LOCUS       NM_012988               2200 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus nuclear factor I/A (Nfia), mRNA.
ACCESSION   NM_012988 XM_346745
VERSION     NM_012988.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2200)
  AUTHORS   Ding,B., Wang,W., Selvakumar,T., Xi,H.S., Zhu,H., Chow,C.W.,
            Horton,J.D., Gronostajski,R.M. and Kilpatrick,D.L.
  TITLE     Temporal regulation of nuclear factor one occupancy by
            calcineurin/NFAT governs a voltage-sensitive developmental switch
            in late maturing neurons
  JOURNAL   J Neurosci 33 (7), 2860-2872 (2013)
   PUBMED   23407945
REFERENCE   2  (bases 1 to 2200)
  AUTHORS   Riffel,A.K., Schuenemann,E. and Vyhlidal,C.A.
  TITLE     Regulation of the CYP3A4 and CYP3A7 promoters by members of the
            nuclear factor I transcription factor family
  JOURNAL   Mol Pharmacol 76 (5), 1104-1114 (2009)
   PUBMED   19706729
REFERENCE   3  (bases 1 to 2200)
  AUTHORS   Royland,J.E. and Kodavanti,P.R.
  TITLE     Gene expression profiles following exposure to a developmental
            neurotoxicant, Aroclor 1254: pathway analysis for possible mode(s)
            of action
  JOURNAL   Toxicol Appl Pharmacol 231 (2), 179-196 (2008)
   PUBMED   18602130
REFERENCE   4  (bases 1 to 2200)
  AUTHORS   Lu,W., Quintero-Rivera,F., Fan,Y., Alkuraya,F.S., Donovan,D.J.,
            Xi,Q., Turbe-Doan,A., Li,Q.G., Campbell,C.G., Shanske,A.L.,
            Sherr,E.H., Ahmad,A., Peters,R., Rilliet,B., Parvex,P.,
            Bassuk,A.G., Harris,D.J., Ferguson,H., Kelly,C., Walsh,C.A.,
            Gronostajski,R.M., Devriendt,K., Higgins,A., Ligon,A.H.,
            Quade,B.J., Morton,C.C., Gusella,J.F. and Maas,R.L.
  TITLE     NFIA haploinsufficiency is associated with a CNS malformation
            syndrome and urinary tract defects
  JOURNAL   PLoS Genet 3 (5), e80 (2007)
   PUBMED   17530927
REFERENCE   5  (bases 1 to 2200)
  AUTHORS   Lin,Y.L., Wang,Y.H. and Lee,H.J.
  TITLE     Transcriptional regulation of the human TR2 orphan receptor gene by
            nuclear factor 1-A
  JOURNAL   Biochem Biophys Res Commun 350 (2), 430-436 (2006)
   PUBMED   17010934
REFERENCE   6  (bases 1 to 2200)
  AUTHORS   Chaudhry,A.Z., Lyons,G.E. and Gronostajski,R.M.
  TITLE     Expression patterns of the four nuclear factor I genes during mouse
            embryogenesis indicate a potential role in development
  JOURNAL   Dev Dyn 208 (3), 313-325 (1997)
   PUBMED   9056636
REFERENCE   7  (bases 1 to 2200)
  AUTHORS   Osada,S., Daimon,S., Ikeda,T., Nishihara,T., Yano,K., Yamasaki,M.
            and Imagawa,M.
  TITLE     Nuclear factor 1 family proteins bind to the silencer element in
            the rat glutathione transferase P gene
  JOURNAL   J Biochem 121 (2), 355-363 (1997)
   PUBMED   9089412
REFERENCE   8  (bases 1 to 2200)
  AUTHORS   Monaci,P., Nuzzo,M., Stampfli,S., Tollervey,D., De Simone,V. and
            Nicosia,A.
  TITLE     A complex interplay of positive and negative elements is
            responsible for the different transcriptional activity of liver NF1
            variants
  JOURNAL   Mol Biol Rep 21 (3), 147-158 (1995)
   PUBMED   8832903
REFERENCE   9  (bases 1 to 2200)
  AUTHORS   Ang,S.L., Wierda,A., Wong,D., Stevens,K.A., Cascio,S., Rossant,J.
            and Zaret,K.S.
  TITLE     The formation and maintenance of the definitive endoderm lineage in
            the mouse: involvement of HNF3/forkhead proteins
  JOURNAL   Development 119 (4), 1301-1315 (1993)
   PUBMED   8306889
REFERENCE   10 (bases 1 to 2200)
  AUTHORS   Paonessa,G., Gounari,F., Frank,R. and Cortese,R.
  TITLE     Purification of a NF1-like DNA-binding protein from rat liver and
            cloning of the corresponding cDNA
  JOURNAL   EMBO J 7 (10), 3115-3123 (1988)
   PUBMED   3053160
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D78017.1.
            
            [WARNING] On Mar 17, 2025 this sequence was replaced by
            NM_012988.3.
