LOCUS       NM_001191904            1393 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus NK2 homeobox 2 (Nkx2-2), mRNA.
ACCESSION   NM_001191904 XM_345446
VERSION     NM_001191904.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1393)
  AUTHORS   Lin,S.T., Huang,Y., Zhang,L., Heng,M.Y., Ptacek,L.J. and Fu,Y.H.
  TITLE     MicroRNA-23a promotes myelination in the central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 110 (43), 17468-17473 (2013)
   PUBMED   24101522
REFERENCE   2  (bases 1 to 1393)
  AUTHORS   Chen,S., Shimoda,M., Chen,J., Matsumoto,S. and Grayburn,P.A.
  TITLE     Ectopic transgenic expression of NKX2.2 induces differentiation of
            adult pancreatic progenitors and mediates islet regeneration
  JOURNAL   Cell Cycle 11 (8), 1544-1553 (2012)
   PUBMED   22433950
  REMARK    GeneRIF: Nkx2.2 targeted to the pancreas by UTMD induces pancreatic
            progenitor cell proliferation and differentiation with subsequent
            islet regeneration and cure of STZ-induced diabetes for three
            months.
REFERENCE   3  (bases 1 to 1393)
  AUTHORS   Wang,T., Jia,L., Yang,G., Ji,S., Yao,L. and Zhang,B.
  TITLE     Identification of Juxtanodin promoter and its transcriptional
            regulation during the ATRA-induced differentiation of C6 cells
  JOURNAL   Mol Cell Biochem 350 (1-2), 177-183 (2011)
   PUBMED   21221725
  REMARK    GeneRIF: Nkx2.2 is one of the essential transcription factors
            delivering the specificity of JN promoter in oligodendrocytes.
REFERENCE   4  (bases 1 to 1393)
  AUTHORS   Anderson,K.R., Torres,C.A., Solomon,K., Becker,T.C., Newgard,C.B.,
            Wright,C.V., Hagman,J. and Sussel,L.
  TITLE     Cooperative transcriptional regulation of the essential pancreatic
            islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3
  JOURNAL   J Biol Chem 284 (45), 31236-31248 (2009)
   PUBMED   19759004
REFERENCE   5  (bases 1 to 1393)
  AUTHORS   Prakash,N., Puelles,E., Freude,K., Trumbach,D., Omodei,D., Di
            Salvio,M., Sussel,L., Ericson,J., Sander,M., Simeone,A. and
            Wurst,W.
  TITLE     Nkx6-1 controls the identity and fate of red nucleus and oculomotor
            neurons in the mouse midbrain
  JOURNAL   Development 136 (15), 2545-2555 (2009)
   PUBMED   19592574
REFERENCE   6  (bases 1 to 1393)
  AUTHORS   Qi,Y., Cai,J., Wu,Y., Wu,R., Lee,J., Fu,H., Rao,M., Sussel,L.,
            Rubenstein,J. and Qiu,M.
  TITLE     Control of oligodendrocyte differentiation by the Nkx2.2
            homeodomain transcription factor
  JOURNAL   Development 128 (14), 2723-2733 (2001)
   PUBMED   11526078
REFERENCE   7  (bases 1 to 1393)
  AUTHORS   Briscoe,J., Pierani,A., Jessell,T.M. and Ericson,J.
  TITLE     A homeodomain protein code specifies progenitor cell identity and
            neuronal fate in the ventral neural tube
  JOURNAL   Cell 101 (4), 435-445 (2000)
   PUBMED   10830170
REFERENCE   8  (bases 1 to 1393)
  AUTHORS   Briscoe,J., Sussel,L., Serup,P., Hartigan-O'Connor,D.,
            Jessell,T.M., Rubenstein,J.L. and Ericson,J.
  TITLE     Homeobox gene Nkx2.2 and specification of neuronal identity by
            graded Sonic hedgehog signalling
  JOURNAL   Nature 398 (6728), 622-627 (1999)
   PUBMED   10217145
REFERENCE   9  (bases 1 to 1393)
  AUTHORS   Sussel,L., Kalamaras,J., Hartigan-O'Connor,D.J., Meneses,J.J.,
            Pedersen,R.A., Rubenstein,J.L. and German,M.S.
