LOCUS       NM_001107519            1851 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus NIPA magnesium transporter 1 (Nipa1), mRNA.
ACCESSION   NM_001107519 XM_001054918 XM_218719
VERSION     NM_001107519.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1851)
  AUTHORS   Botzolakis EJ, Zhao J, Gurba KN, Macdonald RL and Hedera P.
  TITLE     The effect of HSP-causing mutations in SPG3A and NIPA1 on the
            assembly, trafficking, and interaction between atlastin-1 and NIPA1
  JOURNAL   Mol Cell Neurosci 46 (1), 122-135 (2011)
   PUBMED   20816793
  REMARK    GeneRIF: Data suggest that NIPA1 and atlastin-1 are members of a
            common biochemical pathway that supports axonal maintenance, which
            may explain in part the characteristic degeneration of long spinal
            pathways observed in patients with HSP.
REFERENCE   2  (bases 1 to 1851)
  AUTHORS   Goytain A, Hines RM, El-Husseini A and Quamme GA.
  TITLE     NIPA1(SPG6), the basis for autosomal dominant form of hereditary
            spastic paraplegia, encodes a functional Mg2+ transporter
  JOURNAL   J Biol Chem 282 (11), 8060-8068 (2007)
   PUBMED   17166836
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474036.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_218719.4, XM_001054918.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1851
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1851
                     /gene="Nipa1"
                     /gene_synonym="SLC56A1; Spg6"
                     /note="NIPA magnesium transporter 1"
                     /db_xref="GeneID:308668"
                     /db_xref="RGD:1305401"
     exon            1..166
                     /gene="Nipa1"
                     /gene_synonym="SLC56A1; Spg6"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..978
                     /gene="Nipa1"
                     /gene_synonym="SLC56A1; Spg6"
                     /note="spastic paraplegia 6 (autosomal dominant); solute
                     carrier family 56 member 1; non imprinted in
                     Prader-Willi/Angelman syndrome 1 homolog"
                     /codon_start=1
                     /product="magnesium transporter NIPA1"
                     /protein_id="NP_001100989.1"
                     /db_xref="GeneID:308668"
                     /db_xref="RGD:1305401"
                     /translation="MGTAAAAAAAGEGARGPSPAAVSLGLGVAVVSSLVNGSTFVLQK
                     KGIVRAKRRGTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSI
                     LASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTSQAELEEKLTNPVFVGYLC
                     IVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPSSQ
                     RALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFRE
                     WSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKSNMKTD"
     exon            167..214
                     /gene="Nipa1"
                     /gene_synonym="SLC56A1; Spg6"
                     /inference="alignment:Splign:2.1.0"
     exon            215..305
                     /gene="Nipa1"
                     /gene_synonym="SLC56A1; Spg6"
                     /inference="alignment:Splign:2.1.0"
     exon            306..466
                     /gene="Nipa1"
                     /gene_synonym="SLC56A1; Spg6"
                     /inference="alignment:Splign:2.1.0"
     exon            467..1851
                     /gene="Nipa1"
                     /gene_synonym="SLC56A1; Spg6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcatgg ggactgcggc ggcggctgcg gcggccgggg agggggcgcg cggcccgagc
       61 cccgccgccg tgtcgctcgg cctgggcgtg gctgtggtgt cgagcctagt gaacgggtcc
      121 acgttcgtgc tgcagaagaa gggcattgtg cgcgctaaaa ggcgaggtac ttcctactta
      181 acagatatcg tgtggtgggc tggcaccatt gcaatggctg ttggccagat tggaaacttc
      241 ctagcttaca ctgcggtccc tacggtcctg gtgactcctt taggtgccct tggagtgcca
      301 tttgggtcca ttttagcttc ttaccttctg aaggagaagc tcaacatctt gggcaagttg
      361 gggtgtctgc taagctgcgc agggtctgtc gtgctgatca tccattcccc caagtccgag
      421 agcgtgacca gtcaggctga gctggaggag aagctgacca atccagtgtt tgtgggctac
      481 ctgtgcattg tgctgctcat gctgctgctg ttgatcttct ggattgcacc agcccacggg
      541 cccaccaaca tcatggtcta catcagcatc tgctccttgc tgggcagttt cactgtgcct
      601 tccaccaagg gcattgggtt ggcagcccaa gacatcttgc acaacaatcc gtccagtcag
      661 agagccctct gcctgtgcct ggtgctcctg gctgtcctgg gctgcagcat cattgtccaa
      721 ttcaggtaca tcaacaaggc cctggagtgc ttcgactcct ctgtgtttgg ggccatctac
      781 tacgttgtgt ttaccacgct ggtcctgctg gcttcagcca tcctcttccg ggagtggagc
      841 aatgtgggcc tggtggactt cttgggcatg gcctgtggat ttacaactgt ctccgtggga
      901 attgtcctta tacaagtgtt caaagaattc aacttcaacc ttggggagat gaacaaatcc
      961 aatatgaaaa cagactaaga tgcagccaac aggtgggggc ttgaggaaca ggcattggag
     1021 ggggtctgtg gttcttacta tgtatgtcaa gtagaagaga ctctcggaga gagttgccta
     1081 tatactaata gtggacacta ggctttgcaa cagggtgagg tccagacctc tgcagcacag
     1141 agctcccaat ggttgtttgg gtgtaaactc tctctgatga gacaaattct gttttcattt
     1201 ccattaacct agaagctttc attaattact tgtttaaaac attttaacat gatttaccag
     1261 aaaataagga tgaggtcttt ctagttagtc tttgtagagg agatgttctt agagtacctt
     1321 ggaaaaggaa gtgaaatctg gctctgtaaa gtaaacgtga gtgatcttcg tacttgtgtt
     1381 aagcatgtgt agcattcagg tattttattc aaataagtgg tatgtgaatc aaattgtttg
     1441 tagtccttta acaacctgac tctcctacac gtaccccaaa gccgaggtaa gcagagagag
     1501 aagagttcat gacagtgatg cagagttcta tagacagggt gactttccga tagctcaaat
     1561 caattttagt gcctttatga tttgaattat tcacttaatt taactattac tgtgtatatg
     1621 ttaactgttc taaaaaatac tatgttcagt ggaagatagt gaaaagttaa agatacagaa
     1681 aactttgaaa agtgacccac ttgtatattg tctaattaag gacaactaat taagaaagaa
     1741 gagatattta atttccattt aacctctgtt acttgggtcc attatgaaaa acatctgctt
     1801 tctgtttcag gcagtattgt gtccattcag aagaaataaa ctatttaact t
//
