LOCUS       NM_001008349            3098 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus nuclear factor kappa B subunit 2 (Nfkb2), mRNA.
ACCESSION   NM_001008349 XM_219954 XM_347195
VERSION     NM_001008349.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3098)
  AUTHORS   Qiu,J., Yuan,H., Chen,S., Zhou,Y., Song,D. and Chen,R.
  TITLE     TNFalpha up-regulates COX-2 in chronic progressive nephropathy
            through nuclear accumulation of RelB and NF-kappaB2
  JOURNAL   Arch Physiol Biochem 122 (2), 88-93 (2016)
   PUBMED   26824492
  REMARK    GeneRIF: TNFalpha-RelB/p52 pathway may be involved in the early
            stages of renal damage, in part by stimulating COX-2 and
            inflammatory responses
REFERENCE   2  (bases 1 to 3098)
  AUTHORS   Burkitt,M.D., Williams,J.M., Duckworth,C.A., O'Hara,A., Hanedi,A.,
            Varro,A., Caamano,J.H. and Pritchard,D.M.
  TITLE     Signaling mediated by the NF-kappaB sub-units NF-kappaB1,
            NF-kappaB2 and c-Rel differentially regulate Helicobacter
            felis-induced gastric carcinogenesis in C57BL/6 mice
  JOURNAL   Oncogene 32 (50), 5563-5573 (2013)
   PUBMED   23975431
REFERENCE   3  (bases 1 to 3098)
  AUTHORS   Manecka,D.L., Mahmood,S.F., Grumolato,L., Lihrmann,I. and Anouar,Y.
  TITLE     Pituitary adenylate cyclase-activating polypeptide (PACAP) promotes
            both survival and neuritogenesis in PC12 cells through activation
            of nuclear factor kappaB (NF-kappaB) pathway: involvement of
            extracellular signal-regulated kinase (ERK), calcium, and c-REL
  JOURNAL   J Biol Chem 288 (21), 14936-14948 (2013)
   PUBMED   23564451
  REMARK    GeneRIF: PACAP promotes both survival and neuritogenesis in PC12
            cells by activating NF-kappaB pathway, most likely via classical
            and alternative signaling cascades involving ERK1/2 kinases,
            Ca(2+), and c-Rel/p52 dimers.
REFERENCE   4  (bases 1 to 3098)
  AUTHORS   Vogel,K.U., Edelmann,S.L., Jeltsch,K.M., Bertossi,A., Heger,K.,
            Heinz,G.A., Zoller,J., Warth,S.C., Hoefig,K.P., Lohs,C., Neff,F.,
            Kremmer,E., Schick,J., Repsilber,D., Geerlof,A., Blum,H., Wurst,W.,
            Heikenwalder,M., Schmidt-Supprian,M. and Heissmeyer,V.
  TITLE     Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40
            costimulator mRNAs and control follicular helper T cell
            differentiation
  JOURNAL   Immunity 38 (4), 655-668 (2013)
   PUBMED   23583643
REFERENCE   5  (bases 1 to 3098)
  AUTHORS   Droebner,K., Klein,B., Paxian,S., Schmid,R., Stitz,L. and Planz,O.
  TITLE     The alternative NF-kappaB signalling pathway is a prerequisite for
            an appropriate immune response against lymphocytic choriomeningitis
            virus infection
  JOURNAL   Viral Immunol 23 (3), 295-308 (2010)
   PUBMED   20565293
REFERENCE   6  (bases 1 to 3098)
  AUTHORS   Medicherla,R., Leers-Sucheta,S., Luo,Y. and Azhar,S.
  TITLE     Age-dependent modulation of NF-kappaB expression in rat adrenal
            gland
  JOURNAL   Mech Ageing Dev 123 (9), 1211-1227 (2002)
   PUBMED   12020944
REFERENCE   7  (bases 1 to 3098)
  AUTHORS   Poljak,L., Carlson,L., Cunningham,K., Kosco-Vilbois,M.H. and
            Siebenlist,U.
  TITLE     Distinct activities of p52/NF-kappa B required for proper secondary
            lymphoid organ microarchitecture: functions enhanced by Bcl-3
  JOURNAL   J Immunol 163 (12), 6581-6588 (1999)
   PUBMED   10586052
REFERENCE   8  (bases 1 to 3098)
  AUTHORS   Muggia,A., Teesalu,T., Neri,A., Blasi,F. and Talarico,D.
  TITLE     Trophoblast giant cells express NF-kappa B2 during early mouse
            development
  JOURNAL   Dev Genet 25 (1), 23-30 (1999)
   PUBMED   10402669
REFERENCE   9  (bases 1 to 3098)
  AUTHORS   Bundy,D.L. and McKeithan,T.W.
