LOCUS       NM_001271381            2557 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus NKD inhibitor of WNT signaling pathway 1 (Nkd1),
            mRNA.
ACCESSION   NM_001271381 XM_003753088
VERSION     NM_001271381.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2557)
  AUTHORS   Creyghton,M.P., Roel,G., Eichhorn,P.J., Hijmans,E.M., Maurer,I.,
            Destree,O. and Bernards,R.
  TITLE     PR72, a novel regulator of Wnt signaling required for Naked cuticle
            function
  JOURNAL   Genes Dev 19 (3), 376-386 (2005)
   PUBMED   15687260
REFERENCE   2  (bases 1 to 2557)
  AUTHORS   Wharton,K.A. Jr., Zimmermann,G., Rousset,R. and Scott,M.P.
  TITLE     Vertebrate proteins related to Drosophila Naked Cuticle bind
            Dishevelled and antagonize Wnt signaling
  JOURNAL   Dev Biol 234 (1), 93-106 (2001)
   PUBMED   11356022
REFERENCE   3  (bases 1 to 2557)
  AUTHORS   Yan,D., Wallingford,J.B., Sun,T.Q., Nelson,A.M., Sakanaka,C.,
            Reinhard,C., Harland,R.M., Fantl,W.J. and Williams,L.T.
  TITLE     Cell autonomous regulation of multiple Dishevelled-dependent
            pathways by mammalian Nkd
  JOURNAL   Proc Natl Acad Sci U S A 98 (7), 3802-3807 (2001)
   PUBMED   11274398
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Sep 19, 2012 this sequence version replaced XM_003753088.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.55300.1,
                                           SRR26643298.75470.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840117,
                                           SAMN12840120 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               JAXUCZ010000019.1  34722727-34722846   c
            121-153             JAXUCZ010000019.1  34722573-34722605   c
            154-287             JAXUCZ010000019.1  34721845-34721978   c
            288-354             JAXUCZ010000019.1  34667731-34667797   c
            355-461             JAXUCZ010000019.1  34659098-34659204   c
            462-557             JAXUCZ010000019.1  34657236-34657331   c
            558-705             JAXUCZ010000019.1  34653444-34653591   c
            706-790             JAXUCZ010000019.1  34652954-34653038   c
            791-918             JAXUCZ010000019.1  34652058-34652185   c
            919-2557            JAXUCZ010000019.1  34649803-34651441   c
FEATURES             Location/Qualifiers
     source          1..2557
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..2557
                     /gene="Nkd1"
                     /note="NKD inhibitor of WNT signaling pathway 1"
                     /db_xref="GeneID:364952"
                     /db_xref="RGD:1308491"
     exon            1..120
                     /gene="Nkd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1511
                     /gene="Nkd1"
                     /note="naked cuticle 1 homolog; naked cuticle homolog 1;
                     NKD1, WNT signaling pathway inhibitor"
                     /codon_start=1
                     /product="protein naked cuticle homolog 1"
                     /protein_id="NP_001258310.1"
                     /db_xref="GeneID:364952"
                     /db_xref="RGD:1308491"
                     /translation="MGKLHSKPAAVCKRRESPEGDSFAVSAAWARKGIEEWIGRQRCP
                     GSVSGPRQLRLAGTVGRGARELVGDTSREALGEGDEDDFPLEVALPPEKTDSLVSGDE
                     KRMEKLSEPGQASKKQLKFEELQCDVSVEEDSRQEWTFTLYDFDNNGKVTREDITSLL
                     HTIYEVVDSSVNHSPTSSKTLRVKLTVAPDGSQSKRSVLFNHTDLQSARPRADTKPAE
                     ELRGWEKQQRAPLRFQGDSHLEQPDCYHHCVDENIERRNHYLDLAGIENYTSQFGPGS
                     PSVAQKSELPPRISNPTRSRSHEPEAAHIPHRRPQGVDPGSFHLLDTPFVKASEPQQR
                     LRGTQDGNKQFVRSPKAQGKNMGMGHVARGTRSKPPLVPTTHTVSPSAHLATGPALLP
                     TLPPLGHKKHKHRAKESQASCRGLQAPLAAGGSTIMGREQVRELPAVVVYESQAGQSI
                     QRHEHHHHHEHHHHYHHFYQP"
     exon            121..153
                     /gene="Nkd1"
                     /inference="alignment:Splign:2.1.0"
     exon            154..287
