LOCUS       NM_001024784            4631 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus nuclear transcription factor, X-box binding 1
            (Nfx1), mRNA.
ACCESSION   NM_001024784 XM_232897
VERSION     NM_001024784.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4631)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 4631)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 4631)
  AUTHORS   Arlotta,P., Miyazaki,D., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.
            and Ono,S.J.
  TITLE     Murine NFX.1: isolation and characterization of its messenger RNA,
            mapping of its chromosomal location and assessment of its
            developmental expression
  JOURNAL   Immunology 106 (2), 173-181 (2002)
   PUBMED   12047746
REFERENCE   4  (bases 1 to 4631)
  AUTHORS   Lorick,K.L., Jensen,J.P., Fang,S., Ong,A.M., Hatakeyama,S. and
            Weissman,A.M.
  TITLE     RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent
            ubiquitination
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11364-11369 (1999)
   PUBMED   10500182
REFERENCE   5  (bases 1 to 4631)
  AUTHORS   Song,Z., Krishna,S., Thanos,D., Strominger,J.L. and Ono,S.J.
  TITLE     A novel cysteine-rich sequence-specific DNA-binding protein
            interacts with the conserved X-box motif of the human major
            histocompatibility complex class II genes via a repeated Cys-His
            domain and functions as a transcriptional repressor
  JOURNAL   J Exp Med 180 (5), 1763-1774 (1994)
   PUBMED   7964459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 11, 2008 this sequence version replaced NM_001024784.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.850392.1,
                                           SRR26360186.2070256.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               JAXUCZ010000005.1  60901217-60901386
            171-1160            JAXUCZ010000005.1  60906176-60907165
            1161-1319           JAXUCZ010000005.1  60912515-60912673
            1320-1397           JAXUCZ010000005.1  60914673-60914750
            1398-1503           JAXUCZ010000005.1  60916559-60916664
            1504-1575           JAXUCZ010000005.1  60919614-60919685
            1576-1715           JAXUCZ010000005.1  60920659-60920798
            1716-1815           JAXUCZ010000005.1  60922441-60922540
            1816-2033           JAXUCZ010000005.1  60922638-60922855
            2034-2131           JAXUCZ010000005.1  60927960-60928057
            2132-2162           JAXUCZ010000005.1  60930911-60930941
            2163-2242           JAXUCZ010000005.1  60933999-60934078
            2243-2351           JAXUCZ010000005.1  60935591-60935699
            2352-2471           JAXUCZ010000005.1  60936089-60936208
            2472-2551           JAXUCZ010000005.1  60939238-60939317
            2552-2782           JAXUCZ010000005.1  60945987-60946217
            2783-2856           JAXUCZ010000005.1  60946861-60946934
            2857-2958           JAXUCZ010000005.1  60948443-60948544
            2959-3000           JAXUCZ010000005.1  60949074-60949115
            3001-3099           JAXUCZ010000005.1  60952666-60952764
            3100-3166           JAXUCZ010000005.1  60953203-60953269
