LOCUS       NM_001277055            1075 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus nerve growth factor (Ngf), mRNA.
ACCESSION   NM_001277055 XM_001067130 XM_003749364 XM_003753645 XM_227525
VERSION     NM_001277055.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1075)
  AUTHORS   Kadekawa,K., Nishijima,S., Noguchi,K., Matsumoto,S. and Sugaya,K.
  TITLE     Elucidation of the pathophysiology of interstitial cystitis/bladder
            pain syndrome via experimental autoimmune cystitis rat model
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 327 (2), R250-R260 (2024)
   PUBMED   38842512
REFERENCE   2  (bases 1 to 1075)
  AUTHORS   Samario-Roman,J., Velasco,M., Larque,C., Cardenas-Vazquez,R.,
            Ortiz-Huidobro,R.I. and Hiriart,M.
  TITLE     NGF effects promote the maturation of rat pancreatic beta cells by
            regulating GLUT2 levels and distribution, and glucokinase activity
  JOURNAL   PLoS One 19 (6), e0303934 (2024)
   PUBMED   38875221
  REMARK    GeneRIF: NGF effects promote the maturation of rat pancreatic beta
            cells by regulating GLUT2 levels and distribution, and glucokinase
            activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1075)
  AUTHORS   Xiang,L., Deng,H. and Zhou,S.
  TITLE     Effects of TNF-alpha on Behaviour and Inflammation in Rats with
            Rotator Cuff Injury through NGF
  JOURNAL   Discov Med 36 (185), 1241-1249 (2024)
   PUBMED   38926110
  REMARK    GeneRIF: Effects of TNF-alpha on Behaviour and Inflammation in Rats
            with Rotator Cuff Injury through NGF.
REFERENCE   4  (bases 1 to 1075)
  AUTHORS   Fukaya,M., Ibuchi,K., Sugawara,T., Itakura,M., Ito,A.,
            Shiroshima,T., Hara,Y., Okamoto,H., Luton,F. and Sakagami,H.
  TITLE     EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA
            Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells
  JOURNAL   Traffic 25 (5), e12936 (2024)
   PUBMED   38725127
  REMARK    GeneRIF: EFA6A, an Exchange Factor for Arf6, Regulates
            NGF-Dependent TrkA Recycling From Early Endosomes and Neurite
            Outgrowth in PC12 Cells.
REFERENCE   5  (bases 1 to 1075)
  AUTHORS   Wang,Y., Gao,B., Chen,X., Shi,X., Li,S., Zhang,Q., Zhang,C. and
            Piao,F.
  TITLE     Improvement of diabetes-induced spinal cord axon injury with
            taurine via nerve growth factor-dependent Akt/mTOR pathway
  JOURNAL   Amino Acids 56 (1), 32 (2024)
   PUBMED   38637413
  REMARK    GeneRIF: Improvement of diabetes-induced spinal cord axon injury
            with taurine via nerve growth factor-dependent Akt/mTOR pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1075)
  AUTHORS   Parvinen,M., Pelto-Huikko,M., Soder,O., Schultz,R., Kaipia,A.,
            Mali,P., Toppari,J., Hakovirta,H., Lonnerberg,P., Ritzen,E.M. et
            al.
  TITLE     Expression of beta-nerve growth factor and its receptor in rat
            seminiferous epithelium: specific function at the onset of meiosis
  JOURNAL   J Cell Biol 117 (3), 629-641 (1992)
   PUBMED   1315318
REFERENCE   7  (bases 1 to 1075)
  AUTHORS   Hallbook,F., Ibanez,C.F. and Persson,H.
  TITLE     Evolutionary studies of the nerve growth factor family reveal a
            novel member abundantly expressed in Xenopus ovary
  JOURNAL   Neuron 6 (5), 845-858 (1991)
   PUBMED   2025430
REFERENCE   8  (bases 1 to 1075)
  AUTHORS   Whittemore,S.R., Friedman,P.L., Larhammar,D., Persson,H.,
            Gonzalez-Carvajal,M. and Holets,V.R.
  TITLE     Rat beta-nerve growth factor sequence and site of synthesis in the
            adult hippocampus
  JOURNAL   J Neurosci Res 20 (4), 403-410 (1988)
   PUBMED   3184206
REFERENCE   9  (bases 1 to 1075)
  AUTHORS   Hallbook,F., Ebendal,T. and Persson,H.
