LOCUS       NM_001107558            1267 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus NK6 homeobox 2 (Nkx6-2), mRNA.
ACCESSION   NM_001107558 XM_001058301 XM_219447
VERSION     NM_001107558.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1267)
  AUTHORS   Henseleit,K.D., Nelson,S.B., Kuhlbrodt,K., Hennings,J.C.,
            Ericson,J. and Sander,M.
  TITLE     NKX6 transcription factor activity is required for alpha- and
            beta-cell development in the pancreas
  JOURNAL   Development 132 (13), 3139-3149 (2005)
   PUBMED   15944193
REFERENCE   2  (bases 1 to 1267)
  AUTHORS   Vallstedt,A., Klos,J.M. and Ericson,J.
  TITLE     Multiple dorsoventral origins of oligodendrocyte generation in the
            spinal cord and hindbrain
  JOURNAL   Neuron 45 (1), 55-67 (2005)
   PUBMED   15629702
REFERENCE   3  (bases 1 to 1267)
  AUTHORS   Cai,J., Qi,Y., Hu,X., Tan,M., Liu,Z., Zhang,J., Li,Q., Sander,M.
            and Qiu,M.
  TITLE     Generation of oligodendrocyte precursor cells from mouse dorsal
            spinal cord independent of Nkx6 regulation and Shh signaling
  JOURNAL   Neuron 45 (1), 41-53 (2005)
   PUBMED   15629701
REFERENCE   4  (bases 1 to 1267)
  AUTHORS   Southwood,C., He,C., Garbern,J., Kamholz,J., Arroyo,E. and Gow,A.
  TITLE     CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional
            activity for normal structure
  JOURNAL   J Neurosci 24 (50), 11215-11225 (2004)
   PUBMED   15601927
REFERENCE   5  (bases 1 to 1267)
  AUTHORS   Vallstedt,A., Muhr,J., Pattyn,A., Pierani,A., Mendelsohn,M.,
            Sander,M., Jessell,T.M. and Ericson,J.
  TITLE     Different levels of repressor activity assign redundant and
            specific roles to Nkx6 genes in motor neuron and interneuron
            specification
  JOURNAL   Neuron 31 (5), 743-755 (2001)
   PUBMED   11567614
REFERENCE   6  (bases 1 to 1267)
  AUTHORS   Awatramani,R., Beesley,J., Yang,H., Jiang,H., Cambi,F.,
            Grinspan,J., Garbern,J. and Kamholz,J.
  TITLE     Gtx, an oligodendrocyte-specific homeodomain protein, has repressor
            activity
  JOURNAL   J Neurosci Res 61 (4), 376-387 (2000)
   PUBMED   10931524
REFERENCE   7  (bases 1 to 1267)
  AUTHORS   Awatramani,R., Scherer,S., Grinspan,J., Collarini,E., Skoff,R.,
            O'Hagan,D., Garbern,J. and Kamholz,J.
  TITLE     Evidence that the homeodomain protein Gtx is involved in the
            regulation of oligodendrocyte myelination
  JOURNAL   J Neurosci 17 (17), 6657-6668 (1997)
   PUBMED   9254678
REFERENCE   8  (bases 1 to 1267)
  AUTHORS   Komuro,I., Schalling,M., Jahn,L., Bodmer,R., Jenkins,N.A.,
            Copeland,N.G. and Izumo,S.
