LOCUS       NM_001106737            6718 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus ninein (Nin), transcript variant 1, mRNA.
ACCESSION   NM_001106737 XM_001077019 XM_216723
VERSION     NM_001106737.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6718)
  AUTHORS   Wang,C., Li,J., Takemaru,K.I., Jiang,X., Xu,G. and Wang,B.
  TITLE     Centrosomal protein Dzip1l binds Cby, promotes ciliary bud
            formation, and acts redundantly with Bromi to regulate ciliogenesis
            in the mouse
  JOURNAL   Development 145 (6) (2018)
   PUBMED   29487109
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6718)
  AUTHORS   Zhang,X., Chen,M.H., Wu,X., Kodani,A., Fan,J., Doan,R., Ozawa,M.,
            Ma,J., Yoshida,N., Reiter,J.F., Black,D.L., Kharchenko,P.V.,
            Sharp,P.A. and Walsh,C.A.
  TITLE     Cell-Type-Specific Alternative Splicing Governs Cell Fate in the
            Developing Cerebral Cortex
  JOURNAL   Cell 166 (5), 1147-1162 (2016)
   PUBMED   27565344
REFERENCE   3  (bases 1 to 6718)
  AUTHORS   Srivatsa,S., Parthasarathy,S., Molnar,Z. and Tarabykin,V.
  TITLE     Sip1 downstream Effector ninein controls neocortical axonal growth,
            ipsilateral branching, and microtubule growth and stability
  JOURNAL   Neuron 85 (5), 998-1012 (2015)
   PUBMED   25741725
REFERENCE   4  (bases 1 to 6718)
  AUTHORS   Waters,A.M., Asfahani,R., Carroll,P., Bicknell,L., Lescai,F.,
            Bright,A., Chanudet,E., Brooks,A., Christou-Savina,S., Osman,G.,
            Walsh,P., Bacchelli,C., Chapgier,A., Vernay,B., Bader,D.M.,
            Deshpande,C., O' Sullivan,M., Ocaka,L., Stanescu,H., Stewart,H.S.,
            Hildebrandt,F., Otto,E., Johnson,C.A., Szymanska,K., Katsanis,N.,
            Davis,E., Kleta,R., Hubank,M., Doxsey,S., Jackson,A., Stupka,E.,
            Winey,M. and Beales,P.L.
  TITLE     The kinetochore protein, CENPF, is mutated in human ciliopathy and
            microcephaly phenotypes
  JOURNAL   J Med Genet 52 (3), 147-156 (2015)
   PUBMED   25564561
  REMARK    Erratum:[J Med Genet. 2016 Dec;53(12):865. doi:
            10.1136/jmedgenet-2014-102691corr1. PMID: 27738186]
REFERENCE   5  (bases 1 to 6718)
  AUTHORS   Chen,C.T., Hehnly,H., Yu,Q., Farkas,D., Zheng,G., Redick,S.D.,
            Hung,H.F., Samtani,R., Jurczyk,A., Akbarian,S., Wise,C.,
            Jackson,A., Bober,M., Guo,Y., Lo,C. and Doxsey,S.
  TITLE     A unique set of centrosome proteins requires pericentrin for
            spindle-pole localization and spindle orientation
  JOURNAL   Curr Biol 24 (19), 2327-2334 (2014)
   PUBMED   25220058
  REMARK    Erratum:[Curr Biol. 2014 Dec 15;24(24):2975]
REFERENCE   6  (bases 1 to 6718)
  AUTHORS   Delgehyr,N., Sillibourne,J. and Bornens,M.
  TITLE     Microtubule nucleation and anchoring at the centrosome are
            independent processes linked by ninein function
  JOURNAL   J Cell Sci 118 (Pt 8), 1565-1575 (2005)
   PUBMED   15784680
REFERENCE   7  (bases 1 to 6718)
  AUTHORS   Howng,S.L., Hsu,H.C., Cheng,T.S., Lee,Y.L., Chang,L.K., Lu,P.J. and
            Hong,Y.R.
