LOCUS       NM_001107454            4024 bp    mRNA    linear   ROD 23-MAR-2024
DEFINITION  Rattus norvegicus NKD inhibitor of WNT signaling pathway 2 (Nkd2),
            mRNA.
ACCESSION   NM_001107454 XM_001060476 XM_217743
VERSION     NM_001107454.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4024)
  AUTHORS   Wang,H., Zhao,H., Chen,Z., Cai,X., Wang,X., Zhou,P., Tang,Y.,
            Ying,T., Zhang,X., Shen,Y., Wang,B., Zhu,W., Zhu,J., Wang,X. and
            Li,S.
  TITLE     Hypoxic Bone Mesenchymal Stem Cell-Derived Exosomes Direct Schwann
            Cells Proliferation, Migration, and Paracrine to Accelerate Facial
            Nerve Regeneration via circRNA_Nkd2/miR-214-3p/MED19 Axis
  JOURNAL   Int J Nanomedicine 19, 1409-1429 (2024)
   PUBMED   38371458
  REMARK    GeneRIF: Hypoxic Bone Mesenchymal Stem Cell-Derived Exosomes Direct
            Schwann Cells Proliferation, Migration, and Paracrine to Accelerate
            Facial Nerve Regeneration via circRNA_Nkd2/miR-214-3p/MED19 Axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4024)
  AUTHORS   Cui,Z., Zhou,L., Song,Y., Liu,C., Zhu,G., Wu,X., Yan,Y., Xia,X.,
            Duan,C., Zhou,Y., Huang,Y. and Zhang,D.
  TITLE     Up-Regulation of Corticocerebral NKD2 in Lipopolysaccharide-Induced
            Neuroinflammation
  JOURNAL   Cell Mol Neurobiol 36 (1), 47-55 (2016)
   PUBMED   26084600
  REMARK    GeneRIF: NKD2 might be involved in neuronal apoptosis via the
            Wnt/beta-catenin pathway during neuroinflammation.
REFERENCE   3  (bases 1 to 4024)
  AUTHORS   Hu,T., Li,C., Cao,Z., Van Raay,T.J., Smith,J.G., Willert,K.,
            Solnica-Krezel,L. and Coffey,R.J.
  TITLE     Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by
            degrading Dishevelled-1 at the plasma membrane
  JOURNAL   J Biol Chem 285 (18), 13561-13568 (2010)
   PUBMED   20177058
REFERENCE   4  (bases 1 to 4024)
  AUTHORS   Ding,W., Li,C., Hu,T., Graves-Deal,R., Fotia,A.B., Weissman,A.M.
            and Coffey,R.J.
  TITLE     EGF receptor-independent action of TGF-alpha protects Naked2 from
            AO7-mediated ubiquitylation and proteasomal degradation
  JOURNAL   Proc Natl Acad Sci U S A 105 (36), 13433-13438 (2008)
   PUBMED   18757723
REFERENCE   5  (bases 1 to 4024)
  AUTHORS   Cao,Z., Li,C., Higginbotham,J.N., Franklin,J.L., Tabb,D.L.,
            Graves-Deal,R., Hill,S., Cheek,K., Jerome,W.G., Lapierre,L.A.,
            Goldenring,J.R., Ham,A.J. and Coffey,R.J.
  TITLE     Use of fluorescence-activated vesicle sorting for isolation of
            Naked2-associated, basolaterally targeted exocytic vesicles for
            proteomics analysis
  JOURNAL   Mol Cell Proteomics 7 (9), 1651-1667 (2008)
   PUBMED   18504258
REFERENCE   6  (bases 1 to 4024)
  AUTHORS   Li,C., Hao,M., Cao,Z., Ding,W., Graves-Deal,R., Hu,J., Piston,D.W.
            and Coffey,R.J.
  TITLE     Naked2 acts as a cargo recognition and targeting protein to ensure
            proper delivery and fusion of TGF-alpha containing exocytic
            vesicles at the lower lateral membrane of polarized MDCK cells
  JOURNAL   Mol Biol Cell 18 (8), 3081-3093 (2007)
   PUBMED   17553928
REFERENCE   7  (bases 1 to 4024)
  AUTHORS   Creyghton,M.P., Roel,G., Eichhorn,P.J., Hijmans,E.M., Maurer,I.,
            Destree,O. and Bernards,R.
  TITLE     PR72, a novel regulator of Wnt signaling required for Naked cuticle
            function
  JOURNAL   Genes Dev 19 (3), 376-386 (2005)
   PUBMED   15687260
REFERENCE   8  (bases 1 to 4024)
  AUTHORS   Li,C., Franklin,J.L., Graves-Deal,R., Jerome,W.G., Cao,Z. and
            Coffey,R.J.