  TITLE     Gtx: a novel murine homeobox-containing gene, expressed
            specifically in glial cells of the brain and germ cells of testis,
            has a transcriptional repressor activity in vitro for a
            serum-inducible promoter
  JOURNAL   EMBO J 12 (4), 1387-1401 (1993)
   PUBMED   8096811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jun 23, 2009 this sequence version replaced NM_001107558.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.5833.1,
                                           SRR22399481.1558717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-644               JAXUCZ010000001.1  203812479-203813122 c
            645-817             JAXUCZ010000001.1  203812225-203812397 c
            818-1267            JAXUCZ010000001.1  203811582-203812031 c
FEATURES             Location/Qualifiers
     source          1..1267
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1267
                     /gene="Nkx6-2"
                     /note="NK6 homeobox 2"
                     /db_xref="GeneID:309095"
                     /db_xref="RGD:1307280"
     exon            1..644
                     /gene="Nkx6-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..1072
                     /gene="Nkx6-2"
                     /note="NK6 transcription factor related, locus 2"
                     /codon_start=1
                     /product="homeobox protein Nkx-6.2"
                     /protein_id="NP_001101028.1"
                     /db_xref="GeneID:309095"
                     /db_xref="RGD:1307280"
                     /translation="MDANRPGAFVLSSAPLAALHNMAEMKTSLFPYALQGPAGFKTPA
                     LGSLGAQLPLGTPHGISDILGRPVGAAGGGLLGSLPRLNGLASSAGVYFGPAAAVARG
                     YPKPLAELPGRPPIFWPGVVQGSPWRDPRLAGSAQAGGVLDKDGKKKHSRPTFSGQQI
                     FALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEMASAKKKQ
                     DSDAEKLKVGGSDAEDDDEYNRPLDPNSDDEKITRLLKKHKPSNLALVSPCGGSAGDA
                     L"
     exon            645..817
                     /gene="Nkx6-2"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1267
                     /gene="Nkx6-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccgcagcc gcccctaata tccctgcctt ctttctctct gaccgccgcc cattcagcgc
       61 agcagccgtc ggtcctctcg ctttcccgtg agggccgtcg gcgtccgctt gaaacgcgtt
      121 acacgcatcc cagtgcaacc ggcgcccatc ggcgccgcgc gcaaacttcc cgagccggcg
      181 ggagcgggcg gtggcagcgg ggcccggatg ggcgccagga tcggaggcgg cggcgcccat
      241 ggacgctaac cgcccgggcg cgtttgtgct gagcagcgcg cctttagccg cgctgcacaa
      301 catggctgag atgaagacgt cgctgttccc ctacgcgctg cagggcccgg cgggcttcaa
      361 gacaccggcc ctaggcagcc ttggcgcgca gttgcctcta ggcactccgc acggcatcag
      421 cgacatcctg ggacggcctg tgggagcagc gggtggcggc ctcctgggaa gtctgccccg
      481 tctcaacggg ctcgcctcgt ccgcaggtgt ctacttcggg cccgcagctg cggtggctcg
      541 gggctacccc aagccgctgg cggaactgcc tgggcgcccg cccatcttct ggcccggggt
      601 ggtgcagggc tctccctgga gggacccgcg cctggccggc tcggcccaag ccggcggggt
      661 cctggataag gatggcaaga agaaacactc gcggccgact ttctctggcc agcagatctt
      721 cgcgctggag aagactttcg agcagaccaa gtacttggca ggcccagagc gcgcgcggct
      781 tgcctactct ctgggcatga ccgagagcca ggtgaaggtg tggttccaga atcggcggac
      841 caagtggcgc aagcggcacg cggcagagat ggcgtcggct aaaaagaagc aggactcgga
      901 tgccgagaag ctgaaggtgg gtggctcaga cgcggaggat gatgacgagt acaaccggcc
      961 cctggacccc aactccgatg acgagaagat cacgcggctt ctcaaaaagc acaaaccctc
     1021 gaacttggcg cttgttagcc cgtgtggcgg cagcgcgggg gacgccttgt gaggacgcgg
     1081 ccaggccgga gaaccccgag aactgggact cgcggcatac cccgacgcca gccgcccagc
     1141 cgcagtgtgt atatatattt ttacagaata agttataaag cggacgttgg cgcggcctcg
     1201 gcgtgaggcg cggagtgcgg ggtttgggcc gatcactttg tataatcaat aaattattta
     1261 acacgtc
//