  TITLE     A novel ninein-interaction protein, CGI-99, blocks ninein
            phosphorylation by GSK3beta and is highly expressed in brain tumors
  JOURNAL   FEBS Lett 566 (1-3), 162-168 (2004)
   PUBMED   15147888
REFERENCE   8  (bases 1 to 6718)
  AUTHORS   Chen,C.H., Howng,S.L., Cheng,T.S., Chou,M.H., Huang,C.Y. and
            Hong,Y.R.
  TITLE     Molecular characterization of human ninein protein: two distinct
            subdomains required for centrosomal targeting and regulating
            signals in cell cycle
  JOURNAL   Biochem Biophys Res Commun 308 (4), 975-983 (2003)
   PUBMED   12927815
REFERENCE   9  (bases 1 to 6718)
  AUTHORS   Mogensen,M.M., Malik,A., Piel,M., Bouckson-Castaing,V. and
            Bornens,M.
  TITLE     Microtubule minus-end anchorage at centrosomal and non-centrosomal
            sites: the role of ninein
  JOURNAL   J Cell Sci 113 (Pt 17), 3013-3023 (2000)
   PUBMED   10934040
REFERENCE   10 (bases 1 to 6718)
  AUTHORS   Bouckson-Castaing,V., Moudjou,M., Ferguson,D.J., Mucklow,S.,
            Belkaid,Y., Milon,G. and Crocker,P.R.
  TITLE     Molecular characterisation of ninein, a new coiled-coil protein of
            the centrosome
  JOURNAL   J Cell Sci 109 (Pt 1), 179-190 (1996)
   PUBMED   8834802
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473947.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216723.4, XM_001077019.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..6718
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..6718
                     /gene="Nin"
                     /note="ninein"
                     /db_xref="GeneID:299117"
                     /db_xref="RGD:1306492"
     exon            1..109
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            110..156
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            157..360
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..6273
                     /gene="Nin"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ninein (GSK3B interacting protein)"
                     /codon_start=1
                     /product="ninein isoform 1"
                     /protein_id="NP_001100207.1"
                     /db_xref="GeneID:299117"
                     /db_xref="RGD:1306492"
                     /translation="MDEVEQDQHEARLKELFDSFDTLGTGSLGQEELTDLCHVLCLED
                     VGPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSSEEHFEESDCSPEAQPKYVRGG
                     KRYGRRSLPEFQESGEEFAEVTVLEPLEEEARPSHIPAGDCSEHWKTQRSEEYEAEGQ
                     LRFWNPDDLNASHGGSCPPPDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQN
                     VDGAMLEEVFLSLDPDGTMSVEDFFYGLFKTGKSLTPSASTPYRQLKRHLSMQSFDES
                     GRRTTTSSAMMSTIGFRVFSCLDDGMGQASVERILDTWQEEGIENSQEILKALDFSLD
                     GNINLTELTLALENELLVTKNGIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDK
                     AEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRQEREQILQQVGK
                     QRVELEQEIEKAKTEENYIRDRLALSLKENNRLENELLENAEKLAEYENLTSKLQRSL
                     ENVLAEKFGDLDPSSAEFFLQEERLAQMRNEYEQQCRLLQDQVDELQSELEEYQAQGR
