LOCUS       NM_001415012            4065 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus nuclear factor kappa B subunit 1 (Nfkb1),
            transcript variant 1, mRNA.
ACCESSION   NM_001415012 XM_006233358
VERSION     NM_001415012.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4065)
  AUTHORS   Zhang,X., Wang,H., Cai,X., Zhang,A., Liu,E., Li,Z., Jiang,T., Li,D.
            and Ding,W.
  TITLE     alpha7nAChR Activation Combined with Endothelial Progenitor Cell
            Transplantation Attenuates Lung Injury in Diabetic Rats with Sepsis
            through the NF-kappaB Pathway
  JOURNAL   Inflammation 47 (4), 1344-1355 (2024)
   PUBMED   38302679
  REMARK    GeneRIF: alpha7nAChR Activation Combined with Endothelial
            Progenitor Cell Transplantation Attenuates Lung Injury in Diabetic
            Rats with Sepsis through the NF-kappaB Pathway.
REFERENCE   2  (bases 1 to 4065)
  AUTHORS   Tao,X., Hu,Y., Mao,N., Shen,M., Fang,M., Zhang,M., Lou,J., Fang,Y.,
            Guo,X. and Lin,Z.
  TITLE     Echinatin alleviates inflammation and pyroptosis in
            hypoxic-ischemic brain damage by inhibiting TLR4/ NF-kappaB pathway
  JOURNAL   Int Immunopharmacol 136, 112372 (2024)
   PUBMED   38850784
  REMARK    GeneRIF: Echinatin alleviates inflammation and pyroptosis in
            hypoxic-ischemic brain damage by inhibiting TLR4/ NF-kappaB
            pathway.
REFERENCE   3  (bases 1 to 4065)
  AUTHORS   Cao,W., Zeng,Y., Su,Y., Gong,H., He,J., Liu,Y. and Li,C.
  TITLE     The involvement of oxidative stress and the TLR4/NF-kappaB/NLRP3
            pathway in acute lung injury induced by high-altitude hypoxia
  JOURNAL   Immunobiology 229 (3), 152809 (2024)
   PUBMED   38788361
  REMARK    GeneRIF: The involvement of oxidative stress and the
            TLR4/NF-kappaB/NLRP3 pathway in acute lung injury induced by
            high-altitude hypoxia.
REFERENCE   4  (bases 1 to 4065)
  AUTHORS   Liang,S., Cao,W., Zhuang,Y., Zhang,D., Du,S. and Shi,H.
  TITLE     Suppression of microRNA-320 Induces Cerebral Protection Against
            Ischemia/Reperfusion Injury by Targeting HMGB1/NF-kappaB Axis
  JOURNAL   Physiol Res 73 (1), 127-138 (2024)
   PUBMED   38466011
  REMARK    GeneRIF: Suppression of microRNA-320 Induces Cerebral Protection
            Against Ischemia/Reperfusion Injury by Targeting HMGB1/NF-kappaB
            Axis.
REFERENCE   5  (bases 1 to 4065)
  AUTHORS   Jiao,B., Zhang,W., Zhang,C., Zhang,K., Cao,X., Yu,S. and Zhang,X.
  TITLE     Protein tyrosine phosphatase 1B contributes to neuropathic pain by
            aggravating NF-kappaB and glial cells activation-mediated
            neuroinflammation via promoting endoplasmic reticulum stress
  JOURNAL   CNS Neurosci Ther 30 (2), e14609 (2024)
   PUBMED   38334011
  REMARK    GeneRIF: Protein tyrosine phosphatase 1B contributes to neuropathic
            pain by aggravating NF-kappaB and glial cells activation-mediated
            neuroinflammation via promoting endoplasmic reticulum stress.
REFERENCE   6  (bases 1 to 4065)
  AUTHORS   Clemens,J.A., Stephenson,D.T., Smalstig,E.B., Dixon,E.P. and
            Little,S.P.
  TITLE     Global ischemia activates nuclear factor-kappa B in forebrain
            neurons of rats
  JOURNAL   Stroke 28 (5), 1073-80 (1997)
   PUBMED   9158652
REFERENCE   7  (bases 1 to 4065)
  AUTHORS   Shimizu,H. and Yamamoto,K.
  TITLE     NF-kappa B and C/EBP transcription factor families synergistically
            function in mouse serum amyloid A gene expression induced by
            inflammatory cytokines
  JOURNAL   Gene 149 (2), 305-310 (1994)
   PUBMED   7959007
REFERENCE   8  (bases 1 to 4065)
  AUTHORS   Kaltschmidt,C., Kaltschmidt,B., Neumann,H., Wekerle,H. and
            Baeuerle,P.A.
