LOCUS       NM_012866               1941 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus nuclear transcription factor Y subunit gamma
            (Nfyc), mRNA.
ACCESSION   NM_012866
VERSION     NM_012866.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1941)
  AUTHORS   Wang,Y., Wan,C., Yu,S., Yang,L., Li,B., Lu,T., Bi,Y., Jiang,J. and
            Cui,G.
  TITLE     Upregulated expression of NF-YC contributes to neuronal apoptosis
            via proapoptotic protein bim in rats' brain hippocampus following
            middle cerebral artery occlusion (MCAO)
  JOURNAL   J Mol Neurosci 52 (4), 552-565 (2014)
   PUBMED   24014123
  REMARK    GeneRIF: Upregulation of NF-YC might play an important role in the
            pathophysiology via proapoptotic protein Bim after middle cerebral
            artery occlusion.
REFERENCE   2  (bases 1 to 1941)
  AUTHORS   Muller,P.A. and Vousden,K.H.
  TITLE     p53 mutations in cancer
  JOURNAL   Nat Cell Biol 15 (1), 2-8 (2013)
   PUBMED   23263379
  REMARK    Review article
REFERENCE   3  (bases 1 to 1941)
  AUTHORS   Freed-Pastor,W.A. and Prives,C.
  TITLE     Mutant p53: one name, many proteins
  JOURNAL   Genes Dev 26 (12), 1268-1286 (2012)
   PUBMED   22713868
  REMARK    Review article
REFERENCE   4  (bases 1 to 1941)
  AUTHORS   Yang,J. and Fuller,P.J.
  TITLE     Interactions of the mineralocorticoid receptor--within and without
  JOURNAL   Mol Cell Endocrinol 350 (2), 196-205 (2012)
   PUBMED   21784126
  REMARK    Review article
REFERENCE   5  (bases 1 to 1941)
  AUTHORS   Hughes,R., Kristiansen,M., Lassot,I., Desagher,S., Mantovani,R. and
            Ham,J.
  TITLE     NF-Y is essential for expression of the proapoptotic bim gene in
            sympathetic neurons
  JOURNAL   Cell Death Differ 18 (6), 937-947 (2011)
   PUBMED   21164521
  REMARK    GeneRIF: NF-Y cooperates with FOXO3a to recruit CBP/p300 to the bim
            promoter to form a stable multi-protein/DNA complex that activates
            bim transcription after survival factor withdrawal.
REFERENCE   6  (bases 1 to 1941)
  AUTHORS   Huang,C.J., Wu,S.C. and Choo,K.B.
  TITLE     Transcriptional modulation of the pre-implantation embryo-specific
            Rnf35 gene by the Y-box protein NF-Y/CBF
  JOURNAL   Biochem J 387 (Pt 2), 367-375 (2005)
   PUBMED   15516209
REFERENCE   7  (bases 1 to 1941)
  AUTHORS   Chattopadhyay,C., Hawke,D., Kobayashi,R. and Maity,S.N.
  TITLE     Human p32, interacts with B subunit of the CCAAT-binding factor,
            CBF/NF-Y, and inhibits CBF-mediated transcription activation in
            vitro
  JOURNAL   Nucleic Acids Res 32 (12), 3632-3641 (2004)
   PUBMED   15243141
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1941)
  AUTHORS   Hackzell,A., Uramoto,H., Izumi,H., Kohno,K. and Funa,K.
  TITLE     p73 independent of c-Myc represses transcription of
            platelet-derived growth factor beta-receptor through interaction
            with NF-Y
  JOURNAL   J Biol Chem 277 (42), 39769-39776 (2002)
   PUBMED   12167641
  REMARK    GeneRIF: NF-Y binds to p73 and transcriptionally regulates platelet
            derived growth factor beta receptor
REFERENCE   9  (bases 1 to 1941)
  AUTHORS   Haze,K., Okada,T., Yoshida,H., Yanagi,H., Yura,T., Negishi,M. and
            Mori,K.