            3167-3312           JAXUCZ010000005.1  60954807-60954952
            3313-3417           JAXUCZ010000005.1  60955735-60955839
            3418-4631           JAXUCZ010000005.1  60957676-60958889
FEATURES             Location/Qualifiers
     source          1..4631
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..4631
                     /gene="Nfx1"
                     /note="nuclear transcription factor, X-box binding 1"
                     /db_xref="GeneID:313166"
                     /db_xref="RGD:1310277"
     exon            1..170
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..3490
                     /gene="Nfx1"
                     /EC_number="6.3.2.-"
                     /codon_start=1
                     /product="transcriptional repressor NF-X1"
                     /protein_id="NP_001019955.2"
                     /db_xref="GeneID:313166"
                     /db_xref="RGD:1310277"
                     /translation="MAEAPPVSGTFKFNTDAAEFIPQERKNSGLNCGTQRRLDSNRIG
                     RRNYSSSPPCHLPRHIPYDDVSAVHQHGYASGSKPKSPQGFFQSSNKSLKNHGLQNQP
                     WQKLRNEKHQNRIKKAQGLTEQTSDTSSLESVARSESGTNPREHSPSESEKEVVIADP
                     RGAKPKKATQLTYNYGRGPKAKGRLRSEWGNRMSPKSEDENARPVAISHSDSSEASCR
                     KPVVDPCVCRRSEQRRYPQKRPPWEVEGARPRPGRNPPKQESQRHINAGPKNNMPPLP
                     KDNLRERPTKSACDTGNLAVVTKSSRRVDQEKNAGRRQDPQVLSPFPRGKQNHMLKNV
                     ETHTGSLIEQLTTEKYECMVCCELVQVTAPVWSCQSCFHVFHLNCIKKWARSPASHAD
                     GQSGWRCPACQNVSAHVPSTYTCFCGKVKNPEWSRNEIPHSCGEVCRKKQPGQDCPHS
                     CNLLCHPGPCPPCPAFTTKTCECGRTRHTVRCGQPVSVHCSNVCENILNCGQHRCAEL
                     CHAGQCQPCRIILNQVCYCGSTSRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGSHTC
                     SQVCHPQPCQPCPRLPHLVRYCPCGQTPLSQLLEHGSNGRKTCMDPVPSCGKVCGKPL
                     SCGSSDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEDATFMCDKRC
                     NKKRLCGRHKCNEICCVDKEHKCPLICGRKLRCGLHRCEEPCHRGNCQTCWQASFDEL
                     TCHCGASVIYPPVPCGTRPPECTQTCARIHECDHPVYHSCHSEEKCPPCTFLTQKWCM
                     GKHELRSNIPCHLVDISCGLPCSAMLPCGMHKCQRLCHKGECLVDEACKQPCTTPRAD
                     CGHPCMAPCHPSLPCPVTACKAKVELQCECGRRKEMVICSEASGTYQRIAAISMASKI
                     TDMQLGDSVEISKFITKKEVQQARLQCDEECAALERKKRLAEAFDITDDSDPFNVRSS
                     ASKFSDSLKDDARKDFKFVSDIEKEMEALVEAVNKGKSNKKSYCFPPMNRDHRRIIHD
                     LAQVYGLESVSYDSEPKRNVVVTAIRGKSICPPTTLTSVIERETQTRPPPPIPHHRHQ
                     ADKNPGSSNLQKIVKEPVIDYFDVQD"
     exon            171..1160
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1319
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1397
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1503
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1575
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1715
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1815
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..2033
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2131
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2162
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2242
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2351
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2471
