LOCUS       NM_001107444            4468 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus NHL repeat containing 2 (Nhlrc2), mRNA.
ACCESSION   NM_001107444 XM_001072687 XM_006231645 XM_217640
VERSION     NM_001107444.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4468)
  AUTHORS   Paakkola,T., Salokas,K., Miinalainen,I., Lehtonen,S., Manninen,A.,
            Kaakinen,M., Ruddock,L.W., Varjosalo,M., Kaarteenaho,R., Uusimaa,J.
            and Hinttala,R.
  TITLE     Biallelic mutations in human NHLRC2 enhance myofibroblast
            differentiation in FINCA disease
  JOURNAL   Hum Mol Genet 27 (24), 4288-4302 (2018)
   PUBMED   30239752
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before May 14, 2021 this sequence version replaced
            XM_006231645.2, NM_001107444.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.6550.1,
                                           SRR26643287.4179.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-598               JAXUCZ010000001.1  265594915-265595512
            599-751             JAXUCZ010000001.1  265598978-265599130
            752-1207            JAXUCZ010000001.1  265614455-265614910
            1208-1329           JAXUCZ010000001.1  265618550-265618671
            1330-1459           JAXUCZ010000001.1  265622787-265622916
            1460-1559           JAXUCZ010000001.1  265638670-265638769
            1560-1791           JAXUCZ010000001.1  265643234-265643465
            1792-1914           JAXUCZ010000001.1  265643867-265643989
            1915-2121           JAXUCZ010000001.1  265644339-265644545
            2122-2341           JAXUCZ010000001.1  265645460-265645679
            2342-4468           JAXUCZ010000001.1  265647908-265650034
FEATURES             Location/Qualifiers
     source          1..4468
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..4468
                     /gene="Nhlrc2"
                     /note="NHL repeat containing 2"
                     /db_xref="GeneID:307986"
                     /db_xref="RGD:1307348"
     exon            1..598
                     /gene="Nhlrc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             421..2598
                     /gene="Nhlrc2"
                     /codon_start=1
                     /product="NHL repeat-containing protein 2"
                     /protein_id="NP_001100914.1"
                     /db_xref="GeneID:307986"
                     /db_xref="RGD:1307348"
                     /translation="MAVPGARGASLSGLLPAQTSLEYALLDAVTQQEKDDLVYQYLQK
                     VDGWEQDLAVPEFPEGLEWLNTEEPLSIYRDLCGKVVILDFFTYCCINCIHVLPDLHA
                     LERTFSDTDGLLIVGVHSAKFPNEKVLDNIKSAVLRYNITHPVVNDTDASLWQELEVS
                     CWPTLVILGPRGNLLFSLIGEGHKDKLFSYTSIALKYYKDRGQIRDGKIGIKLFKESL
                     PPSPLLFPGKVAADPTTGRLVVADTGHHRILVLQKNGQIQYSIGGPNPGRKDGVFSES
                     SFHSPQGVAIADNVIYVADTENHLIRKIDLEAEKVSTVAGIGVQGTDTEGGEEGDKQP
                     ISSPWDVALGTSGSKVQRNDILWIAMAGTHQIWAFLLDSGTLPKKSDLKKGTCLRFAG
                     SGNEENRNNAYPHKAGFAQPSGLALAPEEPWSCLFVADSESSTVRTVSLRDGAVKHLV
                     GGERDPMNLFAFGDVDGAGISAKLQHPLGVAWDEKRHLLYVADSYNHKIKVVDPNTKV
                     CTTLAGTGDANDASSSFAESAFNEPGGLCIGERGRLLYVADTNNHQIKVMDLEARTVS
                     VLPVFKSDSAVVDGSFPREKQKTVPKVPKSAPNISLPPVTVHPGQALQLGLRLELPPG
