LOCUS       NM_001127534            1755 bp    mRNA    linear   ROD 11-AUG-2024
DEFINITION  Rattus norvegicus notchless homolog 1 (Nle1), mRNA.
ACCESSION   NM_001127534 XM_001081007 XM_220770
VERSION     NM_001127534.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1755)
  AUTHORS   Beck-Cormier,S., Escande,M., Souilhol,C., Vandormael-Pournin,S.,
            Sourice,S., Pilet,P., Babinet,C. and Cohen-Tannoudji,M.
  TITLE     Notchless is required for axial skeleton formation in mice
  JOURNAL   PLoS One 9 (5), e98507 (2014)
   PUBMED   24875805
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1755)
  AUTHORS   Lee,S. and Griep,A.E.
  TITLE     Loss of Dlg-1 in the mouse lens impairs fibroblast growth factor
            receptor signaling
  JOURNAL   PLoS One 9 (5), e97470 (2014)
   PUBMED   24824078
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1755)
  AUTHORS   Yao,L., Yago,T., Shao,B., Liu,Z., Silasi-Mansat,R., Setiadi,H.,
            Lupu,F. and McEver,R.P.
  TITLE     Elevated CXCL1 expression in gp130-deficient endothelial cells
            impairs neutrophil migration in mice
  JOURNAL   Blood 122 (23), 3832-3842 (2013)
   PUBMED   24081661
REFERENCE   4  (bases 1 to 1755)
  AUTHORS   Le Bouteiller,M., Souilhol,C., Beck-Cormier,S., Stedman,A.,
            Burlen-Defranoux,O., Vandormael-Pournin,S., Bernex,F., Cumano,A.
            and Cohen-Tannoudji,M.
  TITLE     Notchless-dependent ribosome synthesis is required for the
            maintenance of adult hematopoietic stem cells
  JOURNAL   J Exp Med 210 (11), 2351-2369 (2013)
   PUBMED   24062412
REFERENCE   5  (bases 1 to 1755)
  AUTHORS   Lossie,A.C., Lo,C.L., Baumgarner,K.M., Cramer,M.J., Garner,J.P. and
            Justice,M.J.
  TITLE     ENU mutagenesis reveals that Notchless homolog 1 (Drosophila)
            affects Cdkn1a and several members of the Wnt pathway during murine
            pre-implantation development
  JOURNAL   BMC Genet 13, 106 (2012)
   PUBMED   23231322
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1755)
  AUTHORS   Cormier,S., Le Bras,S., Souilhol,C., Vandormael-Pournin,S.,
            Durand,B., Babinet,C., Baldacci,P. and Cohen-Tannoudji,M.
  TITLE     The murine ortholog of notchless, a direct regulator of the notch
            pathway in Drosophila melanogaster, is essential for survival of
            inner cell mass cells
  JOURNAL   Mol Cell Biol 26 (9), 3541-3549 (2006)
   PUBMED   16611995
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166567.1.
            
            On or before May 23, 2008 this sequence version replaced
            XM_220770.4, XM_001081007.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1755
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1755
                     /gene="Nle1"
                     /gene_synonym="RGD1308301"
                     /note="notchless homolog 1"
                     /db_xref="GeneID:303372"
                     /db_xref="RGD:1308301"
     exon            1..30
                     /gene="Nle1"
                     /gene_synonym="RGD1308301"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1470
                     /gene="Nle1"
                     /gene_synonym="RGD1308301"
                     /codon_start=1
                     /product="notchless protein homolog 1"
                     /protein_id="NP_001121006.1"
                     /db_xref="GeneID:303372"
                     /db_xref="RGD:1308301"
                     /translation="MAAAVEVSDEAAASDVQRLLVQFQDEGGQLLGSPFDVPVDITPD
                     QLQLVCNALLAQDEPLPLAFYVHDAEIVSSLGKTLESQSVETEKIVDIIYQPQAVFRV
                     RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHW
                     VLSISWSPDGKKLASGCKNGQILLWDPSTGTQVGRTLTGHSKWITGLSWEPLHMNPEC
                     RYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRA
                     HDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEATVNAQDLQGSLKELKERASSR
                     YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLARMTGHQALINQVLFSPDSRIVASA
                     SFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKL
