LOCUS       NM_001191996            2121 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NHERF family PDZ scaffold protein 4 (Nherf4),
            mRNA.
ACCESSION   NM_001191996 XM_576397
VERSION     NM_001191996.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2121)
  AUTHORS   Pouly,D., Chenaux,S., Martin,V., Babis,M., Koch,R., Nagoshi,E.,
            Katanaev,V.L., Gachon,F. and Staub,O.
  TITLE     USP2-45 Is a Circadian Clock Output Effector Regulating Calcium
            Absorption at the Post-Translational Level
  JOURNAL   PLoS One 11 (1), e0145155 (2016)
   PUBMED   26756164
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2121)
  AUTHORS   Zachos,N.C., Hodson,C., Kovbasnjuk,O., Li,X., Thelin,W.R., Cha,B.,
            Milgram,S. and Donowitz,M.
  TITLE     Elevated intracellular calcium stimulates NHE3 activity by an IKEPP
            (NHERF4) dependent mechanism
  JOURNAL   Cell Physiol Biochem 22 (5-6), 693-704 (2008)
   PUBMED   19088451
REFERENCE   3  (bases 1 to 2121)
  AUTHORS   Scott,R.O., Thelin,W.R. and Milgram,S.L.
  TITLE     A novel PDZ protein regulates the activity of guanylyl cyclase C,
            the heat-stable enterotoxin receptor
  JOURNAL   J Biol Chem 277 (25), 22934-22941 (2002)
   PUBMED   11950846
REFERENCE   4  (bases 1 to 2121)
  AUTHORS   Gisler,S.M., Stagljar,I., Traebert,M., Bacic,D., Biber,J. and
            Murer,H.
  TITLE     Interaction of the type IIa Na/Pi cotransporter with PDZ proteins
  JOURNAL   J Biol Chem 276 (12), 9206-9213 (2001)
   PUBMED   11099500
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 17, 2010 this sequence version replaced XM_576397.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.22689.1,
                                           SRR26643288.33331.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                JAXUCZ010000008.1  53485646-53485661   c
            17-44               JAXUCZ010000008.1  53484831-53484858   c
            45-118              JAXUCZ010000008.1  53484625-53484698   c
            119-330             JAXUCZ010000008.1  53484113-53484324   c
            331-520             JAXUCZ010000008.1  53483671-53483860   c
            521-657             JAXUCZ010000008.1  53483428-53483564   c
            658-862             JAXUCZ010000008.1  53483042-53483246   c
            863-1059            JAXUCZ010000008.1  53482653-53482849   c
            1060-1266           JAXUCZ010000008.1  53482369-53482575   c
            1267-1467           JAXUCZ010000008.1  53482043-53482243   c
            1468-2121           JAXUCZ010000008.1  53481213-53481866   c
FEATURES             Location/Qualifiers
     source          1..2121
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2121
                     /gene="Nherf4"
                     /gene_synonym="Pdzd3; RGD1559807"
                     /note="NHERF family PDZ scaffold protein 4"
                     /db_xref="GeneID:500986"
                     /db_xref="RGD:1559807"
     CDS             1..1497
                     /gene="Nherf4"
                     /gene_synonym="Pdzd3; RGD1559807"
                     /note="PDZ domain containing 3"
                     /codon_start=1
                     /product="Na(+)/H(+) exchange regulatory cofactor NHE-RF4"
                     /protein_id="NP_001178925.1"
                     /db_xref="GeneID:500986"
                     /db_xref="RGD:1559807"
                     /translation="MEAAADLRDTALLTLKFKFNPRLGIDNPVLSLAEDQDQSDPWNL
                     HRPRFCLLSKEEEKSFGFHLQQQLGKADHVVCRVDPGSSAQRQGLREGDRILAVNNNI
                     VEHEDYAVVVRYIRASGPRVLLTVLAQHVYDVTRAQQGNEAFPCPTLASGVRPRLCHV
                     VKDEGGFGFSVTHGARGPFWLVLSAGGAAERAGVPPGARLLEVNGICVEKFTYNQLNR
                     KLCQSGDRVTLLVAGPEVEEQCHQLGMPLAAPLAEGWALPAKPRCLNIEKGPQGFGFL
                     LREEKGPDGRLGQFLWEVDPGLPADKAGMKAGDRLVAVAGESMDGLGHEETVSRIRAQ
                     GSCVSLVVVDPEADRFFSMVRLSPLLFLENTEIAAAPLAETKDLPVEDTVEPSGLAGS
                     RQCFLYPGPGGGYGFRLRCVASGPCLFISQVTPGGSAARAGLQMGDAILEVNGCPVGG
                     DSDLDTLQQLAEAEPPLRLKLAPRNSQGSEAWISLESGEDWPLASELL"
     exon            1..16
                     /gene="Nherf4"
                     /gene_synonym="Pdzd3; RGD1559807"
                     /inference="alignment:Splign:2.1.0"
     exon            17..44
