LOCUS       NM_001107805            3701 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus nuclear factor of activated T-cells 2 (Nfatc2),
            mRNA.
ACCESSION   NM_001107805 XM_001072834 XM_001072866 XM_001072905 XM_230877
VERSION     NM_001107805.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3701)
  AUTHORS   Lv,R., Du,L. and Bai,L.
  TITLE     RNF125, transcriptionally regulated by NFATC2, alleviates
            osteoarthritis via inhibiting the Wnt/beta-catenin signaling
            pathway through degrading TRIM14
  JOURNAL   Int Immunopharmacol 125 (Pt B), 111191 (2023)
   PUBMED   37951197
  REMARK    GeneRIF: RNF125, transcriptionally regulated by NFATC2, alleviates
            osteoarthritis via inhibiting the Wnt/beta-catenin signaling
            pathway through degrading TRIM14.
            Erratum:[Int Immunopharmacol. 2024 Jan 25;127:111425. doi:
            10.1016/j.intimp.2023.111425. PMID: 38142206]
REFERENCE   2  (bases 1 to 3701)
  AUTHORS   Cui,C., Zhang,D., Sun,K., Li,H., Xu,L., Lin,G., Guo,Y., Hu,J.,
            Chen,J., Nong,L., Cai,Y., Yu,D., Yang,W., Wang,P. and Sun,Y.
  TITLE     Propofol maintains Th17/Treg cell balance and reduces inflammation
            in rats with traumatic brain injury via the
            miR-145-3p/NFATc2/NF-kappaB axis
  JOURNAL   Int J Mol Med 48 (1) (2021)
   PUBMED   34036377
  REMARK    GeneRIF: Propofol maintains Th17/Treg cell balance and reduces
            inflammation in rats with traumatic brain injury via the
            miR1453p/NFATc2/NFkappaB axis.
REFERENCE   3  (bases 1 to 3701)
  AUTHORS   Zhao,F.Y., Xu,S.L., Zhang,C.F., Liu,J., Zhang,Y., Yang,J. and
            Xing,X.Q.
  TITLE     PDGF mediates pulmonary arterial smooth muscle cell proliferation
            and migration by regulating NFATc2
  JOURNAL   Mol Med Rep 23 (1) (2021)
   PUBMED   33179105
  REMARK    GeneRIF: PDGF mediates pulmonary arterial smooth muscle cell
            proliferation and migration by regulating NFATc2.
REFERENCE   4  (bases 1 to 3701)
  AUTHORS   Liu,M., Zhang,S.B., Luo,Y.X., Yang,Y.L., Zhang,X.Z., Li,B.,
            Meng,Y., Chen,Y.J., Guo,R.X., Xiong,Y.C., Xin,W.J. and Li,D.
  TITLE     NFATc2-dependent epigenetic upregulation of CXCL14 is involved in
            the development of neuropathic pain induced by paclitaxel
  JOURNAL   J Neuroinflammation 17 (1), 310 (2020)
   PUBMED   33070779
  REMARK    GeneRIF: NFATc2-dependent epigenetic upregulation of CXCL14 is
            involved in the development of neuropathic pain induced by
            paclitaxel.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3701)
  AUTHORS   Bai,Y., Li,Z.X., Wang,H.L., Lian,G.C. and Wang,Y.
  TITLE     The protective effects of PCPA against monocrotaline-induced
            pulmonary arterial hypertension are mediated through the
            downregulation of NFAT-1 and NF-kappaB
  JOURNAL   Int J Mol Med 40 (1), 155-163 (2017)
   PUBMED   28560440
  REMARK    GeneRIF: MCT was found to significantly induce PAH, with
            inflammation and remodeling of the lung tissues. This was associatd
            with an increased expression of NFAT-1, p-IKK, p-ERK and nuclear
            p65.
REFERENCE   6  (bases 1 to 3701)
  AUTHORS   Garrett-Sinha,L.A., Eberspaecher,H., Seldin,M.F. and de
            Crombrugghe,B.
  TITLE     A gene for a novel zinc-finger protein expressed in differentiated
            epithelial cells and transiently in certain mesenchymal cells
  JOURNAL   J Biol Chem 271 (49), 31384-31390 (1996)
   PUBMED   8940147
REFERENCE   7  (bases 1 to 3701)
  AUTHORS   Luo,C., Burgeon,E., Carew,J.A., McCaffrey,P.G., Badalian,T.M.,
            Lane,W.S., Hogan,P.G. and Rao,A.
  TITLE     Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells
            and mediates transcription of several cytokine genes
  JOURNAL   Mol Cell Biol 16 (7), 3955-3966 (1996)
   PUBMED   8668213
REFERENCE   8  (bases 1 to 3701)
  AUTHORS   Ho,S.N., Thomas,D.J., Timmerman,L.A., Li,X., Francke,U. and
            Crabtree,G.R.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   9  (bases 1 to 3701)
  AUTHORS   Ho,A.M., Jain,J., Rao,A. and Hogan,P.G.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
REFERENCE   10 (bases 1 to 3701)
  AUTHORS   McCaffrey,P.G., Luo,C., Kerppola,T.K., Jain,J., Badalian,T.M.,
            Ho,A.M., Burgeon,E., Lane,W.S., Lambert,J.N., Curran,T. et al.
