LOCUS       NM_053727               1990 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus nuclear factor, interleukin 3 regulated (Nfil3),
            mRNA.
ACCESSION   NM_053727
VERSION     NM_053727.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1990)
  AUTHORS   Zhang,T., Yu,F., Guo,L., Chen,M., Yuan,X. and Wu,B.
  TITLE     Small Heterodimer Partner Regulates Circadian Cytochromes p450 and
            Drug-Induced Hepatotoxicity
  JOURNAL   Theranostics 8 (19), 5246-5258 (2018)
   PUBMED   30555544
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1990)
  AUTHORS   Zhao,M., Zhang,T., Yu,F., Guo,L. and Wu,B.
  TITLE     E4bp4 regulates carboxylesterase 2 enzymes through repression of
            the nuclear receptor Rev-erbalpha in mice
  JOURNAL   Biochem Pharmacol 152, 293-301 (2018)
   PUBMED   29653076
REFERENCE   3  (bases 1 to 1990)
  AUTHORS   Lin,K.H., Kuo,C.H., Kuo,W.W., Ho,T.J., Pai,P., Chen,W.K., Pan,L.F.,
            Wang,C.C., Padma,V.V. and Huang,C.Y.
  TITLE     NFIL3 suppresses hypoxia-induced apoptotic cell death by targeting
            the insulin-like growth factor 2 receptor
  JOURNAL   J Cell Biochem 116 (6), 1113-1120 (2015)
   PUBMED   25536374
  REMARK    GeneRIF: results demonstrate that NFIL3 is an important negative
            transcription factor, which through binding to the promoter of
            IGF2R, suppresses the apoptosis induced by IGF2R signaling in H9c2
            cardiomyoblast cells under hypoxic conditions.
REFERENCE   4  (bases 1 to 1990)
  AUTHORS   van der Kallen,L.R., Eggers,R., Ehlert,E.M., Verhaagen,J.,
            Smit,A.B. and van Kesteren,R.E.
  TITLE     Genetic Deletion of the Transcriptional Repressor NFIL3 Enhances
            Axon Growth In Vitro but Not Axonal Repair In Vivo
  JOURNAL   PLoS One 10 (5), e0127163 (2015)
   PUBMED   25993115
  REMARK    GeneRIF: removal of NFIL3 in vivo does not recapitulate the
            regeneration-promoting effects that were previously observed in
            vitro.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1990)
  AUTHORS   Yamajuku,D., Shibata,Y., Kitazawa,M., Katakura,T., Urata,H.,
            Kojima,T., Takayasu,S., Nakata,O. and Hashimoto,S.
  TITLE     Cellular DBP and E4BP4 proteins are critical for determining the
            period length of the circadian oscillator
  JOURNAL   FEBS Lett 585 (14), 2217-2222 (2011)
   PUBMED   21635892
  REMARK    GeneRIF: Data show that knockdown of DBP, D-box positive regulator,
            led to a short-period phenotype, and overexpression of DBP produced
            a long-period rhythm, while knockdown and overexpression of E4BP4,
            D-box negative regulator, had the opposite effect of DBP.
REFERENCE   6  (bases 1 to 1990)
  AUTHORS   Kong,S.L., Chui,P., Lim,B. and Salto-Tellez,M.
  TITLE     Elucidating the molecular physiopathology of acute respiratory
            distress syndrome in severe acute respiratory syndrome patients
  JOURNAL   Virus Res 145 (2), 260-269 (2009)
   PUBMED   19635508
REFERENCE   7  (bases 1 to 1990)
  AUTHORS   Junghans,D., Chauvet,S., Buhler,E., Dudley,K., Sykes,T. and
            Henderson,C.E.
  TITLE     The CES-2-related transcription factor E4BP4 is an intrinsic
            regulator of motoneuron growth and survival
  JOURNAL   Development 131 (18), 4425-4434 (2004)
   PUBMED   15306565
  REMARK    GeneRIF: Pathways regulated by E4BP4 are of potential interest both
            for understanding neuromuscular development and for promoting
            neuronal survival and regeneration in pathological situations
REFERENCE   8  (bases 1 to 1990)
  AUTHORS   Newman,J.R. and Keating,A.E.
  TITLE     Comprehensive identification of human bZIP interactions with
            coiled-coil arrays
  JOURNAL   Science 300 (5628), 2097-2101 (2003)
   PUBMED   12805554
REFERENCE   9  (bases 1 to 1990)
  AUTHORS   Nishimura,Y. and Tanaka,T.
  TITLE     Calcium-dependent activation of nuclear factor regulated by
            interleukin 3/adenovirus E4 promoter-binding protein gene
            expression by calcineurin/nuclear factor of activated T cells and
            calcium/calmodulin-dependent protein kinase signaling
  JOURNAL   J Biol Chem 276 (23), 19921-19928 (2001)
   PUBMED   11262393
REFERENCE   10 (bases 1 to 1990)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC072527.1.
            
            On Jun 13, 2004 this sequence version replaced NM_053727.1.
