LOCUS       NM_001024872            1466 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus NFKB activating protein (Nkap), mRNA.
ACCESSION   NM_001024872 XM_216468
VERSION     NM_001024872.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1466)
  AUTHORS   Fiordaliso,S.K., Iwata-Otsubo,A., Ritter,A.L.,
            Quesnel-Vallieres,M., Fujiki,K., Nishi,E., Hancarova,M., Miyake,N.,
            Morton,J.E.V., Lee,S., Hackmann,K., Bando,M., Masuda,K., Nakato,R.,
            Arakawa,M., Bhoj,E., Li,D., Hakonarson,H., Takeda,R., Harr,M.,
            Keena,B., Zackai,E.H., Okamoto,N., Mizuno,S., Ko,J.M.,
            Valachova,A., Prchalova,D., Vlckova,M., Pippucci,T., Seiler,C.,
            Choi,M., Matsumoto,N., Di Donato,N., Barash,Y., Sedlacek,Z.,
            Shirahige,K. and Izumi,K.
  TITLE     Missense Mutations in NKAP Cause a Disorder of Transcriptional
            Regulation Characterized by Marfanoid Habitus and Cognitive
            Impairment
  JOURNAL   Am J Hum Genet 105 (5), 987-995 (2019)
   PUBMED   31587868
REFERENCE   2  (bases 1 to 1466)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   3  (bases 1 to 1466)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 1466)
  AUTHORS   Pajerowski,A.G., Shapiro,M.J., Gwin,K., Sundsbak,R.,
            Nelson-Holte,M., Medina,K. and Shapiro,V.S.
  TITLE     Adult hematopoietic stem cells require NKAP for maintenance and
            survival
  JOURNAL   Blood 116 (15), 2684-2693 (2010)
   PUBMED   20610818
REFERENCE   5  (bases 1 to 1466)
  AUTHORS   Pajerowski,A.G., Nguyen,C., Aghajanian,H., Shapiro,M.J. and
            Shapiro,V.S.
  TITLE     NKAP is a transcriptional repressor of notch signaling and is
            required for T cell development
  JOURNAL   Immunity 30 (5), 696-707 (2009)
   PUBMED   19409814
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098011.1.
            
            On Jun 17, 2005 this sequence version replaced XM_216468.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098011.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1466
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq35"
     gene            1..1466
                     /gene="Nkap"
                     /gene_synonym="2610020o08rik"
                     /note="NFKB activating protein"
                     /db_xref="GeneID:298342"
                     /db_xref="RGD:1565955"
     exon            1..477
                     /gene="Nkap"
                     /gene_synonym="2610020o08rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1345
                     /gene="Nkap"
                     /gene_synonym="2610020o08rik"
                     /note="nuclear NF-kappaB activating protein"
                     /codon_start=1
                     /product="NF-kappa-B-activating protein"
                     /protein_id="NP_001020043.1"
                     /db_xref="GeneID:298342"
                     /db_xref="RGD:1565955"
                     /translation="MAPVSGSRSPVREASGGKRRSSSRSPKSIKSSRSPRCRRSRSRS
                     CSRFGDRNGLSHSLSGFSQSSRNQSYRSRSRSRSRERPSAQRSAPFASSSSSAYYGGY
                     SRPYGGDKPWPSLLDKEREESLRQKRLSERERIGELGAPEVWGLSPKNPEPDSDEHTP
                     VEDEEPKKSTTSASSSEDDKKKKRKSSRSKERAKKKRKKKSSKRKHKKYSEDSDSDSE
                     SDTDSSDEDSKRRAKKAKKKEKKKKRRGKKYKKKKSKKNRKESSDSSSKESQEEFLEN
                     PWKDRSKTEEPSDLIGPEAPKTLASQDDKPLNYGHALLPGEGAAMAEYVKAGKRIPRR
                     GEIGLTSEEIASFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRK
                     RENKILASFREMVYRKTKGKDDK"
     exon            478..558
                     /gene="Nkap"
                     /gene_synonym="2610020o08rik"
                     /inference="alignment:Splign:2.1.0"
     exon            559..629
                     /gene="Nkap"
                     /gene_synonym="2610020o08rik"
                     /inference="alignment:Splign:2.1.0"
     exon            630..770
                     /gene="Nkap"
                     /gene_synonym="2610020o08rik"
                     /inference="alignment:Splign:2.1.0"
     exon            771..834
                     /gene="Nkap"
                     /gene_synonym="2610020o08rik"
                     /inference="alignment:Splign:2.1.0"
     exon            835..944
                     /gene="Nkap"
                     /gene_synonym="2610020o08rik"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1020
                     /gene="Nkap"
                     /gene_synonym="2610020o08rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1170
                     /gene="Nkap"
                     /gene_synonym="2610020o08rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1429
                     /gene="Nkap"
                     /gene_synonym="2610020o08rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgcaagc tctaagaccc taggtatccg agaaccttta ggggacaagg agagcgcctc
       61 cttgtcccgc cccttagccg gttcagctca caccaccatg gctcctgtgt cgggctcgcg
      121 tagccctgta cgggaggcct ccgggggaaa gcgtcgcagt tcgtcgagga gccccaaatc
      181 catcaaatct tcccgctccc cgcgatgtcg ccggtctcgc tcgcgctctt gttctcggtt
      241 cggtgaccgg aatggcctca gccattcgct gagtggcttc agccaaagct ctcgaaacca
      301 atcttatcgc tcccgctctc gatcgcgttc tcgagaacgg ccttctgcac agcggagtgc
      361 cccgttcgcg tcttcatcct cgtccgccta ttatggcggc tactcgcgtc cctacggggg
      421 tgacaagcca tggcctagcc tgctggacaa ggaaagggag gagagtctgc ggcagaagag
      481 attaagtgaa agagagagga ttggagaatt gggagctcct gaagtttggg gactttcccc
      541 aaagaatcct gaaccagact ctgatgaaca tacaccagta gaggatgaag aaccaaagaa
      601 aagcactact tcagcatcta gttcggaaga tgataagaag aagaaaagga aatctagtcg
      661 ttcaaaagaa agagccaaga aaaagagaaa gaaaaagtca tctaaaagaa aacataagaa
      721 gtattctgaa gatagcgaca gtgactcaga gtctgacacc gactctagtg atgaagattc
      781 aaaaagaaga gcaaagaaag ctaagaaaaa ggaaaagaag aagaaacgaa gagggaagaa
      841 atacaagaaa aagaagtcta agaaaaacag aaaggagtcc agtgattcaa gctctaaaga
      901 gtcccaagaa gaatttctag agaatccgtg gaaggatcga tcaaagacag aagaaccatc
      961 agatctgatt ggcccagagg ctcccaaaac acttgcctcc caagatgata agcccttgaa
     1021 ctatggccac gccctgttac ctggtgaagg tgcagctatg gctgaatatg taaaagctgg
     1081 caagcgtatc ccgagaagag gtgaaatcgg cttaacaagt gaagagatcg catcattcga
     1141 atgttccggt tatgtaatga gcggcagcag gcatcgccga atggaggctg tccgacttcg
     1201 gaaagagaac cagatctaca gtgccgatga gaagagagcc cttgcctcct ttaaccaaga
     1261 agaaagacgg aagagggaga acaagattct ggccagcttt cgcgagatgg tgtacagaaa
     1321 gaccaaaggg aaggatgaca agtgagggct ctctgacttt gcaagtggac attttaacat
     1381 caaaaaggaa atgtgggttc tagacataaa tacaaaaagc ttattgttta aaaaaaaaaa
     1441 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
