LOCUS       NM_001413345            3557 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus nuclear transcription factor Y subunit alpha
            (Nfya), transcript variant 1, mRNA.
ACCESSION   NM_001413345 XM_006244409
VERSION     NM_001413345.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3557)
  AUTHORS   Xiao,J., Zhou,Y., Lai,H., Lei,S., Chi,L.H. and Mo,X.
  TITLE     Transcription factor NF-Y is a functional regulator of the
            transcription of core clock gene Bmal1
  JOURNAL   J Biol Chem 288 (44), 31930-31936 (2013)
   PUBMED   24030830
REFERENCE   2  (bases 1 to 3557)
  AUTHORS   Muller,P.A. and Vousden,K.H.
  TITLE     p53 mutations in cancer
  JOURNAL   Nat Cell Biol 15 (1), 2-8 (2013)
   PUBMED   23263379
  REMARK    Review article
REFERENCE   3  (bases 1 to 3557)
  AUTHORS   Dolfini,D., Minuzzo,M., Pavesi,G. and Mantovani,R.
  TITLE     The short isoform of NF-YA belongs to the embryonic stem cell
            transcription factor circuitry
  JOURNAL   Stem Cells 30 (11), 2450-2459 (2012)
   PUBMED   22969033
REFERENCE   4  (bases 1 to 3557)
  AUTHORS   Freed-Pastor,W.A. and Prives,C.
  TITLE     Mutant p53: one name, many proteins
  JOURNAL   Genes Dev 26 (12), 1268-1286 (2012)
   PUBMED   22713868
  REMARK    Review article
REFERENCE   5  (bases 1 to 3557)
  AUTHORS   Hughes,R., Kristiansen,M., Lassot,I., Desagher,S., Mantovani,R. and
            Ham,J.
  TITLE     NF-Y is essential for expression of the proapoptotic bim gene in
            sympathetic neurons
  JOURNAL   Cell Death Differ 18 (6), 937-947 (2011)
   PUBMED   21164521
REFERENCE   6  (bases 1 to 3557)
  AUTHORS   Sinha,S., Maity,S.N., Lu,J. and de Crombrugghe,B.
  TITLE     Recombinant rat CBF-C, the third subunit of CBF/NFY, allows
            formation of a protein-DNA complex with CBF-A and CBF-B and with
            yeast HAP2 and HAP3
  JOURNAL   Proc Natl Acad Sci U S A 92 (5), 1624-1628 (1995)
   PUBMED   7878029
REFERENCE   7  (bases 1 to 3557)
  AUTHORS   Ang,S.L., Wierda,A., Wong,D., Stevens,K.A., Cascio,S., Rossant,J.
            and Zaret,K.S.
  TITLE     The formation and maintenance of the definitive endoderm lineage in
            the mouse: involvement of HNF3/forkhead proteins
  JOURNAL   Development 119 (4), 1301-1315 (1993)
   PUBMED   8306889
REFERENCE   8  (bases 1 to 3557)
  AUTHORS   Maity,S.N. and de Crombrugghe,B.
  TITLE     Biochemical analysis of the B subunit of the heteromeric
            CCAAT-binding factor. A DNA-binding domain and a subunit
            interaction domain are specified by two separate segments
  JOURNAL   J Biol Chem 267 (12), 8286-8292 (1992)
   PUBMED   1569083
REFERENCE   9  (bases 1 to 3557)
  AUTHORS   Hooft van Huijsduijnen,R., Li,X.Y., Black,D., Matthes,H.,
            Benoist,C. and Mathis,D.
  TITLE     Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y
            (CP-1/CBF) subunits
  JOURNAL   EMBO J 9 (10), 3119-3127 (1990)
   PUBMED   1698608
REFERENCE   10 (bases 1 to 3557)
  AUTHORS   Maity,S.N., Vuorio,T. and de Crombrugghe,B.
