LOCUS       NM_001399522            1133 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus NK3 homeobox 2 (Nkx3-2), mRNA.
ACCESSION   NM_001399522 XM_008770239
VERSION     NM_001399522.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1133)
  AUTHORS   Kim,B.M., Woo,J., Kanellopoulou,C. and Shivdasani,R.A.
  TITLE     Regulation of mouse stomach development and Barx1 expression by
            specific microRNAs
  JOURNAL   Development 138 (6), 1081-1086 (2011)
   PUBMED   21307095
REFERENCE   2  (bases 1 to 1133)
  AUTHORS   Verzi,M.P., Stanfel,M.N., Moses,K.A., Kim,B.M., Zhang,Y.,
            Schwartz,R.J., Shivdasani,R.A. and Zimmer,W.E.
  TITLE     Role of the homeodomain transcription factor Bapx1 in mouse distal
            stomach development
  JOURNAL   Gastroenterology 136 (5), 1701-1710 (2009)
   PUBMED   19208343
REFERENCE   3  (bases 1 to 1133)
  AUTHORS   Provot,S., Kempf,H., Murtaugh,L.C., Chung,U.I., Kim,D.W.,
            Chyung,J., Kronenberg,H.M. and Lassar,A.B.
  TITLE     Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation
  JOURNAL   Development 133 (4), 651-662 (2006)
   PUBMED   16421188
REFERENCE   4  (bases 1 to 1133)
  AUTHORS   Lengner,C.J., Hassan,M.Q., Serra,R.W., Lepper,C., van Wijnen,A.J.,
            Stein,J.L., Lian,J.B. and Stein,G.S.
  TITLE     Nkx3.2-mediated repression of Runx2 promotes chondrogenic
            differentiation
  JOURNAL   J Biol Chem 280 (16), 15872-15879 (2005)
   PUBMED   15703179
REFERENCE   5  (bases 1 to 1133)
  AUTHORS   Hecksher-Sorensen,J., Watson,R.P., Lettice,L.A., Serup,P., Eley,L.,
            De Angelis,C., Ahlgren,U. and Hill,R.E.
  TITLE     The splanchnic mesodermal plate directs spleen and pancreatic
            laterality, and is regulated by Bapx1/Nkx3.2
  JOURNAL   Development 131 (19), 4665-4675 (2004)
   PUBMED   15329346
REFERENCE   6  (bases 1 to 1133)
  AUTHORS   Tucker,A.S., Watson,R.P., Lettice,L.A., Yamada,G. and Hill,R.E.
  TITLE     Bapx1 regulates patterning in the middle ear: altered regulatory
            role in the transition from the proximal jaw during vertebrate
            evolution
  JOURNAL   Development 131 (6), 1235-1245 (2004)
   PUBMED   14973294
REFERENCE   7  (bases 1 to 1133)
  AUTHORS   Lettice,L., Hecksher-Sorensen,J. and Hill,R.
  TITLE     The role of Bapx1 (Nkx3.2) in the development and evolution of the
            axial skeleton
  JOURNAL   J Anat 199 (Pt 1-2), 181-187 (2001)
   PUBMED   11523821
  REMARK    Review article
REFERENCE   8  (bases 1 to 1133)
  AUTHORS   Tribioli,C. and Lufkin,T.
  TITLE     The murine Bapx1 homeobox gene plays a critical role in embryonic
            development of the axial skeleton and spleen
  JOURNAL   Development 126 (24), 5699-5711 (1999)
   PUBMED   10572046
REFERENCE   9  (bases 1 to 1133)
  AUTHORS   Lettice,L.A., Purdie,L.A., Carlson,G.J., Kilanowski,F., Dorin,J.
            and Hill,R.E.
