LOCUS       NM_013093               2297 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus NK2 homeobox 1 (Nkx2-1), mRNA.
ACCESSION   NM_013093 XM_001079296 XM_216720
VERSION     NM_013093.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2297)
  AUTHORS   Zang,S., Yin,X. and Li,P.
  TITLE     Downregulation of TTF1 in the rat hypothalamic ARC or AVPV nucleus
            inhibits Kiss1 and GnRH expression, leading to puberty delay
  JOURNAL   Reprod Biol Endocrinol 19 (1), 30 (2021)
   PUBMED   33622350
  REMARK    GeneRIF: Downregulation of TTF1 in the rat hypothalamic ARC or AVPV
            nucleus inhibits Kiss1 and GnRH expression, leading to puberty
            delay.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2297)
  AUTHORS   Xu,B., O'Donnell,M., O'Donnell,J., Yu,J., Zhang,Y., Sartor,M.A. and
            Koenig,R.J.
  TITLE     Adipogenic Differentiation of Thyroid Cancer Cells Through the
            Pax8-PPARgamma Fusion Protein Is Regulated by Thyroid Transcription
            Factor 1 (TTF-1)
  JOURNAL   J Biol Chem 291 (37), 19274-19286 (2016)
   PUBMED   27435678
  REMARK    GeneRIF: data indicate that TTF-1 interacts with PPFP to inhibit
            the pro-adipogenic response to pioglitazone, and that the ability
            of pioglitazone to decrease TTF-1 expression contributes to its
            pro-adipogenic action.
REFERENCE   3  (bases 1 to 2297)
  AUTHORS   Koht,J., Lostegaard,S.O., Wedding,I., Vidailhet,M., Louha,M. and
            Tallaksen,C.M.
  TITLE     Benign hereditary chorea, not only chorea: a family case
            presentation
  JOURNAL   Cerebellum Ataxias 3, 3 (2016)
   PUBMED   26839702
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2297)
  AUTHORS   Uemae,Y., Sakamoto,J., Hidaka,Y., Hiratsuka,A., Susa,T., Kato,Y.
            and Suzuki,M.
  TITLE     Gene expression, function, and diversity of Nkx2-4 in the rainbow
            trout, Oncorhynchus mykiss
  JOURNAL   Gen Comp Endocrinol 206, 193-202 (2014)
   PUBMED   25051213
REFERENCE   5  (bases 1 to 2297)
  AUTHORS   Katagiri,N., Uemae,Y., Sakamoto,J., Hidaka,Y., Susa,T., Kato,Y.,
            Kimura,S. and Suzuki,M.
  TITLE     Molecular cloning and functional characterization of two forms of
            Pax8 in the rainbow trout, Oncorhynchus mykiss
  JOURNAL   Gen Comp Endocrinol 198, 22-31 (2014)
   PUBMED   24380675
REFERENCE   6  (bases 1 to 2297)
  AUTHORS   Yan,C., Sever,Z. and Whitsett,J.A.
  TITLE     Upstream enhancer activity in the human surfactant protein B gene
            is mediated by thyroid transcription factor 1
  JOURNAL   J Biol Chem 270 (42), 24852-24857 (1995)
   PUBMED   7559607
REFERENCE   7  (bases 1 to 2297)
  AUTHORS   Acebron,A., Aza-Blanc,P., Rossi,D.L., Lamas,L. and Santisteban,P.
  TITLE     Congenital human thyroglobulin defect due to low expression of the
            thyroid-specific transcription factor TTF-1
  JOURNAL   J Clin Invest 96 (2), 781-785 (1995)
   PUBMED   7635972
REFERENCE   8  (bases 1 to 2297)
  AUTHORS   Ikeda,K., Clark,J.C., Shaw-White,J.R., Stahlman,M.T., Boutell,C.J.
            and Whitsett,J.A.
  TITLE     Gene structure and expression of human thyroid transcription
            factor-1 in respiratory epithelial cells
  JOURNAL   J Biol Chem 270 (14), 8108-8114 (1995)
   PUBMED   7713914
REFERENCE   9  (bases 1 to 2297)
  AUTHORS   Abramowicz,M.J., Vassart,G. and Christophe,D.
  TITLE     Functional study of the human thyroid peroxidase gene promoter
  JOURNAL   Eur J Biochem 203 (3), 467-473 (1992)
   PUBMED   1735431
REFERENCE   10 (bases 1 to 2297)
  AUTHORS   Guazzi,S., Price,M., De Felice,M., Damante,G., Mattei,M.G. and Di
            Lauro,R.
