LOCUS       NM_033359               1773 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Rattus norvegicus neuroglobin (Ngb), mRNA.
ACCESSION   NM_033359
VERSION     NM_033359.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1773)
  AUTHORS   Li,C.Y., Jiang,H.F., Li,L., Lai,X.J., Liu,Q.R., Yu,S.B., Yi,C.L.
            and Chen,X.Q.
  TITLE     Neuroglobin Facilitates Neuronal Oxygenation through Tropic
            Migration under Hypoxia or Anemia in Rat: How Does the Brain
            Breathe?
  JOURNAL   Neurosci Bull 39 (10), 1481-1496 (2023)
   PUBMED   36884214
  REMARK    GeneRIF: Neuroglobin Facilitates Neuronal Oxygenation through
            Tropic Migration under Hypoxia or Anemia in Rat: How Does the Brain
            Breathe?
REFERENCE   2  (bases 1 to 1773)
  AUTHORS   Liu,Z. and Song,B.
  TITLE     Expression Pattern of Ngb in Astrocytes after Spinal Cord Injury
            and the Clinical Significance
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (6), 160-166 (2022)
   PUBMED   35818200
  REMARK    GeneRIF: Expression Pattern of Ngb in Astrocytes after Spinal Cord
            Injury and the Clinical Significance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1773)
  AUTHORS   Rose,J.J., Bocian,K.A., Xu,Q., Wang,L., DeMartino,A.W., Chen,X.,
            Corey,C.G., Guimaraes,D.A., Azarov,I., Huang,X.N., Tong,Q., Guo,L.,
            Nouraie,M., McTiernan,C.F., O'Donnell,C.P., Tejero,J., Shiva,S. and
            Gladwin,M.T.
  TITLE     A neuroglobin-based high-affinity ligand trap reverses carbon
            monoxide-induced mitochondrial poisoning
  JOURNAL   J Biol Chem 295 (19), 6357-6371 (2020)
   PUBMED   32205448
  REMARK    GeneRIF: A neuroglobin-based high-affinity ligand trap reverses
            carbon monoxide-induced mitochondrial poisoning.
REFERENCE   4  (bases 1 to 1773)
  AUTHORS   Wen,H., Liu,L., Zhan,L., Liang,D., Li,L., Liu,D., Sun,W. and Xu,E.
  TITLE     Neuroglobin mediates neuroprotection of hypoxic postconditioning
            against transient global cerebral ischemia in rats through
            preserving the activity of Na+/K+ ATPases
  JOURNAL   Cell Death Dis 9 (6), 635 (2018)
   PUBMED   29802248
  REMARK    GeneRIF: Ngb upregulation in CA1 after hypoxic postconditioning
            maintained the membranous level of Atp1b1 through Ngb-Atp1b1
            interaction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1773)
  AUTHORS   Guo,Y.C., Song,X.K., Xu,Y.F., Ma,J.B., Zhang,J.J. and Han,P.J.
  TITLE     The expression and mechanism of BDNF and NGB in perihematomal
            tissue in rats with intracerebral hemorrhage
  JOURNAL   Eur Rev Med Pharmacol Sci 21 (15), 3452-3458 (2017)
   PUBMED   28829495
  REMARK    GeneRIF: Cerebral hemorrhage significantly inhibited the spatial
            learning and memory ability of rats; the mechanism may be related
            to decreased cerebral expression of BDNF and NGB
REFERENCE   6  (bases 1 to 1773)
  AUTHORS   Laufs,T.L., Wystub,S., Reuss,S., Burmester,T., Saaler-Reinhardt,S.
            and Hankeln,T.
  TITLE     Neuron-specific expression of neuroglobin in mammals
  JOURNAL   Neurosci Lett 362 (2), 83-86 (2004)
   PUBMED   15193759
  REMARK    GeneRIF: Examination of the cell type-specific expression of
            neuroglobin in neurons and astroglial cells in primary cultures of
            rat fetal hippocampal cells finds neuroglobin is only expressed in
            neurons.
REFERENCE   7  (bases 1 to 1773)
  AUTHORS   Sun,Y., Jin,K., Peel,A., Mao,X.O., Xie,L. and Greenberg,D.A.
  TITLE     Neuroglobin protects the brain from experimental stroke in vivo
  JOURNAL   Proc Natl Acad Sci U S A 100 (6), 3497-3500 (2003)
   PUBMED   12621155
  REMARK    GeneRIF: acts as an endogenous neuroprotective factor in focal
            cerebral ischemia
REFERENCE   8  (bases 1 to 1773)
  AUTHORS   Zhang,C., Wang,C., Deng,M., Li,L., Wang,H., Fan,M., Xu,W., Meng,F.,
            Qian,L. and He,F.
  TITLE     Full-length cDNA cloning of human neuroglobin and tissue expression
            of rat neuroglobin
  JOURNAL   Biochem Biophys Res Commun 290 (5), 1411-1419 (2002)
   PUBMED   11820779
  REMARK    GeneRIF: NGB mRNA and protein are abundantly expressed and widely
            distributed throughout the adult rat brain, as seen in the
            NGB-immunopositive signals of neuronal cell bodies and processes.
REFERENCE   9  (bases 1 to 1773)
  AUTHORS   Zhang,C.G., Li,L., Deng,M.Y., Xie,F., Wang,C.L., Zhou,W.Q.,
            Wang,H.Y. and He,F.C.