  TITLE     Diverse effects of BCL3 phosphorylation on its modulation of
            NF-kappaB p52 homodimer binding to DNA
  JOURNAL   J Biol Chem 272 (52), 33132-33139 (1997)
   PUBMED   9407099
REFERENCE   10 (bases 1 to 3098)
  AUTHORS   Potter,D.A., Larson,C.J., Eckes,P., Schmid,R.M., Nabel,G.J.,
            Verdine,G.L. and Sharp,P.A.
  TITLE     Purification of the major histocompatibility complex class I
            transcription factor H2TF1. The full-length product of the nfkb2
            gene
  JOURNAL   J Biol Chem 268 (25), 18882-18890 (1993)
   PUBMED   8360178
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085800.1.
            
            On or before Dec 16, 2004 this sequence version replaced
            XM_219954.2, XM_347195.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085800.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132296, SAMD00132301
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3098
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..3098
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /note="nuclear factor kappa B subunit 2"
                     /db_xref="GeneID:309452"
                     /db_xref="RGD:1307189"
     exon            1..279
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..2955
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /note="nuclear factor of kappa light polypeptide gene
                     enhancer in B-cells 2, p49/p100"
                     /codon_start=1
                     /product="nuclear factor NF-kappa-B p100 subunit"
                     /protein_id="NP_001008350.1"
                     /db_xref="GeneID:309452"
                     /db_xref="RGD:1307189"
                     /translation="MDRCYDPGLDGIPEYDDFEFSPSIVEPKDPAPETADGPYLVIVE
                     QPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPP
                     RAHAHSLVGKQCSELGVCAVSVGPKDMTAQFNNLGVLHVTKKNMMEIMIQKLQRQRLR
                     SKPQGLTEAERRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIH
                     DSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDF
                     SPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKEE
                     VQRKRRKALPTFSQPFGGGSHMGGGSGGSAGGYGGAGGGGSLGFFSSFAYSPYQSGAA
                     PMGCFPGGGGGAQMAGSGRDAEAGEAEEQPRAPSEAPQSEQQALDTLQRAREYNARLF
                     GLAQRSARALLDYGVTADARALLAGQRHLLMAQDENGDTPLHLAIIHGQTGVIEQIAQ
                     VIYHAQYLGVINLTNHLHQTPLHLAVITGQTRVVSFLLQVGADPTLLDRHGDSAVHLA
                     LRAGAAAPDLLQAVLHSGAHALPQMLHMPDFEGLYPVHLAVHARSPECLDLLVDCGAE
                     VEAAERQGGRTPLHLATEMEELGLVTHLVTKLHANVNARTFAGNTPLHLAAGLGSPTL
                     TRLLLKAGADIHAENEEPLCPLPSPPTSGSDSDSEGPETDTQRNFRGHTPLDLTRSTK
                     VKTLLLNAAQNTTEPPLAPPSPAGPGLSLGDAALQNLEQLLDGPEAQGSWAELAERLG
                     LRSLVDTYRKTPSPSGSLLRSYKLAGGDLVGLLEALSDMGLHEGVRLLKAPETRDKLP
                     STEVKEDSAYGSQSVEQEAEKLCPPPEPPGGLCHGHPQPQVH"
     exon            280..361
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            362..402
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            403..501
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            502..653
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            654..760
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            761..919
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1024
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1110
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1249
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1375
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1582
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1724
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1839
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2053
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2223
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2326
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2478
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2548
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2721
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2833