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2551
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2782
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2856
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2958
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3000
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3099
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3166
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3312
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3417
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..4631
                     /gene="Nfx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtatctt cgggcggcac cacccccttg gccgtctaca cgcgcgtagg aacgaatagt
       61 ctctggacgc cggaaatccg ggacacgtga ccaggtgaca gccctcgctc ggtggcgggg
      121 ctcgcttgag gtgctgcggc acgggatggc ggaggcgcct ccggtctcag gcacttttaa
      181 atttaataca gatgctgctg agttcattcc gcaggagaga aaaaattctg gtctaaattg
      241 tgggacccaa agaagactag attctaatag gattggcaga agaaattata gttcctcacc
      301 tccctgccac cttcctagac acatccctta cgatgatgtc tctgctgttc accagcacgg
      361 ttatgcctcc ggaagcaagc ctaagagtcc acagggtttt ttccagtcat ctaataaatc
      421 actcaagaac catgggcttc agaatcagcc atggcagaaa ttaaggaatg aaaagcacca
      481 aaacagaatc aagaaagcac aagggctcac tgagcagacg tcagatacat ccagtttaga
      541 aagcgtagcc agatccgaga gtggaacaaa ccctagagaa cacagccctt ctgagagcga
      601 gaaggaggta gttattgcag atcccagggg agcgaaaccc aaaaaagcca cgcagcttac
      661 atacaactat ggccgagggc caaaggccaa agggagactc agaagcgagt ggggtaacag
      721 aatgagccca aagtctgagg atgaaaatgc cagacctgtg gccatttccc actctgactc
      781 ttcagaagcc tcctgtagaa aacctgtagt ggatccatgt gtgtgcagac ggagtgagca
      841 gagaagatat ccccagaaaa ggcctccctg ggaagtagag ggggccagac cacggccagg
      901 caggaaccca ccgaaacagg agagtcagcg gcatataaat gcagggccca aaaacaacat
      961 gccccccctt ccaaaggata atctcagaga gaggccaacg aagtcagcct gtgacactgg
     1021 gaatttggca gttgtcacca agtcttccag aagagttgac caagagaaaa atgctggaag
     1081 gagacaggat cctcaagtgc tgtctccttt tcccagaggc aagcagaacc atatgctgaa
     1141 gaatgtggaa actcatacag gttccctgat tgagcagcta actacagaaa agtacgagtg
     1201 tatggtgtgc tgcgagttgg ttcaggtcac agccccggtg tggagctgcc agagctgttt
     1261 ccatgtcttt catctgaact gcatcaagaa atgggctcgc tctccagcgt cccacgcaga
     1321 tggccagagt ggttggaggt gccccgcttg tcagaatgtt tctgcacatg ttcccagtac
     1381 ctacacttgt ttctgtggca aagtaaagaa ccctgaatgg agcagaaatg aaattccgca
     1441 cagttgtggt gaagtttgta gaaagaaaca gcctggccag gactgtccac attcctgtaa
     1501 tcttctctgc catcctggac cctgcccacc ctgccctgct tttacaacta aaacatgtga
     1561 atgtggacgg accaggcaca cggttcgctg tggtcagcct gtctcagtcc actgttctaa
     1621 tgtgtgtgag aatattttga actgtggtca gcaccgctgt gctgagctgt gccatgcggg
     1681 tcagtgccag ccttgccgga tcatattgaa ccaggtgtgc tactgtggca gcacctcccg
     1741 agatgtgttg tgtggaaccg atgtgggcaa gtctgatgga tttggggact tcagctgttt
     1801 aaagatatgt ggcaaggact tgaaatgtgg gagccatacc tgttctcagg tttgccaccc
     1861 tcagccctgt cagccttgcc caaggctccc ccatttggtg cgatattgcc cttgcggcca
     1921 aacacctctc agccagttgc tggaacatgg aagtaatggt cggaagacgt gcatggatcc
     1981 tgttccttcc tgtggaaaag tgtgtggcaa acccttgtcc tgtgggtcct cagatttcat
