LOCUS       NM_001106457            4934 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus nescient helix loop helix 2 (Nhlh2), mRNA.
ACCESSION   NM_001106457 XM_001062697 XM_227524
VERSION     NM_001106457.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4934)
  AUTHORS   Han,C., Liu,H., Liu,J., Yin,K., Xie,Y., Shen,X., Wang,Y., Yuan,J.,
            Qiang,B., Liu,Y.J. and Peng,X.
  TITLE     Human Bex2 interacts with LMO2 and regulates the transcriptional
            activity of a novel DNA-binding complex
  JOURNAL   Nucleic Acids Res 33 (20), 6555-6565 (2005)
   PUBMED   16314316
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4934)
  AUTHORS   Johnson,S.A., Marin-Bivens,C.L., Miele,M., Coyle,C.A., Fissore,R.
            and Good,D.J.
  TITLE     The Nhlh2 transcription factor is required for female sexual
            behavior and reproductive longevity
  JOURNAL   Horm Behav 46 (4), 420-427 (2004)
   PUBMED   15465527
REFERENCE   3  (bases 1 to 4934)
  AUTHORS   Kruger,M., Ruschke,K. and Braun,T.
  TITLE     NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1
            neurons and control necdin gene expression
  JOURNAL   EMBO J 23 (21), 4353-4364 (2004)
   PUBMED   15470499
REFERENCE   4  (bases 1 to 4934)
  AUTHORS   Watanabe,H., Suzuki,Y., Makino,M. and Fujiwara,M.
  TITLE     Toxoplasma gondii: induction of toxoplasmic encephalitis in mice
            with chronic infection by inoculation of a murine leukemia virus
            inducing immunodeficiency
  JOURNAL   Exp Parasitol 76 (1), 39-45 (1993)
   PUBMED   8385626
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474015.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001062697.1, XM_227524.4.
            
            ##Evidence-Data-START##
            CDS exon combination :: CB715677.1, CB727428.1 [ECO:0000331]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4934
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4934
                     /gene="Nhlh2"
                     /note="nescient helix loop helix 2"
                     /db_xref="GeneID:295327"
                     /db_xref="RGD:1308294"
     exon            1..180
                     /gene="Nhlh2"
                     /inference="alignment:Splign:2.1.0"
     exon            181..4934
                     /gene="Nhlh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             2097..2504
                     /gene="Nhlh2"
                     /codon_start=1
                     /product="helix-loop-helix protein 2"
                     /protein_id="NP_001099927.1"
                     /db_xref="GeneID:295327"
                     /db_xref="RGD:1308294"
                     /translation="MMLSPDQAADSDHPSSTHSDPESLGGVDTKVLGSVSDLEPVEEV
                     DGDGKGGSRAALYPHPQQLSREEKRRRRRATAKYRSAHATRERIRVEAFNLAFAELRK
                     LLPTLPPDKKLSKIEILRLAICYISYLNHVLDV"
ORIGIN      
        1 aggctaaatc aattggtacc agaagagcca agaagccaca caggcagctg cctctttgct
       61 ctggctctcc caacctctcc ttcctctgct tccgagtcag tgcactccag aaggcgttca
