LOCUS       NM_001108293            4609 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus NFE2 like bZIP transcription factor 1 (Nfe2l1),
            transcript variant 1, mRNA.
ACCESSION   NM_001108293 XM_001081311 XM_006220824 XM_006247236 XM_340886
VERSION     NM_001108293.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4609)
  AUTHORS   Bartelt,A., Widenmaier,S.B., Schlein,C., Johann,K.,
            Goncalves,R.L.S., Eguchi,K., Fischer,A.W., Parlakgul,G.,
            Snyder,N.A., Nguyen,T.B., Bruns,O.T., Franke,D., Bawendi,M.G.,
            Lynes,M.D., Leiria,L.O., Tseng,Y.H., Inouye,K.E., Arruda,A.P. and
            Hotamisligil,G.S.
  TITLE     Brown adipose tissue thermogenic adaptation requires Nrf1-mediated
            proteasomal activity
  JOURNAL   Nat Med 24 (3), 292-303 (2018)
   PUBMED   29400713
REFERENCE   2  (bases 1 to 4609)
  AUTHORS   Widenmaier,S.B., Snyder,N.A., Nguyen,T.B., Arduini,A., Lee,G.Y.,
            Arruda,A.P., Saksi,J., Bartelt,A. and Hotamisligil,G.S.
  TITLE     NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol
            Homeostasis
  JOURNAL   Cell 171 (5), 1094-1109 (2017)
   PUBMED   29149604
REFERENCE   3  (bases 1 to 4609)
  AUTHORS   Taniguchi,H., Okamuro,S., Koji,M., Waku,T., Kubo,K., Hatanaka,A.,
            Sun,Y., Chowdhury,A.M.M.A., Fukamizu,A. and Kobayashi,A.
  TITLE     Possible roles of the transcription factor Nrf1 (NFE2L1) in neural
            homeostasis by regulating the gene expression of deubiquitinating
            enzymes
  JOURNAL   Biochem Biophys Res Commun 484 (1), 176-183 (2017)
   PUBMED   28088524
REFERENCE   4  (bases 1 to 4609)
  AUTHORS   Baird,L., Tsujita,T., Kobayashi,E.H., Funayama,R., Nagashima,T.,
            Nakayama,K. and Yamamoto,M.
  TITLE     A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis
            through Transcriptional Integration of Proteostatic Stress Response
            Pathways
  JOURNAL   Mol Cell Biol 37 (4), e00439-16 (2017)
   PUBMED   27920251
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4609)
  AUTHORS   Koizumi,S., Irie,T., Hirayama,S., Sakurai,Y., Yashiroda,H.,
            Naguro,I., Ichijo,H., Hamazaki,J. and Murata,S.
  TITLE     The aspartyl protease DDI2 activates Nrf1 to compensate for
            proteasome dysfunction
  JOURNAL   Elife 5, e18357 (2016)
   PUBMED   27528193
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4609)
  AUTHORS   Kwong,M., Kan,Y.W. and Chan,J.Y.
  TITLE     The CNC basic leucine zipper factor, Nrf1, is essential for cell
            survival in response to oxidative stress-inducing agents. Role for
            Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts
  JOURNAL   J Biol Chem 274 (52), 37491-37498 (1999)
   PUBMED   10601325
REFERENCE   7  (bases 1 to 4609)
  AUTHORS   Kobayashi,A., Ito,E., Toki,T., Kogame,K., Takahashi,S.,
            Igarashi,K., Hayashi,N. and Yamamoto,M.
  TITLE     Molecular cloning and functional characterization of a new Cap'n'
            collar family transcription factor Nrf3
  JOURNAL   J Biol Chem 274 (10), 6443-6452 (1999)
   PUBMED   10037736
REFERENCE   8  (bases 1 to 4609)
  AUTHORS   Chan,J.Y., Kwong,M., Lu,R., Chang,J., Wang,B., Yen,T.S. and
            Kan,Y.W.
  TITLE     Targeted disruption of the ubiquitous CNC-bZIP transcription
            factor, Nrf-1, results in anemia and embryonic lethality in mice
  JOURNAL   EMBO J 17 (6), 1779-1787 (1998)
   PUBMED   9501099
REFERENCE   9  (bases 1 to 4609)
  AUTHORS   Johnsen,O., Murphy,P., Prydz,H. and Kolsto,A.B.
