LOCUS       NM_001105720            1583 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NFKB inhibitor alpha (Nfkbia), mRNA.
ACCESSION   NM_001105720 XM_001075778 XM_343065
VERSION     NM_001105720.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1583)
  AUTHORS   Cui,L. and Ma,J.
  TITLE     NEDD4L Promotes IkappaBalpha Ubiquitination and Degradation in the
            Pathogenesis of Diabetic Retinopathy
  JOURNAL   Curr Eye Res 49 (1), 62-72 (2024)
   PUBMED   37768316
  REMARK    GeneRIF: NEDD4L Promotes IkappaBalpha Ubiquitination and
            Degradation in the Pathogenesis of Diabetic Retinopathy.
REFERENCE   2  (bases 1 to 1583)
  AUTHORS   Fan,Y., Wang,J., Feng,Z., Cao,K., Xu,H. and Liu,J.
  TITLE     Pinitol attenuates LPS-induced pneumonia in experimental animals:
            Possible role via inhibition of the TLR-4 and
            NF-kappaB/IkappaBalpha signaling cascade pathway
  JOURNAL   J Biochem Mol Toxicol 35 (1), e22622 (2021)
   PUBMED   32926510
  REMARK    GeneRIF: Pinitol attenuates LPS-induced pneumonia in experimental
            animals: Possible role via inhibition of the TLR-4 and
            NF-kappaB/IkappaBalpha signaling cascade pathway.
REFERENCE   3  (bases 1 to 1583)
  AUTHORS   Li,S., Jiang,L., Yang,Y., Cao,J., Zhang,Q., Zhang,J., Wang,R.,
            Deng,X. and Li,Y.
  TITLE     Siglec1 enhances inflammation through miR-1260-dependent
            degradation of IkappaBalpha in COPD
  JOURNAL   Exp Mol Pathol 113, 104398 (2020)
   PUBMED   32007531
  REMARK    GeneRIF: the present study demonstrated that Siglec1 exerts its
            proinflammatory effects through increasing miR-1260, leading to
            decreased expression of IkappaBalpha.
REFERENCE   4  (bases 1 to 1583)
  AUTHORS   Liang,W.J., Yang,H.W., Liu,H.N., Qian,W. and Chen,X.L.
  TITLE     HMGB1 upregulates NF-kB by inhibiting IKB-alpha and associates with
            diabetic retinopathy
  JOURNAL   Life Sci 241, 117146 (2020)
   PUBMED   31816325
  REMARK    GeneRIF: High IKB-alpha expression is associated with diabetic
            retinopathy.
REFERENCE   5  (bases 1 to 1583)
  AUTHORS   Yuan,F., Xu,X., Wu,Y., Duan,S. and Wu,H.
  TITLE     Gastrodin Ameliorates Acute Rejection via IRE1alpha/TRAF2/NF-kappaB
            in Rats Receiving Liver Allografts
  JOURNAL   Biomed Res Int 2019, 9276831 (2019)
   PUBMED   31828147
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1583)
  AUTHORS   Zabel,U., Henkel,T., Silva,M.S. and Baeuerle,P.A.
  TITLE     Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein
            present in the nucleus
  JOURNAL   EMBO J 12 (1), 201-211 (1993)
   PUBMED   7679069
REFERENCE   7  (bases 1 to 1583)
  AUTHORS   Ganchi,P.A., Sun,S.C., Greene,W.C. and Ballard,D.W.
  TITLE     I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B
            p65 and requires the transactivation domain to inhibit NF-kappa B
            p65 DNA binding
  JOURNAL   Mol Biol Cell 3 (12), 1339-1352 (1992)
   PUBMED   1493333
REFERENCE   8  (bases 1 to 1583)
  AUTHORS   Tewari,M., Dobrzanski,P., Mohn,K.L., Cressman,D.E., Hsu,J.C.,
            Bravo,R. and Taub,R.
  TITLE     Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that
            inhibits NF-kappa B, RelB-p50, and c-Rel-p50) and PHF, a novel
            kappa B site-binding complex
  JOURNAL   Mol Cell Biol 12 (6), 2898-2908 (1992)
   PUBMED   1588976
REFERENCE   9  (bases 1 to 1583)
  AUTHORS   Tewari,M., Mohn,K.L., Yue,F.E. and Taub,R.
  TITLE     Sequence of rat RL/IF-1 encoding an IkappaB, and comparison with
            related proteins containing notch-like repeats [corrected]
  JOURNAL   Nucleic Acids Res 20 (3), 607 (1992)
   PUBMED   1741294
  REMARK    Erratum:[Nucleic Acids Res 1992 Jun 11;20(11):2931]
REFERENCE   10 (bases 1 to 1583)
  AUTHORS   Baeuerle,P.A. and Baltimore,D.
  TITLE     I kappa B: a specific inhibitor of the NF-kappa B transcription
            factor
  JOURNAL   Science 242 (4878), 540-546 (1988)
   PUBMED   3140380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB793714.1, CB316505.1, BF417507.1, CB324027.1 and CA509173.1.
