LOCUS       NM_012610               3266 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Rattus norvegicus nerve growth factor receptor (Ngfr), mRNA.
ACCESSION   NM_012610 XM_001081319
VERSION     NM_012610.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3266)
  AUTHORS   Yang,X.P., Dan-Dai, Chen,R.X., Li,Y.X., Rui Lv,X. and Li,Y.
  TITLE     The expression of ProBDNF and its high affinity receptor P75NTR in
            the neurons of emotion-related brain regions of post-stroke
            depression rats
  JOURNAL   Brain Res 1831, 148829 (2024)
   PUBMED   38423239
  REMARK    GeneRIF: The expression of ProBDNF and its high affinity receptor
            P75NTR in the neurons of emotion-related brain regions of
            post-stroke depression rats.
REFERENCE   2  (bases 1 to 3266)
  AUTHORS   Wu,Z., Yang,Y. and Wang,M.
  TITLE     Silencing p75NTR regulates osteogenic differentiation and
            angiogenesis of BMSCs to enhance bone healing in fractured rats
  JOURNAL   J Orthop Surg Res 19 (1), 192 (2024)
   PUBMED   38504358
  REMARK    GeneRIF: Silencing p75NTR regulates osteogenic differentiation and
            angiogenesis of BMSCs to enhance bone healing in fractured rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3266)
  AUTHORS   Crews,F.T., Fisher,R.P., Qin,L. and Vetreno,R.P.
  TITLE     HMGB1 neuroimmune signaling and REST-G9a gene repression contribute
            to ethanol-induced reversible suppression of the cholinergic neuron
            phenotype
  JOURNAL   Mol Psychiatry 28 (12), 5159-5172 (2023)
   PUBMED   37402853
REFERENCE   4  (bases 1 to 3266)
  AUTHORS   Joshi,S., Frondelli,M.J., Zanin,J.P., Levison,S.W. and
            Friedman,W.J.
  TITLE     Oligodendrocyte progenitor development from the postnatal rat
            subventricular zone is regulated by the p75 neurotrophin receptor
  JOURNAL   Glia 71 (10), 2383-2400 (2023)
   PUBMED   37334743
  REMARK    GeneRIF: Oligodendrocyte progenitor development from the postnatal
            rat subventricular zone is regulated by the p75 neurotrophin
            receptor.
REFERENCE   5  (bases 1 to 3266)
  AUTHORS   Testa,G., Mainardi,M., Vannini,E., Pancrazi,L., Cattaneo,A. and
            Costa,M.
  TITLE     Disentangling the signaling complexity of nerve growth factor
            receptors by CRISPR/Cas9
  JOURNAL   FASEB J 36 (11), e22498 (2022)
   PUBMED   37036720
  REMARK    GeneRIF: Disentangling the signaling complexity of nerve growth
            factor receptors by CRISPR/Cas9.
REFERENCE   6  (bases 1 to 3266)
  AUTHORS   Metsis,M., Timmusk,T., Allikmets,R., Saarma,M. and Persson,H.
  TITLE     Regulatory elements and transcriptional regulation by testosterone
            and retinoic acid of the rat nerve growth factor receptor promoter
  JOURNAL   Gene 121 (2), 247-254 (1992)
   PUBMED   1446821
REFERENCE   7  (bases 1 to 3266)
  AUTHORS   Lee,K.F., Li,E., Huber,L.J., Landis,S.C., Sharpe,A.H., Chao,M.V.
            and Jaenisch,R.
  TITLE     Targeted mutation of the gene encoding the low affinity NGF
            receptor p75 leads to deficits in the peripheral sensory nervous
            system
  JOURNAL   Cell 69 (5), 737-749 (1992)
   PUBMED   1317267
REFERENCE   8  (bases 1 to 3266)
  AUTHORS   Parvinen,M., Pelto-Huikko,M., Soder,O., Schultz,R., Kaipia,A.,
            Mali,P., Toppari,J., Hakovirta,H., Lonnerberg,P., Ritzen,E.M. et
            al.
  TITLE     Expression of beta-nerve growth factor and its receptor in rat
            seminiferous epithelium: specific function at the onset of meiosis
  JOURNAL   J Cell Biol 117 (3), 629-641 (1992)
   PUBMED   1315318
REFERENCE   9  (bases 1 to 3266)
  AUTHORS   Mufson,E.J. and Kordower,J.H.
