LOCUS       NM_021594               1492 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NHERF family PDZ scaffold protein 1 (Nherf1),
            mRNA.
ACCESSION   NM_021594
VERSION     NM_021594.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1492)
  AUTHORS   Tachikawa,M., Yokoyama,R., Akanuma,S.I. and Hosoya,K.I.
  TITLE     Assembly of Taurine Transporter (Slc6a6) with Na+-H+ Exchanger
            Regulatory Factor 1 (Slc9a3r1) Improves GABA Transport Activity by
            Increasing the Maximum Transport Velocity
  JOURNAL   Biol Pharm Bull 41 (3), 338-341 (2018)
   PUBMED   29491210
  REMARK    GeneRIF: The purpose of this study was to clarify the assembly of
            taurine transporter (TauT/Slc6a6) and PSD-95/Disc-large/Zo-1 (PDZ)
            domain of Slc9a3r1 as a regulatory mechanism of Slc6a6-mediated
            GABA transport activity
REFERENCE   2  (bases 1 to 1492)
  AUTHORS   Lu,X., He,L., Zhou,Q., Wang,M., Shen,W.J., Azhar,S., Pan,F., Guo,Z.
            and Hu,Z.
  TITLE     NHERF1 and NHERF2 regulation of SR-B1 stability via ubiquitination
            and proteasome degradation
  JOURNAL   Biochem Biophys Res Commun 490 (4), 1168-1175 (2017)
   PUBMED   28669731
  REMARK    GeneRIF: The results suggest that NHERF1 and NHERF2 down-regulated
            SR-B1 at least in part via the ubiquitin/proteasome pathway.
REFERENCE   3  (bases 1 to 1492)
  AUTHORS   Barati,M.T., Ketchem,C.J., Merchant,M.L., Kusiak,W.B., Jose,P.A.,
            Weinman,E.J., LeBlanc,A.J., Lederer,E.D. and Khundmiri,S.J.
  TITLE     Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase
            regulation in renal proximal tubule cells from rat models of
            hypertension: aged F344 rats and spontaneously hypertensive rats
  JOURNAL   Am J Physiol Cell Physiol 313 (2), C197-C206 (2017)
   PUBMED   28515088
  REMARK    GeneRIF: These results suggest that decreased renal NHERF-1
            expression contributes to the impaired dopamine-mediated inhibition
            of NKA in PTCs from animal models of hypertension.
REFERENCE   4  (bases 1 to 1492)
  AUTHORS   Ritter-Makinson,S.L., Paquet,M., Bogenpohl,J.W., Rodin,R.E., Chris
            Yun,C., Weinman,E.J., Smith,Y. and Hall,R.A.
  TITLE     Group II metabotropic glutamate receptor interactions with NHERF
            scaffold proteins: Implications for receptor localization in brain
  JOURNAL   Neuroscience 353, 58-75 (2017)
   PUBMED   28392297
REFERENCE   5  (bases 1 to 1492)
  AUTHORS   Briffa,J.F., Grinfeld,E., Jenkin,K.A., Mathai,M.L., Poronnik,P.,
            McAinch,A.J. and Hryciw,D.H.
  TITLE     Diet induced obesity in rats reduces NHE3 and Na(+) /K(+) -ATPase
            expression in the kidney
  JOURNAL   Clin Exp Pharmacol Physiol 42 (10), 1118-1126 (2015)
   PUBMED   26173747
REFERENCE   6  (bases 1 to 1492)
  AUTHORS   Shenolikar,S., Voltz,J.W., Minkoff,C.M., Wade,J.B. and Weinman,E.J.
  TITLE     Targeted disruption of the mouse NHERF-1 gene promotes
            internalization of proximal tubule sodium-phosphate cotransporter
            type IIa and renal phosphate wasting
  JOURNAL   Proc Natl Acad Sci U S A 99 (17), 11470-11475 (2002)
   PUBMED   12169661
REFERENCE   7  (bases 1 to 1492)
  AUTHORS   Bonilha,V.L. and Rodriguez-Boulan,E.
  TITLE     Polarity and developmental regulation of two PDZ proteins in the
            retinal pigment epithelium
  JOURNAL   Invest Ophthalmol Vis Sci 42 (13), 3274-3282 (2001)
   PUBMED   11726633
REFERENCE   8  (bases 1 to 1492)
  AUTHORS   Takeda,T., McQuistan,T., Orlando,R.A. and Farquhar,M.G.
  TITLE     Loss of glomerular foot processes is associated with uncoupling of
            podocalyxin from the actin cytoskeleton
  JOURNAL   J Clin Invest 108 (2), 289-301 (2001)
   PUBMED   11457882
REFERENCE   9  (bases 1 to 1492)
  AUTHORS   Fouassier,L., Yun,C.C., Fitz,J.G. and Doctor,R.B.
  TITLE     Evidence for ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50)
            self-association through PDZ-PDZ interactions
  JOURNAL   J Biol Chem 275 (32), 25039-25045 (2000)
   PUBMED   10859298
REFERENCE   10 (bases 1 to 1492)
  AUTHORS   Hall,R.A., Premont,R.T., Chow,C.W., Blitzer,J.T., Pitcher,J.A.,
            Claing,A., Stoffel,R.H., Barak,L.S., Shenolikar,S., Weinman,E.J.,
            Grinstein,S. and Lefkowitz,R.J.
