LOCUS       NM_001109885            3678 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus niban apoptosis regulator 2 (Niban2), mRNA.
ACCESSION   NM_001109885 XM_342417
VERSION     NM_001109885.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3678)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3678)
  AUTHORS   Chen,S., Evans,H.G. and Evans,D.R.
  TITLE     FAM129B/MINERVA, a novel adherens junction-associated protein,
            suppresses apoptosis in HeLa cells
  JOURNAL   J Biol Chem 286 (12), 10201-10209 (2011)
   PUBMED   21148485
REFERENCE   3  (bases 1 to 3678)
  AUTHORS   Zhang,X., Gejman,R., Mahta,A., Zhong,Y., Rice,K.A., Zhou,Y.,
            Cheunsuchon,P., Louis,D.N. and Klibanski,A.
  TITLE     Maternally expressed gene 3, an imprinted noncoding RNA gene, is
            associated with meningioma pathogenesis and progression
  JOURNAL   Cancer Res 70 (6), 2350-2358 (2010)
   PUBMED   20179190
REFERENCE   4  (bases 1 to 3678)
  AUTHORS   Zhang,X., Rice,K., Wang,Y., Chen,W., Zhong,Y., Nakayama,Y., Zhou,Y.
            and Klibanski,A.
  TITLE     Maternally expressed gene 3 (MEG3) noncoding ribonucleic acid:
            isoform structure, expression, and functions
  JOURNAL   Endocrinology 151 (3), 939-947 (2010)
   PUBMED   20032057
REFERENCE   5  (bases 1 to 3678)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 3678)
  AUTHORS   Gejman,R., Batista,D.L., Zhong,Y., Zhou,Y., Zhang,X.,
            Swearingen,B., Stratakis,C.A., Hedley-Whyte,E.T. and Klibanski,A.
  TITLE     Selective loss of MEG3 expression and intergenic differentially
            methylated region hypermethylation in the MEG3/DLK1 locus in human
            clinically nonfunctioning pituitary adenomas
  JOURNAL   J Clin Endocrinol Metab 93 (10), 4119-4125 (2008)
   PUBMED   18628527
REFERENCE   7  (bases 1 to 3678)
  AUTHORS   Zhou,Y., Zhong,Y., Wang,Y., Zhang,X., Batista,D.L., Gejman,R.,
            Ansell,P.J., Zhao,J., Weng,C. and Klibanski,A.
  TITLE     Activation of p53 by MEG3 non-coding RNA
  JOURNAL   J Biol Chem 282 (34), 24731-24742 (2007)
   PUBMED   17569660
REFERENCE   8  (bases 1 to 3678)
  AUTHORS   Zhang,X., Zhou,Y., Mehta,K.R., Danila,D.C., Scolavino,S.,
            Johnson,S.R. and Klibanski,A.
  TITLE     A pituitary-derived MEG3 isoform functions as a growth suppressor
            in tumor cells
  JOURNAL   J Clin Endocrinol Metab 88 (11), 5119-5126 (2003)
   PUBMED   14602737
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Oct 10, 2007 this sequence version replaced XM_342417.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168248.1, SRR22582424.118807.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               JAXUCZ010000003.1  36572356-36572601
            247-377             JAXUCZ010000003.1  36602866-36602996
            378-506             JAXUCZ010000003.1  36606787-36606915
            507-612             JAXUCZ010000003.1  36608212-36608317
            613-780             JAXUCZ010000003.1  36609286-36609453
            781-896             JAXUCZ010000003.1  36615515-36615630
            897-1001            JAXUCZ010000003.1  36616047-36616151
            1002-1164           JAXUCZ010000003.1  36616254-36616416
            1165-1352           JAXUCZ010000003.1  36617546-36617733
            1353-1508           JAXUCZ010000003.1  36618689-36618844
            1509-1625           JAXUCZ010000003.1  36619205-36619321
            1626-1733           JAXUCZ010000003.1  36619506-36619613
            1734-1845           JAXUCZ010000003.1  36619696-36619807
            1846-3678           JAXUCZ010000003.1  36620136-36621968
FEATURES             Location/Qualifiers
     source          1..3678
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..3678