  TITLE     Nerve growth factor receptor expressing human basal forebrain
            neurons: pathologic alterations in Alzheimer's and Parkinson's
            disease
  JOURNAL   Prog Clin Biol Res 317, 401-414 (1989)
   PUBMED   2557638
REFERENCE   10 (bases 1 to 3266)
  AUTHORS   Radeke,M.J., Misko,T.P., Hsu,C., Herzenberg,L.A. and Shooter,E.M.
  TITLE     Gene transfer and molecular cloning of the rat nerve growth factor
            receptor
  JOURNAL   Nature 325 (6105), 593-597 (1987)
   PUBMED   3027580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB725789.1, X05137.1 and JAXUCZ010000010.1.
            
            On Mar 25, 2010 this sequence version replaced NM_012610.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X05137.1, SRR26360172.411174.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               CB725789.1         9-490
            483-1378            X05137.1           483-1378
            1379-3266           JAXUCZ010000010.1  81012077-81013964   c
FEATURES             Location/Qualifiers
     source          1..3266
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..3266
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NTR; RNNGFRR; Tnfrsf16"
                     /note="nerve growth factor receptor"
                     /db_xref="GeneID:24596"
                     /db_xref="RGD:3177"
     exon            1..182
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NTR; RNNGFRR; Tnfrsf16"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1391
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NTR; RNNGFRR; Tnfrsf16"
                     /note="nerve growth factor receptor, fast; low affinity
                     nerve growth factor receptor; tumor necrosis factor
                     receptor superfamily member 16; p75 ICD; gp80-LNGFR; NGF
                     receptor; nerve growth factor receptor (TNFR superfamily,
                     member 16); low affinity neurotrophin receptor p75NTR;
                     low-affinity nerve growth factor receptor p75NGR;
                     low-affinity nerve growth factor receptor p75NGFR"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 16 precursor"
                     /protein_id="NP_036742.2"
                     /db_xref="GeneID:24596"
                     /db_xref="RGD:3177"
                     /translation="MRRAGAACSAMDRLRLLLLLILGMSSGGAKETCSTGLYTHSGEC
                     CKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECLGLQSMSAPCVE
                     ADDAVCRCAYGYYQDEETGHCEACSVCEVGSGLVFSCQDKQNTVCEECPEGTYSDEAN
                     HVDPCLPCTVCEDTERQLRECTPWADAECEEIPGRWIPRSTPPEGSDSTAPSTQEPEV
                     PPEQDLVPSTVADMVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRW
                     NSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQTHTQTASGQALKGDG
                     NLYSSLPLTKREEVEKLLNGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWGAQD
                     SATLDALLAALRRIQRADIVESLCSESTATSPV"
     exon            183..324
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NTR; RNNGFRR; Tnfrsf16"
                     /inference="alignment:Splign:2.1.0"
     exon            325..684
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NTR; RNNGFRR; Tnfrsf16"
                     /inference="alignment:Splign:2.1.0"
     exon            685..937
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NTR; RNNGFRR; Tnfrsf16"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1098
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NTR; RNNGFRR; Tnfrsf16"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..3266
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NTR; RNNGFRR; Tnfrsf16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctccggc gggcagcagg cgctggagcg cagcgcagtt cagctcagcg cagcaccatc
       61 ggtctgcgga gcggactgag ctagaagcgg agcgctgacg ccggaggcgt gcaatgagga
      121 gggcaggtgc tgcctgcagc gccatggacc ggctgcgcct gctgctgctg ctgattctag