            
            On Nov 15, 2007 this sequence version replaced NM_001105720.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ234262.1, BC166886.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-376               CB793714.1         28-403
            377-754             CB316505.1         331-708
            755-1137            BF417507.1         7-389               c
            1138-1316           CB324027.1         267-445             c
            1317-1583           CA509173.1         1-267               c
FEATURES             Location/Qualifiers
     source          1..1583
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..1583
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="NFKB inhibitor alpha"
                     /db_xref="GeneID:25493"
                     /db_xref="RGD:3171"
     exon            1..346
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1064
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /note="ikB-alpha; ikappaBalpha; I-kappa-B-alpha; Inhibitor
                     of nuclear factor of kappa light chain gene enhancer in
                     B-cells, alpha; nuclear factor of kappa light chain gene
                     enhancer in B-cells inhibitor, alpha; nuclear factor of
                     kappa light polypeptide gene enhancer in B-cells
                     inhibitor, alpha"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor alpha"
                     /protein_id="NP_001099190.2"
                     /db_xref="GeneID:25493"
                     /db_xref="RGD:3171"
                     /translation="MFQPAGHGQDWAMEGPRDGLKKERLVDDRHDSGLDSMKDEDYEQ
                     MVKELREIRLQPQEAPLAAEPWKQQLTEDGDSFLHLAIIHEEKTLTMEVIGQVKGDLA
                     FLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPELRDFRGNTPLHLACEQGCLASV
                     AVLTQTCTPQHLHSVLQATNYNGHTCLHLASIHGYLGIVEHLVTLGADVNAQEPCNGR
                     TALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLEN
                     LQTLPESEDEESYDTESEFTEDELPYDDCVFGGQRLTL"
     exon            347..455
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..666
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..755
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1016
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1566
                     /gene="Nfkbia"
                     /gene_synonym="RL/IF-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaatcccct gccagcgttt atagggcgcc gaggcggcgc tgccgagccc acaacagtct
       61 gaactcgcca cccaactgcc agcagcctgc accctgcacc cgctcagctc cgcacagcca
      121 tgtttcagcc agctgggcac ggccaggact gggccatgga gggcccgcgg gacggcctca
      181 agaaggagcg gttggtggac gaccgccacg acagcggctt ggactccatg aaggacgagg
      241 attacgagca gatggtgaag gagctgcggg agatccgcct gcagccgcag gaggcgcctc
      301 tggctgccga gccctggaag caacagctca cggaggacgg agactcgttc ctgcacttgg
      361 caatcatcca tgaagagaag acactgacca tggaagtgat tggtcaggtg aagggagacc
      421 tggccttcct caacttccag aacaacctgc agcagactcc actccacttg gctgtgatca
      481 ccaaccagcc aggaattgct gaggcacttc tgaaagctgg ctgtgatcct gagctccgag
      541 actttcgagg aaatacccct ctccatcttg cctgtgagca gggctgcctg gccagtgtag
      601 cagtcttgac tcagacctgt acgccccagc atctccactc cgtcctgcag gccaccaact
      661 acaacggcca cacgtgtcta cacttagcct ctatccatgg ctacctgggc atcgtggagc
      721 acttggtgac tttgggtgct gatgtcaacg ctcaggagcc ctgtaatggc cggacagccc
      781 tccaccttgc agtggacctg cagaatcctg acctggtctc gctcctgttg aagtgtgggg
      841 ctgatgtcaa cagagtaacc taccagggct actcccccta ccagcttacg tggggccgcc
      901 caagtacccg gatacagcag cagctgggcc agctgaccct ggaaaatctt cagacgctgc
      961 ccgagagtga ggatgaggag agctatgaca cggagtcaga attcacggaa gatgagttgc
     1021 cctacgatga ctgtgtgttt ggaggccagc gtctgacgtt ataagaggaa agtggccaaa
     1081 ggaacgtgga cttgtatatt tgtacaaata gagttttatt tttctaaaaa aaaaaaagaa
     1141 aaagaaaaaa aaataagaaa gggtatactt agcaccacag cacacagcgc ctagccccga
     1201 gcattctatt gtggtgattc agctgttgtt cttgtgaaat ttggggaaac agatcattga
     1261 aattcaaagg aaatgtctcc taaggttcat gtttgtggga tttttttttt ttttttgagg
     1321 tgattttcca gaatctgata aaaggaccac attttattta ttgtgctttt ggttgaaccg
     1381 ccatagactg tagctgaccc cagtgtgccc tctcacgtaa gaaccaggtg ttcagtggta
     1441 tgtgcttaag tcatccccag ctgagatttg taccactttc ttgtaaatgt tgtatatggt
     1501 gtattttgtt ggtaattatt ttggtacttc taagatgtat atttattaaa cagattttta
     1561 cagacaaaaa aaaaaaaaaa aaa
//