                     /gene="Nkd1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..354
                     /gene="Nkd1"
                     /inference="alignment:Splign:2.1.0"
     exon            355..461
                     /gene="Nkd1"
                     /inference="alignment:Splign:2.1.0"
     exon            462..557
                     /gene="Nkd1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..705
                     /gene="Nkd1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..790
                     /gene="Nkd1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..918
                     /gene="Nkd1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..2557
                     /gene="Nkd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccgcgcgc ggactgtgag gaggaggcga gcaaggctgg cgcggggtcg gcggccggac
       61 gcatggctta ggacgcccgg ctgccgcgcc ccagcatggg gaaacttcac tcgaagccgg
      121 ccgccgtgtg caagcgcagg gagagcccgg aaggtgacag ctttgcagta agcgctgctt
      181 gggcaaggaa aggcatcgag gagtggatcg ggaggcagcg ctgtccaggc agcgtctcag
      241 gaccccgaca gctgagattg gcaggcactg ttggtcgagg cgcccgggaa ctcgtgggtg
      301 acacttctag agaggctctc ggtgaggggg acgaggacga cttcccccta gaagtggccc
      361 ttccgcctga gaagaccgac agcctggtca gcggagatga gaagagaatg gagaaactga
      421 gcgaaccggg ccaggcctcc aagaagcagc tcaagtttga agaactgcag tgtgatgttt
      481 ctgtggagga ggacagccgg caagagtgga ctttcactct gtatgacttc gacaacaatg
      541 gcaaagtcac ccgtgaggac attaccagct tgctgcacac catctacgag gtggttgact
      601 cctctgtgaa ccattccccc acatcaagca agacactgcg ggtgaagctc actgtggccc
      661 ctgatgggag ccagagcaag aggagtgtcc ttttcaacca caccgatctg cagagcgcaa
      721 ggccccgagc agacaccaag cctgccgagg agctgcgtgg ctgggagaag cagcagcgag
      781 ccccgctcag gttccagggt gacagccacc tggagcagcc ggactgttac caccattgcg
      841 tggatgagaa catcgagagg agaaaccact acctagacct ggcgggaata gagaactaca
      901 cgtctcagtt tggacccggc tccccttcag tggcccagaa gtcagagctg ccccctcgaa
      961 tctccaaccc cactcgctct cgctcccacg agccagaagc cgcccacatc ccacaccgga
     1021 ggccccaagg tgtggacccg ggctccttcc accttcttga caccccattt gtgaaggcat
     1081 cagaacccca gcaacggctc cggggtaccc aggatgggaa caagcagttt gtgaggtccc
     1141 ccaaggccca gggcaagaac atgggtatgg gccacgtggc cagaggtaca agaagcaagc
     1201 ccccactggt gcccaccacc cacaccgtgt ccccctctgc ccacctggcc accggcccag
     1261 ccctcctccc caccctgcca cccctggggc acaagaagca caagcatcga gccaaggaga
     1321 gccaggcgag ctgccggggc ctgcaggccc cactggctgc aggaggctcc accatcatgg
     1381 ggcgggagca ggtgagggag ctgcctgctg tggtggtgta cgagagccag gctgggcagt
     1441 ccatccagag acatgagcac catcaccacc atgaacatca ccaccattac caccacttct
     1501 atcagcccta aaccccacca ggctgccaca ggaaggaccc accccacacc ctaaggcatt
     1561 attattctat taattattgt tattatggca attattgtta ttaataatta ttgttactcc
     1621 actaatattt agccagcctt catgtagaag acatatggaa acacagaagt aaacttttat
     1681 ttatatgttg tggggatcat ataactcacc caaggagaga ctctgggtct agaagggtcc
     1741 ttgggccacc ccagctgcag gtccacacag atcttcccaa accacaggag ccctcggccc
     1801 agctgcccca ctccagctct tccgggagag cacccttgcc tggcccagct tcagagaccc
     1861 tcaagagctc cagaggacaa cagctgctac ctctcagtgt tattctggtt caacttcacc
     1921 cttaattgat tgtaacatgc cacagggaat ttcagtgggc tgccattgcg ccctctctcc
     1981 cctgtggtct cacacctcaa cctagacacc ttagctgtgt ttcccggagt tactgcctcc
     2041 ccttatcaaa gggaactagc ccttggccca agccagccct gtcctttctc ttttttcctt
     2101 tgccatgcac aatgtggaag cgtcctctct tcctgtgccc ccccccctcg gcttttgaag
     2161 gatgcacctg tgtttaagga ttgtccttgt agtctcctca gtttgggaac tactacagag
     2221 agaagcagct gcataaagaa tcgaggtttc cccaaatggc accattgtgt gacggagggt
     2281 gggaaacctg agttcaccat cagcaaatag tttgcggctc tctagcagcc tttgtagcta
     2341 taggtagatg ctgcctgtcc gtgtctctgt atctttctat aaatacactc tcaggtatct
     2401 ttgctggtat gcagaaatca ctgtgctgct ctatggaggc tcctgcaacc caaatgtacc
     2461 ccatgtgtta cctgtaaagg ctgcctgtcc atcagacgaa agcagccacc accgtctcat
     2521 tccttggctc cgtagtctat ggttttggag agacctg
//
