LOCUS       NM_053868               3322 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus neuroligin 1 (Nlgn1), mRNA.
ACCESSION   NM_053868
VERSION     NM_053868.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3322)
  AUTHORS   Tian,C., Paskus,J.D., Fingleton,E., Roche,K.W. and Herring,B.E.
  TITLE     Autism Spectrum Disorder/Intellectual Disability-Associated
            Mutations in Trio Disrupt Neuroligin 1-Mediated Synaptogenesis
  JOURNAL   J Neurosci 41 (37), 7768-7778 (2021)
   PUBMED   34353896
  REMARK    GeneRIF: Autism Spectrum Disorder/Intellectual
            Disability-Associated Mutations in Trio Disrupt Neuroligin
            1-Mediated Synaptogenesis.
REFERENCE   2  (bases 1 to 3322)
  AUTHORS   Oku,S., Feng,H., Connor,S., Toledo,A., Zhang,P., Zhang,Y.,
            Thoumine,O., Zhang,C. and Craig,A.M.
  TITLE     Alternative splicing at neuroligin site A regulates glycan
            interaction and synaptogenic activity
  JOURNAL   Elife 9, e58668 (2020)
   PUBMED   32915137
  REMARK    GeneRIF: Alternative splicing at neuroligin site A regulates glycan
            interaction and synaptogenic activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3322)
  AUTHORS   Paskus,J.D., Tian,C., Fingleton,E., Shen,C., Chen,X., Li,Y.,
            Myers,S.A., Badger,J.D. 2nd, Bemben,M.A., Herring,B.E. and
            Roche,K.W.
  TITLE     Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF
            Protein-Dependent Neuroligin-1 Mechanism of Action
  JOURNAL   Cell Rep 29 (10), 2944-2952 (2019)
   PUBMED   31801062
REFERENCE   4  (bases 1 to 3322)
  AUTHORS   Xia,Q.Q., Xu,J., Liao,T.L., Yu,J., Shi,L., Xia,J., Luo,J.H. and
            Xu,J.
  TITLE     Neuroligins Differentially Mediate Subtype-Specific Synapse
            Formation in Pyramidal Neurons and Interneurons
  JOURNAL   Neurosci Bull 35 (3), 497-506 (2019)
   PUBMED   30790215
  REMARK    GeneRIF: Results showed that in pyramidal and interneurons,
            neuroligin 1 and neuroligin 3 were involved in excitatory synapse
            formation, and neuroligin 2 in GABAergic synapse formation.
REFERENCE   5  (bases 1 to 3322)
  AUTHORS   Zhao,J.Y., Duan,X.L., Yang,L., Liu,J.P., He,Y.T., Guo,Z., Hu,X.D.
            and Suo,Z.W.
  TITLE     Activity-dependent Synaptic Recruitment of Neuroligin 1 in Spinal
            Dorsal Horn Contributed to Inflammatory Pain
  JOURNAL   Neuroscience 388, 1-10 (2018)
   PUBMED   30049666
  REMARK    GeneRIF: To characterize the possible contribution of NLGN1 to
            inflammatory pain, the present study analyzed the changes of NLGN1
            expression after intraplantar injection of complete Freund's
            adjuvant (CFA). Our data revealed an activity-dependent recruitment
            of NLGN1 into synapses, which was essential for NMDAR hyperfunction
            and pain hypersensitivity.
REFERENCE   6  (bases 1 to 3322)
  AUTHORS   Hirao,K., Hata,Y., Ide,N., Takeuchi,M., Irie,M., Yao,I.,
            Deguchi,M., Toyoda,A., Sudhof,T.C. and Takai,Y.
  TITLE     A novel multiple PDZ domain-containing molecule interacting with
            N-methyl-D-aspartate receptors and neuronal cell adhesion proteins
  JOURNAL   J Biol Chem 273 (33), 21105-21110 (1998)
   PUBMED   9694864
REFERENCE   7  (bases 1 to 3322)
  AUTHORS   Nguyen,T. and Sudhof,T.C.
  TITLE     Binding properties of neuroligin 1 and neurexin 1beta reveal
            function as heterophilic cell adhesion molecules
  JOURNAL   J Biol Chem 272 (41), 26032-26039 (1997)
   PUBMED   9325340
REFERENCE   8  (bases 1 to 3322)
  AUTHORS   Irie,M., Hata,Y., Takeuchi,M., Ichtchenko,K., Toyoda,A., Hirao,K.,
            Takai,Y., Rosahl,T.W. and Sudhof,T.C.
