LOCUS       NM_001107264            3170 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus nuclear factor of activated T-cells 4 (Nfatc4),
            mRNA.
ACCESSION   NM_001107264 XM_001061815 XM_240184
VERSION     NM_001107264.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3170)
  AUTHORS   Li,M., Fang,X.Z., Liu,X.T., Zheng,Y.F., Xie,Y.B., Ma,X.D., Xia,Y.
            and Shao,D.H.
  TITLE     Inhibition of calcineurin/NFATc4 signaling attenuates
            ventilator-induced lung injury
  JOURNAL   Mol Med Rep 21 (2), 607-614 (2020)
   PUBMED   31789412
  REMARK    GeneRIF: Inhibition of calcineurin/NFATc4 signaling attenuates
            ventilatorinduced lung injury.
REFERENCE   2  (bases 1 to 3170)
  AUTHORS   Su,Q., Liu,M., Jiang,M., Wang,Y., Ma,X., Li,S. and Xie,J.
  TITLE     Involvement of calcineurin/NFATc4 pathway in a single-prolonged
            stress-based rat model of post-traumatic stress disorder
  JOURNAL   Mol Biol Rep 46 (6), 6197-6204 (2019)
   PUBMED   31486013
  REMARK    GeneRIF: Our results show that CaN/NFATc4 pathway were involved in
            the development of PTSD model, which suggested that the changes of
            CaN/NFATc4 pathway may be one of the pathological molecular
            mechanism in the dysfunction of hippocampus in PTSD.
REFERENCE   3  (bases 1 to 3170)
  AUTHORS   Kuwata,H., Yuzurihara,C., Kinoshita,N., Taki,Y., Ikegami,Y.,
            Washio,S., Hirakawa,Y., Yoda,E., Aiuchi,T., Itabe,H., Nakatani,Y.
            and Hara,S.
  TITLE     The group VIA calcium-independent phospholipase A2 and NFATc4
            pathway mediates IL-1beta-induced expression of chemokines CCL2 and
            CXCL10 in rat fibroblasts
  JOURNAL   FEBS J 285 (11), 2056-2070 (2018)
   PUBMED   29637744
  REMARK    GeneRIF: the transcriptional activation of nuclear factor of
            activated T-cell proteins (NFATs), but not nuclear factor-kappaB,
            by IL-1beta stimulation was markedly attenuated by the iPLA2
            inhibitor bromoenol lactone, and NFATc4 knockdown markedly
            attenuated the IL-1beta-induced expression of both CCL2 and CXCL10.
REFERENCE   4  (bases 1 to 3170)
  AUTHORS   Li,M., He,H.P., Gong,H.Q., Zhang,J., Ma,W.J., Zhou,H., Cao,D.S.,
            Wang,N. and Zhang,T.C.
  TITLE     NFATc4 and myocardin synergistically up-regulate the expression of
            LTCC alpha1C in ET-1-induced cardiomyocyte hypertrophy
  JOURNAL   Life Sci 155, 11-20 (2016)
   PUBMED   27155398
  REMARK    GeneRIF: results suggest a novel mechanism of the transcriptional
            regulation of LTCC alpha1C by synergistic activities of NFATc4 and
            myocardin in ET-1-induced cardiomyocyte hypertrophy
REFERENCE   5  (bases 1 to 3170)
  AUTHORS   Asadi,F., Razmi,A., Dehpour,A.R. and Shafiei,M.
  TITLE     Tropisetron inhibits high glucose-induced calcineurin/NFAT
            hypertrophic pathway in H9c2 myocardial cells
  JOURNAL   J Pharm Pharmacol 68 (4), 485-493 (2016)
   PUBMED   26945895
  REMARK    GeneRIF: Tropisetron may have protective effects against high
            glucose-induced cardiomyocyte hypertrophy. The mechanism
            responsible for this beneficial effect seems to be, at least in
            part, blockade of calcineurin/NFATc4 signalling pathway.
