LOCUS       NM_001136241            2675 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus neuronal guanine nucleotide exchange factor
            (Ngef), mRNA.
ACCESSION   NM_001136241 XM_001066859
VERSION     NM_001136241.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2675)
  AUTHORS   Rosas,O.R., Figueroa,J.D., Torrado,A.I., Rivera,M., Santiago,J.M.,
            Konig-Toro,F. and Miranda,J.D.
  TITLE     Expression and activation of ephexin is altered after spinal cord
            injury
  JOURNAL   Dev Neurobiol 71 (7), 595-607 (2011)
   PUBMED   20949525
  REMARK    GeneRIF: These results demonstrate the presence of ephexin in the
            adult spinal cord and its activation after traumatic spinal cord
            injury
REFERENCE   2  (bases 1 to 2675)
  AUTHORS   Fu,W.Y., Chen,Y., Sahin,M., Zhao,X.S., Shi,L., Bikoff,J.B.,
            Lai,K.O., Yung,W.H., Fu,A.K., Greenberg,M.E. and Ip,N.Y.
  TITLE     Cdk5 regulates EphA4-mediated dendritic spine retraction through an
            ephexin1-dependent mechanism
  JOURNAL   Nat Neurosci 10 (1), 67-76 (2007)
   PUBMED   17143272
REFERENCE   3  (bases 1 to 2675)
  AUTHORS   Sahin,M., Greer,P.L., Lin,M.Z., Poucher,H., Eberhart,J.,
            Schmidt,S., Wright,T.M., Shamah,S.M., O'connell,S., Cowan,C.W.,
            Hu,L., Goldberg,J.L., Debant,A., Corfas,G., Krull,C.E. and
            Greenberg,M.E.
  TITLE     Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth
            cone collapse
  JOURNAL   Neuron 46 (2), 191-204 (2005)
   PUBMED   15848799
REFERENCE   4  (bases 1 to 2675)
  AUTHORS   Shamah,S.M., Lin,M.Z., Goldberg,J.L., Estrach,S., Sahin,M., Hu,L.,
            Bazalakova,M., Neve,R.L., Corfas,G., Debant,A. and Greenberg,M.E.
  TITLE     EphA receptors regulate growth cone dynamics through the novel
            guanine nucleotide exchange factor ephexin
  JOURNAL   Cell 105 (2), 233-244 (2001)
   PUBMED   11336673
REFERENCE   5  (bases 1 to 2675)
  AUTHORS   Rodrigues,N.R., Theodosiou,A.M., Nesbit,M.A., Campbell,L.,
            Tandle,A.T., Saranath,D. and Davies,K.E.
  TITLE     Characterization of Ngef, a novel member of the Dbl family of genes
            expressed predominantly in the caudate nucleus
  JOURNAL   Genomics 65 (1), 53-61 (2000)
   PUBMED   10777665
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Oct 29, 2008 this sequence version replaced XM_001066859.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.40406.1,
                                           SRR26643297.32276.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000009.1  95628046-95628247   c
            203-345             JAXUCZ010000009.1  95627177-95627319   c
            346-641             JAXUCZ010000009.1  95621548-95621843   c
            642-802             JAXUCZ010000009.1  95607117-95607277   c
            803-955             JAXUCZ010000009.1  95605336-95605488   c
            956-1085            JAXUCZ010000009.1  95603593-95603722   c
            1086-1160           JAXUCZ010000009.1  95602060-95602134   c
            1161-1250           JAXUCZ010000009.1  95600210-95600299   c
            1251-1414           JAXUCZ010000009.1  95598940-95599103   c
            1415-1570           JAXUCZ010000009.1  95598404-95598559   c
            1571-1650           JAXUCZ010000009.1  95597794-95597873   c
            1651-1755           JAXUCZ010000009.1  95597069-95597173   c
            1756-2675           JAXUCZ010000009.1  95594823-95595742   c
