LOCUS       NM_022242               3634 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus niban apoptosis regulator 1 (Niban1), mRNA.
ACCESSION   NM_022242
VERSION     NM_022242.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3634)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 3634)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (bases 1 to 3634)
  AUTHORS   Sun,G.D., Kobayashi,T., Abe,M., Tada,N., Adachi,H., Shiota,A.,
            Totsuka,Y. and Hino,O.
  TITLE     The endoplasmic reticulum stress-inducible protein Niban regulates
            eIF2alpha and S6K1/4E-BP1 phosphorylation
  JOURNAL   Biochem Biophys Res Commun 360 (1), 181-187 (2007)
   PUBMED   17588536
  REMARK    GeneRIF: Together these results suggest that Niban is involved in
            the ER stress response, and that Niban can modulate cell death
            signaling by regulating translation.
REFERENCE   4  (bases 1 to 3634)
  AUTHORS   Matsumoto,F., Fujii,H., Abe,M., Kajino,K., Kobayashi,T.,
            Matsumoto,T., Ikeda,K. and Hino,O.
  TITLE     A novel tumor marker, Niban, is expressed in subsets of thyroid
            tumors and Hashimoto's thyroiditis
  JOURNAL   Hum Pathol 37 (12), 1592-1600 (2006)
   PUBMED   16949643
REFERENCE   5  (bases 1 to 3634)
  AUTHORS   Majima,S., Kajino,K., Fukuda,T., Otsuka,F. and Hino,O.
  TITLE     A novel gene 'Niban' upregulated in renal carcinogenesis: cloning
            by the cDNA-amplified fragment length polymorphism approach
  JOURNAL   Jpn J Cancer Res 91 (9), 869-874 (2000)
   PUBMED   11011112
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB046718.2.
            
            On Jul 25, 2001 this sequence version replaced NM_022242.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB046718.2, SRR8487227.253283.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3634              AB046718.2         1-3634
FEATURES             Location/Qualifiers
     source          1..3634
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..3634
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /note="niban apoptosis regulator 1"
                     /db_xref="GeneID:63912"
                     /db_xref="RGD:71088"
     exon            1..86
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..2845
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /note="family with sequence similarity 129, member A"
                     /codon_start=1
                     /product="protein Niban 1"
                     /protein_id="NP_071578.2"
                     /db_xref="GeneID:63912"
                     /db_xref="RGD:71088"
                     /translation="MGGSASSQLDEGKCAYIRGKTEASIKNFSPYYSRQYSVAFCNHV
                     RSEVEQQRDLTSQFLKTKPPLEPGTVLYEAELSQFAEDIRKWKDRYVVVKNDFAVESY
                     ENKEAYQRGAVPKSRILPAGGKVLTSEEEYSLLSDKHFPDPTASSEKNSQPFLVLPKA
                     FPVYLWQPYLRHGYFCFHEAAEQQKFSALLNDCIRHLNHDYMKQTTFEAQAFLEAVQF
                     FRQEKGHYGAWEVITGDEVQILSKLVMEELLPTLQTDLLPKLKGKKNDRKRAWFGLLE
                     EAYNLVQHQVSEGLSALKEECRALTKDLEGTIRSDMDQIVNSKNFLTGKIRAMVAQPA
                     ENRCGESVQPFLASILEELMGPVSSGFSEVRALFEKEVDELSQSFHTTQDGAQLKECL
                     DQLMKLPLDSVKMEPCYTKVTLLPERLLDLQSRFRFPHVDLVVQRTQNYMQELMENAV
