LOCUS       NM_001034144            1800 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus NK3 homeobox 1 (Nkx3-1), mRNA.
ACCESSION   NM_001034144 XM_224360
VERSION     NM_001034144.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1800)
  AUTHORS   Lee JM, Kim U, Yang H, Ryu B, Kim J, Sakuma T, Yamamoto T and Park
            JH.
  TITLE     TALEN-mediated generation of Nkx3.1 knockout rat model
  JOURNAL   Prostate 81 (3), 182-193 (2021)
   PUBMED   33368416
  REMARK    GeneRIF: TALEN-mediated generation of Nkx3.1 knockout rat model.
REFERENCE   2  (bases 1 to 1800)
  AUTHORS   Jiang J, Liu Z, Ge C, Chen C, Zhao F, Li H, Chen T, Yao M and Li J.
  TITLE     NK3 homeobox 1 (NKX3.1) up-regulates forkhead box O1 expression in
            hepatocellular carcinoma and thereby suppresses tumor proliferation
            and invasion
  JOURNAL   J Biol Chem 292 (47), 19146-19159 (2017)
   PUBMED   28972178
REFERENCE   3  (bases 1 to 1800)
  AUTHORS   Mitani T, Yamaji R, Higashimura Y, Harada N, Nakano Y and Inui H.
  TITLE     Hypoxia enhances transcriptional activity of androgen receptor
            through hypoxia-inducible factor-1alpha in a low androgen
            environment
  JOURNAL   J Steroid Biochem Mol Biol 123 (1-2), 58-64 (2011)
   PUBMED   21056661
REFERENCE   4  (bases 1 to 1800)
  AUTHORS   Akamatsu S, Takata R, Ashikawa K, Hosono N, Kamatani N, Fujioka T,
            Ogawa O, Kubo M, Nakamura Y and Nakagawa H.
  TITLE     A functional variant in NKX3.1 associated with prostate cancer
            susceptibility down-regulates NKX3.1 expression
  JOURNAL   Hum Mol Genet 19 (21), 4265-4272 (2010)
   PUBMED   20716579
REFERENCE   5  (bases 1 to 1800)
  AUTHORS   Kusy S, Gerby B, Goardon N, Gault N, Ferri F, Gerard D, Armstrong
            F, Ballerini P, Cayuela JM, Baruchel A, Pflumio F and Romeo PH.
  TITLE     NKX3.1 is a direct TAL1 target gene that mediates proliferation of
            TAL1-expressing human T cell acute lymphoblastic leukemia
  JOURNAL   J Exp Med 207 (10), 2141-2156 (2010)
   PUBMED   20855495
REFERENCE   6  (bases 1 to 1800)
  AUTHORS   Carson JA, Fillmore RA, Schwartz RJ and Zimmer WE.
  TITLE     The smooth muscle gamma-actin gene promoter is a molecular target
            for the mouse bagpipe homologue, mNkx3-1, and serum response factor
  JOURNAL   J Biol Chem 275 (50), 39061-39072 (2000)
   PUBMED   10993896
REFERENCE   7  (bases 1 to 1800)
  AUTHORS   Schneider A, Brand T, Zweigerdt R and Arnold H.
  TITLE     Targeted disruption of the Nkx3.1 gene in mice results in
            morphogenetic defects of minor salivary glands: parallels to
            glandular duct morphogenesis in prostate
  JOURNAL   Mech Dev 95 (1-2), 163-174 (2000)
   PUBMED   10906459
REFERENCE   8  (bases 1 to 1800)
  AUTHORS   Bhatia-Gaur R, Donjacour AA, Sciavolino PJ, Kim M, Desai N, Young
            P, Norton CR, Gridley T, Cardiff RD, Cunha GR, Abate-Shen C and
            Shen MM.
  TITLE     Roles for Nkx3.1 in prostate development and cancer
  JOURNAL   Genes Dev 13 (8), 966-977 (1999)
   PUBMED   10215624
REFERENCE   9  (bases 1 to 1800)
  AUTHORS   Tanaka M, Kasahara H, Bartunkova S, Schinke M, Komuro I, Inagaki H,
            Lee Y, Lyons GE and Izumo S.
  TITLE     Vertebrate homologs of tinman and bagpipe: roles of the homeobox
            genes in cardiovascular development
  JOURNAL   Dev Genet 22 (3), 239-249 (1998)
   PUBMED   9621431
REFERENCE   10 (bases 1 to 1800)
  AUTHORS   Sciavolino PJ, Abrams EW, Yang L, Austenberg LP, Shen MM and
            Abate-Shen C.
  TITLE     Tissue-specific expression of murine Nkx3.1 in the male urogenital
            system
  JOURNAL   Dev Dyn 209 (1), 127-138 (1997)
   PUBMED   9142502
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100628.1.
