LOCUS       NM_053651               1427 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus NK2 homeobox 5 (Nkx2-5), mRNA.
ACCESSION   NM_053651
VERSION     NM_053651.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1427)
  AUTHORS   Lai,G., Wang,L., Li,Z. and Zhao,Y.
  TITLE     Homocysteine downregulates cardiac homeobox transcription factor
            NKX2.5 via IGFBP5
  JOURNAL   Am J Physiol Heart Circ Physiol 319 (6), H1380-H1386 (2020)
   PUBMED   33035436
  REMARK    GeneRIF: Homocysteine downregulates cardiac homeobox transcription
            factor NKX2.5 via IGFBP5.
REFERENCE   2  (bases 1 to 1427)
  AUTHORS   Wang,H., Liu,Y., Han,S., Zi,Y., Zhang,Y., Kong,R., Liu,Z., Cai,Z.,
            Zhong,C., Liu,W., Li,L. and Jiang,L.
  TITLE     Nkx2-5 Regulates the Proliferation and Migration of H9c2 Cells
  JOURNAL   Med Sci Monit 26, e925388 (2020)
   PUBMED   32780729
  REMARK    GeneRIF: Nkx2-5 Regulates the Proliferation and Migration of H9c2
            Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1427)
  AUTHORS   Liang,X., Chu,G., Wang,L., Lai,G. and Zhao,Y.
  TITLE     Role of Nkx2.5 in H2O2-induced Nsd1 suppression
  JOURNAL   Cell Stress Chaperones 24 (4), 697-707 (2019)
   PUBMED   31104268
  REMARK    GeneRIF: The authors findings suggest that Nkx2.5, as a
            transcription factor, may be a regulatory element connecting
            different signaling pathways in response to oxidative stress and
            that reduced Nsd1 (Nuclear receptor-binding SET domain-containing
            protein 1) expression could lead to the alteration of global H3K36
            and H4K20 methylation, influencing cardiac development.
REFERENCE   4  (bases 1 to 1427)
  AUTHORS   Syam,N., Chatel,S., Ozhathil,L.C., Sottas,V., Rougier,J.S.,
            Baruteau,A., Baron,E., Amarouch,M.Y., Daumy,X., Probst,V.,
            Schott,J.J. and Abriel,H.
  TITLE     Variants of Transient Receptor Potential Melastatin Member 4 in
            Childhood Atrioventricular Block
  JOURNAL   J Am Heart Assoc 5 (5), e001625 (2016)
   PUBMED   27207958
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1427)
  AUTHORS   Fu,Y., Ruiz-Lozano,P. and Evans,S.M.
  TITLE     A rat homeobox gene, rNKx-2.5, is a homologue of the tinman gene in
            Drosophila and is mainly expressed during heart development
  JOURNAL   Dev Genes Evol 207 (5), 352-358 (1997)
   PUBMED   27747432
REFERENCE   6  (bases 1 to 1427)
  AUTHORS   Durocher,D., Charron,F., Warren,R., Schwartz,R.J. and Nemer,M.
  TITLE     The cardiac transcription factors Nkx2-5 and GATA-4 are mutual
            cofactors
  JOURNAL   EMBO J 16 (18), 5687-5696 (1997)
   PUBMED   9312027
REFERENCE   7  (bases 1 to 1427)
  AUTHORS   Biben,C. and Harvey,R.P.
  TITLE     Homeodomain factor Nkx2-5 controls left/right asymmetric expression
            of bHLH gene eHand during murine heart development
  JOURNAL   Genes Dev 11 (11), 1357-1369 (1997)
   PUBMED   9192865
REFERENCE   8  (bases 1 to 1427)
  AUTHORS   Chen,C.Y. and Schwartz,R.J.
  TITLE     Recruitment of the tinman homolog Nkx-2.5 by serum response factor
            activates cardiac alpha-actin gene transcription
  JOURNAL   Mol Cell Biol 16 (11), 6372-6384 (1996)
   PUBMED   8887666
REFERENCE   9  (bases 1 to 1427)
  AUTHORS   Chen,C.Y., Croissant,J., Majesky,M., Topouzis,S., McQuinn,T.,
            Frankovsky,M.J. and Schwartz,R.J.