                     FTFEQLLSPYLQGEASRTAVAIEKVKLRVLKQYDYDSSTIRKKIFQEALIQITLPTVQ
                     KALASTCKPELQKYEQFIFADHTNMIHVENIYEEILYQILLDETLKVITEAAILKKHN
                     LFEDNMALPSESVSSLTDLKTSMGSNQASPARGASAILPGAPGDEAPGSEVFQGPEEK
                     QQQPGVPGSLAREESASISGSSPPSGEDGQVSVSGVDNSAGNPLSADNSAGPLSSHLS
                     EAEAGEPPKDEETAHKRPESSAVPGSLRELKELLTVTVFVESAPEIGNDTLNGTPVPQ
                     EDKKEEEEEEESKIHPEASGPAAIQQDSCEESEVREREAHPMPLEAEAPGVNLGTLPE
                     GRGPTSQSTGEGLTENTSCLGPIEEPSEAQGPTEEVLLATVSTQDSTEAGGEAVHSVT
                     VTPQEDATLSSNPICPVENNEGPQVSEDQEVLGGNDSPALAMDTEQINDAHVYECHWE
                     VEDAPSADILDVHDCDVGSPGEW"
     exon            87..217
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /inference="alignment:Splign:2.1.0"
     exon            218..349
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /inference="alignment:Splign:2.1.0"
     exon            350..464
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /inference="alignment:Splign:2.1.0"
     exon            465..629
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /inference="alignment:Splign:2.1.0"
     exon            630..745
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /inference="alignment:Splign:2.1.0"
     exon            746..850
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1013
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1201
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1363
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1474
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1582
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1694
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..3634
                     /gene="Niban1"
                     /gene_synonym="Fam129a; Niban"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcctctgc ctccggtgca gcaccgcggc catgggcggc tcagcctcca gccaactgga
       61 tgagggcaag tgcgcctata tccgagggaa aactgaggct tctatcaaaa acttcagtcc
      121 ctactacagc cgccaatatt ctgtggcttt ctgcaaccat gtgcgcagcg aggtggaaca
      181 gcagagagat ttaacgtcac agtttctgaa gaccaagccc ccactggaac caggaactgt
      241 tttgtatgaa gctgagctct cacagtttgc tgaggacatc aggaaatgga aggacagata
      301 cgttgtggtt aaaaacgatt ttgctgtgga aagctatgag aacaaagagg cctatcagag
      361 aggagctgtt cctaaaagca gaattcttcc agctggtggc aaggtgttaa cctcagaaga
      421 ggaatatagt ctcttatctg ataagcattt cccagacccc actgcttcca gtgagaagaa
      481 ctctcagccc ttcctggtcc tacccaaggc attcccagtg tacctgtggc agccttacct
      541 caggcacggc tacttctgtt tccacgaggc tgccgagcag cagaagttca gcgctcttct
      601 caacgactgc atcagacacc tgaatcacga ttacatgaag cagaccacat tcgaagccca
      661 agcctttttg gaagctgtgc agttcttccg gcaggagaag ggtcactacg gcgcctggga
      721 agtgattact ggagatgaag tccagatcct gagtaaactg gtgatggagg agctcctgcc
      781 gaccctccag actgacctgc tgcctaaact gaaggggaag aagaatgaca gaaagagagc
      841 ctggtttgga ctcctggagg aagcctacaa tctggttcag caccaagttt cagaaggatt
      901 aagtgccttg aaggaggagt gcagagctct gacaaaggac ctggaaggga ccatccgctc
      961 agacatggat cagattgtga actcaaagaa ctttctaact gggaagatca gagcaatggt
     1021 ggctcagccg gccgagaatc gctgtgggga aagtgtgcag cccttcctgg catccattct
