LOCUS       NM_001401430            4081 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus NFKB inhibitor zeta (Nfkbiz), transcript variant
            1, mRNA.
ACCESSION   NM_001401430
VERSION     NM_001401430.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4081)
  AUTHORS   Chung,K.W., Jeong,H.O., Lee,B., Park,D., Kim,D.H., Choi,Y.J.,
            Lee,E.K., Kim,K.M., Park,J.W., Yu,B.P. and Chung,H.Y.
  TITLE     Involvement of NF-kappaBIZ and related cytokines in age-associated
            renal fibrosis
  JOURNAL   Oncotarget 8 (5), 7315-7327 (2017)
   PUBMED   28099916
  REMARK    GeneRIF: Suggest role for NF-kappaBIZ in age-associated progressive
            renal fibrosis via cytokine signaling.
REFERENCE   2  (bases 1 to 4081)
  AUTHORS   Jeltsch,K.M., Hu,D., Brenner,S., Zoller,J., Heinz,G.A., Nagel,D.,
            Vogel,K.U., Rehage,N., Warth,S.C., Edelmann,S.L., Gloury,R.,
            Martin,N., Lohs,C., Lech,M., Stehklein,J.E., Geerlof,A.,
            Kremmer,E., Weber,A., Anders,H.J., Schmitz,I., Schmidt-Supprian,M.,
            Fu,M., Holtmann,H., Krappmann,D., Ruland,J., Kallies,A.,
            Heikenwalder,M. and Heissmeyer,V.
  TITLE     Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases
            their cooperatively repressed targets to promote T(H)17
            differentiation
  JOURNAL   Nat Immunol 15 (11), 1079-1089 (2014)
   PUBMED   25282160
REFERENCE   3  (bases 1 to 4081)
  AUTHORS   Rossato,M., Curtale,G., Tamassia,N., Castellucci,M., Mori,L.,
            Gasperini,S., Mariotti,B., De Luca,M., Mirolo,M., Cassatella,M.A.,
            Locati,M. and Bazzoni,F.
  TITLE     IL-10-induced microRNA-187 negatively regulates TNF-alpha, IL-6,
            and IL-12p40 production in TLR4-stimulated monocytes
  JOURNAL   Proc Natl Acad Sci U S A 109 (45), E3101-E3110 (2012)
   PUBMED   23071313
REFERENCE   4  (bases 1 to 4081)
  AUTHORS   Kitamura,H., Kanehira,K., Okita,K., Morimatsu,M. and Saito,M.
  TITLE     MAIL, a novel nuclear I kappa B protein that potentiates
            LPS-induced IL-6 production
  JOURNAL   FEBS Lett 485 (1), 53-56 (2000)
   PUBMED   11086164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760400, SAMEA5760476
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-396               JAXUCZ010000011.1  58251721-58252116
            397-467             JAXUCZ010000011.1  58253880-58253950
            468-815             JAXUCZ010000011.1  58268921-58269268
            816-955             JAXUCZ010000011.1  58271317-58271456
            956-986             JAXUCZ010000011.1  58271950-58271980
            987-1090            JAXUCZ010000011.1  58272108-58272211
            1091-1941           JAXUCZ010000011.1  58272454-58273304
            1942-2047           JAXUCZ010000011.1  58274097-58274202
            2048-2194           JAXUCZ010000011.1  58274573-58274719
            2195-2258           JAXUCZ010000011.1  58274912-58274975
            2259-2428           JAXUCZ010000011.1  58275215-58275384
            2429-2539           JAXUCZ010000011.1  58276632-58276742
            2540-2707           JAXUCZ010000011.1  58276870-58277037
            2708-4081           JAXUCZ010000011.1  58278394-58279767
FEATURES             Location/Qualifiers
     source          1..4081
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q12"
     gene            1..4081
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /note="NFKB inhibitor zeta"
                     /db_xref="GeneID:304005"
                     /db_xref="RGD:1310834"
     exon            1..396
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /inference="alignment:Splign:2.1.0"
     exon            397..467
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /inference="alignment:Splign:2.1.0"
     exon            468..815