            
            Summary: The protein encoded by this gene is a transcriptional
            regulator that binds as a homodimer to activating transcription
            factor (ATF) sites in many cellular and viral promoters. The
            encoded protein represses Per1 and Per2 expression and therefore
            plays a role in the regulation of circadian rhythm. [provided by
            RefSeq, Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072527.1, CK364644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1990
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1990
                     /gene="Nfil3"
                     /gene_synonym="E4BP4"
                     /note="nuclear factor, interleukin 3 regulated"
                     /db_xref="GeneID:114519"
                     /db_xref="RGD:620972"
     exon            1..131
                     /gene="Nfil3"
                     /gene_synonym="E4BP4"
                     /inference="alignment:Splign:2.1.0"
     exon            132..1961
                     /gene="Nfil3"
                     /gene_synonym="E4BP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1679
                     /gene="Nfil3"
                     /gene_synonym="E4BP4"
                     /note="E4 promoter-binding protein 4"
                     /codon_start=1
                     /product="nuclear factor interleukin-3-regulated protein"
                     /protein_id="NP_446179.2"
                     /db_xref="GeneID:114519"
                     /db_xref="RGD:620972"
                     /translation="MQLRKMQAIKKEPASLDPTGSSDKMLLLNSALAEVAEDLASGED
                     LLLNEGSMGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLE
                     NKLIALGEENATLKAELLSLKLKFGLISSTVYAQEIQKLSNSTAVYFQDYQTSKAAVS
                     SYVDEHEPAMVAGSCISVIKHSPQSSLSDVSEVSSVEHTQESPAQGGCRSPENKFPVI
                     KQEPVELESFARESREERGAYSASIYQSYMGSSFSTYSHSPPLLQVHGSTSNSPRTSE
                     ADEGVVGKSSDGEDEQQVPKGPIHSPVELQRVHATVVKVPEVNPSALPHKLRIKAKAM
                     QVKVEALDSEFEGMQKLSSPADALAKRHFDLEKHGASGTAHSSLPPFSVQVTNIQDWS
                     LRSEHWHHKELGGKTQGTFKTGVVEVKDSGYKVSEAENLYLKQGVANLSAEVVSLKRF
                     IATQPISASDSR"
ORIGIN      
        1 cacgaatgtg gtggaggctc agtgtggact gccccccggg aatgaagaca ggcatcagat
       61 ttcaaaattc agtcgaaaga acagcttcgt gggtcacagc catccgttcg ttcctccgct
      121 ggcaaccttg gataacccat aaaaggctcc tgacaggttc accctctgcc ggacagcaga
      181 aggaatattg atggattcga gaagctgaag cccttacaac ctgaaagaag actggggaag
      241 tgattcgtct cctcctccat cgggtctgta ggacggggag gtcctttctg atgcagctga
      301 gaaaaatgca ggccatcaaa aaggagcctg catccctgga tcctaccggc agctcagaca
      361 agatgttgct gctgaactct gccttagctg aggtggctga ggacctagcc tcaggggaag
      421 atctgctcct gaatgaaggg agcatgggga aaaacaagtc ctctgcctgt cggagaaaac
      481 gggaattcat cccggatgag aagaaggacg ccatgtattg ggagaaacgg cggaaaaaca
      541 acgaggctgc caaaaggtct cgggagaagc gtcgcctcaa tgacctggtt ctggagaaca
      601 agctgatcgc cctgggagaa gaaaatgcca ctttaaaagc tgagctgctc tccctgaaat
      661 taaagtttgg cttaattagc tccacggtgt acgcccaaga aatccagaaa ctcagtaatt
      721 ccacagctgt gtattttcag gactaccaga catccaaggc tgccgtgagc tcttacgtgg
      781 acgagcatga gcctgcgatg gtagccggaa gttgcatctc tgtcatcaag cactctcctc
      841 agagctcgct ctcggatgtg tctgaggtgt cctctgtgga gcacacacag gaaagccccg
      901 cacagggagg ctgccggagc cctgagaaca agttccctgt gatcaagcag gagcccgtgg
      961 agttggagag ctttgccagg gagtccagag aggagcgggg tgcctattcc gcctccatct
     1021 accagagcta catgggtagc tctttctcca cctactccca ctcccctccc ctcctgcagg
     1081 tccacggctc caccagcaac tccccgagaa cctcggaggc cgacgagggt gtggtgggca
     1141 agtcttctga tggggaagac gagcagcagg tccccaaagg ccccatccat tctccagtgg
     1201 agctgcagcg ggtgcacgcc acggtggtga aggttccgga agtgaaccct tccgccttac
     1261 cgcacaagct ccggattaaa gccaaggcca tgcaggtcaa agtggaagct ttggacagtg
     1321 agttcgaagg catgcagaaa ctctcttcac cggcagatgc gctagccaaa agacattttg
     1381 acctggagaa gcatggcgct tcgggtacgg cccattcctc cctccctcct ttctcggtgc
     1441 aggtgacgaa cattcaagat tggtccctca gatcggaaca ctggcatcac aaagaactgg
     1501 gcggcaaaac tcagggtacc ttcaaaacgg gtgtggtgga agtcaaagac agtggctata
     1561 aggtttccga ggctgagaat ttgtatttga agcagggggt ggcaaactta tccgcagagg
     1621 tggtctcgct caagagattc atagccacac agcctatctc ggcttcggac tccaggtaaa
     1681 tggctactga ctgagctatg cgtggaagag gatgctcttg gtaccatact gaatttccca
     1741 ctggacctct aaagtcattt cactgtagtg tgcacaacgg tgtctgtctg gtgtccttgt
     1801 gtacacaacg ctgaagactt gatgccctca ctctgcctgg cgtgtagtca gatagccctt
     1861 ccctccccac cccccagagg ctgtacatac cgaacgttat ttttgctcta tgataaagtg
     1921 tgtacgttgc cagtttcaat aaaggattgg tggcaaacac aaaaaaaaaa aaaaaaaaaa
     1981 aaaaaaaaaa
//