                     /gene="Nherf4"
                     /gene_synonym="Pdzd3; RGD1559807"
                     /inference="alignment:Splign:2.1.0"
     exon            45..118
                     /gene="Nherf4"
                     /gene_synonym="Pdzd3; RGD1559807"
                     /inference="alignment:Splign:2.1.0"
     exon            119..330
                     /gene="Nherf4"
                     /gene_synonym="Pdzd3; RGD1559807"
                     /inference="alignment:Splign:2.1.0"
     exon            331..520
                     /gene="Nherf4"
                     /gene_synonym="Pdzd3; RGD1559807"
                     /inference="alignment:Splign:2.1.0"
     exon            521..657
                     /gene="Nherf4"
                     /gene_synonym="Pdzd3; RGD1559807"
                     /inference="alignment:Splign:2.1.0"
     exon            658..862
                     /gene="Nherf4"
                     /gene_synonym="Pdzd3; RGD1559807"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1059
                     /gene="Nherf4"
                     /gene_synonym="Pdzd3; RGD1559807"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1266
                     /gene="Nherf4"
                     /gene_synonym="Pdzd3; RGD1559807"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1467
                     /gene="Nherf4"
                     /gene_synonym="Pdzd3; RGD1559807"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..2121
                     /gene="Nherf4"
                     /gene_synonym="Pdzd3; RGD1559807"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaggcag ctgcagatct tcgggacacg gccttgttaa ctctaaagtt taagtttaat
       61 cctagactgg gcattgacaa tcctgtcctc tccctggctg aagaccagga ccaatctgat
      121 ccctggaacc tgcaccggcc tcgcttctgt ctgttgagca aggaggagga aaagagtttt
      181 gggttccatc tgcagcagca gctcggcaag gctgaccatg tggtgtgcag ggtggatcca
      241 ggctcctctg cccagcgcca gggtctccgg gaaggagatc ggatcctagc tgtgaacaat
      301 aatattgtgg aacatgagga ctatgcggtg gtggtgcgtt acatccgggc cagcggtccc
      361 cgggtattgc tgacagtctt ggcacagcat gtgtatgacg tgacacgtgc ccagcaaggg
      421 aatgaagctt tcccctgtcc gaccctagcc tcgggggtca ggccccggtt gtgccatgtg
      481 gtaaaagatg aaggtggctt tggcttcagt gtcacccatg gagctcgagg tcctttctgg
      541 ttggtgctca gtgcaggagg agctgctgag agggcagggg tgccccctgg ggccaggctc
      601 ctagaagtga atgggatctg tgtggagaag ttcacttaca accagctcaa taggaagctt
      661 tgtcagagtg gagatcgggt gactctgctg gtggcagggc cagaggtaga ggaacagtgt
      721 caccaactgg gaatgcctct tgctgcaccc ctggcggagg gctgggcact gcccgccaag
      781 ccccggtgtt taaacataga gaaagggcct caaggctttg ggtttctgct ccgggaggag
      841 aagggcccgg atggtcgact tgggcagttc ttgtgggagg tggatccagg actgccagct
      901 gacaaggccg ggatgaaggc tggagatcgc ctggtggctg tggctgggga gagcatggac
      961 gggctgggcc acgaggaaac agtgtctagg attcgagcac agggctcttg tgtctccctc
     1021 gtcgtcgtcg atcctgaggc tgaccgcttc ttcagcatgg tacgcctgtc tcccctcctc
     1081 ttcttggaga acaccgagat tgctgctgct cctctggcag aaaccaagga tcttccagtg
     1141 gaagacacag ttgagccttc tggccttgct ggctctcgcc aatgcttctt gtaccctggg
     1201 cctggaggtg gctatggatt cagactccgc tgtgtggcca gtgggccttg tcttttcatc
     1261 tcccaggtga ccccaggagg ctcagctgca cgggcggggc tgcagatggg agatgcgatt
     1321 ttggaggtga acggatgtcc tgtgggtgga gacagtgacc tggatacgct tcagcagctg
     1381 gctgaggcag agccacccct ccgcctgaag ctggcaccta ggaattcgca gggctcagaa
     1441 gcctggattt ccttggagtc tggagaggac tggcctctgg cttcagagtt gctataggac
     1501 atccctgctt ggcatagact cgcctattct cctgcccttg ctctgcacac ggagatggga
     1561 ggagccagga acagtctaag ttggaagtgg gaactggagg attcggacac tactgatcgc
     1621 aggactgcag ggaccttcct ctttctcatg agcctacctc cagcacaggg gtgtagacgg
     1681 agacctcagg ccggctagta agggagcctg agactccaca ggatgttatg cagaagtttt
     1741 ggggagctgt gccccaaaga tgaagttctg ttcaagaaga tgaggctgtg gaaccactta
     1801 ggactgaagc taggggacac gtgatgctgt tgtcatgtgg cagaaggact ggagccatat
     1861 gttccttcta ctgataccta ggaatcttgg gagctggttc ttggctattg taatgtcctg
     1921 ttgtagcctt ttccagttgg ccggtgagta ggtaaagctg ctgtcttcta agtctgacaa
     1981 cccgagttca ctcactagaa ccatacagta gaacctcctg gaggttgtcc tctgacatct
     2041 atatgagcac tttagtacaa gtatgctact gttcaaataa ataaataaat aaataaataa
     2101 ataaataaat aaataaataa a
//
