LOCUS       NM_001107594            1472 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus NK2 homeobox 3 (Nkx2-3), mRNA.
ACCESSION   NM_001107594 XM_001056222 XM_219880
VERSION     NM_001107594.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1472)
  AUTHORS   Zheng H, Zhai W, Zhong C, Hong Q, Li H, Rui B, Zhu X, Que D, Feng
            L, Yu B, Huang G, Yin J, Li J, Yan J and Yang P.
  TITLE     Nkx2-3 induces autophagy inhibiting proliferation and migration of
            vascular smooth muscle cells via AMPK/mTOR signaling pathway
  JOURNAL   J Cell Physiol 236 (11), 7342-7355 (2021)
   PUBMED   33928642
  REMARK    GeneRIF: Nkx2-3 induces autophagy inhibiting proliferation and
            migration of vascular smooth muscle cells via AMPK/mTOR signaling
            pathway.
REFERENCE   2  (bases 1 to 1472)
  AUTHORS   Tarlinton D, Light A, Metcalf D, Harvey RP and Robb L.
  TITLE     Architectural defects in the spleens of Nkx2-3-deficient mice are
            intrinsic and associated with defects in both B cell maturation and
            T cell-dependent immune responses
  JOURNAL   J Immunol 170 (8), 4002-4010 (2003)
   PUBMED   12682228
REFERENCE   3  (bases 1 to 1472)
  AUTHORS   Biben C, Wang CC and Harvey RP.
  TITLE     NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is
            required for salivary gland and tooth morphogenesis
  JOURNAL   Int J Dev Biol 46 (4), 415-422 (2002)
   PUBMED   12141427
REFERENCE   4  (bases 1 to 1472)
  AUTHORS   Wang CC, Biben C, Robb L, Nassir F, Barnett L, Davidson NO,
            Koentgen F, Tarlinton D and Harvey RP.
  TITLE     Homeodomain factor Nkx2-3 controls regional expression of leukocyte
            homing coreceptor MAdCAM-1 in specialized endothelial cells of the
            viscera
  JOURNAL   Dev Biol 224 (2), 152-167 (2000)
   PUBMED   10926756
REFERENCE   5  (bases 1 to 1472)
  AUTHORS   Pabst O, Forster R, Lipp M, Engel H and Arnold HH.
  TITLE     NKX2.3 is required for MAdCAM-1 expression and homing of
            lymphocytes in spleen and mucosa-associated lymphoid tissue
  JOURNAL   EMBO J 19 (9), 2015-2023 (2000)
   PUBMED   10790368
REFERENCE   6  (bases 1 to 1472)
  AUTHORS   Pabst O, Zweigerdt R and Arnold HH.
  TITLE     Targeted disruption of the homeobox transcription factor Nkx2-3 in
            mice results in postnatal lethality and abnormal development of
            small intestine and spleen
  JOURNAL   Development 126 (10), 2215-2225 (1999)
   PUBMED   10207146
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001056222.1, XM_219880.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN11044071,
                              SAMN12840112 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1472
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1472
                     /gene="Nkx2-3"
                     /note="NK2 homeobox 3"
                     /db_xref="GeneID:309389"
                     /db_xref="RGD:1308521"
     exon            1..350
                     /gene="Nkx2-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..1090
                     /gene="Nkx2-3"
                     /codon_start=1
                     /product="homeobox protein Nkx-2.3"
                     /protein_id="NP_001101064.1"
                     /db_xref="GeneID:309389"
                     /db_xref="RGD:1308521"
                     /translation="MMIPSPVTSTPFSVKDILNLEQQRHFHGAHLQAELEQHLHSAPC
                     MLAAAEGTQFSDAGEEDEEEEGEKLSYLNSLAAAEGHGVSGLCPQSYVHTVLRDSCSG
                     PKEQEEEVVSERSQKSCQLKKSLEAAGDCKASEDGERPKPRSRRKPRVLFSQAQVFEL
                     ERRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGTHAPPP
                     PPRRVAVPVLVRDGKPCVTPSAQAYGSPYGVGAGAYSYNSFPAYGYGNSAAAAAAAAA
                     AAAAAAAYSGSYGCAYPTGGGGGGGGAASAATTAMQPACSATGGGSFVNVGNLGGFGS
                     GGGAQPLHQGAAAGAACAQGTLQGIRAW"
     exon            351..1472
                     /gene="Nkx2-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgatgata ccaagcccgg tcacctccac ccctttctca gtcaaagaca ttttgaatct
       61 ggaacagcag cggcacttcc acggagcaca cttgcaggcg gaattggagc agcacttaca
      121 ctcggcgccc tgcatgctgg cagctgctga agggacgcag ttttctgatg caggggagga
      181 ggacgaggaa gaagagggag agaaattgtc ctatttgaac tcactagcgg ccgccgaggg
      241 ccacggagtt tcgggtctct gtcctcagag ctatgtccat acagtccttc gagactcttg
      301 cagcgggccc aaggagcaag aagaggaggt tgtgagcgaa cggagccaaa aaagctgcca
      361 gttgaagaag tctctcgaag cggcgggaga ctgtaaagcg agcgaggacg gcgagaggcc
      421 gaagcctcgc agccgccgga agccccgggt gctcttctcg caagctcagg tctttgagct
      481 ggagcgcagg ttcaagcagc agcggtacct gtcggcgccc gagcgcgagc atcttgccag
      541 cagcctgaag ctcacgtcca cacaggtgaa gatctggttc cagaatcgca ggtacaagtg
      601 caagagacag cgacaggaca agtccctgga gctggggacc cacgcgccgc cgccgccgcc
      661 ccgccgcgtg gcagtgccgg tgctcgtgcg ggacggcaaa ccgtgcgtca ctcccagcgc
      721 gcaagcctac ggctcgccct acggcgtggg tgccggcgcc tactcctaca acagcttccc
      781 cgcctacggc tacgggaact cggcggccgc agccgctgca gcagcagcag ccgcagccgc
      841 agccgcggct tacagcggca gctacggctg cgcctacccg acaggcggcg gcggcggtgg
      901 tggcggcgca gcctccgccg cgaccaccgc aatgcaaccc gcctgcagcg ccaccggcgg
      961 cggatctttt gtgaacgtgg gcaacctggg aggcttcggc agcggcggcg gcgcgcaacc
     1021 cttgcatcaa ggtgccgcag ctggagccgc gtgcgcgcag gggaccttgc agggcatcag
     1081 ggcttggtaa ggtctgggca ggacacgcgg ctggcgtcct accgcaagct gggcgccgcg
     1141 ggaacgagac acgagaaagg acagacccaa gggccatgtc ccctcgttaa aataaaatac
     1201 agacgtatcg ctccttccaa ggggccaggg tcgcagcaca ctccaggcct gggaaagggc
     1261 tcagcggaga aaagatgccc tggtccagtc gtcgtcaaga ctgtttgaga cagaaacacc
     1321 ggccgggcgc cagggagcag gtggcctccc caccctggct ctgtggggag tgcgggaggc
     1381 tgtcgcttgc tctccggagg aggagggggt gcttttctct tgccttccct tggccttctc
     1441 gtagtgtggt cagggaaccg gaccgaacag gg
//