REFERENCE   6  (bases 1 to 3170)
  AUTHORS   Bushdid,P.B., Osinska,H., Waclaw,R.R., Molkentin,J.D. and
            Yutzey,K.E.
  TITLE     NFATc3 and NFATc4 are required for cardiac development and
            mitochondrial function
  JOURNAL   Circ Res 92 (12), 1305-1313 (2003)
   PUBMED   12750314
REFERENCE   7  (bases 1 to 3170)
  AUTHORS   Wilkins,B.J., De Windt,L.J., Bueno,O.F., Braz,J.C., Glascock,B.J.,
            Kimball,T.F. and Molkentin,J.D.
  TITLE     Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic
            defect in calcineurin-mediated cardiac hypertrophic growth
  JOURNAL   Mol Cell Biol 22 (21), 7603-7613 (2002)
   PUBMED   12370307
REFERENCE   8  (bases 1 to 3170)
  AUTHORS   Hunton,D.L., Lucchesi,P.A., Pang,Y., Cheng,X., Dell'Italia,L.J. and
            Marchase,R.B.
  TITLE     Capacitative calcium entry contributes to nuclear factor of
            activated T-cells nuclear translocation and hypertrophy in
            cardiomyocytes
  JOURNAL   J Biol Chem 277 (16), 14266-14273 (2002)
   PUBMED   11827959
  REMARK    GeneRIF: Capacitative calcium entry contributes to nuclear factor
            of activated T-cells nuclear translocation and hypertrophy in
            cardiomyocytes.
REFERENCE   9  (bases 1 to 3170)
  AUTHORS   Graef,I.A., Chen,F., Chen,L., Kuo,A. and Crabtree,G.R.
  TITLE     Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the
            developing vasculature
  JOURNAL   Cell 105 (7), 863-875 (2001)
   PUBMED   11439183
REFERENCE   10 (bases 1 to 3170)
  AUTHORS   Molkentin,J.D., Lu,J.R., Antos,C.L., Markham,B., Richardson,J.,
            Robbins,J., Grant,S.R. and Olson,E.N.
  TITLE     A calcineurin-dependent transcriptional pathway for cardiac
            hypertrophy
  JOURNAL   Cell 93 (2), 215-228 (1998)
   PUBMED   9568714
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474049.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_240184.4, XM_001061815.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132296 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3170
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..3170
                     /gene="Nfatc4"
                     /gene_synonym="NF-AT3; NF-ATc4"
                     /note="nuclear factor of activated T-cells 4"
                     /db_xref="GeneID:305897"
                     /db_xref="RGD:1310749"
     exon            1..237
                     /gene="Nfatc4"
                     /gene_synonym="NF-AT3; NF-ATc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..2843
                     /gene="Nfatc4"
                     /gene_synonym="NF-AT3; NF-ATc4"
                     /note="nuclear factor of activated T-cells, cytoplasmic,
                     calcineurin-dependent 4; T-cell transcription factor
                     NFAT3"
                     /codon_start=1
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     4"
                     /protein_id="NP_001100734.1"
                     /db_xref="GeneID:305897"
                     /db_xref="RGD:1310749"
                     /translation="MGAASCEDEELEFKLVFGEEKEAPPLGPGGPGEELDSEDAPPCC
                     RLALGEPLPYGAAPIGIPRPPPPRPGMHSPPPRPAPSPGTWESQPPRSVRLGGPGGTA
