LOCUS       NM_001012224            1684 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus nuclear factor, erythroid 2 (Nfe2), mRNA.
ACCESSION   NM_001012224 XM_345883
VERSION     NM_001012224.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1684)
  AUTHORS   Zhang,Y., Wan,J., Liu,S., Hua,T. and Sun,Q.
  TITLE     Exercise induced improvements in insulin sensitivity are concurrent
            with reduced NFE2/miR-432-5p and increased FAM3A
  JOURNAL   Life Sci 207, 23-29 (2018)
   PUBMED   29802941
  REMARK    GeneRIF: NFE2/miR432-5p is reduced and FAM3a is increased with
            exercise in a rat model of insulin sensitivity
            Erratum:[Life Sci. 2020 Nov 1;260:118515. doi:
            10.1016/j.lfs.2020.118515.. PMID: 33039124]
REFERENCE   2  (bases 1 to 1684)
  AUTHORS   Yang,W., Wang,J., Chen,Z., Chen,J., Meng,Y., Chen,L., Chang,Y.,
            Geng,B., Sun,L., Dou,L., Li,J., Guan,Y., Cui,Q. and Yang,J.
  TITLE     NFE2 Induces miR-423-5p to Promote Gluconeogenesis and
            Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway
  JOURNAL   Diabetes 66 (7), 1819-1832 (2017)
   PUBMED   28411267
REFERENCE   3  (bases 1 to 1684)
  AUTHORS   Khalifeh,S., Oryan,S., Digaleh,H., Shaerzadeh,F., Khodagholi,F.,
            Maghsoudi,N. and Zarrindast,M.R.
  TITLE     Involvement of Nrf2 in development of anxiety-like behavior by
            linking Bcl2 to oxidative phosphorylation: estimation in rat
            hippocampus, amygdala, and prefrontal cortex
  JOURNAL   J Mol Neurosci 55 (2), 492-499 (2015)
   PUBMED   25007950
  REMARK    GeneRIF: Nrf2 silencing induced anxiety-related behavior in rats.
REFERENCE   4  (bases 1 to 1684)
  AUTHORS   Kashif,M., Hellwig,A., Kolleker,A., Shahzad,K., Wang,H., Lang,S.,
            Wolter,J., Thati,M., Vinnikov,I., Bierhaus,A., Nawroth,P.P. and
            Isermann,B.
  TITLE     p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium
            formation, placental vascularization and embryonic growth
  JOURNAL   Development 138 (11), 2235-2247 (2011)
   PUBMED   21558372
REFERENCE   5  (bases 1 to 1684)
  AUTHORS   Zhao,Q., Zhou,W., Rank,G., Sutton,R., Wang,X., Cumming,H.,
            Cerruti,L., Cunningham,J.M. and Jane,S.M.
  TITLE     Repression of human gamma-globin gene expression by a short isoform
            of the NF-E4 protein is associated with loss of NF-E2 and RNA
            polymerase II recruitment to the promoter
  JOURNAL   Blood 107 (5), 2138-2145 (2006)
   PUBMED   16263792
REFERENCE   6  (bases 1 to 1684)
  AUTHORS   Wang,D., Li,Y. and Shen,B.
  TITLE     A novel erythroid differentiation related gene EDRF1 upregulating
            globin gene expression in HEL cells
  JOURNAL   Chin Med J (Engl) 115 (11), 1701-1705 (2002)
   PUBMED   12609092
REFERENCE   7  (bases 1 to 1684)
  AUTHORS   Gavva,N.R., Wen,S.C., Daftari,P., Moniwa,M., Yang,W.M.,
            Yang-Feng,L.P., Seto,E., Davie,J.R. and Shen,C.K.
  TITLE     NAPP2, a peroxisomal membrane protein, is also a transcriptional
            corepressor
  JOURNAL   Genomics 79 (3), 423-431 (2002)
   PUBMED   11863372
REFERENCE   8  (bases 1 to 1684)
  AUTHORS   Li,Y.J., Higgins,R.R., Pak,B.J., Shivdasani,R.A., Ney,P.A.,
            Archer,M. and Ben-David,Y.
  TITLE     p45(NFE2) is a negative regulator of erythroid proliferation which
            contributes to the progression of Friend virus-induced
            erythroleukemias
  JOURNAL   Mol Cell Biol 21 (1), 73-80 (2001)
   PUBMED   11113182
REFERENCE   9  (bases 1 to 1684)
  AUTHORS   Gavva,N.R., Gavva,R., Ermekova,K., Sudol,M. and Shen,C.J.
  TITLE     Interaction of WW domains with hematopoietic transcription factor
            p45/NF-E2 and RNA polymerase II
  JOURNAL   J Biol Chem 272 (39), 24105-24108 (1997)
   PUBMED   9305852
REFERENCE   10 (bases 1 to 1684)
  AUTHORS   Ney,P.A., Farina,S.F., Bodine,D.M., Andrews,N.C., Orkin,S.H. and
            Neinhuis,A.W.