  TITLE     [Coding region cDNA sequence cloning of rat neuroglobin gene, its
            polymorphism feature and tissue expression profile analysis]
  JOURNAL   Yi Chuan Xue Bao 28 (11), 997-1001 (2001)
   PUBMED   11725647
REFERENCE   10 (bases 1 to 1773)
  AUTHORS   Burmester,T., Weich,B., Reinhardt,S. and Hankeln,T.
  TITLE     A vertebrate globin expressed in the brain
  JOURNAL   Nature 407 (6803), 520-523 (2000)
   PUBMED   11029004
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB697453.1, AY066001.1, JAXUCZ010000006.1 and BF411002.1.
            
            On Aug 7, 2012 this sequence version replaced NM_033359.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY066001.1, SRR26643299.28426.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream ORF predicted to
                                                inhibit translation from
                                                upstream AUG
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               CB697453.1         1-200
            201-1150            AY066001.1         1-950
            1151-1725           JAXUCZ010000006.1  112475362-112475936 c
            1726-1773           BF411002.1         1-48                c
FEATURES             Location/Qualifiers
     source          1..1773
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..1773
                     /gene="Ngb"
                     /gene_synonym="Glnh"
                     /note="neuroglobin"
                     /db_xref="GeneID:85382"
                     /db_xref="RGD:621461"
     exon            1..498
                     /gene="Ngb"
                     /gene_synonym="Glnh"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..865
                     /gene="Ngb"
                     /gene_synonym="Glnh"
                     /note="globin h; nitrite reductase"
                     /codon_start=1
                     /product="neuroglobin"
                     /protein_id="NP_203523.2"
                     /db_xref="GeneID:85382"
                     /db_xref="RGD:621461"
                     /translation="MERLESELIRQSWRAVSRSPLEHGTVLFSRLFALEPSLLPLFQY
                     NGRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLATLGRKHRAVGVR
                     LSSFSTVGESLLYMLEKCLGPDFTPATRTAWSQLYGAVVQAMSRGWDGE"
     exon            499..610
                     /gene="Ngb"
                     /gene_synonym="Glnh"
                     /inference="alignment:Splign:2.1.0"
     exon            611..730
                     /gene="Ngb"
                     /gene_synonym="Glnh"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1755
                     /gene="Ngb"
                     /gene_synonym="Glnh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaacagccc aggggctcag caatttctgt tagactctga agcccggaca tttcccaggc
       61 ctcgggtagt ccctaaggcg ggtgcagagg gagcgcgcaa gcctccctgg gccagagtgg
      121 gtgggagcca ccgtagcttt aaagggcggt tctctgggag cttcggggtg cagggcgcag
      181 ctgcccaagc ggggtccccg gaagcgcccg cggccaagct ggccctgcac atcctctggg
      241 ctggaccagc aaagacaccg ttgctgggcc ccgcccgact aaggcactgg gcctggaggg
      301 gggctccccc gcgtctccga ggagatggcg ctgcatgtgc gttgacgccg tgcccacgcc
      361 tcgagggtcc catcactgcg tcccgcgact ctcctgggag agagagagta tggagcgcct
      421 agagtcagag ctgatccggc agagctggcg ggcagtgagc cgcagccctc tggaacatgg
      481 cactgtcctg ttctccaggc tcttcgccct ggaacccagc ctgctgcctc tcttccagta
      541 caatggccgc cagttctcca gtcctgagga ctgtctctcc tctccagaat tcctggacca
      601 cattaggaag gttatgcttg tgattgatgc tgctgtgacc aacgtagagg acctgtcttc
      661 actggaggag tacctggcca ccttgggcag gaagcatcgg gcagtgggag tgaggctcag
      721 ctccttctcg acagtaggtg agtccctgct ctacatgctg gagaagtgcc tgggtcccga
      781 ctttacgccg gctacaagga ccgcctggag ccaactctac ggagctgtgg tgcaagccat
      841 gagccgaggc tgggacgggg agtaagagac aagccagagc ccctatctat gtgtgtctgt
      901 ctgttgatct gcctgttgta gtcttagcct ctcccccagg gtctctctgt acctcagttc
      961 tcatcccctt ggccatccaa gagaggtgat aggagagggc tggctcagct gctggtccac
     1021 agcaaggagg tggatttccc tccctcatcc tcacagatgc actgctgcag gcctggttag
     1081 ctctccccag gaagcagaac agttttggta gtgaggaggc atgggggttc ttctccgaga
     1141 agctttctgt caaggtgagg gaaaagcaaa ctaggcttct agaatgttcc attttgcctg
     1201 cccagtctct ctgatacttt cctgccaggc tgtttacttt ccaacgatga aggagagagg
     1261 ctttagtgtt tgtggggatc tcaggcaagg ggagcatgga agatggcatt cttcagtgtc
     1321 agtgggcacc ctgggtctca gctgctcaga taccacacaa aacctcttat gctcttggtt
     1381 cggcatttct ggtagaagca ccccaatatt ctttttgggg aaacctcgct ggccagccag
     1441 aatggagaag ccagaagggc aaggaagaag agtaacctca tcccatgggg ccctgagttc
     1501 tggggctcct cctgtcacct tactctcaca gggctgaatc ctgtctccac agcctcttct
     1561 gctcacccgc cactctccag ctgcgggccc ctaagtctgt gtttagcact tgaagtggac
     1621 ctgtgtctgg gcagatgagc gagagcaaat agagtgggaa gggcccttgt tcccattccc
     1681 agacacctac actttcttgc tctgtgccgt ggttctgtag actcgcaaaa aataaacacg
     1741 ctctgtgtgc tgaccaaaaa aaaaaaaaaa aaa
//
