LOCUS       NM_001399173            2373 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus NFE2 like bZIP transcription factor 2 (Nfe2l2),
            transcript variant 1, mRNA.
ACCESSION   NM_001399173 XM_006234396
VERSION     NM_001399173.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2373)
  AUTHORS   Dong,J., Gong,Z., Bi,H., Yang,J., Wang,B., Du,K., Zhang,C. and
            Chen,L.
  TITLE     BMSC-derived exosomal miR-219-5p alleviates ferroptosis in neuronal
            cells caused by spinal cord injury via the UBE2Z/NRF2 pathway
  JOURNAL   Neuroscience 556, 73-85 (2024)
   PUBMED   39084457
  REMARK    GeneRIF: BMSC-derived exosomal miR-219-5p alleviates ferroptosis in
            neuronal cells caused by spinal cord injury via the UBE2Z/NRF2
            pathway.
REFERENCE   2  (bases 1 to 2373)
  AUTHORS   Yuan,X.K., Ni,P.S., Yan,Z.H., Yu,Z., Wang,Z.Z., Zhang,C.K., Li,F.H.
            and Yu,X.M.
  TITLE     Effects of Life-Long Exercise on Age-Related Inflammation,
            Apoptosis, Oxidative Stress, Ferroptosis Markers, and NRF2/KAEP
            1/Klotho Pathway in Rat Kidneys
  JOURNAL   Physiol Res 73 (4), 577-591 (2024)
   PUBMED   39264079
  REMARK    GeneRIF: Effects of Life-Long Exercise on Age-Related Inflammation,
            Apoptosis, Oxidative Stress, Ferroptosis Markers, and NRF2/KAEP
            1/Klotho Pathway in Rat Kidneys.
REFERENCE   3  (bases 1 to 2373)
  AUTHORS   Yu,H., Liu,Q., Xie,M., Fan,J., Luo,J., Huang,J. and Chen,L.
  TITLE     Nesfatin-1 inhibits cerebral aneurysms by activating Nrf2 and
            inhibiting NF-kappaB signaling
  JOURNAL   CNS Neurosci Ther 30 (8), e14864 (2024)
   PUBMED   39097921
  REMARK    GeneRIF: Nesfatin-1 inhibits cerebral aneurysms by activating Nrf2
            and inhibiting NF-kappaB signaling.
REFERENCE   4  (bases 1 to 2373)
  AUTHORS   Ning,S., Guo,X., Zhu,Y., Li,C., Li,R., Meng,Y., Luo,W., Lu,D. and
            Yin,Y.
  TITLE     The mechanism of NRF2 regulating cell proliferation and mesenchymal
            transformation in pulmonary hypertension
  JOURNAL   Int J Biol Macromol 275 (Pt 1), 133514 (2024)
   PUBMED   38944076
  REMARK    GeneRIF: The mechanism of NRF2 regulating cell proliferation and
            mesenchymal transformation in pulmonary hypertension.
REFERENCE   5  (bases 1 to 2373)
  AUTHORS   Chen,D., Tang,Q., Song,W. and He,Y.
  TITLE     Platelet-derived exosomes alleviate tendon stem/progenitor cell
            senescence and ferroptosis by regulating AMPK/Nrf2/GPX4 signaling
            and improve tendon-bone junction regeneration in rats
  JOURNAL   J Orthop Surg Res 19 (1), 382 (2024)
   PUBMED   38943181
  REMARK    GeneRIF: Platelet-derived exosomes alleviate tendon stem/progenitor
            cell senescence and ferroptosis by regulating AMPK/Nrf2/GPX4
            signaling and improve tendon-bone junction regeneration in rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2373)
  AUTHORS   Huang,H.C., Nguyen,T. and Pickett,C.B.
  TITLE     Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates
            antioxidant response element-mediated transcription
  JOURNAL   J Biol Chem 277 (45), 42769-42774 (2002)
   PUBMED   12198130
  REMARK    GeneRIF: PKC-catalyzed phosphorylation of Nrf2 at Ser-40 is a
            critical signaling event leading to ARE-mediated cellular
            antioxidant response
REFERENCE   7  (bases 1 to 2373)
  AUTHORS   Gong,P., Stewart,D., Hu,B., Vinson,C. and Alam,J.