  TITLE     Isolation of the cyclosporin-sensitive T cell transcription factor
            NFATp
  JOURNAL   Science 262 (5134), 750-754 (1993)
   PUBMED   8235597
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474005.2.
            
            [WARNING] On Oct 22, 2024 this sequence was replaced by
            NM_001107805.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_230877.4, XM_001072866.1, XM_001072905.1, XM_001072834.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132263, SAMD00132278
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3701
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3701
                     /gene="Nfatc2"
                     /note="nuclear factor of activated T-cells 2"
                     /db_xref="GeneID:311658"
                     /db_xref="RGD:1307690"
     exon            1..214
                     /gene="Nfatc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2880
                     /gene="Nfatc2"
                     /note="nuclear factor of activated T-cells, cytoplasmic,
                     calcineurin-dependent 2"
                     /codon_start=1
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2"
                     /protein_id="NP_001101275.1"
                     /db_xref="GeneID:311658"
                     /db_xref="RGD:1307690"
                     /translation="MDAPEPQSDPDGGDGPGHEPGGSSQDELDFSILFDYDYLNPIEE
                     EPIAHKAISSPSGLAYPDDVLDYGLKPCNPLASLSGEPPGRFGESDSIGFQNFLSPAK
                     PAGASGPSPRIEITPSHELMQAGGALRGRDAGLSPEQPALALAGMAASPRFTLPVPGF
                     EGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNAGPDDLCPQFQNIPAHYSPRT
                     SPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVAPLPAASPQRSRS
                     PSPQPSPHVAPQDDGIPAGYPPTAGSAVLMDALNSLATDSPCGIPSKIWKTSPDPTPV
                     STAPSKAGLARHIYPAVEFLGPCEQEERRNSAPESILLVPPTWPKQLVPAIPICSIPV
                     TASLPPLEWPLSNQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGY
                     MENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPK
                     NNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPEPSGRIVSLQAAS
                     NPIECSQRSAHELPMVERQDMDSCLVYGGQQMILTGQNFTAESKVVFMEKTTDGQQIW
                     EMEATVDKDKSQPNMLFVEIPEYRNKHIRVPVKVNFYVINGKRKRSQPQHFTYHPVPA
                     IKTEPSDEYEPSLICSPAHGGLGSQPYYPQHPMLAESPSCLVATMAPCQQFRSGLSSP
                     DARYQQQSPAAALYQRSKSLSPGLLGYQQPSLLAAPLGLADAHRSVLVHAGSQGQGQG
                     QGSTLPHTSSASQQASPVIHYSPTNQQLRGGGHQEFQHIMYCENFGPSSVRPGLPPVN
                     QGQRLSPGSYPTVIQQQTAPSQRAAKNGPPVSDQKEALPSGVTVKQEQNLDQTYLDDV
                     NEIIRKEFSGPPSRNQT"
     exon            215..1250
                     /gene="Nfatc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1422
                     /gene="Nfatc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1625
                     /gene="Nfatc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1798
                     /gene="Nfatc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1939
                     /gene="Nfatc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..1995
                     /gene="Nfatc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2122
                     /gene="Nfatc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2824
                     /gene="Nfatc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..3701
                     /gene="Nfatc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacagacacg gtgacccctg ctctgcgcca gcctcctccg ggcaccgcaa ccctacacgg
       61 cccgcagccg gaacgccccg agccatggac gccccggagc cgcagtccga ccccgacggc
      121 ggggacggcc ccggccacga gcccgggggc agttcccaag acgagctgga cttttccatc
      181 ctcttcgatt atgactatct gaaccctatc gaagaagaac cgatcgcaca taaggccatc
      241 agctcaccct ccggactcgc atacccggat gatgtcctgg actatggcct caagccatgc
      301 aaccctctcg ccagtctctc tggcgagccc cctggccggt tcggagagtc ggatagtata
