LOCUS       NM_001014217            1445 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus nonhomologous end-joining factor 1 (Nhej1), mRNA.
ACCESSION   NM_001014217 XM_343591
VERSION     NM_001014217.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1445)
  AUTHORS   El Waly,B., Buhler,E., Haddad,M.R. and Villard,L.
  TITLE     Nhej1 Deficiency Causes Abnormal Development of the Cerebral Cortex
  JOURNAL   Mol Neurobiol 52 (1), 771-782 (2015)
   PUBMED   25288157
  REMARK    GeneRIF: These results indicate that the Nhej1 protein is necessary
            for proper rat cortical development.
REFERENCE   2  (bases 1 to 1445)
  AUTHORS   Craxton,A., Somers,J., Munnur,D., Jukes-Jones,R., Cain,K. and
            Malewicz,M.
  TITLE     XLS (c9orf142) is a new component of mammalian DNA double-stranded
            break repair
  JOURNAL   Cell Death Differ 22 (6), 890-897 (2015)
   PUBMED   25941166
REFERENCE   3  (bases 1 to 1445)
  AUTHORS   Lee,J.E., Heo,J.I., Park,S.H., Kim,J.H., Kho,Y.J., Kang,H.J.,
            Chung,H.Y., Yoon,J.L. and Lee,J.Y.
  TITLE     Calorie restriction (CR) reduces age-dependent decline of
            non-homologous end joining (NHEJ) activity in rat tissues
  JOURNAL   Exp Gerontol 46 (11), 891-896 (2011)
   PUBMED   21821112
  REMARK    GeneRIF: Rresults suggest that Caloric Restriction could reduce
            age-dependent decline of NHEJ activity in various tissues of rats
            possibly through up-regulation of XRCC4.
REFERENCE   4  (bases 1 to 1445)
  AUTHORS   Roberts,S.A., Strande,N., Burkhalter,M.D., Strom,C., Havener,J.M.,
            Hasty,P. and Ramsden,D.A.
  TITLE     Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken
            ends
  JOURNAL   Nature 464 (7292), 1214-1217 (2010)
   PUBMED   20383123
REFERENCE   5  (bases 1 to 1445)
  AUTHORS   Lieber,M.R.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   6  (bases 1 to 1445)
  AUTHORS   Ahnesorg,P., Smith,P. and Jackson,S.P.
  TITLE     XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA
            nonhomologous end-joining
  JOURNAL   Cell 124 (2), 301-313 (2006)
   PUBMED   16439205
REFERENCE   7  (bases 1 to 1445)
  AUTHORS   Buck,D., Malivert,L., de Chasseval,R., Barraud,A., Fondaneche,M.C.,
            Sanal,O., Plebani,A., Stephan,J.L., Hufnagel,M., le Deist,F.,
            Fischer,A., Durandy,A., de Villartay,J.P. and Revy,P.
  TITLE     Cernunnos, a novel nonhomologous end-joining factor, is mutated in
            human immunodeficiency with microcephaly
  JOURNAL   Cell 124 (2), 287-299 (2006)
   PUBMED   16439204
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079033.1.
            
            [WARNING] On Aug 3, 2024 this sequence was replaced by
            NM_001014217.2.
            
            On Apr 20, 2005 this sequence version replaced XM_343591.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079033.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1445
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..1445
                     /gene="Nhej1"
                     /note="nonhomologous end-joining factor 1"
                     /db_xref="GeneID:363251"
                     /db_xref="RGD:1359338"
     exon            1..105
                     /gene="Nhej1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1020
                     /gene="Nhej1"
                     /note="XRCC4-like factor; protein cernunnos"
                     /codon_start=1
                     /product="non-homologous end-joining factor 1"
                     /protein_id="NP_001014239.1"
                     /db_xref="GeneID:363251"
                     /db_xref="RGD:1359338"
                     /translation="MEELEQGLLMQPWAWLQLAENSLLAKASITKHGYALLISDLQQV
                     WHEQVDTLEVSQRAKELNKRLTAPPAAFLHHLDEVLRPLFKDSAHQDAAHPSKATFSC
                     DRGEEVLILRVRSELSGLPFNWHFHCLPASSLLVSQHLICPLMGVSLALHSHVRELAA
                     LLRMKDLEIQAYQESGAVLSRGRLKTEPFEENSFLEQFMVEKLPEACAVGDGRPFAMN
                     LQSLYVAVTKQQVQARQKHKGSGEPQTSSSTSPQGTDSQLQNQPEQQISPTPTLSEPE
                     CEPMAASGPVHRAQLVKAKRKKPRGLFS"
     exon            106..282
                     /gene="Nhej1"
                     /inference="alignment:Splign:2.1.0"
     exon            283..510
                     /gene="Nhej1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..649
                     /gene="Nhej1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..708
                     /gene="Nhej1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..826
                     /gene="Nhej1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..945
                     /gene="Nhej1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1413
                     /gene="Nhej1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagactcc tccttagctg gcttcgtgtt ctgcccgctg gactgaatta actttgttac
       61 cctttgggtc caagagcctt acctctgtgc agcggtgttg taaaaatgga ggaactagag
      121 caaggcctgt tgatgcagcc atgggcatgg ttacaacttg ctgagaactc actcttggcc
      181 aaggcttcta tcaccaagca tggttatgcc ttgctgattt cggatcttca acaggtgtgg
      241 catgaacagg tggacacttt ggaggtcagc cagcgagcca aggagctgaa caagcgcctc
      301 accgctcccc ctgcagcttt tctccatcac ttggatgaag tgcttcgccc actgtttaaa
      361 gattctgccc accaggatgc tgctcaccct agcaaagcca ctttctcctg tgatcgtgga
      421 gaggaggtat tgatcctgag ggtgcggagt gagctctctg gtctcccctt caattggcat
      481 ttccactgtc ttccagctag ttctttactg gtctctcagc atttgatttg tcctctgatg
      541 ggtgtgagct tggcattgca cagtcatgtg agggagctag cagcattgct tcggatgaag
      601 gaccttgaga tccaggccta ccaggagagt ggggctgtgc tgagccgagg tcgattgaag
      661 acagagccat ttgaagaaaa ttctttcttg gaacagttta tggtagagaa attgccagag
      721 gcatgtgctg ttggtgatgg aaggccattt gccatgaatc tgcagagcct gtatgtggca
      781 gtcacaaagc agcaggtcca agccaggcag aagcataaag gctctggaga gcctcagaca
      841 tcaagcagca cctcccctca aggaactgat agccagcttc agaaccagcc agaacagcag
      901 atctctccca ctccaaccct ctcagagcct gaatgtgagc ctatggctgc ttcaggccct
      961 gtgcatagag ctcagctggt aaaggccaag aggaagaagc ccaggggact cttcagttag
     1021 ctcaccatgt ctcagccacc gagaagagag caaaaccgct tcctagcatc acccggagag
     1081 gagcttgcgt ggcaaagcat ccgtcagagg cctgagtttg tactgacagg ccacctgagt
     1141 gggaactcca tcagtggagc ctgagtccga cgaactggca gttcagatat gagtgacgcc
     1201 agctcctcgt ttggttgacg ccagctcctc gtttgatagc attctttctc tagaactagc
     1261 atctgtggca aacttagata catgaagcga gtttgcaaag aggtgcatgc ccaaaacacc
     1321 aagctgtctt tcacaggggt ctctcaccag tcctacatga cccttagaaa actgctccct
     1381 caacacagaa taaaagatgc tcacattcct caaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaa
//