  TITLE     Multiple basic-leucine zipper proteins regulate induction of the
            mouse heme oxygenase-1 gene by arsenite
  JOURNAL   Arch Biochem Biophys 405 (2), 265-274 (2002)
   PUBMED   12220541
REFERENCE   8  (bases 1 to 2373)
  AUTHORS   Wang,Y., Devereux,W., Stewart,T.M. and Casero,R.A. Jr.
  TITLE     Characterization of the interaction between the transcription
            factors human polyamine modulated factor (PMF-1) and NF-E2-related
            factor 2 (Nrf-2) in the transcriptional regulation of the
            spermidine/spermine N1-acetyltransferase (SSAT) gene
  JOURNAL   Biochem J 355 (Pt 1), 45-49 (2001)
   PUBMED   11256947
REFERENCE   9  (bases 1 to 2373)
  AUTHORS   Kobayashi,A., Ito,E., Toki,T., Kogame,K., Takahashi,S.,
            Igarashi,K., Hayashi,N. and Yamamoto,M.
  TITLE     Molecular cloning and functional characterization of a new Cap'n'
            collar family transcription factor Nrf3
  JOURNAL   J Biol Chem 274 (10), 6443-6452 (1999)
   PUBMED   10037736
REFERENCE   10 (bases 1 to 2373)
  AUTHORS   Itoh,K., Chiba,T., Takahashi,S., Ishii,T., Igarashi,K., Katoh,Y.,
            Oyake,T., Hayashi,N., Satoh,K., Hatayama,I., Yamamoto,M. and
            Nabeshima,Y.
  TITLE     An Nrf2/small Maf heterodimer mediates the induction of phase II
            detoxifying enzyme genes through antioxidant response elements
  JOURNAL   Biochem Biophys Res Commun 236 (2), 313-322 (1997)
   PUBMED   9240432
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 4, 2022 this sequence version replaced XM_006234396.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061724.1, SRR26360181.2640337.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000003.1  81028847-81028999   c
            154-420             JAXUCZ010000003.1  81005014-81005280   c
            421-510             JAXUCZ010000003.1  81004295-81004384   c
            511-699             JAXUCZ010000003.1  81003544-81003732   c
            700-2373            JAXUCZ010000003.1  81001529-81003202   c
FEATURES             Location/Qualifiers
     source          1..2373
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23"
     gene            1..2373
                     /gene="Nfe2l2"
                     /note="NFE2 like bZIP transcription factor 2"
                     /db_xref="GeneID:83619"
                     /db_xref="RGD:620360"
     exon            1..153
                     /gene="Nfe2l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1923
                     /gene="Nfe2l2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear factor erythroid 2-related factor 2; NFE2-related
                     factor 2; nuclear factor, erythroid 2-like 2; nrf2;
                     NF-E2-related factor 2; nuclear factor, erythroid derived
                     2, like 2"
                     /codon_start=1
                     /product="nuclear factor erythroid 2-related factor 2
                     isoform 1"
                     /protein_id="NP_001386102.1"
                     /db_xref="GeneID:83619"
                     /db_xref="RGD:620360"
                     /translation="MMDLELPPPGLQSQQDMDLIDILWRQDIDLGVSREVFDFSQRQK
                     DYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQTDTSGSVSY
                     SQVAHIPKQDALYFEDCMQLLAETFPFVDDHEVSSPTFQSLALDIPSHVESSVFTTPD
                     QAQSLDSSLETAMTDLSSIQQDMEQVWQELFSIPELQCLNTENKQQAETTTVPSPEAT
                     LTEMDSNYHFYSSIPSLEKEVDSCSPHFLHGFEDSFSSILSTDDASQLNSLDSNPTLN
                     TDFGDEFYSAFLAEPSGGGSMPSSAAISQSLSELLGGPIEGCDLSLCKAFNQKHTEGT
                     VEFNDSDSGISLNTSPSRASPEHSVESSIYGDPPPGFSDSEMEELDSAPGSVKQNGPK
