LOCUS       NM_030867               1491 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus NFKB inhibitor beta (Nfkbib), mRNA.
ACCESSION   NM_030867
VERSION     NM_030867.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1491)
  AUTHORS   Zhao,H. and Gong,N.
  TITLE     miR-20a regulates inflammatory in osteoarthritis by targeting the
            IkappaBbeta and regulates NK-kappaB signaling pathway activation
  JOURNAL   Biochem Biophys Res Commun 518 (4), 632-637 (2019)
   PUBMED   31451219
  REMARK    GeneRIF: Results indicate an increase in articular cavity
            inflammation in rats with osteoarthritis (OA) in the presence of
            miR-20a by targeting on NFKB inhibitor beta (IkappaBbeta) and
            activating the NF-kappa B (NF-kappaB) signaling pathway.
REFERENCE   2  (bases 1 to 1491)
  AUTHORS   Gu,H., Cui,M., Bai,Y., Chen,F., Ma,K., Zhou,C. and Guo,L.
  TITLE     Angiopoietin-1/Tie2 signaling pathway inhibits
            lipopolysaccharide-induced activation of RAW264.7 macrophage cells
  JOURNAL   Biochem Biophys Res Commun 392 (2), 178-182 (2010)
   PUBMED   20060382
REFERENCE   3  (bases 1 to 1491)
  AUTHORS   Hayden,M.S. and Ghosh,S.
  TITLE     Shared principles in NF-kappaB signaling
  JOURNAL   Cell 132 (3), 344-362 (2008)
   PUBMED   18267068
  REMARK    Review article
REFERENCE   4  (bases 1 to 1491)
  AUTHORS   Xu,S., Bayat,H., Hou,X. and Jiang,B.
  TITLE     Ribosomal S6 kinase-1 modulates interleukin-1beta-induced
            persistent activation of NF-kappaB through phosphorylation of
            IkappaBbeta
  JOURNAL   Am J Physiol Cell Physiol 291 (6), C1336-C1345 (2006)
   PUBMED   16822942
  REMARK    GeneRIF: Data suggest that RSK1 directly phosphorylates IkappaBbeta
            and contributes to the persistent activation of NF-kappaB by
            IL-1beta.
REFERENCE   5  (bases 1 to 1491)
  AUTHORS   Nakajima,K., Matsushita,Y., Tohyama,Y., Kohsaka,S. and Kurihara,T.
  TITLE     Differential suppression of endotoxin-inducible inflammatory
            cytokines by nuclear factor kappa B (NFkappaB) inhibitor in rat
            microglia
  JOURNAL   Neurosci Lett 401 (3), 199-202 (2006)
   PUBMED   16580131
REFERENCE   6  (bases 1 to 1491)
  AUTHORS   Stasiolek,M., Gavrilyuk,V., Sharp,A., Horvath,P., Selmaj,K. and
            Feinstein,D.L.
  TITLE     Inhibitory and stimulatory effects of lactacystin on expression of
            nitric oxide synthase type 2 in brain glial cells. The role of
            Ikappa B-beta
  JOURNAL   J Biol Chem 275 (32), 24847-24856 (2000)
   PUBMED   10827092
REFERENCE   7  (bases 1 to 1491)
  AUTHORS   Jaffray,C., Mendez,C., Denham,W., Carter,G. and Norman,J.
  TITLE     Specific pancreatic enzymes activate macrophages to produce tumor
            necrosis factor-alpha: role of nuclear factor kappa B and
            inhibitory kappa B proteins
  JOURNAL   J Gastrointest Surg 4 (4), 370-7 (2000)
   PUBMED   11058855
REFERENCE   8  (bases 1 to 1491)
  AUTHORS   Cheshire,J.L. and Baldwin,A.S. Jr.
  TITLE     Synergistic activation of NF-kappaB by tumor necrosis factor alpha
            and gamma interferon via enhanced I kappaB alpha degradation and de
            novo I kappaBbeta degradation
  JOURNAL   Mol Cell Biol 17 (11), 6746-6754 (1997)
   PUBMED   9343439
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085729.1.