  TITLE     The beta2-adrenergic receptor interacts with the Na+/H+-exchanger
            regulatory factor to control Na+/H+ exchange
  JOURNAL   Nature 392 (6676), 626-630 (1998)
   PUBMED   9560162
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF154336.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF154336.1, FQ213792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1492
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1492
                     /gene="Nherf1"
                     /gene_synonym="Slc9a3r1"
                     /note="NHERF family PDZ scaffold protein 1"
                     /db_xref="GeneID:59114"
                     /db_xref="RGD:708538"
     exon            1..501
                     /gene="Nherf1"
                     /gene_synonym="Slc9a3r1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1140
                     /gene="Nherf1"
                     /gene_synonym="Slc9a3r1"
                     /note="EBP50; NHERF-1; regulatory cofactor of Na(+)/H(+)
                     exchanger; sodium-hydrogen exchanger regulatory factor 1;
                     ezrin-radixin-moesin-binding phosphoprotein 50; solute
                     carrier family 9, subfamily A (NHE3, cation proton
                     antiporter 3), member 3 regulator 1; solute carrier family
                     9 (sodium/hydrogen exchanger), member 3 regulator 1;
                     ERM-binding phosphoprotein; SLC9A3 regulator 1"
                     /codon_start=1
                     /product="Na(+)/H(+) exchange regulatory cofactor NHE-RF1"
                     /protein_id="NP_067605.1"
                     /db_xref="GeneID:59114"
                     /db_xref="RGD:708538"
                     /translation="MSADAAAGEPLPRLCCLEKGPNGYGFHLHGEKGKVGQFIRLVEP
                     GSPAEKSGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLKKL
                     GVPIREELLRAQEKSEHTEPPAAADTKKAGDQNEAEKSHLERCELRPRLCTMKKGPNG
                     YGFNLHSDKSKPGQFIRAVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIKA
                     GGDEAKLLVVDKETDEFFKKCRVTPSQEHLDGPLPEPFSNGEIQKENSREALVEPASE
                     SPRPALARSASSDTSEELNAQDSPKRHDSTEPSSTSSSSDPILDFNISLAVAKERAHQ
                     KRSSKRAPQMDWSKKNELFSNL"
     exon            502..663
                     /gene="Nherf1"
                     /gene_synonym="Slc9a3r1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..817
                     /gene="Nherf1"
                     /gene_synonym="Slc9a3r1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..858
                     /gene="Nherf1"
                     /gene_synonym="Slc9a3r1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..948
                     /gene="Nherf1"
                     /gene_synonym="Slc9a3r1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1492
                     /gene="Nherf1"
                     /gene_synonym="Slc9a3r1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggctcggag agaaaggtcg tgagtccgca gcctccgacg ggaccggttc tgagccttcg
       61 cagagcaaga tgagcgcgga cgcagcggcc ggggagcctc tgccccggct ctgctgcctc
      121 gagaagggtc cgaacggcta cggcttccac ctgcacgggg agaaaggcaa ggtgggccag
      181 tttattcggc tagtggagcc tggctcgccg gccgagaagt cggggttgct ggccggggac
      241 cgattggtgg aggtgaacgg tgagaatgtg gagaaggaga cgcatcagca ggtggtgagc
      301 cgcatccgcg cggcgctgaa cgccgtgcgc ctgctggtgg tcgaccctga gaccgacgag
      361 caactcaaga agctgggcgt cccgatccgg gaagagctgc tgcgcgccca ggagaagtcc
      421 gagcacaccg agccgccagc ggccgccgac actaagaagg ctggggacca gaatgaggcc
      481 gaaaagagcc acttggagcg gtgtgagctc cgaccccggc tctgcaccat gaagaaaggc
      541 cccaatggtt atggcttcaa cctgcacagt gacaaatcca agccaggcca gttcatccga
      601 gcagtggacc cggactcacc agcagaggcg tctggcctcc gggcccagga ccggattgtg
      661 gaggtcaatg gcgtctgcat ggagggcaaa cagcacgggg acgtcgtgtc tgccatcaag
      721 gctggaggtg atgaagccaa gctgctggtg gtagacaagg aaacagatga gttctttaag
      781 aagtgcagag tgaccccgtc ccaggagcac ctggatggcc ccttgcctga acccttcagc
      841 aatggagaga tacagaagga gaacagccgt gaagccctgg tagagccagc ttcagaaagc
      901 cccaggccag ccctggcaag atctgcctcc agcgatacca gtgaggagct aaatgcccaa
      961 gatagtccca agagacacga ttccacagag ccctcatcta cctcctcctc ctctgacccc
     1021 atcttggact tcaacatctc cctggctgtg gctaaagaga gggcccacca gaagcgcagt
     1081 agcaagcggg ccccgcagat ggactggagc aagaaaaatg aactcttcag caacctctga
     1141 gcattccgcc tccgctgttt tgtgctggag ggtggggctg cccacccgac ctagctcccc
     1201 ttttcttctc ccaggtgccc accaatcaac attcaaatca gcatcagcac ccaccccact
     1261 tcccgacaaa tctgattttc ctacaattct gtccttccct catcctaggg aaggagaatg
     1321 tcctgactcc ctgctcttcc cctaagggct tcttcctacc aaagtgtccc ttcaccagtc
     1381 cgccaaggac accactggga ccctcactaa gcaaggacct ttggaccaga caagaagtct
     1441 cccctcggca atgtgtgata accaagtcca aggtttacca agggctgtct at
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