LOCUS       NM_001012005            4782 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus nidogen 2 (Nid2), mRNA.
ACCESSION   NM_001012005 XM_238622
VERSION     NM_001012005.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4782)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 4782)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 4782)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 4782)
  AUTHORS   Soteriou,D., Iskender,B., Byron,A., Humphries,J.D.,
            Borg-Bartolo,S., Haddock,M.C., Baxter,M.A., Knight,D.,
            Humphries,M.J. and Kimber,S.J.
  TITLE     Comparative proteomic analysis of supportive and unsupportive
            extracellular matrix substrates for human embryonic stem cell
            maintenance
  JOURNAL   J Biol Chem 288 (26), 18716-18731 (2013)
   PUBMED   23658023
REFERENCE   5  (bases 1 to 4782)
  AUTHORS   Sage,J., Leblanc-Noblesse,E., Nizard,C., Sasaki,T., Schnebert,S.,
            Perrier,E., Kurfurst,R., Bromme,D., Lalmanach,G. and Lecaille,F.
  TITLE     Cleavage of nidogen-1 by cathepsin S impairs its binding to
            basement membrane partners
  JOURNAL   PLoS One 7 (8), e43494 (2012)
   PUBMED   22952693
REFERENCE   6  (bases 1 to 4782)
  AUTHORS   Oner,H., Oner,J. and Demir,R.
  TITLE     Expression of nidogens in rat uterus and embryo during
            decidualization and implantation
  JOURNAL   J Morphol 267 (7), 822-830 (2006)
   PUBMED   16607619
  REMARK    GeneRIF: Results indicate that nidogen-2 could play an important
            role during embryogenesis, decidualization, and implantation in the
            endometrium of uterus.
REFERENCE   7  (bases 1 to 4782)
  AUTHORS   Tomte,L.T., Annatshah,Y., Schluter,N.K., Miosge,N., Herken,R. and
            Quondamatteo,F.
  TITLE     Hematopoietic cells are a source of nidogen-1 and nidogen-2 during
            mouse liver development
  JOURNAL   J Histochem Cytochem 54 (5), 593-604 (2006)
   PUBMED   16618944
REFERENCE   8  (bases 1 to 4782)
  AUTHORS   Lee,H.K., Seo,I.A., Park,H.K. and Park,H.T.
  TITLE     Identification of the basement membrane protein nidogen as a
            candidate ligand for tumor endothelial marker 7 in vitro and in
            vivo
  JOURNAL   FEBS Lett 580 (9), 2253-2257 (2006)
   PUBMED   16574105
REFERENCE   9  (bases 1 to 4782)
  AUTHORS   Gersdorff,N., Muller,M., Otto,S., Poschadel,R., Hubner,S. and
            Miosge,N.
  TITLE     Basement membrane composition in the early mouse embryo day 7
  JOURNAL   Dev Dyn 233 (3), 1140-1148 (2005)
   PUBMED   15895400
REFERENCE   10 (bases 1 to 4782)
  AUTHORS   Salmivirta,K., Talts,J.F., Olsson,M., Sasaki,T., Timpl,R. and
            Ekblom,P.
  TITLE     Binding of mouse nidogen-2 to basement membrane components and
            cells and its expression in embryonic and adult tissues suggest
            complementary functions of the two nidogens
  JOURNAL   Exp Cell Res 279 (2), 188-201 (2002)
   PUBMED   12243745
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC169012.1.
