LOCUS       NM_012867               1119 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ninjurin 1 (Ninj1), mRNA.
ACCESSION   NM_012867
VERSION     NM_012867.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1119)
  AUTHORS   Kayagaki,N., Kornfeld,O.S., Lee,B.L., Stowe,I.B., O'Rourke,K.,
            Li,Q., Sandoval,W., Yan,D., Kang,J., Xu,M., Zhang,J., Lee,W.P.,
            McKenzie,B.S., Ulas,G., Payandeh,J., Roose-Girma,M., Modrusan,Z.,
            Reja,R., Sagolla,M., Webster,J.D., Cho,V., Andrews,T.D.,
            Morris,L.X., Miosge,L.A., Goodnow,C.C., Bertram,E.M. and Dixit,V.M.
  TITLE     NINJ1 mediates plasma membrane rupture during lytic cell death
  JOURNAL   Nature 591 (7848), 131-136 (2021)
   PUBMED   33472215
REFERENCE   2  (bases 1 to 1119)
  AUTHORS   Kim,S.W., Lee,H.K., Seol,S.I., Davaanyam,D., Lee,H. and Lee,J.K.
  TITLE     Ninjurin 1 dodecamer peptide containing the N-terminal adhesion
            motif (N-NAM) exerts proangiogenic effects in HUVECs and in the
            postischemic brain
  JOURNAL   Sci Rep 10 (1), 16656 (2020)
   PUBMED   33028854
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1119)
  AUTHORS   Lee,H.J., Ahn,B.J., Shin,M.W., Jeong,J.W., Kim,J.H. and Kim,K.W.
  TITLE     Ninjurin1 mediates macrophage-induced programmed cell death during
            early ocular development
  JOURNAL   Cell Death Differ 16 (10), 1395-1407 (2009)
   PUBMED   19557008
REFERENCE   4  (bases 1 to 1119)
  AUTHORS   Ahn,B.J., Lee,H.J., Shin,M.W., Choi,J.H., Jeong,J.W. and Kim,K.W.
  TITLE     Ninjurin1 is expressed in myeloid cells and mediates endothelium
            adhesion in the brains of EAE rats
  JOURNAL   Biochem Biophys Res Commun 387 (2), 321-325 (2009)
   PUBMED   19595672
  REMARK    GeneRIF: Ninj1 may mediate the entry of myeloid cells into the CNS
            in normal and EAE brains, and it is a potential therapeutic target
            for regulating myeloid cell trafficking across the blood-brain
            barrier in CNS immune processes.
REFERENCE   5  (bases 1 to 1119)
  AUTHORS   Araki,T. and Milbrandt,J.
  TITLE     Ninjurin, a novel adhesion molecule, is induced by nerve injury and
            promotes axonal growth
  JOURNAL   Neuron 17 (2), 353-361 (1996)
   PUBMED   8780658
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012867.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            22 bp suspected to be vector contamination from the 5' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215609.1, U72660.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000017.1  15667955-15668031   c
            78-306              JAXUCZ010000017.1  15661630-15661858   c
            307-470             JAXUCZ010000017.1  15660377-15660540   c
            471-1119            JAXUCZ010000017.1  15659208-15659856   c
FEATURES             Location/Qualifiers
     source          1..1119
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1119
                     /gene="Ninj1"
                     /note="ninjurin 1"
                     /db_xref="GeneID:25338"
                     /db_xref="RGD:3179"
     exon            1..77
                     /gene="Ninj1"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..461
                     /gene="Ninj1"
                     /note="nerve injury-induced protein 1"
                     /codon_start=1
                     /product="ninjurin-1"
                     /protein_id="NP_036999.1"
                     /db_xref="GeneID:25338"
                     /db_xref="RGD:3179"
                     /translation="MDPGTEEYELNGDLRPGSPGSPDASPPRWGLRNRPINVNHYANK
                     KSAAESMLDIALLMANASQLKAVVEQGNEFAFFVPLVVLISISLVLQIGVGVLLIFLV
                     KYDLNNPAKHAKLDFLNNLATGLVFIIVVVNIFITAFGVQKPVMDVAPRQ"
     exon            78..306
                     /gene="Ninj1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..470
                     /gene="Ninj1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..1119
                     /gene="Ninj1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccatggatcc cggcaccgag gagtacgagc tcaacggcga cctgcgccct ggctctcccg
       61 gttcccccga cgcctcgcca ccccgctggg gtttgaggaa ccggcccatc aatgtaaacc
      121 attacgccaa caagaagagc gccgcggaga gcatgctgga catcgcactg ctcatggcca
      181 acgcgtcgca gctcaaggcc gtggtggagc agggcaatga gttcgccttc ttcgtgcccc
      241 tcgtggtgct catctccatc tctctcgtgc tgcagatcgg agtgggcgtg ctgctcatct
      301 tcctggtcaa gtatgacctc aacaacccag ccaagcacgc caagctggac ttccttaaca
      361 acctggccac ggggctggtt ttcatcatcg tggtggtcaa catcttcatt acggcctttg
      421 gagtccagaa gcctgtcatg gacgtggcac cccggcagta ggatgcccag agactttgaa
      481 ggtatctgac ctgcagccca gctgtccaga cccctgcaac tgctgtatcc ccaaggcatc
      541 cctctcctgt tcacagccca aggtggcctc cgctggacca tggtcaagga tggacttccg
      601 tccacctgtg actgctgcgt gggcggccac ccgaggcgtg tgggaactgg atgcaaagcc
      661 atgaagatca gaactggaca gttccaccga aacccacgcc cagaggatga tcactgcccg
      721 cccaaggaca tgcaggaaat ccatgattgg actcgatgag gggccagaac tgatctctgt
      781 ctcaggacat tccagaagga ccaggatatg cccctccctt tgctgataca ccagtgaccc
      841 tacttctcat ggagcctgca caggtcaccc tggagactgc tgcctttgtt gtttcctgac
      901 ccagggacct tggacagtca tcagtacctg ctggctccag cctcagtgcc tgggcttggc
      961 agtgtctctt ggcatcgaga ggcagccatg cctgtggggg ctgcaggtca tcctggtacc
     1021 ttctaccagt agtgacttgg gaagagcccc agcccccaac ccaggggctc aggccccaat
     1081 tttctaatca ggaatgacaa taaagcttat gtgcttccc
//