  TITLE     Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG:
            binding-site selection and regulation of transcription
  JOURNAL   Nucleic Acids Res 26 (2), 512-520 (1998)
   PUBMED   9421508
REFERENCE   10 (bases 1 to 4609)
  AUTHORS   Johnsen,O., Skammelsrud,N., Luna,L., Nishizawa,M., Prydz,H. and
            Kolsto,A.B.
  TITLE     Small Maf proteins interact with the human transcription factor
            TCF11/Nrf1/LCR-F1
  JOURNAL   Nucleic Acids Res 24 (21), 4289-4297 (1996)
   PUBMED   8932385
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1 and CK839329.1.
            
            On or before Aug 27, 2019 this sequence version replaced
            XM_006247236.3, XM_006220824.3, NM_001108293.1.
            
            Summary: This gene encodes a protein that is involved in globin
            gene expression in erythrocytes. Confusion has occurred in
            bibliographic databases for genes in the 'nuclear respiratory
            factor' and 'nuclear factor (erythroid-derived 2)' families due to
            a shared symbol or alias pattern of NRF*. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This transcript is based on
            transcript alignments from orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.45181.1,
                                           SRR26360194.1071450.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676789, SAMN16676809
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               JAXUCZ010000010.1  82309254-82309375   c
            123-1133            JAXUCZ010000010.1  82306538-82307548   c
            1134-1349           JAXUCZ010000010.1  82301459-82301674   c
            1350-1508           JAXUCZ010000010.1  82300596-82300754   c
            1509-4591           JAXUCZ010000010.1  82296825-82299907   c
            4592-4609           CK839329.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..4609
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..4609
                     /gene="Nfe2l1"
                     /note="NFE2 like bZIP transcription factor 1"
                     /db_xref="GeneID:360610"
                     /db_xref="RGD:1311972"
     exon            1..122
                     /gene="Nfe2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            123..1133
                     /gene="Nfe2l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             624..2843
                     /gene="Nfe2l1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear factor erythroid 2-related factor 1; nuclear
                     factor, erythroid derived 2,-like 1; endoplasmic reticulum
                     membrane sensor NFE2L1; nuclear factor, erythroid 2-like
                     1"
                     /codon_start=1
                     /product="endoplasmic reticulum membrane sensor NFE2L1
                     isoform 1"
                     /protein_id="NP_001101763.2"
                     /db_xref="GeneID:360610"
                     /db_xref="RGD:1311972"
                     /translation="MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLTSQLPPLREIIL
                     GPSSAYTQTQFHNLRNTLDGYGIHPKSIDLDNYFTARRLLSQVRALDRFQVPTTEVNA
                     WLVHRDPEGSVSGSQPNSGLALESSSGLQDVTVPDNGVRESEPEQGFSEDLEDLGAVA
                     PPVSGDLTKEDIDLIDILWRQDIDLGAGREVFDYSHRQKEQDVDKELQDGGEREDTWS
                     GEGAEALARDLLVDGETGESFPAQFPADVSSITEAVPSESESPALQNSLLSPLLTGTE
