagaagt
     3661 taaaaaaaaa attacagcca caaaggcaca tagggaatca tgtcaaatgt gtttgtgtcc
     3721 ttaggcaaag ctgtgggagt cttgagatgt cacagtagta aataacttat tactttttga
     3781 caaattcttt ttcctgctgg aacactgaac tctgtgcata tgtaaatagg agcaccaatc
     3841 gaaggcctct acctcctgga gttacacagc tcggcttgtt acctccacac gctgatgatg
     3901 actttttttt tttttttttt ttaagttcaa tgtggagact tgaaacttga atgtcccttc
     3961 caacttttat attaaaaata aaaagacaag aaaattgaag agcgtttttc acctgtacga
     4021 ggagtactaa cggatcgtct taaaactggt ctaggaaaaa gcttggtgtg tgttacggac
     4081 aattaactgt taaagttatt gtaagttatc tgtatttagc agagtatttt catcttgagt
     4141 gatctgagct gaatttgaag actattaagt tatatttgga agttttaact tcaatgaagt
     4201 aattatttgc tgtgaaagaa acaaacattg aattactaaa caaagatggt gcaatatctt
     4261 tgttgttgtt gttgttgttg tttttttatg aggctcctga gaatcttccc aaccgaagca
     4321 tttcaattca cttgagtgag aaacgtgttt agtatcaaaa gagcccgaga agacactggt
     4381 atgaaaggta caatctcaga ggttggtcag ttaccgtggc acactttctg gtcactttgt
     4441 acaatgtaga tttgaagtac agtggtgaga acattaaacg tgacattgga aaacga
//