  TITLE     Production and characterization of biologically active recombinant
            beta nerve growth factor
  JOURNAL   Mol Cell Biol 8 (1), 452-456 (1988)
   PUBMED   3336364
REFERENCE   10 (bases 1 to 1075)
  AUTHORS   Barth,E.M., Korsching,S. and Thoenen,H.
  TITLE     Regulation of nerve growth factor synthesis and release in organ
            cultures of rat iris
  JOURNAL   J Cell Biol 99 (3), 839-843 (1984)
   PUBMED   6470042
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Mar 2, 2013 this sequence version replaced
            XM_001067130.4, XM_003753645.1, XM_227525.6, XM_003749364.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ232560.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680422
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                JAXUCZ010000002.1  192589580-192589612
            34-170              JAXUCZ010000002.1  192636123-192636259
            171-1075            JAXUCZ010000002.1  192642067-192642971
FEATURES             Location/Qualifiers
     source          1..1075
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1075
                     /gene="Ngf"
                     /gene_synonym="beta-NGF; Ngfb"
                     /note="nerve growth factor"
                     /db_xref="GeneID:310738"
                     /db_xref="RGD:1598328"
     exon            1..33
                     /gene="Ngf"
                     /gene_synonym="beta-NGF; Ngfb"
                     /inference="alignment:Splign:2.1.0"
     exon            34..170
                     /gene="Ngf"
                     /gene_synonym="beta-NGF; Ngfb"
                     /inference="alignment:Splign:2.1.0"
     exon            171..1075
                     /gene="Ngf"
                     /gene_synonym="beta-NGF; Ngfb"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..908
                     /gene="Ngf"
                     /gene_synonym="beta-NGF; Ngfb"
                     /note="beta-nerve growth factor; nerve growth factor (beta
                     polypeptide); pro-nerve growth factor long"
                     /codon_start=1
                     /product="beta-nerve growth factor precursor"
                     /protein_id="NP_001263984.1"
                     /db_xref="GeneID:310738"
                     /db_xref="RGD:1598328"
                     /translation="MSMLFYTLITAFLIGVQAEPYTDSNVPEGDSVPEAHWTKLQHSL
                     DTALRRARSAPAEPIAARVTGQTRNITVDPKLFKKRRLRSPRVLFSTQPPPTSSDTLD
                     LDFQAHGTISFNRTHRSKRSSTHPVFHMGEFSVCDSVSVWVGDKTTATDIKGKEVTVL
                     GEVNINNSVFKQYFFETKCRAPNPVESGCRGIDSKHWNSYCTTTHTFVKALTTDDKQA
                     AWRFIRIDTACVCVLSRKAARRG"
ORIGIN      
        1 agagagcgcc tggagccgaa ggggagcgca tcgctctcct tcacagagtt ttggcctgtg
       61 gtcgtgcagt ccagggggct ggatggcatg ctggacccaa gctcacctca gtgtctgggc
      121 ccaataaagg ctttgccaag gacgcagctt tctatcctgg ccactctgag gtgcatagcg
      181 taatgtccat gttgttctac actctgatca cagcgttttt gatcggcgta caggcagaac
      241 cgtacacaga tagcaatgtc ccagagggag actctgtccc tgaagcccac tggactaaac
      301 ttcagcattc ccttgacaca gccctccgca gagcccgcag tgcccctgct gaaccaatag
      361 ctgcccgtgt gacagggcag acccgcaaca tcactgtgga ccccaaactg tttaagaaac
      421 ggagactccg ttcaccccgc gtgctgttta gcacccagcc tccacccacc tcttcggaca
      481 ctctggattt agacttccag gcccatggta caatctcctt caacaggact cacaggagca
      541 agcgctcatc cacccaccca gtcttccaca tgggggagtt ttcagtgtgt gacagtgtca
      601 gtgtgtgggt tggagataag accacagcca cggacatcaa gggcaaggag gtgacagtgc
      661 tgggcgaggt gaacattaac aacagtgtat tcaaacagta tttttttgag accaagtgcc
      721 gagccccgaa tcctgtagag agtggatgcc ggggcattga ctccaagcac tggaactcat
      781 actgcaccac gactcacacc tttgtcaagg cgttgacaac agacgacaaa caggctgcct
      841 ggaggttcat caggatagat acagcctgcg tgtgtgtgct cagcaggaag gctgcaagaa
      901 gaggctgact tgcctgcagc ccccttcccc acctgccccc tccacactct cctgggcccc
      961 tccctacctc agcctgtaaa ttattttaaa ttataaggac tgcatgataa tttatcgttt
     1021 atacaatttt aaagtcatta tttattaaat tttcaaagca tcctgtgtac ccaca
//