  TITLE     Myristoylated Naked2 escorts transforming growth factor alpha to
            the basolateral plasma membrane of polarized epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 101 (15), 5571-5576 (2004)
   PUBMED   15064403
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474002.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217743.4, XM_001060476.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4024
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..4024
                     /gene="Nkd2"
                     /note="NKD inhibitor of WNT signaling pathway 2"
                     /db_xref="GeneID:308068"
                     /db_xref="RGD:1311459"
     exon            1..211
                     /gene="Nkd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1563
                     /gene="Nkd2"
                     /note="naked cuticle 2 homolog; naked cuticle homolog 2;
                     NKD2, WNT signaling pathway inhibitor"
                     /codon_start=1
                     /product="protein naked cuticle homolog 2"
                     /protein_id="NP_001100924.1"
                     /db_xref="GeneID:308068"
                     /db_xref="RGD:1311459"
                     /translation="MGKFQSKHACKRRESPEGDSFVVSAYASGRKGAEETDRRAGSGV
                     EHRARDKQELPNGDPKEGPFWEDKGSLEVVLPPEKSEGHEGQLFSVDDGEKAANREGP
                     LRLSKKHLNIDALQCDVSVEEDNRQEWTFTLYDFDNSGKVTREDMSSLMHTIYEVVDA
                     SVNHSSGSSKTLRVKLTVSPEPSSKKEWLPPGQEREPTRGRTESELPDDPRVADRRLS
                     AYSRKPNTDPQPCPVRVPYCVDENTERRNHYLDLAGIENYTSKFGPGSPPEQARQEHH
                     GRATHIPSRSRSQESDAHAIHHRRSQVLAEHIVPANEPAPRALAAQPRLKGQEKQFLR
                     SPKGPGKPLGAPSGSKPGKSLSHCLQAVPLSQGAQDGHHLPQPPPQPPPQPYGHKRYR
                     QKSREGHSPLKGHGQPTMVEHEVVRDLPPMLGPEGYVVPMIQRHEHHHHHEHHHHHHH
                     HHFHPNAS"
     exon            212..238
                     /gene="Nkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            239..342
                     /gene="Nkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..403
                     /gene="Nkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            404..525
                     /gene="Nkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..621
                     /gene="Nkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            622..766
                     /gene="Nkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..851
                     /gene="Nkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..979
                     /gene="Nkd2"
                     /inference="alignment:Splign:2.1.0"
     exon            980..4024
                     /gene="Nkd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catagggagg ccggccgctg cccgcgccgg tgtctccggt tgccgggcca agcctcgccc
       61 gactgccggg ccccggatcc aggctccaca agtctctctc ggcgcgcggt tcacgtgccc
      121 caggctcgaa cctcggacgt gcgcctggga gctcagccgg agggtgggtc cgggtccagc
      181 ggcgacatgg ggaaatttca gtccaagcac gcctgcaaga ggagagagag tcccgaaggg
      241 gacagcttcg tggtgtcggc gtacgcgagc ggtcgcaaag gagcggaaga gaccgaccgg
      301 cgcgcgggca gcggtgtgga acatcgcgca cgggacaagc aggagctgcc caatggagac
      361 cctaaggaag ggcctttctg ggaagacaag ggttccctag aagttgtgct gccccctgag
      421 aagtctgagg gccatgaggg ccagctcttc agcgtagatg atggggagaa ggcagcaaac
      481 cgagagggtc cactaagact cagcaagaag cacttgaaca tcgacgcact ccagtgtgat
      541 gtctcagtgg aagaggacaa ccgtcaagag tggacgttca cgctgtatga ctttgacaac
      601 agtgggaaag tcaccagaga ggacatgtcc agcctgatgc acaccatcta tgaggtcgtc
      661 gacgcctctg tcaatcattc ctcggggagc agcaagaccc tccgagtgaa gctaactgtc
      721 agccctgaac cctccagcaa gaaggaatgg cttccccctg gccaagagcg ggagcccact
      781 cgtggcagaa cagagagtga gctcccagat gacccacgag tggccgacag aaggctgtct
      841 gcctatagca ggaagcccaa cacagatccc cagccctgtc ctgtgcgagt gccctactgt