                     AKLTEGAPSGWFLKAEGNEWLLQEQIPSGDIENISNQPAISLQIPTECLSLEAVVSVT
                     VFLYYCSADSSACMMKGVVFRQPLQINSVQPACAAPVELTYAF"
     exon            599..751
                     /gene="Nhlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1207
                     /gene="Nhlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1329
                     /gene="Nhlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1459
                     /gene="Nhlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1559
                     /gene="Nhlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1791
                     /gene="Nhlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1914
                     /gene="Nhlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2121
                     /gene="Nhlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2341
                     /gene="Nhlrc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..4468
                     /gene="Nhlrc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtttaagag tgggacaact ggggaggctt ttcttaagtc ggctcttttt taactttgca
       61 catagttatt tgaattttat ttgtcttgga aaccttgtcg ggctccaaag gcaatgggtt
      121 cccagttcct ctagagcggg atcccacagc ctttcccgtg tcgaatcagg cgctctgaac
      181 gtccaggctc cacggccgcc cggaacctgg gaggggcggg gggtggacag ctctggagtt
      241 taattacgcg ccggggaagc acggcccttt ggactttggc gtctgaagga aagcttagag
      301 taggcggaag cgtgtgtggc gcaagtccgg gctggtcggg tccctttctg agacaagagg
      361 gcggcgcacg ctggtccgac ccgcgccttc ggacccggag cccttgggag ctcgcgcaac
      421 atggcggtcc ccggagcgcg cggcgcgagt ctctcgggtc ttctgcccgc gcagacctct
      481 ctagagtacg ccctgctgga cgccgtcacc cagcaggaga aggatgacct ggtctatcag
      541 tatctgcaga aggtggacgg ctgggagcag gacctagcgg tgcctgagtt tccggaagga
      601 ctagaatggc tgaatacaga agagcctttg tcgatttaca gagacctgtg tgggaaagtg
      661 gtcatcctcg acttcttcac ttactgctgc atcaactgca tccatgtgct gcccgatctc
      721 cacgccctgg agcgcacgtt ctctgacaca gatggccttc tgattgtcgg tgttcactca
      781 gctaagtttc caaatgaaaa ggtcctggac aacatcaaga gtgctgtcct tcggtacaac
      841 atcacccacc ctgtggttaa cgacacagat gctagccttt ggcaggagct tgaagtctcc
      901 tgctggccaa cactggtcat actgggaccc cgtggaaacc tgctgttttc tttgattgga
      961 gagggtcaca aagataaact gttttcatat acatctattg ctttaaagta ttacaaagac
     1021 agaggacaga tcagagatgg aaaaattggg ataaaactct ttaaagagtc tttgccgcct
     1081 tcaccattgc tgttccctgg caaagtagcc gcagacccta ctactggtcg gctggtggta
     1141 gcagacaccg ggcaccacag gatcttggtt cttcagaaga acgggcagat tcagtacagt
     1201 attggaggac ctaatcctgg aaggaaagat ggggtgtttt cagagtcgtc ttttcattct
     1261 ccacagggtg tagctatcgc agataatgtc atctatgtgg ccgacactga aaaccacctt
     1321 ataagaaaga tagacttaga agctgagaag gtgagcactg tagctggcat cggtgttcaa
     1381 gggacagata cagaaggcgg tgaggaggga gacaaacagc ccatcagctc cccgtgggac
     1441 gttgcacttg ggacctcagg ttcaaaggtc caaagaaatg acatcctgtg gatagccatg
     1501 gcagggactc atcagatatg ggccttcctc ctggactctg gcacactgcc aaagaaaagt
     1561 gacctaaaga aaggaacctg cctccgtttt gctggaagtg gaaatgaaga gaaccgaaac
     1621 aacgcatatc ctcacaaggc gggcttcgcc cagccatcag gcctcgctct cgctccagaa
     1681 gagccctgga gctgcctctt tgtggctgac agcgagagca gcactgtgag gactgtctcg
     1741 ctgagagacg gagccgtgaa acacctcgtt ggcggagagc gagaccccat gaatttattt