  TITLE     Binding of neuroligins to PSD-95
  JOURNAL   Science 277 (5331), 1511-1515 (1997)
   PUBMED   9278515
REFERENCE   9  (bases 1 to 3322)
  AUTHORS   Ichtchenko,K., Nguyen,T. and Sudhof,T.C.
  TITLE     Structures, alternative splicing, and neurexin binding of multiple
            neuroligins
  JOURNAL   J Biol Chem 271 (5), 2676-2682 (1996)
   PUBMED   8576240
REFERENCE   10 (bases 1 to 3322)
  AUTHORS   Ichtchenko,K., Hata,Y., Nguyen,T., Ullrich,B., Missler,M.,
            Moomaw,C. and Sudhof,T.C.
  TITLE     Neuroligin 1: a splice site-specific ligand for beta-neurexins
  JOURNAL   Cell 81 (3), 435-443 (1995)
   PUBMED   7736595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U22952.1 and JAXUCZ010000002.1.
            
            On Oct 11, 2007 this sequence version replaced NM_053868.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U22952.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1880              U22952.1           365-2244
            1881-251714588      JAXUCZ010000002.1  1-251712708
            251714589-251714725 U22952.1           2246-2382
            251714726-503427433 JAXUCZ010000002.1  1-251712708
            503427434-503428454 U22952.1           2384-3404
            503428455-503428736 U22952.1           3406-3687
FEATURES             Location/Qualifiers
     source          1..3322
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..3322
                     /gene="Nlgn1"
                     /note="neuroligin 1"
                     /db_xref="GeneID:116647"
                     /db_xref="RGD:621117"
     exon            1..163
                     /gene="Nlgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            164..970
                     /gene="Nlgn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             478..3009
                     /gene="Nlgn1"
                     /note="neuroligin I"
                     /codon_start=1
                     /product="neuroligin-1 precursor"
                     /protein_id="NP_446320.1"
                     /db_xref="GeneID:116647"
                     /db_xref="RGD:621117"
                     /translation="MALPRCMWPNYVWRAMMACVVHRGSGAPLTLCLLGCLLQTFHVL
                     SQKLDDVDPLVTTNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPS
                     PWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYV
                     PTEDVKRISKECARKPGKKICRKGDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLA
                     SYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRIT
                     VFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYAR
                     ILATKVGCNVSDTVELVECLQKKPYKELVDQDVQPARYHIAFGPVIDGDVIPDDPQIL
                     MEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGVSASDFDFAVSNFVDNLYGYPEGKD
                     VLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAF
                     YHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNF
                     AKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVN
                     LWLELVPHLHNLNDISQYTSTTTKVPSTDITLRPTRKNSTPVTSAFPTAKQDDPKQQP
                     SPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTN
                     DLTHAPEEEIMSLQMKHTDLDHECESIHPHEVVLRTACPPDYTLAMRRSPDDVPLMTP
                     NTITMIPNTIPGIQPLHTFNTFTGGQNNTLPHPHPHPHSHSTTRV"
     exon            971..1030
                     /gene="Nlgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1183
                     /gene="Nlgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1396
                     /gene="Nlgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..2186
                     /gene="Nlgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..3322
                     /gene="Nlgn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagttccaga ggttgaaaag aaagcatctg caaactggta aatactttga ccatttcggc
       61 ttgaatttga ctgggaagtg ttgttaaaac tgtctccttg aataatttaa agaggactgg
      121 gggaagatga gggggctccc tccgtggacg tgcttccctg agggagatag acccacagct