  TITLE     Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and
            displays a novel DNA binding specificity
  JOURNAL   EMBO J 9 (11), 3631-3639 (1990)
   PUBMED   1976511
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On or before Nov 23, 2008 this sequence version replaced
            XM_216720.4, XM_001079296.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB894119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-373               JAXUCZ010000006.1  79734495-79734867   c
            374-2297            JAXUCZ010000006.1  79731677-79733600   c
FEATURES             Location/Qualifiers
     source          1..2297
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..2297
                     /gene="Nkx2-1"
                     /gene_synonym="Titf1; TTF1"
                     /note="NK2 homeobox 1"
                     /db_xref="GeneID:25628"
                     /db_xref="RGD:3866"
     CDS             1..1119
                     /gene="Nkx2-1"
                     /gene_synonym="Titf1; TTF1"
                     /note="TTF-1; thyroid nuclear factor 1; thyroid
                     transcription factor 1 TTF-1 NK-2; thyroid-specific
                     transcription factor 1"
                     /codon_start=1
                     /product="homeobox protein Nkx-2.1"
                     /protein_id="NP_037225.1"
                     /db_xref="GeneID:25628"
                     /db_xref="RGD:3866"
                     /translation="MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQG
                     QAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNVSELPPYQD
                     TMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAP
                     RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR
                     QAKDKAAQQQLQQDSGGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAP
                     APGAASLQGHAQQQAQQQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHH
                     AASPAALQGQVSSLSHLNSSGSDYGAMSCSTLLYGRTW"
     exon            1..373
                     /gene="Nkx2-1"
                     /gene_synonym="Titf1; TTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..2297
                     /gene="Nkx2-1"
                     /gene_synonym="Titf1; TTF1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtcgatga gtccaaagca cacgactccg ttctcagtgt ctgacatctt gagtcccctg
       61 gaggaaagct acaagaaagt gggcatggag ggcggcggcc tcggggctcc gctcgcagct
      121 tacagacagg gccaggcggc cccgccggcc gcggccatgc agcagcacgc cgtggggcac
      181 cacggcgccg tcaccgccgc ctaccacatg acggcggcgg gggtgcccca gctctcccac
      241 tccgccgtgg ggggctactg caacggcaac ctgggcaacg tgagcgagct gccaccttac
      301 caggacacca tgcggaacag cgcttcgggc cccggatggt acggcgccaa cccagatccg
      361 cgcttccccg ccatctcccg cttcatgggc ccggcgagcg gcatgaatat gagcggcatg
      421 ggcggcctgg gctcgctggg ggacgtgagc aagaacatgg ccccgctgcc cagcgcaccc
      481 cgccggaagc gtcgggtgct cttctcccag gcgcaggtgt acgagctcga gcgacgcttc
      541 aagcagcaga agtacctgtc ggcgccggag cgcgagcatc tggccagcat gattcacctg
      601 acacccacgc aggtcaagat ctggttccag aaccaccgct acaagatgaa gcgccaggcg
      661 aaggacaagg cggcgcagca gcaactgcag caggacagcg gcggcggcgg aggcggcggc
      721 ggcggcgcgg gttgcccgca gcagcagcaa gctcagcagc agtcgccgcg ccgggtggcc
      781 gtgccggtcc tggtgaaaga cggcaaaccc tgccaagcgg gcgcccctgc accgggagcc
      841 gccagcctgc aaggccacgc gcaacaacaa gctcagcagc aggcgcaggc ggcacaagcg
      901 gctgccgcgg ccatctctgt gggcagcggt ggtgcgggtc taggagcaca cccaggccac
      961 cagcccggca gcgcagggca gtccccggac ctggcgcacc acgcagccag ccccgcagcg
     1021 ctgcagggcc aggtctctag cctatctcat ctgaactcct ctggctcgga ctatggcgcc
     1081 atgtcttgct ctactttgct ttatggtcgg acctggtgag atgtgggacg cgcctgagcc
     1141 ctgtgcgacc tcaccgcttt ccctctaccc tccgcaaaga ccaccattcg cccgctgctc
     1201 cacgcccttc tacttttttc tcatgtttag accaaggaaa agtacacaaa gaccaaactg
     1261 ctggactcct tcttcttctt cttcttcttc ttcttcttct tcttcttctt cttcttcttc
     1321 ttcttcttct tcttcttctt cttcttcttc ttcttcttct tcttcttctt cttcttttct
     1381 tcttcttctt cttctccttc ttctttttct gcttcttctt cttcttcctc ttcttcctct
     1441 tcttcctcct cctccttctt cctccttttt ctccttgtcc ccactcctcc ttttctcttt
     1501 ctccttttcc tacgtttccc ctttttttcc ttcatccttc tccctttcct ttctctttcc
     1561 tacctaaaac ttgtggactt ttttttaaca taaaaagaaa atagaaacag tcaagcaaat
     1621 ccaacccctt tacgaattct ttaaccagag aaggacaaag aacaaatttg ggggtctttc
     1681 tggtagttca aatgggttct caagcttagg catggcacaa ttttggggcc tgctctatgc
     1741 ttccacggcc ctgaactctg aagccggaaa acttccctgt ggatgcactc tgccagcaaa
     1801 gagagcttgc ttgtaaatac caggattttt cgtttgtttg tttcagaagg gaggacagaa
     1861 actggagaga ggaaagattc ttcagcataa cccacttgtc cctgacacaa aggaagtgtc
     1921 ccctcccagg tgccctctgg ccctataggt tcagtccagg ctggcctttc agaaaattgt
     1981 tttaggtttg atgtgaactt gtagctgtaa aatgctgtca aaagttggac taaatgccta
     2041 gtttttagta acctgtacat tatgttgtaa aaagaactcc agtcccagtc cctggcccct
     2101 cactttttaa aagggcatca tggacaagcc tgtgtatatt actccacggt ttggtatttg
     2161 cagcaccagt tgccccctcc cttttttctg ttgtaactta tgtagatatt tggcttaaat
     2221 atagttccta agaagcttct aataaattat acgaatttaa aaagatgctt tttctgatta
     2281 aaaccctttt tcttttt
//