  TITLE     Constitutive NF-kappa B activity in neurons
  JOURNAL   Mol Cell Biol 14 (6), 3981-3992 (1994)
   PUBMED   8196637
REFERENCE   9  (bases 1 to 4065)
  AUTHORS   Hamil,K.G. and Hall,S.H.
  TITLE     Cloning of rat Sertoli cell follicle-stimulating hormone primary
            response complementary deoxyribonucleic acid: regulation of TSC-22
            gene expression
  JOURNAL   Endocrinology 134 (3), 1205-1212 (1994)
   PUBMED   8161377
REFERENCE   10 (bases 1 to 4065)
  AUTHORS   Kunsch,C., Ruben,S.M. and Rosen,C.A.
  TITLE     Selection of optimal kappa B/Rel DNA-binding motifs: interaction of
            both subunits of NF-kappa B with DNA is required for
            transcriptional activation
  JOURNAL   Mol Cell Biol 12 (10), 4412-4421 (1992)
   PUBMED   1406630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 20, 2022 this sequence version replaced XM_006233358.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.13691.1,
                                           SRR26643284.3723.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               JAXUCZ010000002.1  226805080-226805462 c
            384-453             JAXUCZ010000002.1  226782982-226783051 c
            454-493             JAXUCZ010000002.1  226781715-226781754 c
            494-572             JAXUCZ010000002.1  226776937-226777015 c
            573-613             JAXUCZ010000002.1  226772604-226772644 c
            614-712             JAXUCZ010000002.1  226769323-226769421 c
            713-861             JAXUCZ010000002.1  226737367-226737515 c
            862-1025            JAXUCZ010000002.1  226727111-226727274 c
            1026-1184           JAXUCZ010000002.1  226723508-226723666 c
            1185-1289           JAXUCZ010000002.1  226721740-226721844 c
            1290-1381           JAXUCZ010000002.1  226719732-226719823 c
            1382-1520           JAXUCZ010000002.1  226716885-226717023 c
            1521-1667           JAXUCZ010000002.1  226712473-226712619 c
            1668-1757           JAXUCZ010000002.1  226710897-226710986 c
            1758-1946           JAXUCZ010000002.1  226709374-226709562 c
            1947-2088           JAXUCZ010000002.1  226708113-226708254 c
            2089-2203           JAXUCZ010000002.1  226705878-226705992 c
            2204-2405           JAXUCZ010000002.1  226699489-226699690 c
            2406-2575           JAXUCZ010000002.1  226698887-226699056 c
            2576-2678           JAXUCZ010000002.1  226698492-226698594 c
            2679-2803           JAXUCZ010000002.1  226696310-226696434 c
            2804-2870           JAXUCZ010000002.1  226695546-226695612 c
            2871-3043           JAXUCZ010000002.1  226695095-226695267 c
            3044-3221           JAXUCZ010000002.1  226694135-226694312 c
            3222-4065           JAXUCZ010000002.1  226689745-226690588 c
FEATURES             Location/Qualifiers
     source          1..4065
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..4065
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /note="nuclear factor kappa B subunit 1"
                     /db_xref="GeneID:81736"
                     /db_xref="RGD:70498"
     exon            1..383
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            384..453
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            454..493
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     CDS             461..3382
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear factor NF-kappa-B p105 subunit; DNA-binding factor
                     KBF1; nuclear factor NF-kappa-B p50; nuclear factor of
                     kappa light polypeptide gene enhancer in B-cells 1, p105;
                     nuclear factor of kappa light chain gene enhancer in
                     B-cells 1, p105"
                     /codon_start=1
                     /product="nuclear factor NF-kappa-B p105 subunit isoform
                     1"
                     /protein_id="NP_001401941.1"
