LOCUS       NP_001385449            1246 aa            linear   ROD 03-JUN-2025
DEFINITION  nidogen-1 precursor [Rattus norvegicus].
ACCESSION   NP_001385449 XP_213954
VERSION     NP_001385449.1
DBSOURCE    REFSEQ: accession NM_001398520.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1246)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (residues 1 to 1246)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (residues 1 to 1246)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (residues 1 to 1246)
  AUTHORS   Soteriou,D., Iskender,B., Byron,A., Humphries,J.D.,
            Borg-Bartolo,S., Haddock,M.C., Baxter,M.A., Knight,D.,
            Humphries,M.J. and Kimber,S.J.
  TITLE     Comparative proteomic analysis of supportive and unsupportive
            extracellular matrix substrates for human embryonic stem cell
            maintenance
  JOURNAL   J Biol Chem 288 (26), 18716-18731 (2013)
   PUBMED   23658023
REFERENCE   5  (residues 1 to 1246)
  AUTHORS   Sage,J., Leblanc-Noblesse,E., Nizard,C., Sasaki,T., Schnebert,S.,
            Perrier,E., Kurfurst,R., Bromme,D., Lalmanach,G. and Lecaille,F.
  TITLE     Cleavage of nidogen-1 by cathepsin S impairs its binding to
            basement membrane partners
  JOURNAL   PLoS One 7 (8), e43494 (2012)
   PUBMED   22952693
REFERENCE   6  (residues 1 to 1246)
  AUTHORS   Konrad,L., Albrecht,M., Renneberg,H., Ulrix,W., Hoeben,E.,
            Verhoeven,G. and Aumuller,G.
  TITLE     Mesenchymal entactin-1 (nidogen-1) is required for adhesion of
            peritubular cells of the rat testis in vitro
  JOURNAL   Eur J Cell Biol 79 (2), 112-120 (2000)
   PUBMED   10727019
REFERENCE   7  (residues 1 to 1246)
  AUTHORS   Miosge,N., Quondamatteo,F., Klenczar,C. and Herken,R.
  TITLE     Nidogen-1. Expression and ultrastructural localization during the
            onset of mesoderm formation in the early mouse embryo
  JOURNAL   J Histochem Cytochem 48 (2), 229-238 (2000)
   PUBMED   10639489
REFERENCE   8  (residues 1 to 1246)
  AUTHORS   Noakes,P.G., Miner,J.H., Gautam,M., Cunningham,J.M., Sanes,J.R. and
            Merlie,J.P.
  TITLE     The renal glomerulus of mice lacking s-laminin/laminin beta 2:
            nephrosis despite molecular compensation by laminin beta 1
  JOURNAL   Nat Genet 10 (4), 400-406 (1995)
   PUBMED   7670489
REFERENCE   9  (residues 1 to 1246)
  AUTHORS   Durkin,M.E., Chakravarti,S., Bartos,B.B., Liu,S.H., Friedman,R.L.
            and Chung,A.E.
  TITLE     Amino acid sequence and domain structure of entactin. Homology with
            epidermal growth factor precursor and low density lipoprotein
            receptor
  JOURNAL   J Cell Biol 107 (6 Pt 2), 2749-2756 (1988)
   PUBMED   3264556
REFERENCE   10 (residues 1 to 1246)
  AUTHORS   Durkin,M.E., Carlin,B.E., Vergnes,J., Bartos,B., Merlie,J. and
            Chung,A.E.