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..3070
                     /gene="Nfkb2"
                     /gene_synonym="RGD1307189"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactttctgc cccttccccg gcccagcccc gatccggatc tcgacctcca ccggatcttt
       61 cccgccacgc ccggacgggc ggctggagga gatcagaccc tcccccagat ctgaaccccc
      121 ctctcctgcc cacccctatc ctgagctctt cccctcttcc ccctcctgtg cctctcttca
      181 ccttaggcgg gcgtctgaaa ctctgggaag ctgaaccggg ccgaagccaa aagacacagc
      241 agggcctagc ccagaaatat ggaccgttgc tacgatccag gtttggatgg catccctgaa
      301 tatgatgatt ttgaattcag cccctccatt gtggagccca aggatccagc cccagagaca
      361 gctgatggcc cctatctggt gattgtggaa cagcctaaac agcgaggctt cagatttcga
      421 tatggctgtg aaggcccctc ccatggaggt ctgccaggtg cctccagtga gaagggccgg
      481 aagacctatc ctactgtcaa gatctgtaac tacgaggggc cggccaagat tgaggtggac
      541 ctggtgacac acagtgaccc accccgtgca catgcccaca gtctggtggg caagcagtgc
      601 tctgagctgg gggtgtgtgc cgtgtctgtg ggacccaagg acatgactgc tcaatttaat
      661 aatctgggtg tcctgcatgt aaccaagaag aacatgatgg agattatgat tcagaaactc
      721 cagaggcagc ggctccgctc caagcctcag ggccttacag aggccgagcg ccgggagctg
      781 gagcaggagg ccaaggagct gaagaaagtc atggatttga gcattgtacg gctacgcttc
      841 tcagctttcc ttcgagctag tgatggctcc ttctccctgc ccctgaagcc tgtgatctcc
      901 cagcccatcc acgacagcaa gtctccaggg gcctcaaacc tgaagatttc ccgaatggac
      961 aaaacagcag gttccgtgcg cggtggagac gaagtttatt tgctttgcga taaggtgcag
     1021 aaagatgaca ttgaggttcg tttctatgag gatgacgaga acggatggca agcctttggg
     1081 gacttctctc ccacagacgt tcataaacag tatgccattg tgttccggac accgccctat
     1141 cacaagatga agattgagag gcctgtaacg gtgttcctgc agctgaaacg caagcgtggg
     1201 ggcgatgtct ccgactccaa acagttcacg tattaccctc tggtggaaga caaggaggaa
     1261 gtacagagga agcggagaaa ggccttgcct accttctccc agcccttcgg gggcggatcc
     1321 cacatgggtg gaggttctgg gggctccgct gggggttatg gaggcgctgg aggaggtggc
     1381 agcctcggct ttttctcctc cttcgcctac agcccctacc aatccggtgc agccccaatg
     1441 ggctgcttcc cgggtggggg aggtggagcg cagatggccg gctctggacg ggacgcggag
     1501 gctggcgagg cagaggagca gcccagagca ccctccgagg ccccccagag cgagcagcag
     1561 gccctggaca cgctgcagcg agctcgcgag tacaacgcgc gcctgttcgg tctggcgcag
     1621 cgcagcgccc gagcgttgct ggactacggc gtcaccgcgg acgcgcgtgc tctgctagcg
     1681 ggacagcgcc acctgctgat ggcacaggac gagaacggag acacgccgct gcacctggcc
     1741 attatccatg ggcagactgg tgtcattgag cagatagccc aagtcattta tcatgctcag
     1801 taccttgggg tcatcaacct caccaatcac ctgcaccaga cacctctgca cctggcagta
     1861 atcactgggc agacacgggt ggtgagcttc ctgctgcagg tgggtgcaga ccccacactg
     1921 ctggatcgcc atggtgactc agctgtccac ttggctctcc gggcaggtgc tgcagcccca
     1981 gacctgctgc aggcagtgtt gcacagtgga gcccacgctc tgccccaaat gttacacatg
     2041 cctgattttg agggactata cccagtacac ctggcggtcc atgcccgaag ccctgagtgc
     2101 ctggatctgt tagttgactg tggagctgaa gtggaggcag cagagaggca aggaggccga
     2161 accccactgc atctagccac agagatggag gagctggggt tggtcaccca tctggtcacc
     2221 aagctccatg ctaatgtgaa tgcccggacc tttgctggaa acacacccct ccacctggcg
     2281 gctggacttg gatccccaac cctcacccgc ctccttctaa aggctggtgc tgacatccat
     2341 gcggagaatg aagagcctct ctgcccactg ccctcacccc ctacctctgg gagcgattca
     2401 gactctgagg ggcctgagac agatacccaa agaaacttcc gaggccatac ccctcttgac
     2461 ctcactcgca gtaccaaggt gaagaccctg ctgttgaacg ctgctcagaa caccacggag
     2521 ccacccctgg ccccacccag ccctgcaggg ccagggctgt cactggggga tgcagccctg
     2581 cagaacctgg agcaactgct agatgggcca gaagcccagg gcagctgggc agagctggca
     2641 gagagactgg ggctgaggag cctggtggac acatacagga agaccccctc ccccagtggc
     2701 agtctccttc gtagttacaa gctggctggt ggagacttgg tgggtctatt ggaagccttg
     2761 tccgacatgg gtcttcatga gggagttagg ctgctgaagg cgcctgagac ccgagacaag
     2821 ctgcccagca cagaggtgaa agaagacagt gcctacggga gccagtcagt ggagcaggag
     2881 gcagagaagc tgtgtccacc ccctgagcct ccaggagggc tctgccacgg gcacccccag
     2941 cctcaggtgc actgaatgct acccggtcaa cttccacctg gatccctctg tacagcatcc
     3001 ctgcctaatt gaaatcttat ttaaacttca agcccacacc tcagtgggcc aaataaaggg
     3061 aaagacccct aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