  TITLE     The B subunit of a rat heteromeric CCAAT-binding transcription
            factor shows a striking sequence identity with the yeast Hap2
            transcription factor
  JOURNAL   Proc Natl Acad Sci U S A 87 (14), 5378-5382 (1990)
   PUBMED   2196566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Oct 31, 2022 this sequence version replaced XM_006244409.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.36630.1,
                                           SRR26643290.31730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000009.1  20085081-20085205
            126-266             JAXUCZ010000009.1  20093841-20093981
            267-353             JAXUCZ010000009.1  20095358-20095444
            354-500             JAXUCZ010000009.1  20098819-20098965
            501-632             JAXUCZ010000009.1  20101131-20101262
            633-738             JAXUCZ010000009.1  20101369-20101474
            739-905             JAXUCZ010000009.1  20102171-20102337
            906-1079            JAXUCZ010000009.1  20102614-20102787
            1080-1181           JAXUCZ010000009.1  20103258-20103359
            1182-3557           JAXUCZ010000009.1  20109146-20111521
FEATURES             Location/Qualifiers
     source          1..3557
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..3557
                     /gene="Nfya"
                     /gene_synonym="CBF-A; CBF-B"
                     /note="nuclear transcription factor Y subunit alpha"
                     /db_xref="GeneID:29508"
                     /db_xref="RGD:70976"
     exon            1..125
                     /gene="Nfya"
                     /gene_synonym="CBF-A; CBF-B"
                     /inference="alignment:Splign:2.1.0"
     exon            126..266
                     /gene="Nfya"
                     /gene_synonym="CBF-A; CBF-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1235
                     /gene="Nfya"
                     /gene_synonym="CBF-A; CBF-B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear transcription factor Y subunit A; nuclear
                     transcription factor-Y alpha; CCAAT-binding transcription
                     factor subunit B; CAAT box DNA-binding protein subunit A;
                     CCAAT-binding transcription factor subunit A"
                     /codon_start=1
                     /product="nuclear transcription factor Y subunit alpha
                     isoform 1"
                     /protein_id="NP_001400274.1"
                     /db_xref="GeneID:29508"
                     /db_xref="RGD:70976"
                     /translation="MEQYTANSNSSTEQIVVQAGQIQQQQQGGVTAVQLQTEAQVASA
                     SGQQVQTLQVVQGQPLMVQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQ
                     QIQLVPPGQIQIQGGQAVQVQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVA
                     QTAEGQTIVYQPVNADGTILQQVTVPVSGMITIPAASLAGAQIVQTGANTNTTSSGQG
                     TVTVTLPVAGNVVNSGGMVMMVPGAGSVPAIQRIPLPGAEMLEEEPLYVNAKQYHRIL
                     KRRQARAKLEAEGKIPKERRKYLHESRHRHAMARKRGEGGRFFSPKEKDSPHMQDPNQ
                     ADEEAMTQIIRVS"
     exon            267..353
                     /gene="Nfya"
                     /gene_synonym="CBF-A; CBF-B"
                     /inference="alignment:Splign:2.1.0"
     exon            354..500
                     /gene="Nfya"
                     /gene_synonym="CBF-A; CBF-B"
                     /inference="alignment:Splign:2.1.0"
     exon            501..632
                     /gene="Nfya"
                     /gene_synonym="CBF-A; CBF-B"
                     /inference="alignment:Splign:2.1.0"
     exon            633..738
                     /gene="Nfya"
                     /gene_synonym="CBF-A; CBF-B"
                     /inference="alignment:Splign:2.1.0"
     exon            739..905
                     /gene="Nfya"
                     /gene_synonym="CBF-A; CBF-B"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1079
                     /gene="Nfya"
                     /gene_synonym="CBF-A; CBF-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1181
                     /gene="Nfya"
                     /gene_synonym="CBF-A; CBF-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..3557
                     /gene="Nfya"
                     /gene_synonym="CBF-A; CBF-B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agattcgcca ttttgcgagg cagcggcagt ggcggcggcg gcggcggctg gagcctctga