                     GGTGGGRVLECPSIRITSISPTPDPPTSLEDAPETWGDGSPRDYPPPEGFGGYREAGG
                     QGGGAFFSPSPGSSSLSSWSFFSDASDEAALYAACDEVESELNEAASRFGLSSPLPSP
                     RASPRPWTPEDPWSLYGPSSGGRAPEDSWLLLSAPGPIPASPRPASPCGKRRYSSSGT
                     PSSASPALSRRGSLGEEGPEPPPPPPLPLVRDPSSSGPFDYVGAPPTESVPQKTRRTS
                     SEQAVALPRSEEPASCNGKLPSGTEDSVAAPGALRKEMAGMDYLAVPSPLAWSKARIG
                     GHSPIFRTSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHP
                     VVKLLGYNEKPLTLQMFIGTADERSLRPHAFYQVHRITGKMVATASYEAVVSGTKVLE
                     MTLLPENNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGGKVV
                     SVQAASVPIECSQRSAQELPQVEAYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGP
                     DGKLQWEEEAAVNRLQSSEVTLTLTIPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFK
                     FLPVIFKEEPLPDSSLRGFPSTSGPPFGPDMDFSPPRPPYPSYPHEDPAYETPYLSEG
                     FGYSTPALYPQTGPPPSYRSGLRMFPETGGTTGCARLPSVSFLPRPFPGDQYGGQGSS
                     FPLGLPFSPPAPFRPPLPSSPPLEDPFNPQSAVHPLPAEGYNEVGPGYTPGEGASEQE
                     KSRGGYGSGFRDNVPIQGITLEEVSEIIGRDLSGFPARPGEEPPA"
     exon            238..1333
                     /gene="Nfatc4"
                     /gene_synonym="NF-AT3; NF-ATc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1496
                     /gene="Nfatc4"
                     /gene_synonym="NF-AT3; NF-ATc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1696
                     /gene="Nfatc4"
                     /gene_synonym="NF-AT3; NF-ATc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1869
                     /gene="Nfatc4"
                     /gene_synonym="NF-AT3; NF-ATc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2010
                     /gene="Nfatc4"
                     /gene_synonym="NF-AT3; NF-ATc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2066
                     /gene="Nfatc4"
                     /gene_synonym="NF-AT3; NF-ATc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2193
                     /gene="Nfatc4"
                     /gene_synonym="NF-AT3; NF-ATc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2775
                     /gene="Nfatc4"
                     /gene_synonym="NF-AT3; NF-ATc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..3170
                     /gene="Nfatc4"
                     /gene_synonym="NF-AT3; NF-ATc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagggagg tggcagcgac agaagagggg gcgtctcaga gaaaaggagg gagggaacca
       61 ccctcgcgtg aagctacagc agcgtccaga gcctccccct cccacccagg cgggacctgg
      121 gggctccggc cggatccatg ggggcggcaa gctgcgagga tgaggagctg gaatttaagc
      181 tggtgttcgg ggaggaaaag gaggcccccc cgctgggccc tgggggccct ggggaagagc
      241 tggactcgga ggatgcccct ccgtgctgtc gtttggccct gggggaaccc cttccttatg
      301 gtgctgcccc tattggtatt ccccgacccc caccccctcg gccagggatg cactcaccac
      361 caccccgtcc tgccccttca cctggcacct gggagagcca gccacctcgg tcggtgaggc
      421 tggggggccc aggaggcact gcggggggta ctgggggcgg tcgtgttctt gagtgtccca
      481 gcatccggat cacctctatc tctcccacgc ctgacccacc gacctcacta gaggatgctc
      541 ctgaaacttg gggggacggc tctcctagag attaccctcc accagaaggc tttgggggct
