LOCUS       NP_001401208             153 aa            linear   ROD 31-MAR-2024
DEFINITION  H/ACA ribonucleoprotein complex subunit 2 [Rattus norvegicus].
ACCESSION   NP_001401208 XP_003750866
VERSION     NP_001401208.1
DBSOURCE    REFSEQ: accession NM_001414279.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 153)
  AUTHORS   Nguyen,T.H.D., Tam,J., Wu,R.A., Greber,B.J., Toso,D., Nogales,E.
            and Collins,K.
  TITLE     Cryo-EM structure of substrate-bound human telomerase holoenzyme
  JOURNAL   Nature 557 (7704), 190-195 (2018)
   PUBMED   29695869
REFERENCE   2  (residues 1 to 153)
  AUTHORS   Freund,A., Zhong,F.L., Venteicher,A.S., Meng,Z., Veenstra,T.D.,
            Frydman,J. and Artandi,S.E.
  TITLE     Proteostatic control of telomerase function through TRiC-mediated
            folding of TCAB1
  JOURNAL   Cell 159 (6), 1389-1403 (2014)
   PUBMED   25467444
REFERENCE   3  (residues 1 to 153)
  AUTHORS   Egan,E.D. and Collins,K.
  TITLE     An enhanced H/ACA RNP assembly mechanism for human telomerase RNA
  JOURNAL   Mol Cell Biol 32 (13), 2428-2439 (2012)
   PUBMED   22527283
REFERENCE   4  (residues 1 to 153)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (residues 1 to 153)
  AUTHORS   Watkins,N.J. and Bohnsack,M.T.
  TITLE     The box C/D and H/ACA snoRNPs: key players in the modification,
            processing and the dynamic folding of ribosomal RNA
  JOURNAL   Wiley Interdiscip Rev RNA 3 (3), 397-414 (2012)
   PUBMED   22065625
  REMARK    Review article
REFERENCE   6  (residues 1 to 153)
  AUTHORS   Egan,E.D. and Collins,K.
  TITLE     Specificity and stoichiometry of subunit interactions in the human
            telomerase holoenzyme assembled in vivo
  JOURNAL   Mol Cell Biol 30 (11), 2775-2786 (2010)
   PUBMED   20351177
REFERENCE   7  (residues 1 to 153)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
REFERENCE   8  (residues 1 to 153)
  AUTHORS   Fu,D. and Collins,K.
  TITLE     Purification of human telomerase complexes identifies factors
            involved in telomerase biogenesis and telomere length regulation
  JOURNAL   Mol Cell 28 (5), 773-785 (2007)
   PUBMED   18082603
REFERENCE   9  (residues 1 to 153)
  AUTHORS   Wang,C. and Meier,U.T.
  TITLE     Architecture and assembly of mammalian H/ACA small nucleolar and
            telomerase ribonucleoproteins
  JOURNAL   EMBO J 23 (8), 1857-1867 (2004)
   PUBMED   15044956
REFERENCE   10 (residues 1 to 153)
  AUTHORS   Wang,C., Query,C.C. and Meier,U.T.
  TITLE     Immunopurified small nucleolar ribonucleoprotein particles
            pseudouridylate rRNA independently of their association with
            phosphorylated Nopp140
  JOURNAL   Mol Cell Biol 22 (24), 8457-8466 (2002)
   PUBMED   12446766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 17, 2022 this sequence version replaced XP_003750866.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ106084.1, BQ206824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..153
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     Protein         1..153
                     /product="H/ACA ribonucleoprotein complex subunit 2"
                     /note="nucleolar protein family A, member 2; H/ACA
                     ribonucleoprotein complex subunit 2-like"
                     /calculated_mol_wt=17161
     Region          32..130
                     /region_name="SNU13"
                     /note="U4/U6.U5 small nuclear ribonucleoprotein SNU13;
                     cl42391"
                     /db_xref="CDD:455736"
     Site            order(61..66,69,73,85..86,90,111,120..123)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411046"
     Site            order(65,68..69,72,87,89..90,92..93,96)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:411046"
     CDS             1..153
                     /gene="Nhp2"
                     /gene_synonym="Nola2"
                     /coded_by="NM_001414279.1:46..507"
                     /db_xref="GeneID:287273"
                     /db_xref="RGD:1309435"
ORIGIN      
        1 mtkikvvpee seaqaegcse ertyeellvn lnpiaqplas rrltrklykc ikkavkqkqi
       61 rrgvkevqkf vnkgekgimv lagdtlpiev ychlpvmced qnlpyvyips ktdlgaatgs
      121 krptcvimvk phedyqeayd kcleevqalp tpl
//