       61 ttgggtttcg gggtccggta ctggagccaa tcagcgcggg cagcgaaccg ggggagcgag
      121 gcacggagtc cctacctggc agctgcctgg gatctgtaga gtgaagcttc aggacacaac
      181 gtggccgggc catggagcag tatacagcaa acagcaatag ttccacagag cagatcgtgg
      241 tgcaggctgg ccagattcag cagcagcagc agggtggtgt cactgctgtc cagctgcaga
      301 ctgaggccca ggtggcatcc gcctcaggcc agcaagtcca gaccctccag gtagttcagg
      361 ggcagccatt aatggtgcaa gtcagtggag gccagctgat tacatcaact ggccaaccca
      421 tcatggtaca ggctgtgcct ggtggacaag gccaaactat catgcaagta cctgtgtctg
      481 gaacacaagg tttacagcag atacagttgg taccccctgg acagatccag atccagggcg
      541 ggcaggctgt gcaggtgcaa ggccagcagg gacagaccca gcagatcatc attcagcagc
      601 cacagaccgc ggtcaccgct ggccagactc agacacaaca acagattgct gtccagggac
      661 agcaagtggc ccagactgct gaagggcaga ctattgtcta ccagccagtt aatgcagatg
      721 gcacaatcct ccagcaagtt acagtccctg tttcaggcat gatcaccatc ccagcagcca
      781 gtttggcagg ggcacagatc gttcagacag gagccaatac caacacaacc agtagtggac
      841 aagggactgt cactgtgaca ctgccagtgg cagggaatgt ggtcaactca ggaggaatgg
      901 tcatgatggt accaggggct ggctctgtgc ctgctatcca aagaatccct ttacctgggg
      961 cagagatgct ggaagaagag cccctgtacg tgaacgccaa acagtatcac cgcatcctta
     1021 agaggagaca agcgagggcc aagctagagg cagaagggaa gatcccaaag gaaagaagga
     1081 aatacctcca tgagtctcgg caccgacacg ccatggcacg gaagcgtggg gaagggggcc
     1141 gcttcttctc tccaaaagaa aaggacagtc ctcacatgca ggatccaaac caagctgatg
     1201 aagaagccat gacacagatc atccgagttt cctaaccaca ggagggtggc agagcggatg
     1261 agtcacagtc ctctccactg ttcctggaaa tggactgact tccagttggg cactgacagt
     1321 ctcactctgc cctttctcag gacagaaact acttagctca gtattacagc tgcagtgatg
     1381 gctgacaaac tgaagaggca agcttttgtc tctccctttc attgaggacc tgttcagact
     1441 gttggtgaca ttgacctttt acaaatttgg atgattaaag aggtatttgc cagcccagca
     1501 ttacaaaccc agcacttatg ttgagtggtt aagccagcca gtcagccatt gcagtagggg
     1561 agaacagcct tctcaacctg gtcctcagtc aaggcagcca cagcctctgc ccccctgtgg
     1621 agtctcaaca gcgtccatcc cctggtggga tgtcgggctg cctgatgcaa ggcactgcac
     1681 tcaggtggct ccctgttaag acaaactaag ctgcagtctt ctgacctgtg ctgataggag
     1741 tctgcccaca tgctaggttg gtattttttt acttcagtca agaaagtaca aagaagatat
     1801 ttttggactc aggatgaaag gatagaaaac ctagggggtc tagaaggtac atttctagct
     1861 ttgactgtgg tctgcgcatt tctgttaaca gccattctgg gccatagttc acactgtggc
     1921 cactttagag acagtttaga gagtagagaa caaaacttca caacatctgt gctgaagtat
     1981 tgaggatgtt cacagttgtt cttcaacaga ggcaaagcta ggagatttaa tcatgggctt
     2041 tatggcagca agtaggaact ggaagggtct gtgcatttca atccagagaa cacgtgccct
     2101 gccggccgaa gtgcttgggt agagcatggg tctccagcac ggctctcagg atgaagaaag
     2161 cagccacatt cacactgaca cttcggacgt gcactagaag agaaagaatc ctcattgcct
     2221 gaagaagcac tgttgagacc gctgtcctgg acgcagactg gagcacagcg tggaggagag
     2281 acatatgtgt cgcccttgct tgggtggatg aatgttcttc ccatggcagc tgatttcttt
     2341 ggtgccagtt cccactgttt tctcctttct ctgtaggcct tgcagcaagg tttgctcact
     2401 gcatcagtgc tgtgggaacc aacaacctgc caggattcct gcagggtcag gaattgggcc
     2461 tcagaaatat gttttctgga caagcactct accactgagc cacacacata ccctagcccc
     2521 agccccagct ctgtagatgc tgaggcctgg aaaaaaagac caaggttgat acatcagaag
     2581 agttggctgc cttctctgca atcaaagtca aacgcagtcc ttccaaagac acgtctaaag
     2641 actggctctt tgactttgtt aaagatggaa agactctaac cttataaaga attatcacgg
     2701 ggagaccagt ttaattggag aagcatgaag taagccatct cttcctatcc caggagtctt
     2761 gccatttctt ctggcttcca gaggtcagag ggggctgatc ctttttagta aactcactac
     2821 aaacttctgg ctctcacatg agcttccggg tgtcactgaa aaccgtgagg aatctctacc
     2881 tttgaggggg agaggattct aagggtttct ccagggattc ctcagactta actgtagtgc
     2941 ttcagccagc aattgtagag tgctatttat ttgtgtctgt gagtttgtac ataaccctaa
     3001 cctcatattg ttgctgagtt tcattttgag gaaggcaagt ttgagttttc tttcctttaa
     3061 tgtagatgct cgggtttcca ttttgttgct gcattgcagt tggcccatgg ccctgtgggt
     3121 gtggtccttc tgattctagc acagcgtaaa aagagcccac agaggccaga gaggctcact
     3181 tggatttctt tttgtttgtt tgtttaactt agttcttttt acttgtttgt tcttgtgatt
     3241 gtagtgatgg cttcaaagat acagagtaag tggaggagtg ggctgctggt ctactgggca
     3301 ctctacttcc tgttacagga taactgtaaa tgtacatatt ttaattgcac tggtaatggg
     3361 acacgccagt gtctagacca ctgcaccaac agcctctcct ggctacaggg tgcctgataa
     3421 taatgtcttg attttccttt gggactcagc tatgtaggtc ttcccccgcc cccgcccccc
     3481 agtaggggag tacaggtgat cactgtcatt gcaattgctt ttctttttta ataaatttat
     3541 aaaaatacta aaaagta
//