      181 aactggattt gatttatacg agggaaatct acatcaatgg ccactctcac cacattgctg
      241 ctatgggaaa cagaatggtc aataggagat gttctgatga atagtgatga ttgaagatcc
      301 ggcatcagtc tgtgtgaaat caatgggagc tacttgctgc atgaagagtg ttttcagctt
      361 tccttaacaa gttcctatct gagaaactgg agctgcattc taccaccatt ccatctttct
      421 ccagcggata caaatatttt tgcctcactg taccagatag acaactaatg tgggaccatg
      481 gcacttccca gatgcatgtg gccaaattat gtttggagag ccatgatggc atgtgtggtc
      541 cacaggggat cgggtgcccc gttgactctc tgcttgttgg gatgtttgct acagactttc
      601 cacgtactct ctcaaaagtt ggatgatgta gacccattgg ttactactaa ctttggcaaa
      661 ataaggggaa ttaagaaaga actcaataat gaaattttgg ggcctgtcat tcagtttctt
      721 ggggttccat atgctgctcc accaacagga gaacatcgat ttcagcctcc agaaccacca
      781 tctccctggt ctgatatccg gaatgccact cagtttgctc ctgtatgtcc ccagaatatc
      841 attgatggca gattgcctga agttatgctt cctgtgtggt tcactaataa cttggatgtg
      901 gtttcctcat atgtgcaaga ccagagtgaa gactgtctat acttaaacat ctatgtccca
      961 actgaagatg taaaaagaat atccaaggaa tgtgccagaa aacccggcaa gaaaatatgt
     1021 agaaaaggag atattcggga cagtgggggt cccaaaccag tgatggtgta catccatggt
     1081 ggctcttaca tggaaggtac tggaaatcta tatgatggga gtgtgttggc aagctacggt
     1141 aatgtgatcg tcatcacagt caactatcgg cttggggtac ttggcttctt gagcacaggg
     1201 gatcaggctg ccaaaggaaa ctacgggctc cttgacctca tccaggccct cagatggacc
     1261 agcgagaaca ttgggttctt tggtggtgac cccttgcgaa tcaccgtgtt tggatcaggc
     1321 gctgggggtt catgtgtcaa tctgctgact ttatcccatt attctgaagg taaccgttgg
     1381 agcaattcaa ccaaaggact ttttcaacga gcaatagctc agagtggaac agccctttcc
     1441 agctgggctg ttagtttcca gcctgcaaaa tacgctagaa ttctagccac aaaagttggc
     1501 tgcaatgtgt cagatacagt agagttagta gaatgcctgc agaagaagcc ttacaaagaa
     1561 cttgttgatc aagatgttca accagcccga taccacatag cctttggacc tgtgatcgat
     1621 ggtgatgtaa taccagatga ccctcagata ctgatggaac aaggagagtt cctcaattat
     1681 gatatcatgt taggagttaa ccaaggggaa gggttgaagt ttgtggaaaa catagtagat
     1741 agtgatgatg gtgtatcagc cagtgatttt gactttgctg tctctaattt tgttgataat
     1801 ttatatggat atcctgaagg caaagatgtt ttgagagaaa ccattaaatt catgtatact
     1861 gactgggctg atcgccataa tcctgaaact agaaggaaga cattgttggc tttgtttaca
     1921 gaccatcagt gggtagcacc cgctgtggct acagcagacc ttcactcgaa ctttggctca
     1981 cctacatact tctatgcctt ttatcatcat tgccaaacag accaagttcc agcttgggct
     2041 gatgcagctc atggggatga ggttccctat gtattgggaa tccccatgat tggccctaca
     2101 gagttatttc cttgcaattt ctccaagaat gatgtgatgt tgagtgctgt agtaatgaca
     2161 tactggacga attttgctaa aaccggtgac ccaaatcaac cagttcctca agacacaaaa
     2221 ttcattcata ccaaacccaa ccgctttgaa gaagtagcat ggaccagata ttcccagaaa
     2281 gaccaacttt atctccatat tggattaaaa ccgagagtta aagaacatta cagagccaat
     2341 aaggtaaatc tctggttgga gctggtacct catctgcata atctcaatga catttctcag
     2401 tatacctcga caacaactaa agtgccatca acagacatca ctctcagacc tacaaggaaa
     2461 aattccactc cagtcacatc agcctttccc actgccaagc aggatgatcc caaacaacaa
     2521 ccaagtccct tctcggtaga tcaaagggac tactccacag agctaagtgt cacaatcgca
     2581 gtgggagcct ctctgctgtt tctgaacatc ttggcttttg cagccctata ctacaagaaa
     2641 gacaagagga gacatgatgt ccaccggagg tgcagccctc agcgcaccac gaccaacgac
     2701 ctaacccatg ctccagaaga ggaaattatg tctctccaaa tgaagcacac tgacttggat
     2761 cacgagtgtg agtccatcca tccacatgag gtggttcttc ggaccgcctg ccccccagat
     2821 tatactcttg ctatgaggag gtcaccggat gatgttcctt taatgacacc taacaccatc
     2881 acaatgattc ccaacactat accagggatt cagcccttac atacattcaa cacatttact
     2941 ggaggacaga ataatacact gccccacccc caccctcacc cccattcaca ttcaacaacc
     3001 agggtatagc cagatgagag agacaaactg attttttttt ctgatggagt gcagtaaaag
     3061 attattggaa gattccttgg ctttcaactt ggaagactct cactatttaa ataaggagga
     3121 atattgtgtg aatatacata tcaagaactt tgggggtttt gaaaaaaatg aattgtatat
     3181 agatatacac acaaatcaac tttaaaaaaa gcaaattcca attgctagaa gcaatggttc
     3241 tgaatgatac tttttcattc actttcaaga attaatttgt tgaagattta agttacataa
     3301 tggagttagg catgtggatc gc
//