                     VLRLPCQNALSEELDGHGDGIEQDQEPGSGECNPLNMSIEAELVIEQLKEQHHRDLCH
                     LRLELEDKVRHYEKQLDHTRVACEKEQVAMKQKYEQGMRTLEKQISELQSEIADLQGQ
                     AAVLKEAHHKASCRHEEEKKQLQMVFDEEKTQLQEELRLEHEQELKARLQQAEESFRQ
                     EREGLAQAAAWTEEKARSLTRDLEQSHQEQLLSLMEKHALEKEELRKELSEYHQRELQ
                     EGREEMETECNRRVSQIEAQFQADCEKVTERCEQTLQSLEGRYRQELKDLLDQHLEER
                     SQWEFEKDELTQECTEAQEQLEEVLQREKATALARSQEQETLEKTHKERLAILSMERE
                     QLLQDLKDLQNTSERQHSLLSDQMLELKRSQERELREPEHVLCQTGVSEQLGSQQLAR
                     LQVEHEQERREMAGKIAALESAHRVSCERADQEKAEMSAEIRRLQSTVKDLQQATSLL
                     VLQGGCRATAGEEAEGNGALSLLQQGEQLLEENGDVLISLQKAHERAVKENAKMATEI
                     SRLQQRLKKLEPGSAISSCLEERMTEISGSSREHAEPVMKRGTATKHFLSDPGDHEAQ
                     GLGSTGTSSVQRQECRTEESEASLECFSELENSEDTRTESWDLKSQIIQLQEQLTVLR
                     ADCDRASERKRDLLFDISVLKKKLKMLERLPEASSKYKVLYEDAARENACLQEELRLM
                     EMRYADSLDSNKELTAEVYRLQDEMKKMEEVTGTFLSLENSYDEVKLENEKLSALVLR
                     LQGKMEEVLERAALQGDSYSLWEGPSENLEVTSDEKMLELHQTEEECTPEVMSRHHII
                     EECRQETRCCEQGSTQLLAGIKAHEIAWFRRKIETHQEKPSVQNRVILEESAALLGLQ
                     GTHLQHEATIAELELEKQKLQELTRNLRERVTTLAKQKDAPSQGEEEEELKAVMHDLQ
                     ITCGEMQRKVELLRYESEKLQEENSILRNEITTLNEEDSISNLKLEELNGSQEELWQK
                     IETIEQEKASIQKMVEKLKKQVSDLKLKNQQLDSENKELSQKNSQNKEELKTLNQRLA
                     EMLCQKEDPGTCTSEKWEQENESLKEELDRYKVQTSTLVSSLEAELSEVKLQTHIVEQ
                     ENLLLKDELERLKQLHRCPDLSDFQQKMCSILSYNENLLKEKEVLSEELKSCADKLAE
                     SSLLEHRIATIKEEREAWEEQSQDLKSQLALSQEKVQNLEDILKNVNLQMAQIESDLQ
                     VTRQEKEALKQEVMSLHLQLQNAIDKDWVSETATHLSGLQGQQKRLSWNKLDHLMSEE
                     PELLCQESKRLQTVVQNTQADLTHSREKIRQLESNLLPTKHQKQLNQSCTVKPIEQEK
                     LALKRECEQSRKERSPTSRKVSQMSSLERELETIHLENEGLKKKQMQPLRSAGTHSPS
                     SHWDLQLLQQQACPMVPREQFLQLQQQLLQAEKRSQHLQEELDNRTSEPNTVQALLPE
                     QRAVHADSCRRIGHL"
     exon            361..442
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            443..612
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            613..652
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            653..843
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            844..990
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1158
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1295
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1436
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1611
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1722
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1812
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1951
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2073
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2579
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..4700
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            4701..4826
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            4827..4896