                     SPFDLEQQWQDLMSIMEMQAMEVNTSASEILYSAPPGDPLTTNYSLAPNTPINQNVSL
                     HQASLGGCSQDFSLFSPEVESLPVASSSTLLPLVPSNSTSLNSTFGSTNLAGLFFPSQ
                     LNGTANDTSGPELPDPLGGLLDEAMLDEISLMDLAIEEGFNPGQASQLEEEFDSDSGL
                     SLDSSHSPSSLSSSEGSSSSSSSSSSASSSASSSFSEEGAVGYSSDSETLDLEEAEGA
                     VGYQPEYSKFCRMSYQDPSQLSCLPYLEHVGHNHTYNMAPSALDSADLPPPSTLKKGS
                     KEKQADFLDKQMSRDEHRARAMKIPFTNDKIINLPVEEFNELLSKYQLSEAQLSLIRD
                     IRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLREKVEFLRSLRQMKQKVQ
                     SLYQEVFGRLRDENGRPYSPSQYALQYAGDGSVLLIPRTMADQQARRQERKPKDRRK"
     exon            1134..1349
                     /gene="Nfe2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1508
                     /gene="Nfe2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..4592
                     /gene="Nfe2l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccgaggct gggcgctcca ggccggccgg aggtggcggc ggcggcggcg gtggtggcga
       61 agctgggact tgggctgagg gcctgctgta gcagcagcgg catactgcga cctcagcagc
      121 ggggttctct ggaaaccccc ctggtaagtg cagaggaggc gggacactct gacccaagac
      181 aaagacctgt agctctggcc aaagaaaata gaccttagga aggagaagaa aaaaaaaaaa
      241 aaaaagggaa gaaagaaatc catcagctgt tcatgtgagc agcctgcagt ggatctccat
      301 agaggacaac taatgtgaat ggaaagtgac tgtgtatgga ctgtggagaa gtaagttgag
      361 agggccctga gtgcctggac tgggttagga acggctcgac tttgcgaggt gaggttgcaa
      421 gaagggaaaa gtgaatgtgg ctttggctcc actgggtgtg ctttcctctg gggccatcag
      481 gaagctcagc cctgtgttgt gccgggtggg gggtctcgca ctgaggaggg taacctgctg
      541 gctgcagtgg cagagcggtg gccttgattt gtcttgtgga agatttgaaa acaaaagagc
      601 ataaatattc tggtccttca gcaatgcttt ctctgaagaa atatttaacc gaaggacttc
      661 tccagttcac cattctgctg agtctgattg gggttcgggt ggacgtggat acttacctga
      721 cctcacagct cccccctctc cgggagatca tcctggggcc cagctctgcc tatacccaga
      781 cccagttcca caacctgagg aataccttgg acggctatgg tatccaccct aagagcatag
      841 acctggacaa ttacttcact gcccggaggc tccttagtca ggtgagggcc ctggataggt
      901 tccaggtgcc tactactgag gtaaatgctt ggctggttca ccgggacccg gaggggtctg
      961 tctctggcag ccagcccaac tcaggccttg ccctcgagag ttccagtggc ctccaagatg
     1021 tgacagtccc agacaacggg gtgagagaaa gcgaaccgga gcagggattc agtgaagatt
     1081 tggaggactt aggggccgta gcccctcctg tcagtggaga cttaaccaaa gaggatatag
     1141 atctgattga catcctttgg cgacaggata ttgatctggg ggctgggcgt gaggtttttg
     1201 actacagtca tcgccagaag gagcaagatg tggataagga actacaagat ggaggagagc
     1261 gagaggacac ctggtcaggc gagggcgcgg aagctctggc ccgagacctg ctagtagatg
     1321 gagagactgg agagagcttc cctgcacagt tcccagcgga cgtttccagc atcacagaag
     1381 cagtgcctag tgagagcgag tcccccgccc ttcagaacag ccttctatct cctcttctga
     1441 cggggacaga atcaccattt gatttggaac aacagtggca agatctcatg tccatcatgg
     1501 aaatgcaggc tatggaagtg aatacgtcag caagtgaaat tctgtacagt gcccctcctg
     1561 gagaccctct taccaccaac tacagccttg ctcccaacac tcctatcaat cagaatgtca
     1621 gcctgcatca ggcctccctg gggggctgca gtcaggactt ttccctcttc agccccgagg
     1681 tggagagcct gcctgtggcc agcagctcta cactgcttcc actcgtcccc agcaactcca
     1741 ccagtctcaa ctccaccttt ggctctacca acctagcagg gcttttcttt ccatcccagc
     1801 tcaatggcac cgccaatgat acatcaggcc ctgagctgcc tgatcccctt gggggcctgt
     1861 tagacgaggc catgctggat gagatcagcc tgatggacct ggccattgag gagggcttca