     1081 ggaggagcta atggggccgg tgagctccgg tttcagtgaa gtccgtgcac ttttcgaaaa
     1141 agaagtagat gaactcagtc agagcttcca caccacccag gacggtgccc agctgaagga
     1201 gtgtctagac cagctaatga agcttcctct ggattctgtg aagatggagc cttgttacac
     1261 taaagtcacc ctgcttccag agcgcctgct ggacctccag agtcgcttca gattccctca
     1321 cgttgatctg gtggtccaga ggactcagaa ctacatgcag gagctcatgg agaatgctgt
     1381 gttcacattt gagcagttgc tctccccata tcttcaagga gaggcttcca gaacagcagt
     1441 ggccatcgag aaggttaagc tccgtgtctt aaagcaatac gattacgaca gcagcaccat
     1501 ccgcaagaag atcttccagg aggcattgat tcagatcaca ctacccactg tgcagaaggc
     1561 gctggcgtcc acatgcaaac cagagcttca gaaatatgag cagttcatct tcgcagacca
     1621 caccaatatg atccatgttg agaacatcta tgaagagatt ttgtatcaga tcctcctcga
     1681 tgagaccctg aaagtgataa cggaagcagc tatcttgaag aaacacaact tatttgaaga
     1741 caacatggcc ttacccagtg aaagtgtgtc cagtctgaca gacctcaaaa cctccatggg
     1801 gtcaaaccag gccagcccag ccagaggagc atctgccatt ctcccaggag ctccaggcga
     1861 tgaggctcca ggcagcgaag tgttccaggg gcctgaggaa aagcagcagc agcctggggt
     1921 ccctggctcg ctggccagag aagaaagtgc ttccatctct gggtccagcc ctccttcagg
     1981 tgaggatggg caggtgtctg tgtccggtgt ggataactct gccgggaacc ctctcagtgc
     2041 agataattca gcaggacctc tcagctcaca cttgtcagag gcagaagctg gggagccccc
     2101 taaagatgag gaaacagccc acaaaaggcc agagtctagc gccgtgccag ggtccttgag
     2161 ggaactgaag gagttgttga ctgtgacggt gttcgtcgag tctgccccag agattggaaa
     2221 tgatacactc aacgggacac ctgttcccca agaagataaa aaagaagaag aagaggagga
     2281 ggaaagcaag atccacccag aagccagcgg cccagctgcc atccagcagg acagctgtga
     2341 agaaagtgaa gtcagagaga gggaggccca tcctatgcct ttggaagctg aggctcctgg
     2401 ggtgaacttg gggacactgc cagagggtag agggcctacc tctcagtcta ccggtgaggg
     2461 actcactgag aacaccagct gtctaggccc catagaggag ccatctgagg ctcaagggcc
     2521 cactgaggag gtgctcctag ccacagtttc cacacaggac agcaccgagg caggaggtga
     2581 ggctgtgcat tctgtgacag tcacacctca agaagatgcc acgttaagtt ctaaccccat
     2641 ctgtcccgtg gagaataatg aggggcccca ggtttctgag gatcaggaag tgctgggagg
     2701 gaatgatagc ccagcccttg ctatggatac agagcaaatc aacgatgccc atgtgtatga
     2761 gtgccactgg gaggtagaag atgccccgag cgccgacatc ctagatgttc acgattgtga
     2821 tgtgggctcc ccaggggagt ggtagaatca gtttgccggt cttttttctt ttaaaactgt
     2881 cagtcaaggg gtattagtta tgggtatcct tagggggttg catgtgactc gctataaaaa
     2941 ttatgaaatg tttctttaat ttgaaagatg aagccagagt gcacagacgg tgggagcagt
     3001 gagcaggctt tggggcgctg aagtgctccc catgaatgat ctatcacttt ggcattttaa
     3061 taggaatggt aagagaactg aagcattggg gcaaagtcaa aggggatcca gaaaggggag
     3121 cagaaaatga cacatcaata atctcttcac tgaaacgtgg tacacatttt gaactgagtg
     3181 ttaaggcctt tttagcaagc atgagaagga ctccagcctc aacacctgct cagctgtcac
     3241 tcctcacctg gtcggctgca ctgtctcctg tccttagaca ggtcacaaga aagaggaagt
     3301 catgaaccag gcacccctgt cctgcaaagt acagagccag tcaccgctgg tagagctcag
     3361 gggatgcaga gcagaaaccc aaggtggaag gtctgtggaa ctatggagcc ctgttcctaa
     3421 ccctgctagc aatcccttgc tggttaattc tgctggttta cattaattaa tcacccttta
     3481 aggaaattca ggcagggtaa gagatttcac tggcatgaat cagccttagg ttgtacaaag
     3541 tgcttgtcta aattttctag ctcgaaacct accagtgaca cagacatgac ttgaacagat
     3601 actgcatgct ctgttagtcg tcataataaa taaa
//