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /note="niban apoptosis regulator 2"
                     /db_xref="GeneID:362115"
                     /db_xref="RGD:1307018"
     exon            1..246
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..2435
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /note="niban-like protein 1; family with sequence
                     similarity 129, member B"
                     /codon_start=1
                     /product="protein Niban 2"
                     /protein_id="NP_001103355.1"
                     /db_xref="GeneID:362115"
                     /db_xref="RGD:1307018"
                     /translation="MGDVLSTHLDDARRQNIAEKTEKILREFLRFYEDQYGVSLFNSM
                     RHEIEGTGPPQAQLLWRKVPLDERIIFSGNLFQYQEDNKKWRNRFSLVPHNYGLVLYE
                     NKVAYERQIPPRAVINSAGYKVLTSLDQYLELVGNSLPGTTSKSGSTPILKCPTQFPL
                     ILWHPYARHYYFCMMTEAEQDKWQAVLQDCVRHCNNGIPENSKVEGPAFTDAIRMYRQ
                     SKEQYGTWEMLCGNEVQILSNLVMEELGPALKTELGPRLKGKPQERQRQWIQISDAVY
                     RLVFEQAKVHFEEVLCKLQLARPAMEAVIRTDMDQIITSKEHLASKIRAFILPKAEVC
                     VRNHVQPYIPSILEALMVPTSQGFTEVRDVFFKEVTDMNLNVINEGGIDKLGEYMEKL
                     SQLAYHPLKMQSCYEKMEPLRLDGLQQRFDVSSTSVFKQRAQIHMREQMDNAVYTFET
                     LLHQELGKGPTKEELCKSIQRILERVLKKYDYDSSSVRKRFFREALLQITIPFLLKKL
                     APTCKSELPRFQELIFEDFARFILVENTYEEVVLQTVMKDILQAVKEAAVQRKHNLYR
                     DSVVLHNSDPNLHLLAEGAPIDWGEQYGDGGDGSDSGGSPCPSEAATLTEKRRRAKQV
                     VSVVQDEESGLPFEAGSEPPSPASPDNVTELRGLLAQDLQAESSPPASPLLNGAPVQE
                     SPQPMTVLEASPPASPLRHLPPGKAVDLEPPKPSDQETGEKVSSPGSRPPIHTTTEDS
                     AGVQTEF"
     exon            247..377
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /inference="alignment:Splign:2.1.0"
     exon            378..506
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /inference="alignment:Splign:2.1.0"
     exon            507..612
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /inference="alignment:Splign:2.1.0"
     exon            613..780
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /inference="alignment:Splign:2.1.0"
     exon            781..896
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1001
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1164
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1352
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1508
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1625
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1733
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1845
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..3678
                     /gene="Niban2"
                     /gene_synonym="Fam129b; Meg-3; RGD1307018"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagcctgg gcgcgggcta gagaggcagc agcgccggcg ggagggacgc agcggggatc
       61 tcggtaccag cgcagaggag cctaggcggc agccgggcta cgggcggcgg gagcggggcc
      121 tgcggactcc atggcgccag cggcgtccgt ctgagtagcg gtgggcggat ccggcttggc
      181 ttcttctcgc catgggagac gtactgtcca cacacctgga tgacgcgcgg cgccagaaca
      241 tcgcagagaa aactgagaag atcctgagag agttccttcg tttctatgag gaccagtatg
      301 gtgtctccct cttcaacagc atgcgccatg agattgaggg caccgggcct ccgcaggcac
      361 agctgctctg gcgcaaggtg cccctggatg aacgcatcat cttctccggg aaccttttcc
      421 agtaccagga agacaataag aagtggagaa accgcttcag cctggtgccc cataactatg
      481 ggctggtgct gtatgagaac aaagtggcct atgagcggca gataccaccc cgggccgtca
      541 tcaacagtgc tggctacaag gttctcacct ctctcgacca gtacctggag cttgtgggga
      601 attccctacc agggaccacg tcgaaatcag gctccacccc catccttaag tgcccaacgc
      661 agttccctct catcctgtgg catccgtatg cccggcacta ttacttctgc atgatgactg