            
            On Apr 12, 2007 this sequence version replaced NM_012988.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D78017.1, AB060652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..2200
                     /gene="Nfia"
                     /note="nuclear factor I/A"
                     /db_xref="GeneID:25492"
                     /db_xref="RGD:3170"
     exon            1..182
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1685
                     /gene="Nfia"
                     /note="CTF; NF1-A; NFI-A; NF-I/A; nuclear factor 1/A;
                     TGGCA-binding protein; CCAAT-box-binding transcription
                     factor"
                     /codon_start=1
                     /product="nuclear factor 1 A-type"
                     /protein_id="NP_037120.1"
                     /db_xref="GeneID:25492"
                     /db_xref="RGD:3170"
                     /translation="MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKH
                     EKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPC
                     CVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPG
                     LCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFV
                     TSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTK
                     RLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSP
                     SPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHP
                     QETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVP
                     LPMPDTKPPTTSTEGGAASPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQTQSWYL
                     G"
     exon            183..714
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            715..780
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            781..855
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            856..973
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1101
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1230
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1409
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1575
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1667
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..2200
                     /gene="Nfia"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgagttgga aatgtgaacg caagaagcag gcttgatttt tttttcctcc cccctctcct
       61 agctctctcc tcctctctct ccctctcgca cccacactca cgcacacctc cagcccgcac
      121 acagacgtgc acgcaccccc cgccgcccgg cagttatgta ttctccgctc tgtctcaccc
      181 aggatgagtt tcatcctttc attgaagcac ttctgcccca tgtccgcgcc ttcgcctaca
      241 catggttcaa cctgcaggcc cgaaagcgga aatacttcaa aaagcatgag aagcgcatgt
      301 cgaaagaaga ggagagggct gtgaaggatg aactgctaag tgagaagcct gaggtcaagc
      361 aaaagtgggc ttcccgactt ctggccaagt tacggaaaga tatccgaccc gagtaccgag
      421 aggattttgt tcttacagtt acagggaaaa aacctccatg ctgtgttctt tccaacccag
      481 accagaaagg caagatgcgg agaattgact gcctccgcca ggcagataaa gtatggaggt
      541 tggacctcgt catggtgatc ttgttcaaag gtattccgct ggaaagtact gatggtgaac
      601 gccttgtgaa gtccccacag tgctcgaatc cagggctctg tgtccagccc catcacatag
      661 gggtttctgt aaaggaactc gatttatatt tggcatactt tgtacatgca gcagattcaa
      721 gtcaatctga aagtcccagc caaccaagtg atgctgacat taaggaccag ccagaaaatg
      781 gacatttggg cttccaggac agcttcgtca catcaggtgt tttcagtgtg actgagctag
      841 taagagtgtc acaaacacca atagctgcag gaaccggccc caatttttct ctctctgatt
      901 tggaaagttc ctcatactac agcatgagtc caggagcaat gaggaggtct ctacccagca
      961 catcctctac cagctctacc aagcgcctca agtctgtgga ggacgaaatg gacagtcctg
     1021 gtgaagaacc attttacaca ggccaagggc gctccccagg gagtggcagc cagtccagcg
     1081 gatggcatga agtagagcca ggcatgccat ctccaaccac tctgaagaag tctgagaagt
     1141 ctggtttcag cagcccctcc ccttcgcaga cctcctccct cggaacagca ttcacacagc
     1201 atcaccgacc tgtcataaca ggaccgagag caagcccaca tgcgacgcca tcgactctcc
     1261 actttccaac gtcacctatc atccagcagc ctgggcctta tttctcacac ccagccatcc
     1321 gttaccaccc tcaggagacg ctgaaggagt ttgtccaact tgtctgcccc gatgctggtc
     1381 agcaagctgg acaggtgggg ttcctcaatc ccaatggaag cagtcaaggc aaggtgcaca
     1441 acccattcct ccccacccca atgttgccgc cgccaccgcc accaccgatg gccaggcctg
     1501 tgcctctgcc catgccagac accaagcctc caaccacatc aacagaaggc ggtgcagcct
     1561 cccccacctc accgacctac tcgacaccca gcacctcccc cgcaaaccga ttcgtcagtg
     1621 ttggaccacg ggatccaagc tttgtaaata tccctcaaca gacacagtcc tggtacctgg
     1681 gataaaagtt gcagcgtccc accatcctcc agacagacca cctgacccct tctcaactct
     1741 gtaacatgga cgcaacctca acccggcgca gttacaactt cactgtcagt ggaaggggag
     1801 agacaccaac tcgaatcaac ttgtacatgg aaacagcgaa cgtcgtggtc aaacagcaaa
     1861 ggccataact tttcgggatt cttttttttt ttttaatact ttagggactg tcgtaatttc
     1921 tcatatggtg ctggaaatgg ttgggctgtg tgacatttga agtgttccag tggtggtgtg
     1981 agcagtaggt gaagcggctg gtaggggatg agccttgctc acgaacttcc tgttgtaaca
     2041 cttgtgagcc tggccttttc acagtatttc aagaatttgc ccgcgcaggt gtgtgaccct
     2101 cccggagcac ttggagacac ctggagaatg aaatctttcg tagtagctaa gatctgtgat
     2161 ctgtaactta caggacactc aaagggcaat gttttttggg
//