      121 cttctctcca acctttctca aacatctcca agctactgac tgtatacatt ttaccacaag
      181 ccctaagagt ggggaagcgc gaggtttcaa cacttcgact taaaaagatc aacaacgaat
      241 tttccgaaat gtttaagaac aattaaaaag cacgggcgtt ttcaatccat caactaagtg
      301 aacaaccgta ccttgcaccc gctaagacac cgccgctcgt tgtggcggtc ggcgagatga
      361 cagctgcttt ctcatctgcg aatgtaataa atattggctg cttgtaatat ttgctaggat
      421 ctctcctcct tgtttcctgg aattttaact ccaaaagatt ggcgaaaaga ttatcgacag
      481 ggctcttgca aggtaagaca tctttacgtc tctttttctt tagattaagt tgactcatat
      541 tatattttat agacgcattt cccacacatg gtcgtagaca tagatgccca cgagaaatat
      601 catttatgac tatttaaata tctggaaaat ttaaacacgt agggaacaac cctggaactt
      661 tttgtccgat ttgtaactat gtcgtggttt gttgtggttt ttctccctgt gtatttctgc
      721 ctcttcgtgc caactgcgta ggtgtgagtt gttttacttg taaacgtaga gataagccct
      781 tatggggatc gcacgcggtt cgtttggatc atttattgtt attctgtggg tccgttttcc
      841 ttgcacgaaa agctgtttcc gagctcaggt cgctcctggg caagtccgcg gccaggagcc
      901 gaacctacat cccctggctt ttgtttcttt ggagcgagcc tcttactcag gacgggttct
      961 gagccttgcc tgctaggggc acggcggggc acaggagtcg cagtcccgtc ctccctcccg
     1021 gtggccgagg cccaaacgct caactcgggc aggtttctgt ccccacccgc ctgcccggat
     1081 cccccgcaag ctcagcggtt cccgaggacc cgcagcccgg gcccttcctc caggagcccg
     1141 cgagcagcca gcgggaggtg gcttttccag gagggcagcg tctggggaag ctgggcacag
     1201 acaaggggcc gcggccaggc ctcccggggc caccggtgcg ctgcgggctc cagtaccctg
     1261 agctcgcgaa cttcacccgc agagatgcag cttgtgcccg gggcgtcccg cactcggagc
     1321 ccatccctct cttgccctcc ccagcccctt agcccgcagc agcccggccg cctgcgtttt
     1381 cccgggaggt ggtcggcaga ctgccgggca ttgtgtgatt cacgtcccta ggtccccaat
     1441 gtgtgtggca gtctgcgtga cagatggtgc tccgggagag tatgagggcc gaggagtcaa
     1501 ttttcttttg aaaggaccga acacatgtgt tgggtcattt ctttattatt tcagagaaac
     1561 acggggaggg ggcgacagga aagcatttct atcaccggcc taggttccag gatgaggttc
     1621 gcccgcaccc cagcgcagcc cagaccctca ggcgctggga gtctccagct gccttgcccc
     1681 aggccctcgg atgggaagat cactctgcat ctccattaaa acccagatgc atccatcctt
     1741 cgggcatcca tccttcggga tcattcgtgt ctgggaaggg gacagagcaa gggaggcggg
     1801 atagagcagc tgatgtctgg ccagaggaga cacaagatgt cagccggccc cggaggtcca
     1861 cggtccttct ccagccccag ggctactggt tgcaggcttc ggcgtggtgt tcgggatgca
     1921 ctctggtgcc ggctccttgc ctccctattt gcgtgggtct gatacaagga gaggaacctg
     1981 gtcccctcct aggagtgcag gcttgctagg ccctcgcctg ccattcctcc ttgcaaacca
     2041 aggagaacca gattcctttt attaactgac tttctgactc cccatcagcc tccaaaatga
     2101 tgctgagtcc agaccaagcc gcagactcag atcaccccag ctcgacgcac tcggacccgg
     2161 agtctctggg tggcgtagac accaaggtgc tgggcagcgt gtcggacctg gagccagtgg
     2221 aggaggtgga cggcgacggc aagggcggca gccgggccgc gctctacccg cacccgcagc
     2281 agctgagccg cgaggagaag cgccgccgcc ggcgcgccac ggccaagtac cgctctgccc
     2341 acgccacccg cgagcgcatc cgagtggagg ccttcaacct ggccttcgcc gagctccgca
     2401 aactgctacc tacgctgccc ccggataaga agctctccaa gatcgagatc ctgcgcttgg
     2461 ccatctgcta catctcctat ctcaaccacg tcctggacgt gtagggaggg ggacgccgcg