      901 gtggatgaga acacagagcg aagaaaccac tacctagacc ttgctggcat tgagaactac
      961 acatctaagt ttggtcctgg gtcaccacct gagcaggcca ggcaagaaca tcatggcagg
     1021 gccacacaca ttccaagcag gtcccggtct caggagtcgg acgcccatgc tatacaccac
     1081 cgcaggtctc aggtcctggc tgagcatatt gtgccagcta atgagcctgc tcctcgggcc
     1141 ctggctgcac agccccgact caaggggcag gagaagcagt tcctcaggtc tcccaagggt
     1201 ccgggaaaac ctcttggggc accaagcggc agcaagccag ggaaatcgct cagccattgc
     1261 ctgcaggctg tgccgctgtc ccagggtgct caggacggcc accaccttcc tcaaccccca
     1321 ccgcagcctc cgccacagcc ctatggtcac aagcggtacc ggcagaaaag cagagaaggc
     1381 cactcaccac ttaaggggca cggccagcct accatggtgg agcatgaagt ggtccgggac
     1441 cttcctccca tgctggggcc tgagggctac gtggtgccta tgatccagag gcatgaacac
     1501 caccatcacc atgaacacca ccaccatcac caccaccacc acttccaccc aaacgcctcc
     1561 tagcgcccaa acaagcactc cgcccaaatg cccttgggga catagaccag atgctggcag
     1621 gtgcccggta gtctagcgtc ccctggcccc agggagatga caccagcctg gatattcgtg
     1681 gacaaagcta cctttctcca tgccgtttgg atgccagtgc atttgatgca gctgatgatt
     1741 acagtaaaat gtgctcccgt gtggtccaga aagcccatac gagtacacaa aagcatgtgc
     1801 tcccactttt actgcagtgt cgccgtggga cgttggaagg gctgtgccta ggcattcttt
     1861 gtatccgcat ggtcctttga cctttgggtg cctaaatgga aaaggcaatg ctttttgtga
     1921 agttcagaca ttggaaagtc tgagggctgg gattgggaag tgcttcttaa gtgtaccctg
     1981 ttaaacgagg cagaacaaag aagccagatt atcagcaacc gtggaggggg cgtggctgag
     2041 cagaggggcg tggctgagca gaggggcgtg gctgagcaga ggggcgtggc tgagcagagg
     2101 ggcgtggctg agcagagggg cgtggctgag cagaggggcg tggctgagca gaggggcagg
     2161 gtggtgatgt ccagtggcag cgtgaggctt ggtgtccaga gctcctagca tcctaggtag
     2221 atgtggataa gacccagaca ggttggggtg ggtggatcag gtactatgct ggaggtcccc
     2281 aaacaggctg tgcatagcta agtgacactt agatgtccct ccataaaggc tgcaagggtg
     2341 tggagacttc gacaagccat gatccttgtg gtcccaccag caggctacag cgaggggacc
     2401 tctttgcctt gtgagtttgt gcaggtggca ttacgccttc ctgacataat aaaagatggc
     2461 gcgttctgta acatggcata tccttgtatt aaaacacttt ctgagcgctg cggtcagtct
     2521 accgacacac cgcagctaca ggtgaaggtg gcaggtcctt gtggagggta agtgctgtag
     2581 gaccattttg acttatgctg gtcacgcaca tgactccata gtaatactac tcactaagcg
     2641 attctcagac taagaaaaat cagcactcta aacccggagc tcagctcatg ttaacaagga
     2701 acaccaagcc ccacgtggac tccgtgggct acagcttatg caggctgttg ggaagcaaca
     2761 caaccttgtg cttatcccct ctccctaaaa ccctgtgcct attctaagga gttactgaag
     2821 atctgagtgt gatggttctt gggacctggc tgcacatgtg tagggagacc tggggatcaa
     2881 ccccctgtag gctgttgcta gtcacttcag ctagagatgc tcatgaaaac caaaacgtgc
     2941 caccctttcc tacatgacta aagcgctcac atcatggacg tcgagatggc acattcataa
     3001 ggtcccacca cccacgccac agcagaggga ctgcacagga ggtcagcgtg gactcccagt
     3061 ttgcttctca atgtgcagca ttcttacact gggtttgtaa gacgtccttt caggaagaga
     3121 tgatgatgat aagagcactg gttgctcttc tgaggacctg ggctcaattt ccagcgcccc
     3181 acgtggcagt tcacgcctgt ctgtaacccc agctccaggg cttcgggcac cctcacacag
     3241 acatccatgt ggataaaaca cctatgaaca taagctaaaa aataaaataa aaaagccagc
     3301 gatgtcacat aggatatccc caatgacatg gttcagctga gcaccgtggg aagcggtgag
     3361 attcagccaa gtctgagccc tggcttcaca ttttaaaaac tcagggcagg cggtaaccct
     3421 aacgcgcttg tggcaggggc cgagcatctg ccgctgtgtg agtgttaagc agaggactgt
     3481 gcaacactcc agacagcagg atcctccatg ccgcgtgtca gacctaaaga gatgggaaac
     3541 aaacgcccgg accatttagt tgggtgtggc agtgaatgct tgcgggagcc tacagcaaga
     3601 gctacaattc aggatcaggc tgggctgtct agtgacactg cctcgcctgc cccacactgc
     3661 tggtgctctc cagcatttag ccactctaga catggtcacc agtgtctgca catgtcgttt
     3721 agaagagtgg atctgctgag gtgcagaaac ttgggttgat ttagagactc caggactaaa
     3781 agtaaagagg taaaacagcc atgttgcaag tggaacgaga ggtaagaaag ccaggggtgg
     3841 ggatgccttg cccaccctgt gctgtgcgcc aggacggtgt ctccatggca gttggtagca
     3901 cctggcaaca ggagagggtg gccattgtgg ggaaaacaac caaccttggc cgtgtatgtg
     3961 gaggttgtgg ctactgtgtg ttcctagaac tgaacagcct gatctacgta catccccaaa
     4021 taaa
//