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            4897..5109
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            5110..5223
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            5224..5346
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            5347..5460
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            5461..5607
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            5608..5787
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            5788..5937
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            5938..6012
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            6013..6210
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
     exon            6211..6718
                     /gene="Nin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggagcga gcgcgctggg cgcggccgtc ccgtgccgcc gggccaagcc tgagagtccc
       61 gcggtcatgg tctgtgcggt ggcgcggggc gcctaaaccc caggacgcga gctccggagg
      121 cggccggcgt gggcgctccc cagaggccga aggaaggtgt gccctgtggg ctatgggatg
      181 gatgaggtgg agcaggacca acatgaggcc cgactcaagg agctgtttga cagttttgac
      241 accctgggaa ctgggtctct gggtcaagag gagctcactg acctctgcca tgtgctatgc
      301 ttggaagatg tgggcccggt gctgcaacag acgctactcc aggacaacct cttgggcagg
      361 gtacatttcg accaatttaa agaagcatta atacttatct tgtctagaac tctgtccagt
      421 gaggagcact ttgaggagtc agactgctca ccagaagctc agcccaaata cgttagaggc
      481 gggaagcgtt atggacggag atccctgccc gagtttcaag agtctgggga agagtttgca
      541 gaggtgacag tgcttgagcc actggaggaa gaagccaggc catcacacat cccagctggt
      601 gactgcagtg agcactggaa gacacaacgc agtgaggagt atgaagcgga aggccagctg
      661 aggttttgga atccagacga cctgaatgct tcacatggtg ggtcttgccc tcctccagac
      721 tggatagaag agaagctgca agaggtttgt gaggatctgg ggatcactcg agatggtcac
      781 ctgaaccgga agaagctggt ttccatctgc gaacagtatg gattgcagaa tgtggatgga
      841 gcgatgctgg aagaggtgtt tctcagcctc gaccctgatg gtacaatgag tgtggaagac
      901 tttttctatg gtctgtttaa gactgggaaa tcccttacac catcagcatc tactccctat
      961 agacaactaa aacggcatct gtctatgcag tcttttgatg agagtggacg gcggaccaca
     1021 acctcgtcag caatgatgag taccattggc ttccgggtct tctcctgctt ggatgatggg
     1081 atgggccagg catcggtgga gaggatcctg gacacctggc aggaggaggg cattgagaac
     1141 agccaggaga tcctgaaggc tttggatttc agcctggatg gaaacatcaa cctgacagag
     1201 ctgacgctcg ctcttgagaa tgaactcttg gttaccaaga atggcattca ccaggcagct
     1261 ctagccagct tcaaggctga gatccggcat ttgttagaac gagttgacca agtagtcaga
     1321 gaaaaagaga aactacggtc ggacttggac aaagcagaaa agctgaagtc gctaatggct
     1381 tctgaggtgg atgatcacca tgcggccatt gaacggagga acgagtacaa cctcaggaaa
     1441 ctggatgaag aatacaagga gcgcatagca gccttaaaga atgaactccg ccaagagagg
     1501 gaacagatcc tgcagcaagt gggcaagcag cgggtggagc tggaacagga gattgaaaag
     1561 gccaaaacag aagagaatta catccgggac cgccttgccc tctccctcaa ggaaaacaat
     1621 cgcctggaaa atgagcttct ggaaaacgca gagaagttgg cagagtacga gaacctgaca
     1681 agcaaacttc agcgcagttt ggaaaatgtg ttagcggaga agtttggtga cctcgatccc
     1741 agcagtgctg aattctttct tcaagaggag aggctggcac agatgcgaaa tgaatatgaa