            
            On Nov 15, 2004 this sequence version replaced NM_030867.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085729.1, FQ235103.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1491
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1491
                     /gene="Nfkbib"
                     /note="NFKB inhibitor beta"
                     /db_xref="GeneID:81525"
                     /db_xref="RGD:621887"
     exon            1..438
                     /gene="Nfkbib"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1339
                     /gene="Nfkbib"
                     /note="ikB-B; ikB-beta; ikappaBbeta; NF-kappa-BIB; nuclear
                     factor of kappa light chain gene enhancer in B-cells
                     inhibitor, beta; I-kappa-B-beta; nuclear factor of kappa
                     light polypeptide gene enhancer in B-cells inhibitor,
                     beta"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor beta"
                     /protein_id="NP_110494.2"
                     /db_xref="GeneID:81525"
                     /db_xref="RGD:621887"
                     /translation="MAGVACLGKTADADEWCDSGLGSLGPDAAAPGGPGLVAELSPEL
                     SWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYLDLQNDLGQTALHLAA
                     ILGEASTVEKLYAAGAGVLVTERGGHTALHLACRVRAHTCAYVLLQPRPSHPRDASDT
                     YLTQSQDHTPDTSHAPVATDPQPNPGNEEELRDEDWRLQLEAENYDGHTPLHVAVIHK
                     DAEMVQLLRDAGADLNKPEPTCGRTPLHLAVEGQAAGVLALLLKAGADPTARMYGGRT
                     PLGSALLRPNPVLARLLRAHGAPEPEDEDDKLSPCSNSSSDSDSDNRDEGDEYDDIVV
                     HSRRSQNQPPPSPAAKPLPDDPNPA"
     exon            439..544
                     /gene="Nfkbib"
                     /inference="alignment:Splign:2.1.0"
     exon            545..878
                     /gene="Nfkbib"
                     /inference="alignment:Splign:2.1.0"
     exon            879..967
                     /gene="Nfkbib"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1237
                     /gene="Nfkbib"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1399
                     /gene="Nfkbib"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaaaggctt ggcgccggcg gccatattaa taaagggcgt ctggaaaatc tggggaaact
       61 cagcgagcga atgtccatct cattattctg attggttctg gtgcagtaca gaggcggggt
      121 gtggctattt aacacagttt gattgggtat atgagggggc gtgttgggga attcccaata
      181 gggcggaagc gctggagctc tcggcagaac ccagcgtcag gcaggcgacc gcagggggcc
      241 acccgaggtg gcaggggcaa tggccggggt cgcgtgcttg gggaaaactg cagacgccga
      301 tgaatggtgc gacagtggcc tgggctctct aggtcccgac gcagcagctc ccggaggacc
      361 aggtctggtc gcagagctta gcccagagct gtcttgggcg cccttagtct ttggctacgt
      421 cactgaggat ggggacacag ccctgcactt ggccgtgata catcagcacg agcccttcct
      481 ggatttcctc ctgggcttct ctgccggcac tgagtacctg gacttgcaga acgacctagg
      541 ccaaacagcc ctgcacctag cagccatcct tggagaggca tctacagtag agaaactcta
      601 tgcagctggc gcaggagtgt tggtgactga gagagggggc cacacagcac tgcacttggc
      661 ctgccgtgtg agggcacaca cgtgtgcata tgtactgctt cagccccgtc ccagccaccc
      721 aagagatgcc tcagatacct acctcactca gagccaggac cacaccccag acaccagcca
      781 tgcccctgtt gccacggacc cccaacccaa cccagggaac gaagaggagc tgcgtgatga
      841 agattggagg ctgcagctag aagctgaaaa ctatgatggc cacaccccac tccatgtagc
      901 tgtcatccac aaagatgcag agatggtcca actgctcagg gatgctgggg ccgacctcaa
      961 taaaccggag cctacgtgtg gccggacccc tctgcacctg gcagtagaag gccaggcagc
     1021 cggcgtgctg gcgcttctcc tcaaagctgg cgctgacccc accgcacgca tgtatggggg
     1081 ccgcacccca cttggcagtg ccctgctccg gcccaaccct gtcctcgccc gcctcctccg
     1141 tgcacatggg gctcctgagc ccgaggatga ggatgataag cttagccctt gcagcaacag
     1201 cagcagtgac agcgacagtg acaacagaga tgaaggcgat gaatatgatg acatcgtggt
     1261 tcacagtcgc aggagccaaa accagccacc tccttcccca gcagccaaac ctcttcctga
     1321 tgaccccaac cctgcctgac ttaagatcta atattaatat agtttccaat ttaataaaat
     1381 ttcagacctg acaaccagaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