  TITLE     Carboxyl-terminal sequence of entactin deduced from a cDNA clone
  JOURNAL   Proc Natl Acad Sci U S A 84 (6), 1570-1574 (1987)
   PUBMED   3470744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Dec 20, 2021 this sequence version replaced XP_213954.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.61787.1,
                                           SRR26643285.49549.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1246
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     Protein         1..1246
                     /product="nidogen-1 precursor"
                     /note="entactin; NID-1; nidogen (entactin)"
                     /calculated_mol_wt=133937
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3121
     Region          106..269
                     /region_name="NIDO"
                     /note="Extracellular domain of unknown function in nidogen
                     (entactin) and hypothetical proteins; smart00539"
                     /db_xref="CDD:214712"
     Region          389..424
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          428..659
                     /region_name="nidG2"
                     /note="Nidogen, G2 domain; Nidogen is an important
                     component of the basement membrane, an extracellular
                     sheet-like matrix. Nidogen is a multifunctional protein
                     that interacts with many other basement membrane proteins,
                     like collagen, perlecan, lamin, and has a...; cd00255"
                     /db_xref="CDD:238158"
     Site            order(432,458,460,467,469,471,640,645,649,651)
                     /site_type="other"
                     /note="collagen/perlecan interaction surface [polypeptide
                     binding]"
                     /db_xref="CDD:238158"
     Region          671..707
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          709..750
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(709,712,728)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          761..799
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          810..838
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          848..918
                     /region_name="Thyroglobulin_1"
                     /note="Thyroglobulin type-1 repeat; pfam00086"
                     /db_xref="CDD:459665"
     Site            order(852,872,890,894)
                     /site_type="active"
                     /note="protease interaction site [active]"
                     /db_xref="CDD:238114"
     Region          991..1029
                     /region_name="Ldl_recept_b"
                     /note="Low-density lipoprotein receptor repeat class B;
                     pfam00058"
                     /db_xref="CDD:459654"
     Region          1013..1054
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1055..1099
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1100..1136
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1211..>1235
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     CDS             1..1246
                     /gene="Nid1"
                     /gene_synonym="Nid"
                     /coded_by="NM_001398520.2:36..3776"
                     /db_xref="GeneID:25494"
                     /db_xref="RGD:3178"
ORIGIN      
        1 mldasgwswe mwtwallqll llagpagcls rqelfpfgpg qgdleleagd dvvspsleli
       61 gelsfydrsd itsvyvttng iiamseppat efhpgtfpps fgsvapflad ldttdglgnv
      121 yyredlspfi iqmaaeyvqr gfpevsfqpt svvvvtwesm apyggpsgsl veegkrntfq
      181 avlassnsss yaiflypddg lqffttfskk denqvpavvg fskglegflw ksngaynifa
      241 ndresienla kssnaghqgv wvfeigspat akgvvpadvn ldvdddgady ededydlqts
      301 hlgledvatq pfpshsprrg ypdphnvprt lapsyeater phgiptertk sfqlpverfp
      361 qkhpqvidvd eveetgvvfs yntgsqqtca nnrhqcsvha ecrdyatgfc crcvanytgn
      421 grqcvaegsp qrvngkvkgr ifvgnsqvpv vfentdlhsy vvmnhgrsyt aistipesvg
      481 ysllplapig giigwmfave qdgfkngfsi tggeftrqae vtflghpgkl ilkqqfsgid
      541 ehghltinte legrvpqipy gasvhiepyt elyhysssvi tssstreytv tepdqdsavp
      601 shthvyqwrq titfqecahd dsrpalpstq qlsvdsvfvl ynkeerilry alsnsigpvr
      661 dgspdalqnp cyigthgcds naacrpgpgt qftcecsvgf rgdgkacydi decseqpsrc
      721 gnhaicnnhp gtfrcecmeg yhfsdrgicv aavdqrpiny cetglhncdi pqraqciymg
      781 gssytcsclp gfsgdgracq dvdecqhsrc hpdafcyntp gsfrcqckpg yqgdgfrcvp
      841 gevgktrcql erehilgaag atdaqrptlq gmfvpqcdey ghytptqchh stgycwcvdr
      901 dgqeledtrt ppgmrppcls tvappihqgp vvptaviplp pgthllfaqt gkierlpler
      961 ntmkkteaka flhipakvii glafdcvdkv vywtdiseps igraslhgge pttiirqdlg
     1021 spegialdhl grtifwtdsh ldrievakmd gtqrrvlfdt glvnprgivt dsvrgnlywt
     1081 dwnrdnpkie tshmdgtnrr ilaqdnlglp ngltfdafss qlcwvdagth raeclnpaqp
     1141 srrkvleglq ypfavtsygk nlyytdwktn sviamdlavs kemdafhphk htrlygitia
     1201 lsqcpqghny csvnnggcth lclptpgsrt crcpdntlgv dcierk
//