     1801 gcttttggtg atgttgatgg agcaggcatc agtgcgaagc ttcagcaccc acttggggtt
     1861 gcatgggatg agaagaggca tctgctctat gtggccgact cctacaatca caagattaaa
     1921 gttgtggatc caaacacaaa agtctgtaca acgttagcag gcactggaga tgcgaatgac
     1981 gccagttcca gttttgcgga gtcggccttt aatgagccgg gaggcttgtg tatcggtgag
     2041 cgtggtcggc tgctctatgt agcagacact aataatcacc agattaaagt gatggattta
     2101 gaagcaagaa cagtttctgt gctccctgtc ttcaagtctg acagtgctgt ggtagacggc
     2161 tccttcccta gagagaaaca gaagacagtg cccaaagtgc cgaagtccgc cccaaatatc
     2221 agcctccccc ctgtgacagt gcatccgggc caggctctgc agctcgggct ccggctagag
     2281 cttccgccag gagcaaagct gacagaaggt gcccccagcg gctggttcct gaaagctgaa
     2341 ggcaatgaat ggcttcttca ggaacagatc ccatctggag acatagagaa tatttccaat
     2401 cagccggcaa tctccctgca gatccctact gagtgcttgt ccctggaggc cgtggtgtct
     2461 gtcaccgtgt ttctttatta ctgcagtgct gacagcagtg catgtatgat gaagggagtt
     2521 gtgttcaggc agcctttgca gataaacagt gtccagccag cgtgtgcagc tcctgtggag
     2581 ctcacgtacg cattctagag cgctggccag cagccagcag cacaggcctg tcatcctgcc
     2641 acctatcatt tacggaagaa gcgttataga aacccattgc tcagttgtaa caactgacac
     2701 cacaataaag ctgtcctcct tattagtatt ttaattgcaa accaattcct tcatttgagc
     2761 agtgtgctgt ccaagtcatt gaccatcgtt taagcacggc actctaaact ctgcagttat
     2821 ctgacccgag gtgacactcc atgctgtatc agaggacatt atatttgtag tcaaaactaa
     2881 tcatgcccga tatgttagat agcctctatg cctttatcag agaaaaagcc atttcacgga
     2941 taactttcca gtgacttggg atgggcctga gctctgcacc ttggtgtcag gacacctgct
     3001 tagccggcac caagagcgca catgcggtag aagcttctct cctgtgactt ttctcacctg
     3061 agatttttta aaagagagtt ttaatctatt tttattataa attatttgtt ttcacattcc
     3121 attattaatg ccttataact ttatataaaa aaagaaaaat atataggatt tctaagggca
     3181 tgccgaccac cccttgacta tgtaatgagc atattcctag caggcaaagc ctagatcccc
     3241 gtgctgactt aggggtgtcg gagactgctg tgctgctgtg tgtgatggtt tattgtaatg
     3301 gttgagcgtg aggtaaatga gtattgtgtt attttggaaa tttacatttc agttttaaga
     3361 gttaagtagc agaattgttg ggtttaagac ttttgttatt gttttggttt ccgtatttag
     3421 aatttaaatt atgatcattc tgatattttt gaaaaatcac atataaacct tcaatttgct
     3481 attgtcaatg taaatatttt aatttaattg atgggtgtag ttttactaat atacctccat
     3541 ctaaaatatt agggctgaaa cagtgattta ctgatactgt tttgatattt gttttcttta
     3601 accccataag aaacagcact gggagggata ttggagaggt ttggttttca tttactgtaa
     3661 ttatcagaga ttattgtaac catttaaaag ccttgttttt ataaaactga gttgacatag
     3721 tttttactaa gattacagga tttcagaaac atttgagcct tgcctataaa tcagtaagtg
     3781 tctgtacaca ctgcctcctg ccttccatgg acgttctaga tcgggagtat agtcatttaa
     3841 gtacagtcta cctatttatt gattgttttt tgaagtagtt tttcataggc aacatttgct
     3901 tgttttatta ttcagttagc taaagaaaaa tctgaagtaa aagcttcatg actttaatta
     3961 gtaacatgca actcttttcc aggagcaggg cggttgtaaa gtggaagtga ccgcgttgag
     4021 agtcacacac ggtcacgtca gaaacctttg tttctagaac caaccagagc agaggatgtg
     4081 cagctgtagt gtactgtgct ggcccgtggt gggggaggtg ccgtggagta tgtcagccgt
     4141 gtttgctttg tagtcctcat ttccagttgg acagggtgag aggatgagaa tattttggct
     4201 cagtcatttc ctgtttgagg acatgaacag tttcactctc tgaaacaggg tgtatacagt
     4261 ttcactcatg tggagattat tttccactct gagaacacaa gcgtgtgttc tatagtgaga
     4321 atcccttcct tttccttctg cctgggtagg accctgcttg agtcttcagt gaccgagagt
     4381 accttgagga tgcacaatgg cgcaccccac acacccgtgc ctccacactg ctggctacat
     4441 agaaggtgtt ggacctagaa aatccatg
//