  TITLE     The mouse bagpipe gene controls development of axial skeleton,
            skull, and spleen
  JOURNAL   Proc Natl Acad Sci U S A 96 (17), 9695-9700 (1999)
   PUBMED   10449756
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jan 10, 2022 this sequence version replaced XM_008770239.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.51950.1,
                                           SRR21887620.1563527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680442
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               JAXUCZ010000014.1  73396198-73396673
            477-1133            JAXUCZ010000014.1  73397929-73398585
FEATURES             Location/Qualifiers
     source          1..1133
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1133
                     /gene="Nkx3-2"
                     /note="NK3 homeobox 2"
                     /db_xref="GeneID:682329"
                     /db_xref="RGD:1584617"
     exon            1..476
                     /gene="Nkx3-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1012
                     /gene="Nkx3-2"
                     /codon_start=1
                     /product="homeobox protein Nkx-3.2"
                     /protein_id="NP_001386451.1"
                     /db_xref="GeneID:682329"
                     /db_xref="RGD:1584617"
                     /translation="MAVRSSSTLTPFSIQAILNKKEERGGLAAPEGRPAPGGTEVAVA
                     AAPAVCCWRLFGETEAGALGGAEDSLLASPARTRTAVGHSAESPGGWDSDSALSEENE
                     GRRRCADVPGASGTGHARVTLGLEQHAAKDLEEEARIRSDSEMSASVSGDHSPRGEDG
                     SVSPGGARVPGLCGTAGGGASSGQAGGVEEEEEPAAPKPRKKRSRAAFSHAQVFELER
                     RFNHQRYLSGPERADLAASLKLTETQVKIWFQNRRYKTKRRQMAADLLASAPAAKKVA
                     VKVLVRDDQRQYLPGEVLRPPSLLPLQPSYYYPYYCFPGWALSTCAAAAGTQ"
     exon            477..1133
                     /gene="Nkx3-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgccggctc cgatccgcgg cgcagatggc tgtgcgcagc agcagcacct tgacgccctt
       61 ctccatccag gcgatcctca acaagaaaga ggagcgtggc gggctggccg cgcccgaggg
      121 gcgcccggca ccagggggca cagaggtggc agtggccgcg gcgcccgccg tctgctgctg
      181 gcggctcttc ggggagaccg aggccggtgc gctggggggc gccgaggact ctcttctggc
      241 gtctcccgcc cgaaccagaa cagctgtggg gcacagcgcg gagagccccg gaggttggga
      301 ctcggactca gccctgagcg aagagaatga gggcaggagg cgctgcgccg acgtcccggg
      361 agccagtgga acgggccacg ctagggtgac cctgggcctg gagcagcacg ccgccaagga
      421 cctggaggag gaagcccgga tccgcagcga cagcgagatg tcagccagcg tttcaggcga
      481 ccacagccca agaggcgagg acggcagtgt tagccctgga ggtgcacgcg tgcctgggtt
      541 gtgcggcaca gcgggcggcg gggctagcag cgggcaggcg ggcggcgtgg aggaggagga
      601 agagcccgca gcccctaagc cgcgaaagaa gcgctctcgg gcagccttct ctcacgccca
      661 ggtcttcgag ctggagcgcc ggtttaacca tcagcgctac ctgtccggac cggaacgcgc
      721 tgacctggca gcttcactga agctcacaga gacgcaagtg aagatctggt ttcagaaccg
      781 tcgctacaag accaaacgcc ggcagatggc cgccgacctg ctcgcctcag cacccgccgc
      841 caagaaagtg gccgtaaagg tgctggtgcg tgacgaccaa agacagtatt tgcccggaga
      901 ggtgttgagg ccaccttctc ttctgccact gcagccctcc tactactacc cttactactg
      961 cttcccgggc tgggcgctgt ccacatgcgc ggccgctgct ggtacccagt gaagcgtttg
     1021 ggaccaggca gagaaggatc cccagtttgc atcgccgcgg acaggtgtag aaattgtacc
     1081 cagtgtaggc gagctctggc aacctgggca aggtgcaggt ggagaatgaa atc
//