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /inference="alignment:Splign:2.1.0"
     CDS             530..2761
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /note="IkappaB-zeta; molecule possessing ankyrin-repeats
                     induced by lipopolysaccharide; nuclear factor of kappa
                     light polypeptide gene enhancer in B-cells inhibitor,
                     zeta"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor zeta"
                     /protein_id="NP_001388359.1"
                     /db_xref="GeneID:304005"
                     /db_xref="RGD:1310834"
                     /translation="MIVDKLLDDSRGGEGLLDAAGDCGLMTSPLNLAYFYGASPPSAP
                     GAGDTGYLSAVPSAPGSPGSDSSDFSSTSSVSSCGAVESRPRGGARAERPQVEPHMGV
                     GRQQRGPFQGVRVKNSVKELLLHIRSNKQKTSGQAVDEFKTQSVNIEQLTDLKSAVSA
                     VGKRKGPDPLADGPVCKRPALLPTHFVTSPQTSPRGESMEDARHSESKLESSAALLQN
                     IINIKNECNPVSLNTVQVSWMSPVVPQNSPRDQRQDFHGGQSFSPPQKYQPFQVGGSP
                     QMMEQASMFQYSPQGQNMQQPQPLPPQQQQQQQQQQQQQQQQQQQQQQNYPHNPPLQF
                     SPYSRISQSPKYDSNLFDNQDSQFCTSQSFVSLLTGQGESETMAVPVQASHSVPPQNE
                     TQLQNFSLMPSSACEAVGAHDAGSHSLGGSLSLQNIMGGPMNTTQLGKSFFQWQVEQE
                     ESKLANISQEQFLSRDGDGDTFLHIAVAQGRRALSYVLARKMNALHMLDVKEHNGQSA
                     FQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVRSNQ
                     FVDLEATNYDGLTPLHCAVLAHNSVVHDLQRSQQPHSPEVQDLLLKNKSLVDTIKCLI
                     QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAA
                     SLQYRVTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRV
                     PPY"
     exon            816..955
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /inference="alignment:Splign:2.1.0"
     exon            956..986
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1090
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1941
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2047
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2194
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2258
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2428
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2539
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2707
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..4081
                     /gene="Nfkbiz"
                     /gene_synonym="Mail; RGD1310834"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtggaaaa agtccacaaa cttagtcctc actgcccgcc tcgcctcctc cggcccttct
       61 cggtgcccac gcaccccccg atcgaacccg aggatgagca tagggtgtat tttaggcgtg
      121 ctgggcttcc ccgcccccct ctgcccactt agctggcaag aagaaagcca gcactataaa
      181 ggaggccagg gccaaggact ggcctcctct tgccacgagg tcagacggcg agctctagag
      241 aaaggctgct taactgttct ttatcatgta acctcaaaag gaaacccatc agtcttctga
      301 tgctctcacg tacttggggg cattatcgct gcttacagct ggaaacagtt gatttgcttt
      361 tacgtatttg tgtgacttga atcttcaaat acaaagctta ccaagaagat cctgaggccc
      421 atgctgaact tcacgtttga ttgtggcttg atgctgaagt ccagaggcca accgcgtagc
      481 cagccggtgg cgcaggtgtc tggggacccc gagcgcctag cctgggagca tgatcgtgga
      541 caagctgctg gacgacagcc gcggcggaga ggggctgctg gacgcggccg gcgactgcgg
      601 cctcatgacc agcccgctca acctcgctta cttctacgga gcctcgcctc cctccgcccc
      661 cggcgccggc gacaccggtt acctgtccgc ggttccctcc gcgcccggct cgcccggctc
      721 cgactcttcc gatttctcct ccacttcctc cgtgtcctcc tgcggggccg tggagtcccg
      781 tccgagaggt ggcgcccgcg ccgagcgccc gcaagttgag ccccatatgg gggtgggcag
      841 gcagcagaga ggcccctttc aaggtgttcg agtgaagaac tcggtgaaag agctgctgct
      901 gcacatccga agtaataaac agaagacttc cggccaagcg gtggacgagt ttaagaccca
      961 gagtgtgaac attgagcaac tgacagacct gaagagtgca gtgtctgcag tggggaaaag
     1021 aaagggacct gaccctctgg ccgatggacc agtttgcaag aggccagctc tgttgcccac