      721 aagcggaaca ggacaagtgg caggcggtgc ttcaggattg cgtccgacac tgcaacaacg
      781 ggatcccgga gaactccaag gtggagggcc cagcattcac agatgccatc cgtatgtacc
      841 gccagtcgaa ggagcagtac ggcacctggg aaatgctatg tgggaacgag gtgcagatcc
      901 taagcaacct ggtgatggag gagctgggcc cagcgctgaa gacagagctt gggccacggc
      961 tgaagggaaa gcctcaggag cggcagcgac agtggatcca gatctcggat gctgtgtacc
     1021 gcctggtatt tgaacaggcc aaggtgcact ttgaggaggt gctgtgtaag ctgcagttgg
     1081 cccggccagc catggaggca gttatccgta cagacatgga ccagatcatc acctccaagg
     1141 agcatctggc cagcaagatc cgagccttca tcctccccaa ggcagaggtg tgcgtgagga
     1201 accatgtcca gccctacatc ccatccatcc tagaggctct gatggtgccc accagccagg
     1261 gcttcaccga ggtgcgggac gtcttcttca aagaggtcac agacatgaat ctgaatgtca
     1321 tcaacgaggg tggcatcgac aagctgggcg agtacatgga gaagctgtcc caactggcgt
     1381 accaccccct gaagatgcag agctgctacg agaagatgga gccgctgcgg ctcgatgggc
     1441 tgcagcagcg ctttgacgtg tctagcactt ctgtgttcaa gcagcgagcc cagatccaca
     1501 tgcgagagca aatggacaat gctgtgtaca ccttcgaaac cctcctgcac caagagctgg
     1561 ggaagggacc caccaaggag gagctgtgca agtccatcca gcggattctg gagcgggtgc
     1621 tgaagaaata cgactatgac agcagttctg tgcgcaagag attcttccga gaggcgctgc
     1681 tgcagatcac cattcccttc ctgctcaaaa agctggcccc cacctgcaag tcggagctgc
     1741 cacgcttcca ggagctgatc tttgaagact ttgccaggtt catcctggtg gagaacacat
     1801 acgaggaggt ggtgctgcag acggtcatga aggacatcct gcaggctgtg aaggaggcgg
     1861 cagtgcagcg caaacataac ctctaccggg acagcgtggt tctgcataac agcgacccca
     1921 atctacacct gctggctgag ggtgcaccca ttgactgggg cgaacagtat ggtgacggcg
     1981 gtgacggcag tgacagtggt ggcagcccct gcccctccga agcagccacc ctcacagaaa
     2041 agcgcaggcg tgccaagcag gtggtgtccg tggtccagga cgaggagtca gggctgccct
     2101 ttgaggctgg ctctgaaccg ccatcacctg catccccgga caatgtcact gagctccgag
     2161 gcctgttggc ccaggatctg caggctgaaa gttctccacc agccagcccc ctcctcaatg
     2221 gggccccggt ccaagagagc ccccagccca tgacagtcct agaggcttcg ccaccagcct
     2281 cacccctccg gcacctccca cctggaaaag ctgtggacct tgagccccct aaacccagtg
     2341 atcaagagac cggggagaaa gtgtctagcc ctggtagccg tccccccatc cataccacca
     2401 ccgaggacag cgcaggagtg cagacggagt tctaggcatg gcctcccagc ttctgttgga
     2461 ctctgcactg gggcgcttct ccttgggcac cgcagcctca tctctgggga ggggtactcc
     2521 agtctgtgcc ttgtggagaa ggtagctggg gtggtgtggc acctccaggg gtctggccta
     2581 tccaagtcac tttatggggt ttagtacacc tgttactgcc tcgttttctg tgggctggtc
     2641 tccgatgcta ggtctggttt tgagggtttc ctctttgtgc aaggggctgg ggagcccctc
     2701 catcctgccc tcacgctgtt acctgtttcc ctcccggtgg ttcttgacgg aggtagatga
     2761 aagcattggt gcaactcatg tctaggaagc tggaaagctg tcatctcact ctggggcccc
     2821 ttgcctaagt ggcaaggaag aggcggaggc ctggcctctg tcctgcccac tccctgcagg
     2881 tcccaaggtt agacagacac tagagtgctc actggccaca ctttgcgggt tactggtgcg
     2941 ggagggcggg gcttaggggt ctggtagggg agcgatggaa tgagaaaggc ccagaatgtg
     3001 ttaagtctgt gcaggggaag tgtcctgagg ggagggtctt tgggagggtc gaaggccagg
     3061 atggcaaagt gaaggtagct gaggttgcag tcttgggtgc ccactgctgt gcatctgtct
     3121 ggttatctac ccctactttg ggctgacaac tgcagggttg ggtgtaggct gtctcactgc
     3181 atgccgggaa gctggagaag ctccacggga acattgaggg ccatggcttt gagacactgc
     3241 agagcatcct tggtctctgt aactcacgtc acctaaccct gacaattcca gacccttctt
     3301 ccattgtcct tgtgaaccat ttgggcttat ctttccctct tagtcgcaag ggtcaaacca
     3361 agggtcagtc aagtagatga ctgtcacctt gggcctcccc agactctgct gccggggttg
     3421 ggagaccaaa gtagaaactg ccactacaag gccccaggat gaggtctctg ttctgtggac
     3481 ctgctcccca gatacaggcc tcagacccat aggacgtggc cggtgctcag ggacacccag
     3541 tccccggccc tcactccatc gagtactgac ttctttctct agtgccttgg gggtctccat
     3601 ccttccagtt atggtatgaa gaatctatgc aaactgtata agcttctgct caccaataaa
     3661 cgctttattt aaagctca
//