  TITLE     Identification of the G13 (cAMP-response-element-binding
            protein-related protein) gene product related to activating
            transcription factor 6 as a transcriptional activator of the
            mammalian unfolded protein response
  JOURNAL   Biochem J 355 (Pt 1), 19-28 (2001)
   PUBMED   11256944
REFERENCE   10 (bases 1 to 1941)
  AUTHORS   Sinha,S., Maity,S.N., Lu,J. and de Crombrugghe,B.
  TITLE     Recombinant rat CBF-C, the third subunit of CBF/NFY, allows
            formation of a protein-DNA complex with CBF-A and CBF-B and with
            yeast HAP2 and HAP3
  JOURNAL   Proc Natl Acad Sci U S A 92 (5), 1624-1628 (1995)
   PUBMED   7878029
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_012866.4.
            
            On Mar 25, 2021 this sequence version replaced NM_012866.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093619.1, SRR26643289.16028.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000005.1  139679697-139679884 c
            189-301             JAXUCZ010000005.1  139654671-139654783 c
            302-373             JAXUCZ010000005.1  139645904-139645975 c
            374-487             JAXUCZ010000005.1  139643325-139643438 c
            488-583             JAXUCZ010000005.1  139638522-139638617 c
            584-757             JAXUCZ010000005.1  139633592-139633765 c
            758-916             JAXUCZ010000005.1  139630042-139630200 c
            917-1024            JAXUCZ010000005.1  139626200-139626307 c
            1025-1084           JAXUCZ010000005.1  139623870-139623929 c
            1085-1941           JAXUCZ010000005.1  139622020-139622876 c
FEATURES             Location/Qualifiers
     source          1..1941
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1941
                     /gene="Nfyc"
                     /gene_synonym="CBF-C"
                     /note="nuclear transcription factor Y subunit gamma"
                     /db_xref="GeneID:25337"
                     /db_xref="RGD:3173"
     exon            1..188
                     /gene="Nfyc"
                     /gene_synonym="CBF-C"
                     /inference="alignment:Splign:2.1.0"
     exon            189..301
                     /gene="Nfyc"
                     /gene_synonym="CBF-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1204
                     /gene="Nfyc"
                     /gene_synonym="CBF-C"
                     /note="NF-YC; nuclear transcription factor Y subunit C;
                     CCAAT-binding transcription factor subunit C; CAAT box
                     DNA-binding protein subunit C; CCAAT binding factor of
                     CBF-C/NFY-C; nuclear transcription factor-Y gamma"
                     /codon_start=1
                     /product="nuclear transcription factor Y subunit gamma"
                     /protein_id="NP_036998.1"
                     /db_xref="GeneID:25337"
                     /db_xref="RGD:3173"
                     /translation="MSTEGGFGSTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELP
                     LARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIA
                     MAITKFDQFDFLIDIVPRDELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQ
                     QQGQQTTSSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSG
                     TGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQ
                     ITQTEVQQGQQQFSQFTDGQQLYQIQQVTMPAGQDLAQPMFIQSANQPSDGQTPQVTG
                     D"
     exon            302..373
                     /gene="Nfyc"