     1081 tcactttgtg acatcaccac aaacatctcc acgtggggag agcatggaag atgctcgcca
     1141 cagtgaatcc aaactggaga gcagtgctgc tctgctccag aatattataa acatcaagaa
     1201 cgagtgcaac ccggtctcat taaacactgt ccaggttagc tggatgagcc ctgtggttcc
     1261 ccagaactcc ccaagagacc aacgccagga tttccatgga ggccagtcct tctctccacc
     1321 tcagaaatac caaccgttcc aagtcggtgg ctctccacag atgatggagc aggcttctat
     1381 gttccagtat tcaccacaag ggcagaacat gcagcagcca cagccactgc caccgcagca
     1441 gcagcagcag cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcaaca
     1501 gaattatccc cacaacccac ccctgcagtt tagtccttat tccagaatat cccagtcccc
     1561 caagtatgat tcaaacctct ttgataatca agactcacag ttctgcacaa gccagagttt
     1621 tgtgtctcta ctgactggcc aaggggaatc ggagaccatg gccgttcccg tccaggcttc
     1681 ccacagcgtt ccaccacaaa atgagactca gctgcagaac ttcagcctga tgccaagcag
     1741 tgcctgcgag gccgtcgggg cgcacgatgc tggctcccac tctttaggtg gttccctgtc
     1801 actccagaac atcatgggag gcccgatgaa caccacacag ctagggaagt catttttcca
     1861 gtggcaggtg gagcaggaag aaagcaaact ggcaaatatt tcccaggaac agttcctctc
     1921 tagggatgga gatggtgaca cgtttctcca tattgctgtt gcccaaggaa gacgggcact
     1981 ctcctatgtt cttgcaagaa aaatgaatgc tctccacatg ctggacgtta aggagcacaa
     2041 cggacagagt gcctttcagg tggctgtcgc tgccaatcag cacctcattg tgcaagacct
     2101 ggtgaacctt ggtgcccagg tgaacaccac agactgctgg ggaaggacac ctctgcatgt
     2161 ctgtgcagag aagggccact cccaggtgct ccaggcaatc cagaagggag cagtgaggag
     2221 caatcagttt gtggatctgg aggcaacgaa ctatgatggc ctgactcccc tccactgtgc
     2281 ggtcctggct cacaattcgg tggtgcacga cctgcagaga agccagcagc ctcattcgcc
     2341 cgaggtgcag gatctcttac tgaagaataa gagcttggtt gacaccatta agtgtctgat
     2401 tcagatggga gcggccgtgg aggcgaagga tcgtaaaagt ggccgcacgg ccctgcattt
     2461 ggcagcggag gaagcaaatc tggaactcat tcgcctcttt ttggagttgc cgagttgcct
     2521 gtctttcgtg aatgcaaagg cttacaatgg aaacaccgcc ctccatgttg ctgccagcct
     2581 gcagtatcgg gtgacacagt tggatgcagt ccgtctgttg atgaggaagg gagccgaccc
     2641 cagtactcgg aacttggaga atgaacagcc ggtgcatttg gtccctgatg gccctgtggg
     2701 agaacagatc cgacgtatcc tgaaggggaa gtccattcag cagcgagtac caccatacta
     2761 gcttcattgg cacggagcct ggttcagcga cactcactgt cagttaggca gtcctgatgt
     2821 atctgtacat agaccatttg ccctgtattg gcaaatgtaa gttgtttcta tgaaacaaat
     2881 ccatttagtt cactattata tagtggatta tattaaaaga aaagaagaca gatatctaat
     2941 tttcttggca gatttgcata tttcataccc aggtatctgg gaatctatat atctgaattt
     3001 gatctcgaat ggtaaaattg ccttcaataa acagtagctt tctgggtagg aaaaagactc
     3061 atgggaaaag acttgatttg tggcataaag cattgctcac ggagtgatcg ccagtgattc
     3121 aaattaggtg ggcttgaaat gtgaaatgaa aaatgaaagc atttgaaagg ggacaaaaat
     3181 ttggatgtac cgttgatggt tctttggtct gatgcacgac ctggtggtta atgctctcac
     3241 tgtttcacta ggtgagggag gcctcttgtt aggatgtgat ctttgaagct gtatataata
     3301 atttttacct tttaaaatgt tgtacatact tgattgttaa acacggatgt ttgaagtgtg
     3361 tagatcaata aaatagctag tgaattgtta ccactttaaa gattaggcac cctcaaagca
     3421 acttttattg tataatcggc caactcaagt tttcacagat aaagcaaatg gggaagtggg
     3481 tcccaaagtt gctctggttg caaatgggcg tctcttgcat tggaaacaga cacatttgta
     3541 ggtctctgca tatgcttgaa gaggcttttt tttaatgaat cacctgttag atttatatga
     3601 tttacataag ttgttgaagt ttctgtttct ccttactaga aattataaaa gttcaacatt
     3661 gaagcgtcgt tttctgttgt caaatagtaa taatgtgctg tgatgtttat acaattcatg
     3721 aagatgtttt actttttagt gcaatgttag ttcttttgac attttgctta aatttgatat
     3781 gcctggcaag gatatattta gcttggatta tacaatgatt ctttgtgaca aatatgaccc
     3841 attaaaaatg atgcctttta atggactaac ttacctttta gaactaagta ctcatgttct
     3901 tttttaaaag atgccctttg gattggattg attatgttgt ttatattgat catgttgttt
     3961 aagttagtgt attttttgga cagtcatttg tcatctctga ggtggaatga acccaatcca
     4021 catactgaca aactcatgca tagttttaaa tgaacattaa taaactcatg ttgtcttaga
     4081 a
//