            
            On Oct 14, 2005 this sequence version replaced XM_224360.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100628.1, CA339706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1800
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..1800
                     /gene="Nkx3-1"
                     /gene_synonym="Nkx3.1"
                     /note="NK3 homeobox 1"
                     /db_xref="GeneID:305999"
                     /db_xref="RGD:1305369"
     exon            1..299
                     /gene="Nkx3-1"
                     /gene_synonym="Nkx3.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..721
                     /gene="Nkx3-1"
                     /gene_synonym="Nkx3.1"
                     /note="NK-3 transcription factor, locus 1"
                     /codon_start=1
                     /product="homeobox protein Nkx-3.1"
                     /protein_id="NP_001029316.1"
                     /db_xref="GeneID:305999"
                     /db_xref="RGD:1305369"
                     /translation="MLRVAEPQEARLEAGGRSPWAAPPTQSKRLTSFLIQDILRDHAE
                     RRGGQPSTPQHQCQPDPKRDSASELDEAEGSSVTLEDPPGIRSSPTETRAETESDAHF
                     ETYLLDCEHTPVLSSAPQVTKQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLA
                     KNLKLTETQVKIWFQNRRYKTKRRQLSEDLGVLEKNSTLSLPTLKDDSLSRASLVSVY
                     ASYPYYPYLYCLGSWHPTFW"
     exon            300..1782
                     /gene="Nkx3-1"
                     /gene_synonym="Nkx3.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggatgctt agggtagcgg agccccaaga ggcacggttg gaggcgggtg gtcgcagtcc
       61 ctgggcagcg ccacccacgc agtccaagcg gctcacgtcc ttcctcatcc aggacatcct
      121 gcgggaccac gcagagcggc gtgggggaca gccgagcacc ccgcagcacc agtgccaacc
      181 agaccctaag agggattctg cttcagagct cgacgaagca gagggtagca gtgtgactct
      241 ggaggacccg ccaggtatcc ggtcgagccc cacagagaca cgggctgaaa ccgagtcaga
      301 tgcacatttt gagacttatc tgttggactg tgaacatact ccagtcttat caagtgcccc
      361 ccaggtcacc aagcagccac agaagcgttc ccgggctgct ttctctcaca ctcaggtgat
      421 tgagttggag aggaagttca gccatcagaa gtacctgtcc gcccctgaaa gggctcacct
      481 ggccaagaac ctcaaactca ccgaaaccca agtaaaaata tggttccaga acagacgcta
      541 caagactaag cgaaggcagc tgtcagaaga cctgggagtc ttggagaaga actccacatt
      601 gtctttgcca accctgaaag atgacagcct atccagggcc tccttggtct ccgtgtatgc
      661 tagctacccc tactacccct acctatactg tctgggcagc tggcatccaa ctttctggta
      721 acaacagttc agatgacaac tgcatagatc agaaactgcc ttccctgggg gtccctggga
      781 aaaagccaga gtggctgatg tcaaggagtt gaaagcaaga agtgtacaga cacaaactgt
      841 tgggtgttcc cagggaatac tccgattctt ctctggtggc caatgaaaga tctggggcag
      901 tggacatttt attatgtagt cacagttcca agtgttctgt aggtcacggc tgtcagttcc
      961 ctgtttagag agagctagac aagttcaagt cttatttcca gagcttagag tggctatggc
     1021 tgcaatggct acatcgttcc taagaattct gttgctgcaa tttcatcctc tcccataact
     1081 gggtatcatg aaagggccaa gcaaggggag ggatggcccc ttagatgagg atttcctctt
     1141 gaattaaact tgtgtttaaa agtctcttgt tggccttgga ctctgaccag agtttccctc
     1201 tgcccttgta aaagtgaggg taaacgggag atttgaagaa ggggagaaaa aaccttagtg
     1261 attaagcagg ttggcatagg acatgaaggg gctggaaggt ggcattttca acttcttact
     1321 ccttttgcag tgatgtgcca atccaaggat ttacagggca gcctgagtgc agcagggtac
     1381 atatactgaa gggggttaag acaagctgtg taaacagttt gcctgcaggg gtgggcttca
     1441 gaacagactt cctgtccaag acaagggcct atggggtttc caaactccag gtgagctgct
     1501 tcggtcatga cattttatta ccagtgaagg gggaggggag atcttagact caggagatcc
     1561 tgcagcttcc ctggtctgag aattcacacc tcattatgac agaggtgcca tcatttttaa
     1621 acaaaggatc ttccttctat tcttttattt cttgttcttt cttacaggac tcctcagttc
     1681 attgttttca tatatgcctg tcttatttag tgtaagattt gctcccacca cctcccaagt
     1741 tttatctttc ccagtttaat aactaactag cttcagacag ataaaaaaaa aaaaaaaaaa
//