     1801 cagcagtgca ggctactaca agaccaagtg gatgagctcc agtctgaact agaggagtac
     1861 caggcgcagg gcagagtgct cagactgccc tgtcagaacg cgctgtcaga agaactggac
     1921 ggtcacgggg atggtatcga gcaggaccaa gagcctggtt ctggagaatg caacccactg
     1981 aatatgagca ttgaggcaga gctggtcatc gaacagctga aagagcagca ccacagggac
     2041 ctgtgtcacc tgagactgga gctggaagac aaagtgcgcc actatgaaaa gcagctggat
     2101 cacaccaggg tcgcctgtga aaaggagcag gtggccatga agcaaaagta tgagcaggga
     2161 atgcgcacct tggagaagca aatcagtgag cttcagagtg agattgcaga ccttcagggg
     2221 caggcagcgg tgctgaagga ggcccaccac aaggccagct gcaggcacga ggaggaaaag
     2281 aaacagctgc aaatggtgtt tgatgaggaa aagactcagc ttcaggagga gctgcggctg
     2341 gagcatgagc aggagctcaa ggccaggctg cagcaggcag aggaaagctt tcgtcaggag
     2401 agagagggac tcgctcaggc tgccgcctgg actgaagaga aggcgaggag cttgactcgg
     2461 gacctggagc agtctcacca ggagcagcta ctgagcctga tggagaagca tgctctagag
     2521 aaagaagagc tgagaaaaga gctctcggaa tatcaccaac gggaactcca ggagggacgg
     2581 gaagaaatgg aaacagagtg taatagaaga gtctctcaga tagaagccca gtttcaggct
     2641 gactgtgaga aagtcactga gcgctgtgaa caaacgctgc aaagccttga gggtcgctac
     2701 cgccaagagc tgaaggacct cctggaccag cacctggagg agagatctca gtgggagttc
     2761 gaaaaggatg agctcactca agagtgcacg gaagcccagg aacagctgga ggaggtgctc
     2821 caaagggaga aggcgaccgc tctggccagg agccaggaac aggagacgct ggagaagacg
     2881 cacaaggagc gtttggctat cctgagcatg gaaagagagc agctgttgca agacctgaaa
     2941 gacctacaga acacatctga gcgccagcac agcctcctgt ctgaccagat gcttgagttg
     3001 aagagaagtc aggagagaga gctgagggag ccagagcacg tgctgtgcca gaccggggtc
     3061 tctgagcagc taggcagcca gcagctggca agactacagg tagagcatga gcaagagagg
     3121 cgagaaatgg caggcaagat tgccgccctg gagagcgccc acagggtgag ctgtgagaga
     3181 gcggatcaag agaaggcaga gatgagcgct gaaatccgca ggcttcagag tacagttaag
     3241 gacctacagc aggcaacatc tctcttggtg cttcagggtg gctgccgggc aacggcgggg
     3301 gaggaggcag aaggaaacgg agccctgtcc ctgcttcagc aaggggagca gctgttggaa
     3361 gaaaatggag acgtcctcat cagcctgcag aaagctcacg agcgcgcagt gaaggaaaat
     3421 gcaaaaatgg ccactgaaat ttctagattg caacagaggc tgaaaaagtt agagccgggg
     3481 tcagcgatct cctcttgttt ggaggagcgg atgactgaga tttctggaag ttccagggaa
     3541 catgcagaac ccgtaatgaa acgaggtaca gccactaagc acttcctaag tgacccagga
     3601 gaccacgagg cccagggcct ggggagtaca gggacgagct ctgttcagag gcaggagtgc
     3661 agaacggagg agtcggaagc ttccctggag tgcttttctg agcttgaaaa cagtgaagac
     3721 accaggacag agtcctggga cctgaagagt cagatcatcc agcttcagga gcaactaaca
     3781 gtcttgcgtg cagactgcga tcgggcttct gagaggaagc gggacctgct ttttgatatc
     3841 tctgtgctga aaaagaaact aaagatgttg gagaggctcc ccgaggcgtc ttccaagtat
     3901 aaggtgttgt atgaggatgc ggctagagaa aacgcctgcc tccaggagga gttgaggctc
     3961 atggagatgc gctacgcgga ctcgctggac agcaacaaag agctcaccgc tgaggtctac
     4021 aggttgcagg atgagatgaa gaaaatggag gaggtgacgg ggacattcct cagcctggag
     4081 aacagctacg atgaggtcaa actggagaat gagaagctca gtgctctggt gttgagactt
     4141 caagggaaga tggaggaggt gctggaaagg gctgccctgc agggtgacag ctactccctg
     4201 tgggaaggtc cttcagagaa tctggaggtc acctctgatg aaaagatgct tgaactccat