     2041 ccacacctgt gaaaagctct gccatgaggg agactgtggg ccgtgctcgc gcacatcagt
     2101 catttcctgc agatgctcct tcagaacaaa ggagctcccg tgtaccagtc ttaaaagtga
     2161 agatgctaca ttcatgtgtg acaagcggtg taacaagaaa cgattgtgtg gacggcataa
     2221 atgtaacgag atctgctgtg tggacaagga gcacaagtgt cctttgattt gtgggaggaa
     2281 actccgttgt ggccttcatc ggtgtgaaga accttgtcac cgagggaact gtcagacctg
     2341 ctggcaagcc agctttgatg aattaacctg ccattgtggc gcctctgtga tctacccacc
     2401 agttccctgt gggactaggc ctcctgagtg tacccagacc tgtgcgagga tccatgaatg
     2461 tgaccatcca gtatatcatt cttgtcatag tgaggagaag tgtccccctt gtactttcct
     2521 aactcagaag tggtgcatgg gcaagcatga gttacgaagc aacatcccct gtcacctggt
     2581 tgatatctct tgcggattac cctgcagtgc catgctaccc tgtgggatgc acaaatgtca
     2641 aagactctgt cacaaaggag aatgtcttgt ggatgaggcc tgcaagcagc cctgtaccac
     2701 acccagagct gactgtggcc acccatgtat ggctccctgc caccccagtt taccctgccc
     2761 tgtgacagct tgtaaagcca aggtagagtt acagtgtgaa tgtggaagaa gaaaggagat
     2821 ggtgatttgc tctgaagcat ccgggactta tcaaaggata gctgccattt cgatggcctc
     2881 taaaataacg gacatgcagc ttggagactc agtggagatc agcaagttca ttaccaagaa
     2941 ggaagtccaa caagccaggt tgcagtgtga tgaggagtgt gctgccctgg aaaggaaaaa
     3001 gagattggca gaggcattcg acatcactga tgactctgat cctttcaacg tacgctcttc
     3061 agcatcgaaa ttcagtgaca gcctgaaaga cgatgccagg aaagacttca agtttgtcag
     3121 tgacatcgag aaggaaatgg aagcgcttgt ggaggccgtg aataagggaa agagtaataa
     3181 gaaaagctac tgcttccctc ccatgaacag agaccaccgc cgcatcatcc atgacctagc
     3241 ccaggtttat ggcctggaga gtgtgagcta tgacagtgaa ccaaagcgca atgtcgtggt
     3301 cactgccatc agagggaagt ccatctgtcc tcctaccacg ctgaccagtg ttattgaaag
     3361 ggagacacag acacggcctc caccaccaat tcctcatcac cgacaccaag cagacaagaa
     3421 tcctgggagc agtaatttac agaagatcgt gaaggagcct gtgattgact actttgacgt
     3481 ccaggactga gaagatagat atatttagat aaaaggataa tgctgtgcac tggagactca
     3541 tttgccggca gataaatcat gcccgctcct cctgcctggc atggccgcag cacccgtgct
     3601 gtcttgttcc gatacagcca agcatgaatg tgtcaggacc ccagtctctc cagcccacag
     3661 gcccctggct ccgtggccac tggattttta gtcacgtttt gaagaggctg ctcacaccat
     3721 cactgtgatt actaagagat tgggggagta tcagatttta tttggataaa ccagaatttt
     3781 tatcccaaac tggctttgtg gcacttggtg tcccacttgt tcccccgtgg gcctcacctt
     3841 cctcatgagg aaagacacac gaagccctga ccgtcagtaa gctgtctgga accatgtgtc
     3901 ttaaacctag ccatcttatc caaaagcttc cgatgtctct cacgactggt caggttgctt
     3961 gatagaattc cgtcttctca aatccctggc attctctcac catgtcacca agcctaccca
     4021 ggaacagttt agctgtctgc cataatggta agaccttggg caagctcttc tgtcgtgttc
     4081 acaactgtgg gtctatgcac tgtccactgt agccctaagt tctctgtggt tgatagcagc
     4141 tctcacatag acagcaggac ggggtagctt ttccctgggc tttcagcagc cacagactct
     4201 ccctacatct gagctctgaa ccactgttcc gatattcaaa gaagtgtgtg gacagtccag
     4261 ggcctgtgcc aagtgcccta ctgtaggccc tcagcctcct taaagcaggc gtgtgccttc
     4321 tgtgtcggcc ccctctgcac aagctggact cctctctttg ttgttttttc tttttctttc
     4381 tttttttttt tttttgtttt ttctttcttt gtttttgttt tttgtttgtt ttggttttgg
     4441 ctttttttca agacagggtt tttctgtgta gccctggctg tcctggagct cactcctgta
     4501 gatccatctg cctctgcctt ctgagtgctg ggattaaagg catgtgccac caccgcctag
     4561 cttctttttg ctttaaaata aactttgagc ccccaaaact tggaatcatt aaacaaggta
     4621 cttagtttgt a
//
