LOCUS       NM_001414279             730 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus NHP2 ribonucleoprotein (Nhp2), mRNA.
ACCESSION   NM_001414279 XM_003750818
VERSION     NM_001414279.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 730)
  AUTHORS   Nguyen,T.H.D., Tam,J., Wu,R.A., Greber,B.J., Toso,D., Nogales,E.
            and Collins,K.
  TITLE     Cryo-EM structure of substrate-bound human telomerase holoenzyme
  JOURNAL   Nature 557 (7704), 190-195 (2018)
   PUBMED   29695869
REFERENCE   2  (bases 1 to 730)
  AUTHORS   Freund,A., Zhong,F.L., Venteicher,A.S., Meng,Z., Veenstra,T.D.,
            Frydman,J. and Artandi,S.E.
  TITLE     Proteostatic control of telomerase function through TRiC-mediated
            folding of TCAB1
  JOURNAL   Cell 159 (6), 1389-1403 (2014)
   PUBMED   25467444
REFERENCE   3  (bases 1 to 730)
  AUTHORS   Egan,E.D. and Collins,K.
  TITLE     An enhanced H/ACA RNP assembly mechanism for human telomerase RNA
  JOURNAL   Mol Cell Biol 32 (13), 2428-2439 (2012)
   PUBMED   22527283
REFERENCE   4  (bases 1 to 730)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 730)
  AUTHORS   Watkins,N.J. and Bohnsack,M.T.
  TITLE     The box C/D and H/ACA snoRNPs: key players in the modification,
            processing and the dynamic folding of ribosomal RNA
  JOURNAL   Wiley Interdiscip Rev RNA 3 (3), 397-414 (2012)
   PUBMED   22065625
  REMARK    Review article
REFERENCE   6  (bases 1 to 730)
  AUTHORS   Egan,E.D. and Collins,K.
  TITLE     Specificity and stoichiometry of subunit interactions in the human
            telomerase holoenzyme assembled in vivo
  JOURNAL   Mol Cell Biol 30 (11), 2775-2786 (2010)
   PUBMED   20351177
REFERENCE   7  (bases 1 to 730)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
REFERENCE   8  (bases 1 to 730)
  AUTHORS   Fu,D. and Collins,K.
  TITLE     Purification of human telomerase complexes identifies factors
            involved in telomerase biogenesis and telomere length regulation
  JOURNAL   Mol Cell 28 (5), 773-785 (2007)
   PUBMED   18082603
REFERENCE   9  (bases 1 to 730)
  AUTHORS   Wang,C. and Meier,U.T.
  TITLE     Architecture and assembly of mammalian H/ACA small nucleolar and
            telomerase ribonucleoproteins
  JOURNAL   EMBO J 23 (8), 1857-1867 (2004)
   PUBMED   15044956
REFERENCE   10 (bases 1 to 730)
  AUTHORS   Wang,C., Query,C.C. and Meier,U.T.
  TITLE     Immunopurified small nucleolar ribonucleoprotein particles
            pseudouridylate rRNA independently of their association with
            phosphorylated Nopp140
  JOURNAL   Mol Cell Biol 22 (24), 8457-8466 (2002)
   PUBMED   12446766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 17, 2022 this sequence version replaced XM_003750818.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ106084.1, BQ206824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               JAXUCZ010000010.1  36378020-36378224
            206-275             JAXUCZ010000010.1  36378325-36378394
            276-381             JAXUCZ010000010.1  36380515-36380620
            382-730             JAXUCZ010000010.1  36381014-36381362
FEATURES             Location/Qualifiers
     source          1..730
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..730
                     /gene="Nhp2"
                     /gene_synonym="Nola2"
                     /note="NHP2 ribonucleoprotein"
                     /db_xref="GeneID:287273"
                     /db_xref="RGD:1309435"
     exon            1..205
                     /gene="Nhp2"
                     /gene_synonym="Nola2"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..507
                     /gene="Nhp2"
                     /gene_synonym="Nola2"
                     /note="nucleolar protein family A, member 2; H/ACA
                     ribonucleoprotein complex subunit 2-like"
                     /codon_start=1
                     /product="H/ACA ribonucleoprotein complex subunit 2"
                     /protein_id="NP_001401208.1"
                     /db_xref="GeneID:287273"
                     /db_xref="RGD:1309435"
                     /translation="MTKIKVVPEESEAQAEGCSEERTYEELLVNLNPIAQPLASRRLT
                     RKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVMCEDQN
                     LPYVYIPSKTDLGAATGSKRPTCVIMVKPHEDYQEAYDKCLEEVQALPTPL"
     exon            206..275
                     /gene="Nhp2"
                     /gene_synonym="Nola2"
                     /inference="alignment:Splign:2.1.0"
     exon            276..381
                     /gene="Nhp2"
                     /gene_synonym="Nola2"
                     /inference="alignment:Splign:2.1.0"
     exon            382..730
                     /gene="Nhp2"
                     /gene_synonym="Nola2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgcgtgg ttcctctatg ccctgactga gttgtgattg ctaagatgac caaaataaag
       61 gtggttcccg aggaatctga ggcgcaggcg gagggctgca gcgaggagcg cacgtacgaa
      121 gagctgctgg tcaacctgaa ccccatcgcg cagcccctgg cttcccgccg cctgacgcgc
      181 aagctttaca aatgcatcaa gaaggccgta aagcagaagc agattcgtcg cggggtgaag
      241 gaagttcaga aatttgtcaa caagggcgag aaagggatca tggtcttggc aggagatacg
      301 ttgccgattg aggtgtactg ccatcttcca gttatgtgcg aggaccagaa cttgccctac
      361 gtctatattc cctctaagac ggacttgggt gcagctacag gatcgaaacg tcccacttgt
      421 gtgatcatgg tgaagcccca tgaagactat caggaggcct atgacaagtg cctggaggag
      481 gtgcaggcac tgcctacacc tctgtgagag acttgggctg caacccagcc cgttctaaga
      541 gatgctggct gactacaggc ggctgcccac ccttgccgca tcttcccgat ttcttgacgt
      601 gtgaatcttc ccaggcagct ccacagctgt tcttggaggg agagccagca tctttgccat
      661 ctcccgttga gctctggtga agacagttcc aagaatatgg gatagaagta aatgctaagg
      721 cgaaaatgtg
//