                     /db_xref="GeneID:81736"
                     /db_xref="RGD:70498"
                     /translation="MADDDPFGTGQMFHLNTALTHSIFNAELYSTDIPLSTADGPYLQ
                     ILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNG
                     KNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEAC
                     IRGYNPGLLVHSDLAYLQAEGGGDRQLTDREKEIIRQAALQQTKEMDLSVVRLMFTAF
                     LPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQK
                     DDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRR
                     KSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGG
                     GGGSTGSPGPGYGFPHYGFPAYGGIAFHPGATKSNTGITHGTINTKFKNEPRDCAKSD
                     DREILNPPEKETQGEGPSLFMASTKTEAIAPASTMEDKEEDVGFQDNLFLEKALQLAK
                     RHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSG
                     SISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLHLAAKEG
                     HDKILGVLLKNSKAALLINHPNGEGLNAIHIAVMSNSLSCLQLLVAAGAEVNAQEQKS
                     GRTALHLAVEYDNISLAGCLLLEGDALVDSTTYDGTTPLHIAAGRGSTRLAALLKAAG
                     ADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPVFTSD
                     DILPQGDIKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTL
                     MDNYEVSGGTIKELVEALRQMGYTEAIEVIQAAFRTPETTASSPVTTAQAHLLPLSSS
                     STRQHIDELRDNDSVCDSGVETSFRKLSFSESLTGDGPLLSLNKMPHNYGQDGPIEGK
                     I"
     exon            494..572
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            573..613
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            614..712
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            713..861
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1025
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1184
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1289
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1381
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1520
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1667
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1757
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1946
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2088
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2203
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2405
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2575
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2678
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2803
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2870
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..3043
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3221
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..4065
                     /gene="Nfkb1"
                     /gene_synonym="EBP-1; NF-kB; NFKB-p50; p50"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggaatt tccagccagg aagtgagaga gtgagcgaga gaggacgaga gagaagtacc
       61 gaggcgagcc gggcaggaag aggaggtttc gccacccgag cagcccggct gcgcgctgac
      121 ggcttcccgt gccctgcgcg cccccggcct gccgccgccg ccgccgccgc cctcggcctg
      181 ctcgcgggcc ggctccagca gcgcaggccg gagctcaggg ccccgccgcg cccggcccgc
      241 cccgcgcttc tccgcccgcg ccgcagccat ggcgcgccgc tgagccgccg gccggcgcca
      301 ggaccttact cgggctcccg ccggtccacg ctgccccgca gcgggagccc gcaggcgcgg
      361 aaaggccgcg cctcacctcc agggtaccct cagaggccag aagagggtgt tggccccctg
      421 taactggagc ttgaccgtcg tgagctgccc catcttcaac atggcagacg acgatccttt
      481 cggaactggg caaatgtttc atttgaatac tgctttgact cactccatat ttaatgcaga
      541 attatattca acagatatac cactgtcaac agcagatggc ccataccttc aaatactaga
      601 gcaaccgaaa cagagaggat ttcgattccg ctacgtgtgc gaaggcccgt cccacggagg
      661 gcttcccggt gcctccagtg agaagaacaa gaaatcttac ccgcaggtca aaatttgcaa
      721 ctatgtgggg cctgcaaagg ttatcgttca gttggtcaca aatggaaaaa atattcacct
      781 gcacgcccac agcctggtgg gcaagcactg tgaggacggc atatgcaccg tgacagcagg
      841 acccaaggac atggtggttg gctttgcaaa cctgggaata cttcacgtga ctaagaaaaa