            
            On Aug 29, 2008 this sequence version replaced NM_001012005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169012.1, SRR8487231.71051.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132306,
                                           SAMD00155331 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4782
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..4782
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /note="nidogen 2"
                     /db_xref="GeneID:302248"
                     /db_xref="RGD:1311685"
     exon            1..251
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..4214
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /note="nidogen 2 (osteonidogen)"
                     /codon_start=1
                     /product="nidogen-2 precursor"
                     /protein_id="NP_001012005.2"
                     /db_xref="GeneID:302248"
                     /db_xref="RGD:1311685"
                     /translation="MSWDPTAGRLAPPSPLSLLLVLVLLSRVGALRPEELFPYGESWG
                     DRLLPEGDDESSAAVKLAVPLRFYDAQFSNLYVGTNGIISTQDFPRETQYVDDDFPTD
                     FPAIAPFLADIDTSHSRGRILYREDTSQAVLSLAARYVRTGFPLTGSSFTPTHAFLAT
                     WEHVGAYEEVRRGAAPSGELNTFQAVLASDESDTYALFLYPANGLQFFGTRPKESYNV
                     QLQLPARVGFCRGEADDLKREALYFSLTNTEQSVKNLYQLSNLGIPGAWAFHIGSRLA
                     LDNVRPATVGGDHSTARSSALEHSFNHAAALESYTEDSFDYYNENEEDVEYPPIEPGE
                     ALEGHSRIDVSFNSEVNPTSPDSDHASPLPHPAPGNWPSYRETESASLDPQTKQGPPV
                     GEVEVLDFKDPAELLDQTGTRTPAPPGADAAFLTPGREDLGNRDTQSYPEARPVPSEP
                     DVPVAPLEREILPNYPESGHVPPLSGGRYVVGLEDHVSSKDQVFTYNGANRETCEHSH
                     GQCSRHAFCTDYTTGFCCHCQSRFYGNGRHCVPEGAPHRVNGKVSGHLQVGHMPVHFT
                     DVDLHAYIVSNDGRAYTAISQIPQPAAQALLPVLPIGGLFGWLFALEKPGSENGFSLT
                     GATFVHDVEVTFHPGEERVRITQTAEGLDPENYLSLNTNIEGQVPFIPANFTAHIAPY
                     QEFYHHRDSVVTSSSSRSFSLISGSINQTRSYRIDQNITYKACSHAPRHLAVPATQQL
                     TVDRAFALYSEEEGVLRFAVTNQIGPVEVDSAPTAVNPCYDGSHTCDTTARCHPGTGV
                     DYTCECTPGFQGDGRSCVDVNECATGFHRCGPNSVCVNLVGSYRCECRSGYEFADDRH
                     TCVLIAPPPNPCLDGSHTCAPEGQARCIHHGGSSFSCACLPGFVGTGHQCSDVDECAE
                     NRCHGAAICYNTPGSFSCRCQPGYHGDGFHCASDTVPEDSISGLKPCEYQQRYAQAQH
                     AHAGSRIHIPQCDDQGNFVPLQCHGSTGFCWCVDQNGHEVPGTQTPPGSTPPHCGPPP
                     EPTQRPRTVCERWRESLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKD
                     GRELPGTRSQPGTMPACIPTVAPPVVRPTPRPDVTPPAVGTFLLYAQGQQIGHLPLNG
                     SRLQKDAARTLLSLHGSIVVGIDYDCRERMVYWTDVAGRTISRASLEAGAEPETIITS
                     GLISPEGLAIDHFRRTMYWTDSGLDKIERAGLDGSERKVLFHTDLVNPRAITVDPIRG
                     NLYWTDWNREAPKIETSSLDGENRRILINKDIGLPNGLTFDPFSKLLCWADAGTKKLE
                     CTLPDGTGRRVIQNHLNYPFSVVSYADHFYHTDWRRDGVISVSKDSGQLTDEYLPEQR
                     SHLYGITAVYPYCPTGRK"
     exon            252..560
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            561..793
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1500
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1650
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1896
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2097
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2328
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2472
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2601