FEATURES             Location/Qualifiers
     source          1..2675
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..2675
                     /gene="Ngef"
                     /gene_synonym="Besh3"
                     /note="neuronal guanine nucleotide exchange factor"
                     /db_xref="GeneID:246217"
                     /db_xref="RGD:1309055"
     exon            1..202
                     /gene="Ngef"
                     /gene_synonym="Besh3"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1946
                     /gene="Ngef"
                     /gene_synonym="Besh3"
                     /note="brain-enriched SH3-domain protein Besh3;
                     eph-interacting exchange protein"
                     /codon_start=1
                     /product="ephexin-1"
                     /protein_id="NP_001129713.1"
                     /db_xref="GeneID:246217"
                     /db_xref="RGD:1309055"
                     /translation="MELLAAAFSAACAVDHDSSTSESDTRDSAAGHLPGSESSSTPGN
                     GTTPEECPALTDSPTTLTEALQMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETR
                     RQQDAEIQGNSDGSQAGEDNAEEEEEEEEEPASPPERRALPQICLLSNPHSRFNLWQD
                     LPEIQSSGVLDILQPEETKLQEAMFELVTSEASYYKSLNLLVSHFMENERLKKILHPS
                     EAHILFSNVLDVMAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQ
                     TYQERTYKQLLQEKTAFRELIAQLELDPKCKGLPLSSFLILPFQRITRLKLLVQNILK
                     RVEEGSEREGTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISH
                     SRWLLKQGELQQMSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGDKYQVFDSAP
                     RGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRT
                     KFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILEKTEDGWIFGERLHDQER
                     GWFPSSMTEEILNPKIRSQNLKECFRVHKMEDPQRSQNKDRRKLGSRNRQ"
     exon            203..345
                     /gene="Ngef"
                     /gene_synonym="Besh3"
                     /inference="alignment:Splign:2.1.0"
     exon            346..641
                     /gene="Ngef"
                     /gene_synonym="Besh3"
                     /inference="alignment:Splign:2.1.0"
     exon            642..802
                     /gene="Ngef"
                     /gene_synonym="Besh3"
                     /inference="alignment:Splign:2.1.0"
     exon            803..955
                     /gene="Ngef"
                     /gene_synonym="Besh3"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1085
                     /gene="Ngef"
                     /gene_synonym="Besh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1160
                     /gene="Ngef"
                     /gene_synonym="Besh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1250
                     /gene="Ngef"
                     /gene_synonym="Besh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1414
                     /gene="Ngef"
                     /gene_synonym="Besh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1570
                     /gene="Ngef"
                     /gene_synonym="Besh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1650
                     /gene="Ngef"
                     /gene_synonym="Besh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1755
                     /gene="Ngef"
                     /gene_synonym="Besh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..2675
                     /gene="Ngef"