      901 ggtattcgaa acactggaag cacggatgac agaggcgtgt ataaggggct ataaccctgg
      961 acttctggtg cattctgacc ttgcctatct acaggcagaa ggcggaggag accggcaact
     1021 cacagacaga gagaaggaga tcatccgcca ggcagctctg cagcagacca aggagatgga
     1081 cctgagtgtg gtgcgcctca tgttcacagc cttcctcccc gacagcacgg gcagcttcac
     1141 tcggagactg gaacctgtgg tgtcagacgc catctatgac agcaaagccc ccaacgcgtc
     1201 caacctgaag atcgtaagaa tggacagaac agcaggctgc gtgacgggag gggaagaaat
     1261 ctatcttctc tgtgacaagg tccagaaaga tgacatccag attcggtttt atgaagagga
     1321 agaaaatggt ggagtttggg aaggatttgg ggacttttcc cccacggatg ttcacagaca
     1381 gtttgccatt gtcttcaaaa caccgaagta taaggatgtc aacattacaa agccagcttc
     1441 cgtgtttgtt cagcttcgga gaaaatcgga tttggaaact agtgaaccga aaccctttct
     1501 ctactacccc gaaatcaaag acaaggagga agtacagagg aaacgccaga agctcatgcc
     1561 caacttctcc gacagtttcg gcggcggcag tggagcggga gcgggtggcg gaggcatgtt
     1621 cggtagtggc ggtggcggtg gagggagtac cggaagtcct ggcccagggt atggcttccc
     1681 gcactatgga tttcctgctt acggtgggat tgcattccat cccggagcca ctaaatccaa
     1741 cacaggcatc acccatggca ccataaacac caaatttaaa aacgagccta gagattgtgc
     1801 caagagtgac gacagggaga ttctgaatcc ccctgagaaa gaaacacaag gtgaggggcc
     1861 cagcctgttc atggccagca ccaagaccga agcaattgcc ccggcatcca ccatggaaga
     1921 caaggaagag gatgtggggt ttcaggataa cctctttctt gagaaggcgc tgcagctcgc
     1981 caagcggcat gccaacgccc tcttcgacta cgcggttacg ggagatgtga agatgctgct
     2041 ggcggtacag cgccatctca ccgcggtgca ggatgagaac ggggacagtg tcctacactt
     2101 agccatcatc caccttcatg ctcagctcgt gagggatctg ctagaagtga catctggttc
     2161 gatctctgat gacatcatca acatgagaaa cgatctgtat cagacacctt tgcacttggc
     2221 cgtgatcacc aagcaggaag atgtggtgga ggacttgctg agggttgggg ctgacctgag
     2281 tcttctggac cgctggggca actctgtcct gcacctagct gccaaagaag gacatgataa
     2341 aatcctcggg gtcctactca agaacagcaa ggcagcactc cttatcaacc accccaacgg
     2401 ggaaggtctg aatgccattc acatagctgt gatgagcaac agcctgtcat gtctgcagct
     2461 gcttgtggct gctggggcag aagtcaacgc tcaggagcag aagtctgggc gcacggcact
     2521 gcacctggcc gtggagtacg acaacatctc gttggccggc tgcctgctcc tggagggtga
     2581 cgccctcgtg gacagcacca cctacgatgg gacgacacct ctacacatag cagctggaag
     2641 agggtccacc aggctggcag ctcttctcaa agcagcagga gcagaccccc tggtggagaa
     2701 ctttgagcct ctctatgacc tggacgactc ttgggagaag gctggagaag atgagggagt
     2761 agtgccaggc accacacccc tggacatggc tgccaactgg caggtatttg acatactaaa
     2821 tgggaaacca tatgagccag tgttcacatc tgatgacata ctcccacaag gggacattaa
     2881 gcagctgaca gaagacacga ggctgcaact ctgcaagctc ttggaaattc ctgatcccga
     2941 caagaactgg gccactctgg cgcagaagtt aggtctgggg atattgaaca atgccttccg
     3001 gctgagtccc gccccttcta aaactcttat ggacaactat gaggtctctg gggggaccat
     3061 caaagagctg gtggaggccc tgcgacagat gggctacaca gaggccattg aagtgatcca
     3121 ggcagccttc cgcaccccgg aaaccacagc ctccagcccc gtgaccactg ctcaggccca
     3181 cttgctgcct ctctcgtcct cctccacaag acagcacata gatgagctcc gagataatga
     3241 cagcgtgtgt gacagtggtg tggagacatc cttccgcaaa ctcagcttct cggagtccct
     3301 cactggagat ggcccactgc tatctctgaa caaaatgcct cacaattatg ggcaggatgg
     3361 acctatagaa ggcaaaattt agcctgctgg cggttcccca cactgtaaac caaagccctg
     3421 aaaggccatc atatcgttcc gaaggagaag gcaaaaaacg catcccaagg tgctggaagg
     3481 tcaccggcct gcagggtcaa tcttgatgtc attcgaggcc ttccgaattt ggcttccttt
     3541 cttggctctg aaatgaaatt tagttgtcat atacagatgg tgtctagcaa tcacggctgc
     3601 actcggtgtg gcttggggta tggtggcttg agcttttcca gctgctattg gattacactt
     3661 gctttgtgtt gtcactgctg tccctctgct gggtccccgc tgtcattaag gtatcgcagt
     3721 ccccacctgg tgttctttct agccatctac agtacagtca tgcactcaaa ttaagattaa
     3781 ggaaaaagat atttttaagt gagtaacttc atgcgcaata aaaaaaagac atggcttttt
     3841 ctaatgtggt ttatctgtga tttaaaaaaa aaaaagacat gaacttaaca atatttaaaa
     3901 cctgctataa tcagtgctga aaatagtatt ttcccccttt tctgcatttt actattgtaa
     3961 atatgttttc taaatcaaat actttaaaag aagaaatgtt ggatttataa atgctatttt
     4021 ttattttact tttataataa aagtacaagc acactgttga cctca
//