      181 ggatgtcctc tggaggtgcc aaggagacat gttccacagg cctgtacacc cacagcggag
      241 agtgctgcaa agcctgcaac ttgggcgaag gcgtggccca gccctgcgga gccaaccaga
      301 ccgtgtgtga accctgcctg gacagtgtta cattctccga tgtggtgagc gccactgagc
      361 cgtgcaagcc gtgcaccgag tgcctgggcc tgcagagcat gtccgctccc tgtgtggagg
      421 cagacgatgc agtgtgcaga tgtgcctatg gctactacca ggacgaggag actggccact
      481 gtgaggcttg cagcgtgtgc gaggtgggct cgggactcgt gttctcctgc caggacaaac
      541 agaacacagt gtgtgaagag tgcccagagg gcacatactc agacgaagcc aaccacgtgg
      601 acccgtgcct accctgcacg gtgtgcgagg acactgagcg ccagttacgc gagtgcacgc
      661 cctgggctga tgctgaatgc gaagagatcc ctggtcgatg gatcccaagg tctacgcccc
      721 cggagggctc cgacagcaca gcgcccagca cccaggagcc tgaggttcct ccagagcaag
      781 accttgtacc cagtacagtg gcggatatgg tgaccactgt gatgggcagc tcccagcctg
      841 tagtgacccg cggcaccacc gacaacctca ttcctgtcta ttgctccatc ttggctgctg
      901 tggtcgtggg ccttgtggcc tatattgctt tcaagaggtg gaacagctgc aaacaaaata
      961 aacaaggcgc caacagccgc cccgtgaacc agacgccccc accggaggga gagaaactgc
     1021 acagcgacag tggcatctct gtggacagcc agagcctgca cgaccagcag acccatacgc
     1081 agactgcctc aggccaggcc ctcaagggtg atggcaacct ctacagtagc ctgcccctga
     1141 ccaagcgtga ggaggtagag aaactgctca acggggatac ctggcgacat ctggcaggcg
     1201 agctgggtta ccagcctgaa catatagact cctttaccca cgaggcctgc ccagtgcgag
     1261 ccctgctggc cagctggggt gcccaggaca gtgcaacgct tgatgccctt ttagccgccc
     1321 tgcgacgcat ccagagagct gacattgtgg agagtctatg cagcgagtcc actgccacgt
     1381 ccccagtgtg aactcacaga ctgggagccc ctgtcctgtc ccacattccg acgactgatg
     1441 ttctagccag cccccacaga gctgccccct ctccctcggg gatggcccaa cggtcagaac
     1501 ggagcatctc tgtgcagggc ctctgtgttc ccactcctga ctccgttgct gctcccgagg
     1561 gggcccttgc ttctgaccac cctctcctca gcaagagaga gagagaggac cacccgagcc
     1621 tgacttgctc catttccatc tcaggccttt ccttcctttc tacacattag ctgtgtcaga
     1681 tctgggggtt tgacactagg agaagggagc gggggcaccc ctaagactca ggaggtactg
     1741 aagaaccaga gccatggact ccacactgtg aaccggagaa caaggggcgg ggcattgtgg
     1801 taggctagac cttccttagc ccctcccttc tcccctctgg ccaaagaaga ggattacgga
     1861 cctatctgag ctgaaagcag gtttggaacc cagcccacac ttctctctca cacacaggat
     1921 ggtaaaaccc agagaaaggc agggactgac ctaggccacc caaccacagg aagaacaaat
     1981 gaaggctgat acactccttt ctgaatgagg gcgtcaagtg tgcttgttga cagggatggc
     2041 gtgactttca gggaaatatc tggaagccat gtctgccccg ccctcaacca cttccaggcc
     2101 cctacccaac ccttgtgcag atgaactgtt tgttcaaggg ctggtccatt ggtctattct
     2161 gatggagtca agctaagggc tcaggcttat ccataaggca tttgtggaga gatgaatctg
     2221 ttagtgcgct cattcttggc ataagcctga agccaacacg gcccttaatg tcagccctcg
     2281 gggtcaggaa ccaaggactc ccaccccaca atccaacact atactacatt acacacacac
     2341 acacacacac acacacacac acacacacac acagagatat cttgcttttc tccccatggc
     2401 tcttttgggg ctgagactag atcctgctgg gagtcactgc cagtgagaga tccggagggg
     2461 acagagctga gcttcatggg gctgtcttcc tcgcccccgg gtctggcagg ccaagaatga
     2521 ctgcatctga gctggtgtct gtcttccaat ggcctgtgcg tggaggaaat gctcccactc
     2581 ctccccttct tgaagctgcc cccagaagac tacagtgcaa aagagcagac tggtgtgaga
     2641 acacaagaaa aagcagatgc tggccctgca gtctgtggca gctttctcct cagcttcaag
     2701 gcccctgcaa aggacggatt tcctgagcac ggccaggaag gggcaagagg gttcggttca
     2761 gtggcgcttt ctcccggctc cttggcctgt tctgttttgc ttgctgttgg aatgagtggg
     2821 caccccctct atttagcatg aaggagcccc aggcagggta tgcacagact gaccaccatc
     2881 cctccccacc cagggtccac ccaacccggt gaagagacca ggagcattgt acgcatacgc
     2941 gggtggtatt tttatggacc ccaatctgca attcccagac acctgggaag tgggacattc
     3001 tttgtgtatt tattttcctc cccaggagct ggggagtggt ggggggctgc aggtacggtt
     3061 tagcatgtgt ttggttctgg gggtctctcc agccttgttt tgggccaagt tggaacctct
     3121 ggccctccag ctggtgacta tgaactccag accccttcgt gctccccgac gccttcccct
     3181 tgcatcctgt gtaaccattt cttgggccct cccaaaacct acacataaaa catacatgat
     3241 gaccattaaa tagcaaaaaa aaaaaa
//