                     /gene_synonym="CBF-C"
                     /inference="alignment:Splign:2.1.0"
     exon            374..487
                     /gene="Nfyc"
                     /gene_synonym="CBF-C"
                     /inference="alignment:Splign:2.1.0"
     exon            488..583
                     /gene="Nfyc"
                     /gene_synonym="CBF-C"
                     /inference="alignment:Splign:2.1.0"
     exon            584..757
                     /gene="Nfyc"
                     /gene_synonym="CBF-C"
                     /inference="alignment:Splign:2.1.0"
     exon            758..916
                     /gene="Nfyc"
                     /gene_synonym="CBF-C"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1024
                     /gene="Nfyc"
                     /gene_synonym="CBF-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1084
                     /gene="Nfyc"
                     /gene_synonym="CBF-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1941
                     /gene="Nfyc"
                     /gene_synonym="CBF-C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagcgaccc tttctttctt tctttttttt tttttgtttt ttgtttttaa gaacaattct
       61 aaatttgccc tcccctgttt tagaagcgca tgagaccata tgtgtctgct cgtgcatttg
      121 ctaaatattt ccgatcctta agttcttgtg tttgagtgaa gaatctgacc cctgttctgc
      181 ttctcaaggt gtcaaaatgt ccacagaagg agggtttggc agtaccagca gcagtgatgc
      241 ccagcaaagc ctccagtcct tctggcccag agtcatggaa gaaatccgaa acttaacagt
      301 gaaagatttc cgagtacaag aactaccact ggctcgtatt aagaagatta tgaaactgga
      361 tgaagatgtg aagatgatca gtgcagaagc ccctgtgctg tttgctaagg cagcccagat
      421 cttcatcaca gagctgactc ttcgagcctg gatccacaca gaggataaca agcgtcgtac
      481 tcttcagagg aatgatattg ctatggcaat tacaaaattt gatcagtttg actttctcat
      541 cgacattgtt ccaagagatg aactgaaacc tccaaagcgc caggaggagg tacgccagtc
      601 tgtgactccc gcggagcctg tccagtacta cttcacgctg gctcagcagc ccactgctgt
      661 ccaggtccag ggacagcagc aaggccagca gaccaccagt tctacgacca ccatccagcc
      721 tggccagatc atcattgcgc agcctcaaca gggtcagacc acacccgtga ccatgcaggt
      781 tggagaaggt cagcaggtgc agattgtgca ggcccaacct cagggtcagg cccagcaggc
      841 ccagagtggt actggacaga ccatgcaggt gatgcagcag atcattacca acacaggaga
      901 gatccaacag atcccggtgc agctgaatgc cggccagttg cagtatatcc gcttagccca
      961 gcctgtatca ggcacccaag ttgtgcaggg acagatccag acccttgcta ccaatgccca
     1021 acagatcaca cagacagagg tccaacaagg acagcagcag ttcagccagt tcacagacgg
     1081 acagcagctg taccagatcc agcaagtcac catgcctgca ggccaagacc ttgcccagcc
     1141 catgtttatt cagtcagcca accagccctc tgatgggcag accccccagg tgactggaga
     1201 ctgaggcctg agctgcaaag ccaaggaccc ccaacacaat atttgccata gagcccccag
     1261 gcgatgggga cacaccttcc ctcaccagag gacccgggac ttcattgcct cctgcaggct
     1321 aagatactgg tgcactactc tccacgcctg gggactgaga gcctacaaca gaaagatgca
     1381 atatttttta ttttttattt tctttttttc atttttgtct ccaaggaatc aatatttcaa
     1441 tatatcgagc tatgtgtcca atgctatgaa acgagaatat taaataacat atttatggca
     1501 ttttcttgaa acgtgtggtt gaagaaataa ttctcttgtg tgtttcctgg cttgggcact
     1561 caccaccact gctaaagggc agggcagcct gtgctcttcc ttcccaaggg tgtacaggat
     1621 ttccactctg ccagttctgc cctcagaaaa agagaaaggg tcagaccctt ttccaccagc
     1681 attcttctct gcccctttcc tagagccttc cgcatccaga agatgtggga acatttcttg
     1741 cctgtgggcc atgaactcat tctccacaga gagctggttt cctccccatc ccttctctcc
     1801 aagatccagg agaaccagga ctttgtgcac tgttctgccc actgttttat tttttaaata
     1861 cattaaagat tgtgctcatc tccattgctg catggacttc aaactgcatg aaatgcaata
     1921 aatcttgttt tcggtacttg a
//