                     TTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR"
     exon            31..174
                     /gene="Nle1"
                     /gene_synonym="RGD1308301"
                     /inference="alignment:Splign:2.1.0"
     exon            175..392
                     /gene="Nle1"
                     /gene_synonym="RGD1308301"
                     /inference="alignment:Splign:2.1.0"
     exon            393..472
                     /gene="Nle1"
                     /gene_synonym="RGD1308301"
                     /inference="alignment:Splign:2.1.0"
     exon            473..549
                     /gene="Nle1"
                     /gene_synonym="RGD1308301"
                     /inference="alignment:Splign:2.1.0"
     exon            550..647
                     /gene="Nle1"
                     /gene_synonym="RGD1308301"
                     /inference="alignment:Splign:2.1.0"
     exon            648..840
                     /gene="Nle1"
                     /gene_synonym="RGD1308301"
                     /inference="alignment:Splign:2.1.0"
     exon            841..976
                     /gene="Nle1"
                     /gene_synonym="RGD1308301"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1023
                     /gene="Nle1"
                     /gene_synonym="RGD1308301"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1226
                     /gene="Nle1"
                     /gene_synonym="RGD1308301"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1386
                     /gene="Nle1"
                     /gene_synonym="RGD1308301"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1457
                     /gene="Nle1"
                     /gene_synonym="RGD1308301"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1727
                     /gene="Nle1"
                     /gene_synonym="RGD1308301"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcaggatgg cggcggccgt ggaggtttct gacgaggcgg cggcaagcga cgtacagcgg
       61 ctgctcgtgc agttccagga tgagggcggc cagctgctgg gttccccgtt cgacgtgccg
      121 gtggacatca cgccggacca gctgcagctc gtgtgcaacg cgctgctggc ccaggacgag
      181 cccctgcccc ttgctttcta tgtccacgat gctgagattg tgtcctcgct ggggaagaca
      241 ctggagtcgc agtctgtgga gacagagaaa atcgtagaca tcatctacca gcctcaagct
      301 gtcttcaggg tccgcgccgt gacacggtgc actagctcat tggagggtca cagcgaagcc
      361 gtcatttctg tggccttcag ccccacggga aagtacctgg ccagtggttc cggagacacc
      421 acagtgcgct tctgggatct cagcactgag acaccgcact tcacatgcaa aggacaccgg
      481 cactgggtcc ttagcatatc ctggtcccca gatggcaaga aacttgcctc aggctgcaag
      541 aatggccaga ttctcctgtg ggacccaagc acagggacac aggtgggcag gaccctcact
      601 ggccacagca agtggatcac aggcctaagc tgggagcccc ttcacatgaa ccccgagtgc
      661 cgctacgtgg ccagcagctc caaggatggc agtgtacgag tctgggatac aacggcaggc
      721 cgctgtgaac gcatcctcac cgggcacaca cagtcagtca cctgcctccg atggggagga
      781 gatgggcttc tatattctgc ttcccaggac cgaactatca aagtctggag ggctcatgac
      841 ggtgtgctgt gccgtactct tcaaggtcat ggtcactggg tgaataccat ggcgctcagc
      901 acagactatg ccctgcgcac gggggccttt gagcctgctg aagccacagt gaatgcccaa
      961 gacctgcagg ggtccttgaa ggagctgaag gagagggcat cgagccgcta caaccttgtg
     1021 cggggccaag gcccagagag gctggtctct ggctcagacg acttcacctt attcctgtgg
     1081 tccccagcag aggacaagaa gccccttgcc cggatgacag gacaccaggc cctcatcaac
     1141 caggtgctct tctctcctga ctcacgcatc gtggccagtg cctccttcga caagtctatc
     1201 aagctgtggg atggcaggac gggcaagtac ctagcttccc tgcgtggcca tgtggctgct
     1261 gtgtaccaga ttgcctggtc agctgacagc cgattgctgg tcagtggcag cagtgacagc
     1321 acgctgaagg tgtgggatgt gaaggcccag aaactgacca cagacctgcc tggccacgcc
     1381 gatgaggtat atgctgttga ctggagtcca gatggccaga gagtagcaag cggtgggaaa
     1441 gacaagtgcc tccggatatg gagaagatga atctacagct tcctgacccc tctccggact
     1501 caggctctgc ccactctgcc agtaaccaag gagacctgcc cagaacaggt ctccagtgtg
     1561 tgacagtcag gacattacaa catagagcta agccatggac acttcctgtc tggtgctaac
     1621 agcagtggga aagccacgcc tctggcccct ggctcctttt ccgagtgtca gctgtgcagg
     1681 cccagaccct aggcttgtgg ccaaataaat aacttatatt ttgtgttaaa aaaaaaaaaa
     1741 aaaaaaaaaa aaaaa
//