                     AQPTHSSGDTVQPLSPAQGHSAAVHESQCENTTKKEVPVSPGHQKVPFTKDKHSSRLE
                     AHLTRDELRAKALHIPFPVEKIINLPVDDFNEMMSKEQFNEAQLALIRDIRRRGKNKV
                     AAQNCRKRKLENIVELEQDLGHLKDEREKLLREKGENDRNLHLLKRKLSTLYLEVFSM
                     LRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDTKKN"
     exon            154..420
                     /gene="Nfe2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..510
                     /gene="Nfe2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            511..699
                     /gene="Nfe2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            700..2373
                     /gene="Nfe2l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctatctg ctggttcccc actgctccga ctagccattg acgccgcctc acctctgctg
       61 ccagtagcct cgccgtcggg gagccctagc gcagcgtccg ccctcagcat gatggacttg
      121 gaattgccac cgccaggact acagtcccag caggacatgg atttgattga catcctttgg
      181 aggcaagaca tagatcttgg ggtaagtcga gaagtgtttg actttagtca gcgacagaag
      241 gattatgagc tggaaaaaca gaaaaaactc gaaaaggaga gacaagagca actccagaag
      301 gaacaggaga aggccttttt cgctcagtta caactggatg aagagaccgg agaattcctc
      361 ccaattcagc cagcccagca catccagaca gacaccagtg gatctgtcag ctactcccag
      421 gttgcccaca ttcccaaaca agatgccttg tactttgaag actgtatgca gcttttggca
      481 gagacattcc catttgtaga tgaccatgag gtttcttcac ctacatttca gtcgcttgcc
      541 ctggatattc ccagccacgt tgagagctca gtcttcacca cccctgatca ggctcagtca
      601 ctcgatagct ctctggagac ggccatgact gatttaagca gcatacagca ggacatggag
      661 caagtttggc aggagctatt ttccattccc gagttacagt gtcttaatac ggaaaacaag
      721 cagcaggctg agactaccac tgtccccagc ccagaggcca cactgacaga gatggacagc
      781 aattaccatt tttactcatc gatcccctca ctggaaaaag aagtggacag ctgtagtcca
      841 catttccttc atggttttga ggattctttt agtagcatcc tctccacgga tgatgccagc
      901 cagctgaact ccttagactc aaatcccacc ttgaacacag atttcggtga tgaattttac
      961 tctgctttcc tagcagagcc cagtggcggt ggcagcatgc cttcctctgc tgccattagt
     1021 cagtcgctct ctgaacttct gggcgggccc attgagggct gtgatctgtc cctgtgtaaa
     1081 gctttcaacc agaagcacac tgaaggcacg gtggagttca atgactctga ctccggcatt
     1141 tcgctgaaca caagtcccag ccgagcatcc ccagagcact ctgtggagtc ttccatttac
     1201 ggagacccac cgcctgggtt cagtgactcg gaaatggaag agctagacag tgcccctgga
     1261 agtgtcaaac agaatggacc taaagcacag ccaacacatt cttctgggga tacagtacag
     1321 cctctgtcgc cagctcaagg gcacagtgct gctgtgcacg aatcccagtg tgaaaataca
     1381 acaaaaaaag aagtacctgt gagtcctggt catcaaaaag tcccattcac aaaagacaaa
     1441 cattcaagcc gattagaggc tcatctcaca agagatgagc ttagggcaaa agctctccat
     1501 attccattcc ctgttgaaaa aatcattaat ctccctgttg atgacttcaa tgaaatgatg
     1561 tccaaggagc aattcaacga agctcagctt gcattaattc gagatatacg caggagaggg
     1621 aagaataaag ttgccgctca gaactgtagg aaaaggaagc tggaaaacat tgtagagctg
     1681 gagcaagact tgggccactt aaaagacgag agagaaaaac tactcagaga aaagggagaa
     1741 aacgacagaa acctccatct tctgaaaaga aaactcagca ctttgtatct ggaagtcttc
     1801 agcatgttac gtgatgagga tgggaaacct tactctccca gtgagtactc tctgcagcag
     1861 accagagatg gcaacgtgtt ccttgttccc aagagcaaga agccagatac aaagaaaaac
     1921 taggttcggg aggatggagc cttttctgag ctagtgtttg ttttgtacgg ctaaaacttc
     1981 ctactgtgat gtgaaatgca gaaacacttt ataagtaact atgcagaatt atagccaaag
     2041 ctagtgtaga aataatatga aactttacaa agcattaaag tctcaatgtt gaatcagttt
     2101 cattttaact ctcaagttaa tttcttgggc accatttggg ctagtttctg tgtaagtgta
     2161 aatactacag aacttattta tactgttctc atttgttaca gtcatagact tatatgacat
     2221 ctggctaaaa gcaaactatt gaaaactaac caaaccacta tactttttta tatactgtat
     2281 gaacaagaaa tgacattttt atattaaatt gtttagctct gataaaaatt aaaaggagct
     2341 agcactaata aaggaatatc atgacttaaa tta
//