  TITLE     Mice lacking the homeodomain transcription factor Nkx2.2 have
            diabetes due to arrested differentiation of pancreatic beta cells
  JOURNAL   Development 125 (12), 2213-2221 (1998)
   PUBMED   9584121
REFERENCE   10 (bases 1 to 1393)
  AUTHORS   Ericson,J., Rashbass,P., Schedl,A., Brenner-Morton,S., Kawakami,A.,
            van Heyningen,V., Jessell,T.M. and Briscoe,J.
  TITLE     Pax6 controls progenitor cell identity and neuronal fate in
            response to graded Shh signaling
  JOURNAL   Cell 90 (1), 169-180 (1997)
   PUBMED   9230312
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jul 17, 2010 this sequence version replaced XM_345446.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.19201.1,
                                           SRR26360194.1505905.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-555               JAXUCZ010000003.1  155075068-155075622 c
            556-1393            JAXUCZ010000003.1  155073250-155074087 c
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1393
                     /gene="Nkx2-2"
                     /note="NK2 homeobox 2"
                     /db_xref="GeneID:366214"
                     /db_xref="RGD:1308443"
     exon            1..555
                     /gene="Nkx2-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..1118
                     /gene="Nkx2-2"
                     /note="NK2 transcription factor related, locus 2"
                     /codon_start=1
                     /product="homeobox protein Nkx-2.2"
                     /protein_id="NP_001178833.1"
                     /db_xref="GeneID:366214"
                     /db_xref="RGD:1308443"
                     /translation="MSLTNTKTGFSVKDILDLPDTNDEEGSVAEGPEEENEGPEPAKR
                     AGPLGQSALDAVQSLPLKSPFYDSSDNPYTRWLASTEGLQYSLHGLAASAPPQDSSSK
                     SPEPSADESPDNDKETQGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREH
                     LASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHAL
                     KAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW"
     exon            556..1393
                     /gene="Nkx2-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagttacaaa ctgaggccgc gcggcgctgg gcccgcaggc cgccagtcac agcctacatt
       61 tctgcgtgct ttccgagaag agagaggcgc cgggtgggct ttattatttt tccctcttcc
      121 cttttcccac agtgtcctct cattttaaat aataattatc ccaataatta aaacccatcc
      181 ccctccctcc cctattcctt cccttaaccc ctcccccccc cgccggggct ggggagagcc
      241 acgaattgac caagtgaggc tacaactttg tggcataaat tgcggggtcc ggaaccatgt
      301 cgctgaccaa cacaaagacg gggttttcag tcaaggacat cttggacctt ccggacacca
      361 acgatgaaga aggctcggtg gccgaagggc cggaggagga gaacgaaggg ccggagccgg
      421 ccaagagggc cgggccgcta gggcagagcg ccttggatgc tgtgcagagc ctgcccctta
      481 agagtccttt ctacgacagc agcgacaacc cctacactcg ctggctggcc agcaccgagg
      541 gcctccaata ctccctgcac ggactggcgg cgagcgctcc cccccaagac tcgagctcca
      601 agtccccaga gccctcggct gacgagtcac cggacaatga caaggagacc cagggcggcg
      661 ggggggacgc aggcaagaag cggaagcgcc gagtgctctt ctccaaagcg cagacctacg
      721 agctggagcg gcgcttccgg cagcagcggt acctgtcggc gcccgagcgc gagcacctgg
      781 ccagcctcat ccgtctcacg cccacgcagg tcaagatctg gttccaaaac catcgctaca
      841 agatgaaacg tgcccgggct gagaaaggta tggaggtgac gcctctaccc tcgccgcgcc
      901 gtgtggcagt gccggtcttg gtcagggacg gcaaaccgtg ccacgcgctc aaagcccagg
      961 acctggcagc tgccaccttc caggcaggca tccccttttc cgcctacagc gcgcagtcgc
     1021 tgcagcacat gcaatacaac gcccagtaca gctcggccag caccccccag tacccgacag
     1081 cacaccccct ggtccaggcc cagcagtgga cttggtgagc gccgcccctc caagactgga
     1141 ggccttaggc cctggcccca ccccagcggc ggcggtggcg aggaggactc gatccttacc
     1201 acggttgtta ttattattat tataattatt atagagtcgg actctcggct cggttgagga
     1261 ggcaccggga ggttgcctgt gcctcctcga gtggcagatt ccatcgactc tgccccaccg
     1321 ctctctcctt tgaacttttg gagagggtag aactctaagc cgtgtttaca gaatgtttgt
     1381 gcagcttcgc ttc
//