                     /gene_synonym="Besh3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acctcgcttc gagcccgcgc gttgcccccg gcccggccct gggtcccccg cgcggccccc
       61 caccggctcc tgagcctacc ctgtctctgg tccccatgga gctgctggct gccgctttca
      121 gcgctgcctg cgccgtggac cacgacagct ccacctcgga gagcgacacg cgcgactcgg
      181 cggcgggaca cctgcccggc agcgagtcat cctccacccc tggaaatgga accacacccg
      241 aggagtgccc ggccctcacc gacagcccca ccacgctcac cgaggccctg cagatgatcc
      301 atcccattcc cgccgactcc tggagaaacc tcattgaaca aatagggctc ctgtaccaag
      361 agtatagaga caaatcgact ctccaagaga tcgaaacccg gaggcaacag gatgcagaaa
      421 tacaaggcaa ctcggatggg tcccaggctg gggaagacaa tgcagaggag gaggaagagg
      481 aggaggagga gccggccagc ccccctgaga ggagagctct gcctcagatc tgcctgctca
      541 gcaaccccca ctccaggttc aacctctggc aggaccttcc tgagatccag agcagcgggg
      601 tgctggacat cctccagcct gaggagacca agctgcagga ggccatgttt gagttggtca
      661 cctctgaggc ctcctactat aagagcctga acctgctggt gtcgcacttc atggagaacg
      721 agcggctgaa gaagatcctg cacccgtccg aggcccacat cctcttctcc aatgtcctgg
      781 atgtcatggc tgtcagtgag cggtttttgc tagagctgga acaccgcatg gaggagaaca
      841 ttgtcatctc ggatgtgtgt gacatcgtgt accgttatgc ggctgatcac ttctcggtct
      901 atatcaccta cgtcagtaac cagacctacc aggaaaggac gtacaagcaa ctcctacagg
      961 agaagacggc ttttcgggaa ctgatcgcac agctggagct ggaccccaag tgcaagggcc
     1021 tgcccttgtc ctccttcctc atcttgccct tccagaggat cacgagactc aagctgctgg
     1081 tccagaacat cctgaagagg gtggaggaag ggtctgaacg tgaaggcact gccttggatg
     1141 cccacaagga gctagaaatg gtggtaaagg cgtgcaacga gggtgtccgg aagatgagcc
     1201 gcacagaaca gatgatcagc attcagaaga agatggagtt caagatcaag tcggtaccta
     1261 tcatctcaca ctcccggtgg ctgctgaagc aaggtgaact acagcagatg tccggcccca
     1321 agacctcccg caccctgcgg accaagaagc tcttcagaga gatttacctc ttcctcttca
     1381 atgacctgct ggtgatctgc cggcagatcc ctggagacaa gtaccaggtg ttcgattccg
     1441 ctccaagggg cctgctgcga gtggaggagc tggaggacca gggccagaca ctggctaatg
     1501 tgttcatcct gcggctgctg gaaaacgcag atgaccggga ggccacctat atgctgaagg
     1561 catcctccca gagcgagatg aagcgttgga tgacttcact ggcccccaac aggaggacca
     1621 agtttgtatc cttcacatct cggctgttgg actgtccgca ggtccagtgt gtccacccct
     1681 acgtggccca gcagcccgat gagctgacac tggaactggc agacatcctg aacatcctag
     1741 agaagacgga ggatgggtgg atctttggtg agcggctgca tgaccaggag agaggctggt
     1801 tccccagttc catgacagag gagatcctga accccaagat ccgctcccaa aacctcaagg
     1861 aatgtttccg agtgcataag atggaggacc ctcagcgcag ccagaataag gaccgcagga
     1921 agttgggcag ccggaatcgt caatgaatcc cccccagctc aggcaccagc ctgaaggagg
     1981 gggtgtgggc agggatggga agcaggccca gcagagatgc ctgacagatt cagagggttt
     2041 tagggaagaa tgtcagtgcc ttcccaggca gcaggagtgg cttgggcctg ttctgtccct
     2101 gcccacgcag tggatgttcc agcatcctgg ccactcgctt gcttacacac tggcggaagg
     2161 ctaagtactt aggcagtatt agaccaccac cctccagcct ctcagaggga ggagggcagg
     2221 cattctccag agaccttccg gggactggag gagacccaca caagggtccc tggcagcagg
     2281 gaggtggaag gtaaccaccg tcaggatccc ctgaactgca cgtgtccttc cctaccttgg
     2341 aagcagctaa gagtctactg ggcacaccga tggaccaccc ctgcccaagg gagcttggtg
     2401 agcagtgctg actctgcctg cccatccccg tgcctctgcc agcctctttt gcacggccaa
     2461 gccctgccct cagcaggcct cccagagctt agctgagggt tcatgccacc tctagctccc
     2521 tgaagggctt gatgtcacgt gtgtctcctg gcccctgaag gagcccaggt gttttgcaga
     2581 atgaattggt cactgcatcc tttatggtca tggttttgag aaaagcaaat atcatttttg
     2641 gctgcattaa aagaagcatc ctgtatgaaa cgaga
//