  TITLE     Microcytic anemia in mk/mk mice is not corrected by
            retroviral-mediated gene transfer of wild-type p45 NF-E2
  JOURNAL   Exp Hematol 23 (1), 74-80 (1995)
   PUBMED   7995373
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078925.1.
            
            On Feb 11, 2005 this sequence version replaced XM_345883.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078925.1, FQ234994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1684
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1684
                     /gene="Nfe2"
                     /note="nuclear factor, erythroid 2"
                     /db_xref="GeneID:366998"
                     /db_xref="RGD:1306888"
     exon            1..255
                     /gene="Nfe2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..422
                     /gene="Nfe2"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..1430
                     /gene="Nfe2"
                     /note="p45 NF-E2; leucine zipper protein NF-E2; nuclear
                     factor, erythroid-derived 2 45 kDa subunit; nuclear
                     factor, erythroid derived 2"
                     /codon_start=1
                     /product="transcription factor NF-E2 45 kDa subunit"
                     /protein_id="NP_001012224.1"
                     /db_xref="GeneID:366998"
                     /db_xref="RGD:1306888"
                     /translation="MPPCPPQPNRNRLPQLPTGELGEMELTWQEIMSITELQGLNVPS
                     EPSFEPQAPTPYPGPLPPPTYCPCSIHPDAGFTLPPPPYELPASTPHAPDLPYSYGNI
                     AIPVSKPLTLSGLLNEPLPDPLALLDIGLPVGQPKPQEDPESDSGLSLNYSDAESLEL
                     EGTEAGRRRSEYVDMYPVEYPYSLMPNSLAHPNYTLPPTETPLVLESSSGPVRAKPAV
                     RGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLAQYPLTESQLALVRDIRRRGKN
                     KVAAQNCRKRKLETIVQLERELERLGSERERLLRARGEADRTLEVMRQQLTELYHDIF
                     QHLRDESGNSYSPEEYVLQQAADGAIFLVPRGTKMEATD"
     exon            423..1658
                     /gene="Nfe2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaagggtt ggaggaagca ctgctaactc tgactgaggg cttcggagag accgccggtg
       61 cgccggcttc tacccgggcc aaccggtgct ccgcgcccag ccatggcccg ggggcggggc
      121 tcggccctca atagtgctca gaggcagcgc tcagcgccca ggaggtgtca gctctgaccc
      181 agcctctcag ggacactacc cgcagcctca tctctcttct cgccgggctt ggaatctgcc
      241 acaggtgcct aaaaggttgc gggaacctgt gcttggggga agctggggct atcagctggc
      301 acagtaggat gcccccgtgt cctccccagc caaacagaaa cagattacca cagctgccta
      361 ctggggagct tggagagatg gaactgactt ggcaagagat catgtccatt actgagctgc
      421 agggtctaaa tgttccaagt gagccatctt ttgagcctca agcacccacc ccataccctg
      481 ggccactgcc acctccaaca tactgcccct gttcaattca tccagatgca ggcttcaccc
      541 ttcctccacc accttatgag ctcccagcat ccactcccca tgctccagac ctcccatact
      601 cctatggcaa catagccata cccgtgtcaa agccacttac cctttcaggc ctgctcaatg
      661 agcccctccc agacccctta gctctcttgg acattgggct gccagtgggg caacccaagc
      721 cccaagaaga tccagaatct gactcgggat tatccctcaa ctacagcgat gcagaatctc
      781 ttgagctaga aggtacagag gctggcaggc ggaggagcga gtatgtggac atgtacccgg
      841 tggagtaccc ttactcactt atgcccaact ctttggccca ccccaactat actcttccgc
      901 ccactgaaac acccttggtc ttagagtcat cctccggtcc agtgcgggct aagcctgctg
      961 tccgtgggga ggcagggagt cgggatgagc ggcgggccct ggccatgaag attcctttcc
     1021 ctacggacaa gatagttaac ttgccggtag atgactttaa tgagttgttg gcacagtatc
     1081 cgctaacgga gagccagctg gctctagttc gggacatccg tcggcggggc aagaacaagg
     1141 tggcagccca gaactgtcgc aagagaaaac tggaaaccat tgtgcagttg gagcgagagc
     1201 tggagcggct gggcagtgaa agggagcggc tcctcagagc cagaggggag gctgaccgca
     1261 ctctggaggt catgcgccaa cagctgacag agctgtacca tgatattttc cagcatcttc
     1321 gggatgaatc tggcaacagt tattcaccag aggaatatgt actgcaacag gctgctgatg
     1381 gggccatctt tctggtaccc cgtgggacca aaatggaggc cacagattga gctggcctag
     1441 agggggtgga cactggtgct aggaactccc ctcattccct tctgataaag gtacttccca
     1501 atccccaatc aaggctgagt tctccagacc aaaagaccat ttggaagttc aaagatgtat
     1561 ttgaggtttg cctggaggcc aggtgagtgt tggcttctca ggtccccacc tctacctctt
     1621 gtccaagctt tggtccataa agagctgtgt ggaaatagaa aaaaaaaaaa aaaaaaaaaa
     1681 aaaa
//