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2745
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2865
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..3114
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3336
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3506
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3507..3636
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..3808
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3809..3966
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3967..4090
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4091..4203
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4204..4754
                     /gene="Nid2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagagcca aggaggagtg agcatgtctt gggacccgac agccgggcgg ctggcaccgc
       61 catcaccgct atcgctgctc ctggtgctgg tgctgctgtc acgagtcggg gctctgcgtc
      121 ctgaagagct ctttccttac ggggagtcgt ggggagaccg actgctgccg gagggtgacg
      181 atgaaagctc agcggctgtg aagctagcag tacctctacg cttctacgat gcccagttca
      241 gcaacctcta cgtgggcacc aacggcatca tctccaccca ggacttcccc agggagactc
      301 aatatgtaga tgatgatttt cctactgact tcccagccat cgccccattc ctggctgaca
      361 tcgacactag tcacagcagg ggccggatcc tgtaccgcga ggacacctcc caggctgtgc
      421 tgagtctggc tgcccgctac gtgcgcacag gcttcccgct gaccgggtcc agcttcaccc
      481 ctacccacgc cttcctggcc acctgggagc acgtgggcgc ctatgaggag gtcaggcgcg
      541 gggctgcgcc atccggagag ctgaacactt tccaggccgt tctggcatcc gatgagtctg
      601 atacctacgc cctctttctc tatcctgcca atggtcttca gttctttgga actcgcccca
      661 aagagtccta caatgtccag ctgcagcttc ctgccagggt gggcttctgc cgaggggaag
      721 cagacgacct gaagagagaa gcgctgtatt tcagcctgac taacactgag cagtcggtga
      781 agaatctcta ccaactaagc aacctgggga ttcctggagc gtgggccttt cacatcggca
      841 gcaggctggc cctggacaat gtccggccag ccacagttgg aggtgaccat tccacagccc
      901 gctcctcagc gctggagcac tccttcaacc atgctgcagc cctggagagc tatactgagg
      961 acagtttcga ttactacaat gagaatgaag aggatgtaga atacccaccc attgaaccag
     1021 gggaggccct ggaaggccac agcagaatcg atgtgtcttt caattcagag gttaatccca
     1081 cgtctccaga ttctgatcac gcttctcctt tgccacaccc agcacctggt aactggccat
     1141 cctaccggga aacagaatcg gcttctttgg accctcaaac caaacagggg ccacctgtgg
     1201 gagaggtaga ggtcctggat ttcaaggacc cagcagaact tttggatcag acgggcacca
     1261 gaaccccagc tcctccaggg gcagatgcag ctttcctaac tccaggcagg gaagaccttg
     1321 ggaacagaga cacccagtcc tatccagagg cacggccagt gccttcagag ccagatgttc
     1381 ctgtcgctcc tctggaaaga gaaatccttc ctaattaccc cgagtctggt cacgtgccac
     1441 ccctgagtgg agggaggtat gtggtaggac tggaggacca cgtgagttct aaagatcaag
     1501 tcttcactta caatggcgcc aaccgggaaa cctgtgaaca cagccacggc cagtgctccc
     1561 ggcatgcctt ctgcaccgac tacaccactg gcttttgctg ccactgccag tctaggtttt
     1621 atggaaacgg gaggcactgc gtgccagaag gggcgcctca ccgagtgaat gggaaggtga
     1681 gtggccatct ccaagtgggc cacatgcctg tgcacttcac ggatgtggat ctacacgctt
     1741 acatcgtgag caatgacggc agagcctaca ctgccatcag tcagatcccg cagcccgcag
     1801 cccaggccct cctccctgtc ctgcccatcg gaggcctgtt tggctggctc tttgctttgg
     1861 agaagccagg ctctgagaat ggcttcagcc tcacaggagc tacctttgtc catgatgtgg
     1921 aagtcacttt tcaccctgga gaggagagag ttcgtatcac tcaaaccgcc gaggggcttg
     1981 acccagagaa ctatctgagc cttaacacca acatcgaagg ccaggtgccc tttatcccag
     2041 caaatttcac agcccacatt gctccgtacc aagagttcta tcatcacaga gactcagtcg