     2521 ggaggccgcc ggtcctggcg cccgccaagg gcgacacacc tggactgcta ggctagagat
     2581 ttgcccagag acacctgaac gcaggagaaa gctttgcaac ctgctctttc tggtcatcaa
     2641 ggctacagag gaagatttcc aagcctggga ggtgggggtt gcatagaaag acctggggct
     2701 tgcaagggta tttttcctag ccagaaaaac cttctggaag cacctagcat gagttgccct
     2761 agggcctccc ctcggtgtat taggatcccc cgagggggtg gtagctttaa ccctggaggt
     2821 tttcagttcc cctgtattta tagcctacac atcttcaccg ttctgaaaga atgagggcag
     2881 ttcagcccag gctgatggct tcagactaag actatctggg atatttctaa ctgacaaatc
     2941 accaaatctt ggggagaaaa aaaaagatga atatcttttc catacagaga ttaagacaca
     3001 gaaaggtgta ccagcaaact ttttgttgcc atgtccaatg aaaaattata ttctaatcta
     3061 aataaaatcc tgaatatttg gtaaggtaaa aaaaaacatt cagaacaggc acactgtgga
     3121 aggatttaag cttggtgaga ctttaacccc aaggcaggac actaaagcag atagaaaaat
     3181 ccacatttaa atgagaaatt taacatctga ttgctttttc gggcaaagtg cccctttaaa
     3241 tatccaaaaa accccatctg tttgtgacct taacgtggac tcatagatgc agttagaaaa
     3301 agacaaccta tttttattta tgttagaagg agtagagtat ttttttcaag acatttattt
     3361 ttcagagtgg tgataatttt actttggata ctctgtgcca atttatttat agtcaagtgt
     3421 ttacactccc cctccccacc cccaccccta ccccggtgaa ataatggcgt ctaactcttt
     3481 atgtgtttgt tgagattatc ttgtggtctt gccttttctt ttctgattat attgcacttg
     3541 tataagagag ttcctgctcc ccccctgttt ctaagcatat tttctatatt gagaagttgg
     3601 ttctttggtt gtgagatcag caacactagc ccctcgctat tatagtttta taaaaagtta
     3661 agtgttgtta ttcttacccg tagttttgtc tgaaaagtac tttacaaact gtttttaagg
     3721 agagtagctt ctttgtgtgc gtgtgtgtgt gtgacatttg tgtgtgggat gattttagga
     3781 aattacatta ttttcctaaa aaagaaaaga aaaaaagaat tcagaactac tttcctctgt
     3841 gacaaccaaa aagaaaagtc tatgacctag aaatgtttca tgttctcagc tgtgaaactc
     3901 tttaaagtaa gaggtgtatt ttagagacaa ggaagaaaga agaagaagaa aaaaccacat
     3961 ctgctatcca aagattttag tctttttcag ggtttttttg tgtctctgtt gctttatata
     4021 atgcaatatt ttgtagtgaa aatagatata acctggtttc tacctgacga gtttttcata
     4081 tctcatgact ggtgcgctgt tttgcatata aataaaggta tcagattaaa gttctcctcc
     4141 ttcttttaag catctgtcta gaattcaaac ctgctggcca ggtgtgaaat gtcataatgg
     4201 gctcagttcc ttagaaagga attagtaaac caaagcaaga acaaggcaga acatgcacac
     4261 atataagatt tggatacaac acagcctggg acagtataga tcatgtcaca tctgtgggga
     4321 aaagcagggt gatgtgtcta taaaacagta tagagatcat aagatgccta ttttgctcta
     4381 aaaagaaact ttgtaactgt ctaacccaag ctcttaggaa acgcagggcc aagtaggtgt
     4441 ctacattaag tggcaggcaa gagcagggcg tggtgccctg caccctcagt ccatgaacct
     4501 gagagttgga gatgggagaa ccaggagctc aaggtcatcc tcagctatgc agtgaatttg
     4561 aggccagcct tggctacatg agaccctgcc caaaagaaaa agtcactgag cagaccattt
     4621 tgacagcttt gcctctgggc acttgagcac aagcaagaca tgtgtcactg gaacatctat
     4681 ctaatcagca tccacattca gcacatgaca tacttgcaaa gagaaatggc cgtaggacaa
     4741 ccttaaacag gaaaagtcat ctgcacaaac ctgtgtctgg cataaaacat gaactacggt
     4801 atcagcagaa cccatgaata attataaccg tatccctgta tgcacatgca catatagagc
     4861 attgtgaact atatcacacc aaatctctgg tttccgtata aaaaaggaat tatatggatt
     4921 ctcagttgat gttc
//