     4261 cagaccgaag aagagtgtac acccgaggtc atgagcaggc accatatcat agaagagtgt
     4321 agacaggaaa cccggtgctg tgaacaggga agcacgcagc tcctggctgg cataaaagca
     4381 cacgaaatcg cctggttccg cagaaaaatt gagacgcatc aagaaaagcc tagcgtgcag
     4441 aaccgagtta tcctggagga gagtgctgct ctcctgggcc ttcagggcac acatcttcag
     4501 cacgaggcca caatcgcaga gttagaactg gagaagcaaa agctacagga gctgactaga
     4561 aatttgaggg agcgagtcac taccttagct aagcaaaaag acgcaccttc tcaaggagag
     4621 gaggaggaag agctgaaggc cgtgatgcac gacttgcaga tcacgtgcgg tgagatgcag
     4681 aggaaggttg aacttctgag atatgaatct gaaaagcttc aagaggaaaa ttctattttg
     4741 agaaatgaaa ttactacttt aaatgaggaa gatagcatct ctaacctgaa attggaggag
     4801 ttaaatgggt ctcaggaaga attgtggcag aaaatagaaa ccatagagca ggaaaaggct
     4861 tccattcaga agatggttga aaaactaaag aaacaggttt cagatttaaa actcaaaaac
     4921 caacagttgg attcagaaaa taaagaactc agccaaaaga actcccaaaa caaggaagaa
     4981 ctgaaaaccc ttaatcaacg tctggcagaa atgctgtgcc agaaggagga cccaggaact
     5041 tgcacctctg agaaatggga gcaagaaaat gagagcctca aagaagaact ggatcgctac
     5101 aaagttcaga cgtccacttt ggtgtcttct ctggaggccg agctttctga agttaaactg
     5161 cagactcaca ttgtggagca agaaaacctc ctcctcaagg atgaactgga gagattgaag
     5221 caactgcaca gatgtcctga cctctctgac ttccagcaaa aaatgtgtag cattctaagc
     5281 tacaacgaaa acctgctgaa ggagaaagaa gttctcagtg aagaattaaa gagctgtgcc
     5341 gataagttgg cagaatcaag ccttttagag cacagaattg ctacaataaa ggaggaacgg
     5401 gaggcctggg aagagcagag ccaggacctg aagtcccagc tggcgctttc ccaggaaaag
     5461 gttcagaatt tagaagatat cctgaagaat gtaaaccttc aaatggccca gatagaatca
     5521 gacctccaag tgactcgaca ggaaaaggag gctctaaagc aggaagtgat gtcattacac
     5581 ctacagcttc agaatgccat cgacaaggac tgggtctcgg aaacagctac ccatctctca
     5641 gggctccagg gccagcagaa aaggctatcc tggaacaaac tggatcatct gatgagtgag
     5701 gaaccagagc tgctttgtca agaaagcaag aggctccaga ctgtagttca gaacacccaa
     5761 gcagacctca cacactcccg ggagaagatc cgtcaactgg aatccaacct tctgcccacc
     5821 aagcaccaaa agcaactcaa ccaatcgtgt actgtgaagc ccatagaaca agaaaaattg
     5881 gccttaaaga gagagtgtga acagtctcgg aaggagcgat ctcctaccag caggaaggtc
     5941 agtcagatga gttcccttga gcgagaatta gaaacaatcc atttggaaaa tgaaggtctg
     6001 aagaagaaac agatgcagcc cctgaggtcc gctgggacgc atagcccatc ctctcactgg
     6061 gatctgcagt tgctccagca gcaagcctgt ccgatggtgc ccagggagca gtttctgcag
     6121 cttcaacagc agctgctgca ggcagaaaag agaagccagc acctgcagga ggagcttgac
     6181 aacaggacct ccgaacccaa cacagtgcag gccttgctac cggagcagcg agcggtgcac
     6241 gcagattcct gcaggaggat tgggcacctc tgaaaactgg gctgctgtta ccatgacagt
     6301 ctcaaatgca cacatgcaca catgtacacg cacaccgtac acagacatga gctgggacat
     6361 gttggaatca agtgctcttt taaattattc gactgttact tcacggctaa agccttcaca
     6421 gtattgtttc tcctttatgc agacgtgaaa gactttgtga atcagtcaca aacttcagct
     6481 tgctacaaat cagcttattt atatggttta aagagtggat ttaagattct tgaaagcata
     6541 tattctatat attttctcat tccatatgat gtaattattt ttaaaagaag gtactacttt
     6601 tatatatgga atttgaagaa aatcagggtt atttatactg tttttgtata agatgtacca
     6661 tactttttga cagaaaaaag ggaaattttg atgcaacaat aaaacaaaat ttaaatgt
//