     2101 tgacatcctc cagctcccga agtttctccc tcatttctgg ttctatcaac caaactcggt
     2161 cctaccgcat cgaccagaac atcacttaca aggcgtgcag tcatgccccc agacacctgg
     2221 ccgtccctgc cacccagcag ctgactgtgg accgggcctt tgctttgtac agtgaggagg
     2281 agggcgtgct gaggtttgcc gtgaccaatc agattggccc tgtcgaagtg gactcggccc
     2341 ctactgcagt gaatccttgc tatgacggga gccacacctg tgacacaaca gcaaggtgcc
     2401 acccggggac gggtgtggac tacacctgcg agtgcacgcc cgggttccag ggtgacggac
     2461 ggagctgtgt ggatgttaat gagtgtgcca ctggcttcca tcgctgcggc cccaattctg
     2521 tgtgtgtcaa cttggtgggg agctacaggt gcgagtgccg cagcggctat gaattcgcag
     2581 atgaccggca cacttgtgtc ttgatcgccc cacctcccaa cccttgcctg gatggcagtc
     2641 acacctgtgc ccctgagggg caggcccggt gcattcacca tggaggcagt tcgttcagct
     2701 gtgcctgcct gcccggcttt gttggcaccg ggcaccagtg ttctgatgtt gacgaatgtg
     2761 cggaaaacag atgtcatggg gcagccatct gttacaatac ccccgggtcc ttctcctgcc
     2821 ggtgccagcc tgggtaccac ggggacgggt ttcactgcgc ctctgacaca gttccagaag
     2881 attccatctc aggactgaaa ccctgtgaat accagcagcg ctatgcccag gcacagcatg
     2941 cccacgctgg gtcacggatc cacatccccc agtgcgacga ccagggaaac tttgtgccgc
     3001 tgcagtgcca tggcagcact ggcttctgct ggtgtgtgga ccaaaatggc catgaagtcc
     3061 ctggcaccca gactccacct ggctccactc cgccccactg tggaccacct ccagagccca
     3121 cccagaggcc tcggacagtc tgtgagcgct ggagggaaag cctgctggaa cactacgggg
     3181 gcacacccag ggacgaccag tatgtgcccc agtgtgacga cctgggccac ttcatccccc
     3241 tgcagtgtca cgggaagagt gatttctgtt ggtgtgtgga caaggatggc agagaacttc
     3301 caggcacccg ctcccagcca ggcaccatgc ctgcatgcat acccactgtc gccccacccg
     3361 tggtccggcc cacaccccgg cctgatgtga ctcctccggc tgtgggcacc ttcctgctct
     3421 atgcccaggg ccagcagatc ggtcacttgc ccctcaatgg cagcaggctt cagaaggatg
     3481 cagccaggac cctgctgtca ctacatggct ccatagtcgt ggggattgac tatgactgcc
     3541 gggagaggat ggtctactgg acagacgttg ccgggaggac catcagccgt gccagcttgg
     3601 aggcaggagc cgaacccgag accatcatta cctcaggtct gataagccca gaaggacttg
     3661 ccatcgacca cttccggaga acgatgtact ggacagacag cggcctggat aagatagagc
     3721 gggctggact ggacggttcc gagcgtaagg tcctcttcca cacagatctg gtgaatccac
     3781 gagctatcac tgtggatcca atccgaggca acttgtactg gacagactgg aatagagaag
     3841 ctcctaaaat tgaaacatca tctttagatg gtgaaaacag aagaattctg atcaacaaag
     3901 atattggatt acccaatgga ttgacctttg accccttctc caaacttctc tgctgggcag
     3961 atgcaggaac caaaaaactg gagtgtacac tacctgatgg aactggacgc cgcgtcatcc
     4021 aaaaccacct caattacccc ttcagtgttg tcagttacgc ggatcacttc taccacacgg
     4081 actggcggag ggatggtgtt atatcagtga gtaaagacag tggccagctt actgatgagt
     4141 atcttcctga acagcgctct cacctctatg gcatcactgc agtctatccc tactgtccaa
     4201 caggaagaaa gtgaacatta aatgtacagg aggatttcaa gtttacaaga acctaagaac
     4261 attgctacga aggcaaagag tgaaggagga attggccatt atgagctctt ggcacacaaa
     4321 acgagcattt tcagtggagt gagactcaag tctatcttgt gaaatgtata cctcaatcct
     4381 gactactgta tttttaaaaa caaaggttat cacaagtttc agatagaatg ttatataaac
     4441 aatcagctag agcagacacc aagtctgact tttgtttgcc acggattcta cctggccaag
     4501 aaaagtgaag caaacgaatg ttatgaaaac ttattcctaa agctcagaga cccctgtcca
     4561 gcagaccatg gggttgaccc agcctattta tactgcccgg tgaagtcctc agactgtatt
     4621 tatactaaag gtgctagaat gattccccaa gtgcctctgc agaagcatcc ctcaaaagta
     4681 ttctgtataa aacaccaaag actgcagcag ttcttaaatt ttctatataa ctccaataaa
     4741 atattttaaa gcttaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