      601 accgagaggc tggaggtcag ggcggaggag ccttcttcag cccgagccct ggcagcagca
      661 gcctgtcttc gtggagcttc ttctctgatg cctcagacga ggcagccctg tatgcagcat
      721 gcgacgaagt ggagtctgaa cttaatgaag cagcctctcg tttcggcttg agctctccac
      781 tgccctcgcc ccgggcttct cctaggccat ggaccccgga ggatccgtgg agcctatatg
      841 gtccaagctc cggaggccga gcgccagagg atagctggct acttctcagc gctcctgggc
      901 ccatcccagc ctcccctcgg cctgcttctc cctgcggcaa gcggcgctat tccagttccg
      961 gaaccccatc ttcggcctcc ccagctttgt cccgccgggg tagccttggg gaagagggtc
     1021 cagagccacc tccaccaccc ccattgcctc tggtccggga ccctagttcc tctggccctt
     1081 ttgactatgt gggtgctcca ccaaccgaga gcgtccctca gaaaaccagg aggacttcta
     1141 gcgagcaagc agtggccttg cctcggtctg aggagcctgc ctcgtgcaat gggaagctgc
     1201 cctctggtac agaggactcc gtggctgctc ccggggctct gcggaaagag atggctggca
     1261 tggattactt agcagttcct tctcccctcg cttggtccaa ggcccggatt gggggacaca
     1321 gccccatctt caggacctct gccctacctc ccctggactg gcctttaccc agccagtacg
     1381 agcagctgga gctgaggatt gaggtgcagc ccagagctca ccaccgagct cattatgaga
     1441 ctgagggcag ccggggagct gtcaaagctg ctcctggagg tcaccctgtg gtcaagctcc
     1501 taggctacaa tgagaagcca ttgactcttc agatgttcat tggcactgca gacgagagga
     1561 gcctgcggcc ccatgccttc taccaggtgc accggatcac tggcaagatg gtggctacag
     1621 ccagctatga agctgtagtc agtggtacta aagtgttgga gatgactttg ctcccagaga
     1681 acaacatggc tgccaacatt gactgtgctg gaatcctgaa gcttcggaat tcagacattg
     1741 agctacggaa gggcgagaca gacatcgggc gcaaaaacac acgtgtgcga ctggtgttcc
     1801 gtgtgcatgt gcctcagggc ggcgggaagg tcgtctctgt gcaggcagca tcggtgccca
     1861 tcgagtgctc ccagcgctca gcccaggagc tgccccaagt ggaggcctac agccccagtg
     1921 cctgctccgt gagaggaggg gaggagctag tgttgactgg atccaacttc ctgccagact
     1981 ctaaagtggt gttcattgag aggggccctg atggaaaact gcagtgggag gaagaggccg
     2041 cagtgaaccg gctgcagagc agtgaggtga cactgactct gaccatccct gagtacagca
     2101 acaagcgggt gtcccggcca gtccaggtct acttttatgt ctccaatggg cggaggaagc
     2161 gcagtcccac ccaaagtttc aagttcctgc ctgtgatctt caaggaggag cccctaccag
     2221 actcatctct ccggggcttc ccttccacat cgggtccccc ctttggcccc gacatggact
     2281 tctcaccgcc caggccccct tatccctcct atccccatga agaccctgct tatgagactc
     2341 cttatctgtc agaaggcttt ggttatagca cacccgctct gtacccccag acagggcccc
     2401 caccgtctta tagatctggc ctacggatgt tccctgagac tgggggtacc acaggttgtg
     2461 cccgcctacc ttcagtctcc tttcttccgc gcccctttcc tggtgatcag tatggaggac
     2521 agggctcctc ttttcccctg gggcttccat tctcccctcc ggcccccttt aggcctccat
     2581 taccttcctc cccaccactc gaagacccct ttaaccccca gagtgctgtc caccccttac
     2641 ctgctgaggg ctacaatgag gtggggccag gctatacccc tggggagggg gcttcggagc
     2701 aggagaaatc caggggtggc tacggcagcg gcttcagaga caatgtgcct atccagggta
     2761 tcaccctgga ggaagtgagt gagatcattg gccgagacct gagtggcttc cctgcacgtc
     2821 ctggagaaga gcctcctgcc tgaaccacat gtagtggccc cagaagtccc gcctccttgc
     2881 cctcttaacc tgggtgctgg ctccagaagc ttggggccaa ctctagtttc tctttgccca
     2941 gcttctacct tcctgtatcc cctttctctc ctggctaagg tgtggccccc aggcctggtg
     3001 ctgccttgaa agggactgag ggtgtggagg acagggcgag ggtggagcct gaggctgggt
     3061 gccagagctg actgggacga agatgctgtc caggctgtgc aggctatgat gctggcaggc
     3121 tggacaggtt gatgggtaat aaactgcttg ctgcccggtg cctcaggctc
//