  TITLE     Activation of the cardiac alpha-actin promoter depends upon serum
            response factor, Tinman homologue, Nkx-2.5, and intact serum
            response elements
  JOURNAL   Dev Genet 19 (2), 119-130 (1996)
   PUBMED   8900044
REFERENCE   10 (bases 1 to 1427)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053651.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF006664.1, CK359509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-437               JAXUCZ010000010.1  16848600-16849036
            438-1427            JAXUCZ010000010.1  16850469-16851458
FEATURES             Location/Qualifiers
     source          1..1427
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1427
                     /gene="Nkx2-5"
                     /gene_synonym="Csx; Nkx2.5"
                     /note="NK2 homeobox 5"
                     /db_xref="GeneID:114109"
                     /db_xref="RGD:620520"
     exon            1..437
                     /gene="Nkx2-5"
                     /gene_synonym="Csx; Nkx2.5"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1066
                     /gene="Nkx2-5"
                     /gene_synonym="Csx; Nkx2.5"
                     /note="rNKx-2.5; homeobox protein NK-2 homolog E"
                     /codon_start=1
                     /product="homeobox protein Nkx-2.5"
                     /protein_id="NP_446103.2"
                     /db_xref="GeneID:114109"
                     /db_xref="RGD:620520"
                     /translation="MFPSPALTHTPFSVKDILNLEQQQRSLAAGDLSARLEATLAPAS
                     CMLAAFKPEAYSGPEAAAPGLAELRAELGPAPSPPKCSPAFPTAPTFYPRAYGDPDPA
                     KDPRADKKELCALQKAVELDKAETDGAERPRARRRRKPRVLFSQAQVYELERRFKQQR
                     YLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQDQTLELLGPPPPPARRIAVPV
                     LVRDGKPCLGDSAAYAPAYGVGLNAYGYNAYPYPGYGGAACSPAYSCAAAYPAAPPAA
                     QPPAAAANSNFVNFGVGDLNTVQSPGMPQGNSGVSTLHGIRAW"
     exon            438..1427
                     /gene="Nkx2-5"
                     /gene_synonym="Csx; Nkx2.5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggtgcgcg ggcggacagc gggcaccatg cgggaaggct atccccgggg gtgggcagtg
       61 ccactctctg ccacccacct ggcgctgtga gaccggcgtc gccaccatgt tccccagccc
      121 tgcgctcaca cacacgccct tctcagtcaa agacatcctg aacctggagc agcagcagcg
      181 cagcctggcg gctggggacc tgtctgcgcg cctcgaggcc accctggcgc ccgcctcctg
      241 catgctggcc gccttcaagc cggaggccta ctcaggcccc gaggcggcag cgcccggcct
      301 ggcagagctg cgcgcggagc tgggccccgc gccttcgccc cccaagtgct ctcctgcttt
      361 cccaaccgcc cctacatttt atccgcgagc ctacggtgac cctgaccccg ccaaggaccc
      421 tcgggcggat aagaaagagc tgtgcgcgct gcagaaggcg gtggagctgg acaaagccga
      481 gacagacggc gccgagcgac cacgcgcgcg gcggcgacgg aagccacgcg tgctcttctc
      541 gcaggcgcag gtctatgagc tggagcggcg cttcaagcaa cagcggtacc tgtcggcgcc
      601 tgagcgcgac caactggcca gcgtgctgaa gctcacgtcc acgcaggtca agatctggtt
      661 ccagaaccgc cgctacaagt gtaagcgaca gcggcaggac cagactctgg agctgctggg
      721 gccgccgccg ccgcccgcgc gcaggatcgc ggtgccggtg ttggtgcgcg acgggaagcc
      781 ctgcctgggg gactcggcgg cctacgctcc cgcctacggc gtgggtctca acgcctacgg
      841 ctacaacgcc tacccctatc ccggctacgg tggcgcggcc tgcagtcccg cctacagctg
      901 cgcagccgcg taccccgccg cgccccccgc cgcgcagccc ccagccgcag cggccaacag
      961 caacttcgtg aacttcggcg tcggggactt gaacacggtg cagagtcccg ggatgccaca
     1021 gggcaattcg ggcgtctcca cgctgcacgg catccgagcc tggtagggaa agggcccgtc
     1081 tggggcaccc cggaccgact cccaccttta ggagaagggc gatgactccg gggatggaaa
     1141 ggctcccact gtgtcctgtc cctcggattt cacacccaca cttgcgcagg cctgggacct
     1201 ttctccgatc catccccttt tgttgaccta acctgatgcc tcggtcctgg gaaagccctt
     1261 ccagggccaa ggcaccctcc acggattccc atactaggac ccggagcctg ggccgggcgc
     1321 ccgggccctg ggtgccttgc cgccacccac ccacccgtat ttatgttttt acctgttgct
     1381 gtaagaaatg agaaccctct tcccattaaa gtgagtgcgc taacgca
//