     1921 acccggggca ggcctcccag ctcgaggagg agttcgactc tgactctggc ctctccctgg
     1981 actccagcca tagcccttcc tctctgagca gctctgaagg gagctcttct tcctcttcct
     2041 cttcttcttc tgcttcctcc tctgcctctt cttccttctc tgaggagggt gctgttggtt
     2101 acagctctga ctctgagacc ctagatctag aagaggctga gggtgcagtg ggctaccagc
     2161 cagaatactc caagttctgc cgcatgagct atcaggatcc ttctcagctc tcttgccttc
     2221 cctacttaga gcatgtgggc cacaatcaca cgtacaatat ggcacccagt gcccttgact
     2281 ctgctgatct accaccaccc agcaccctca agaaaggtag caaggaaaag caggctgact
     2341 tcttggacaa gcagatgagc agagatgagc acagagcccg agccatgaag atcccattta
     2401 ccaatgacaa aatcatcaac ctgcctgtag aagaattcaa tgagctgctg tccaaatacc
     2461 agttgagcga ggcccagctg agcctcatca gggatatccg gcgccggggc aaaaacaaga
     2521 tggctgcaca gaactgccgc aagcgcaagt tggacaccat cctgaaccta gaacgtgatg
     2581 tggaggactt gcagcgagat aaggcccgat tgctccgaga aaaggtagag ttcctgcggt
     2641 ctctgcgaca gatgaagcag aaggtccaaa gcttatacca ggaggtgttt gggcggctgc
     2701 gggatgagaa tgggaggccc tactcaccca gtcagtatgc ccttcagtat gctggggatg
     2761 gcagtgtcct cctcattcct cgcacgatgg ctgaccagca ggcccggcga caggagagaa
     2821 agccaaagga ccggaggaag tgagcttggg gaggcagggg gtggacgctc actaagaccg
     2881 aaactggaga agggctgggc ctggacctaa tgttggggac ttaaatgcct tcttatccaa
     2941 tatatcttct cagatgggat gactgcgggt cagtgcaccg aagaggcggg cgcaggcgct
     3001 gtctggctta gctgccccac tgggagtggg cagggatgac cagactattt gggtgatggg
     3061 ggccccagcc catttccttt ctcctgaggg aaggtggttg gcatgctgga ggaagcagag
     3121 ctgtgtggag tggggcaggc agagggaaag gagagaaagt agtgggaagt ctcagtcctg
     3181 gacggagaaa aggaaggatc cctaaaatca aagcagtcag aaagaccagc gcgctgttga
     3241 gggctttggc cagcgctcga ggcagtgagt gcaggagact ccagtgggcc tgggttgagt
     3301 tggtaaggct ggtatggaga cacagacatg gtggggccac tgaagggctc tttagctgtt
     3361 tcttgaactc ttgcatccct gaagaggaag aaactctcgg atggcacctg taatatttca
     3421 gttactaaaa cgagacatgt agggcccaat acctccatgg ttaggcccaa ggagggcaga
     3481 gctgtaggaa gtgatgatga ggcctgtgtt gcagcagccc caatatcaag catgtcactc
     3541 actgccccac cacagccacc tcctccctag ccatcccaga gctgaggctc ccactgtcct
     3601 cagagagcct gcatggaaat gctgtcctct tccattctct tccctttcgt ggtaccaccc
     3661 tcactggctg cctccagctc tggagtgggg tgctattctg gcggtatctg gaacttggcc
     3721 tacagcttcc tctgcagggt ctaaacaggg aaggagatgg tgtggaggag aggccccagt
     3781 gacatccagg cactgttcag cacaacactg ggaagtgact cttccctcag gcccctctgc
     3841 ctactaacac ctgggctcct catggggaaa caaaagccta taaaccccag cagcagaacc
     3901 tagtcctctt agaatttttt gcgctttgat tttttagggc gtgtgccctg ttacacttac
     3961 agggccctag gatgcttgtg ttgagtaaaa aggagatgcc cccatattca aagctgctaa
     4021 atgttctctt tgccataaag actccgtgtt aactgtgtaa acacttggga tttttctcct
     4081 ctgtcccgag gtctggtctt gctttctttt ttgggtttct ttctaggaaa aggagaagtg
     4141 catgcaaggg gcaggagatg accctcccct aggctttcag cttcaggcag cttcttcaca
     4201 gcccgtttag cctggggtcc tggaggacag ccctggggag gcagtgaggg gcagcaccaa
     4261 gacagccaga tggttcccgg accacagtgt cttttttttt tttttttttt ttctaaactg
     4321 ccactgccgc cccccaatct tgatcagctc tggagtactg cctgccccag actagcaggg
     4381 gtgaggggtg ggaagcactg atcctcctcc ctgtgcaggg aggaggggtt tcctaactga
     4441 gcagtaggga tagaaagtgg agcctgggag tgctttttat aaattatttt ccttgtagat
     4501 tttattttta atttatctct gtgacctgcc agggagagga gagaaagaga aatgctgtga
     4561 gcacatgaca aaataaaatc aaataaaatg gaaaaaaaaa aaaaaaaaa
//