      361 gggttccaga actttctgag cccggccaag ccagcagggg cttcgggccc gagccctcgg
      421 atcgagatca ctccatccca cgaactgatg caggcagggg gggccctccg tgggagagat
      481 gccggcctgt cccccgagca gccggccctg gctctggccg gcatggccgc cagcccgagg
      541 ttcacactgc ccgtgcccgg cttcgagggc taccgcgagc cgctttgctt gagccccgct
      601 agcagcggct cctctgccag cttcatttct gacaccttct ccccctacac ctcgccctgc
      661 gtctcaccca ataacgccgg gcccgacgac ctgtgtcccc agtttcaaaa catccctgct
      721 cattattccc ccagaacctc tccaataatg tcacctcgaa ccagcctcgc cgaggacagc
      781 tgcctgggcc gacactcgcc cgtgccccgt ccggcatccc gctcctcctc acccggtgcc
      841 aagcggaggc attcgtgcgc agaggccttg gttgcccctc tgcccgcagc ctcaccccag
      901 cgctcccgga gcccctcgcc acagccctcg cctcacgtgg caccccagga cgacggcatc
      961 cccgctgggt acccccccac ggccggctct gctgttctca tggatgccct caacagcctg
     1021 gccaccgact cgccctgcgg gatcccctct aagatatgga agaccagtcc tgatccaact
     1081 cccgtgtcca ctgctccatc caaggcaggc ctggcccgcc acatctaccc tgctgtggag
     1141 ttcctggggc cgtgtgagca ggaggagagg aggaattccg ctccagagtc catcctgctg
     1201 gtaccaccca cctggcccaa gcaattggtg ccggccattc ccatctgcag catccccgtg
     1261 actgcatccc tcccaccact agagtggcca ctctccaacc agtcgggctc ctatgagctt
     1321 cggattgagg tccagcccaa gccccatcac cgagcccact atgagacaga gggcagccgt
     1381 ggcgctgtca aagccccaac aggaggacac cctgtggtgc agctccacgg ctacatggag
     1441 aacaagcctc tggggcttca gatcttcatc gggacggctg atgaacggat ccttaagcca
     1501 cacgccttct accaagtaca caggatcact gggaaaacag tgacaaccac tagctatgag
     1561 aagattgtgg gcaacaccaa ggtcctggag atccccctgg agccaaagaa caacatgcgg
     1621 gccaccatcg actgcgcagg catcctgaag ctccgaaacg ctgacatcga gctgcggaag
     1681 ggtgagacag acataggcag aaagaacacg cgtgtgcgcc ttgtgttccg tgtgcacatc
     1741 ccggagccca gtggacgcat cgtctccctg caggctgcat ccaaccccat cgagtgctct
     1801 cagcgctctg cccacgagct gcccatggtg gagagacaag acatggacag ctgcctggtc
     1861 tacggcggcc agcagatgat cctcacgggc cagaacttca cagctgagtc caaggttgtg
     1921 ttcatggaga agactacaga tgggcagcag atttgggaga tggaagctac agtggataaa
     1981 gacaagagcc agcctaacat gctttttgtt gagatccccg agtatcggaa caagcacatc
     2041 cgggtgcccg tgaaagtgaa cttctacgtc atcaacggaa agagaaaacg aagtcagcca
     2101 cagcacttta cttaccaccc agtccccgcc atcaagacag agcccagcga tgagtatgaa
     2161 ccgtctttga tctgcagccc cgcccacgga ggcctgggga gccagccata ttacccacag
     2221 cacccaatgc tggccgagtc cccctcctgt cttgtggcca ccatggcccc ttgccaacag
     2281 ttccgctcag ggctctcatc ccctgatgct cgctaccagc agcagagccc cgcagccgcc
     2341 ctctaccaga ggagcaagag cctgagtcca ggcctgctgg gctaccagca gccgtccctc
     2401 ttggcagcac ccttgggtct ggctgatgcc caccgttctg tgctggtgca tgctggttcg
     2461 caggggcagg ggcaggggca gggctccacc ttgccacaca cctcctcggc cagccagcag
     2521 gcctcacccg tgatccacta ctcacccacc aaccagcagc ttcgtggtgg gggtcaccag
     2581 gagttccagc atatcatgta ctgtgagaac ttcggcccca gctctgtcag gcctggcctg
     2641 cctcccgtca accaaggtca gaggctgagc ccagggtcct accccacggt catccaacaa
     2701 cagactgccc cgagccaaag agctgccaaa aacggacccc cggtcagtga ccagaaggaa
     2761 gccctgccca gtggagtgac agtcaaacag gagcagaacc tggaccagac ttacctggat
     2821 gacgttaatg aaatcatcag gaaggagttt tcgggacctc cctcccgaaa tcagacctag
     2881 aagcaaacag tatcgcacga cgccttctac tttggacccc ttctgtctcc tcccgccgtc
     2941 tctgactgga acactgcacg tgcgcagtgc aggcagttgg tgttggagcc tgggagcctg
     3001 ctgcctctcg aagagcatct tagctgatgt ccacggtgac tggacaagaa aagcaactgc
     3061 ctgctgacca aagcctcact ctcaactcac caggatgctg agcccgagac ctgggggctg
     3121 cgctggcggg agaaccggag gaaccatggt accccacaga catggctcca tcgagaaggg
     3181 tcttcagaca gagcaaccaa aagcgcatgg cccaagagtc ccgcccggtc tctgtaggag
     3241 ctgaactgga cagtcatcta tgcaccagct gggccatacc aaagcttcat tttgaatttt
     3301 ctctttccaa agtcaaactg ccttgaccct gacaggacca cctgttccac cttctcagcc
     3361 ttaagttata acacatgtac gtgtttgcta gcttctgggc ctttgttgtg ttttcctctg
     3421 cttcgaagag ccaaccaaag aggctgcccg gctgcgccct ccctcgtcca gctactccct
     3481 ctcacccagc tactccctct tggccagcta ctccctaacc ctgctgcctg caccagacct
     3541 ctggtgggat ccagcctggg ctgcctgttg agcacaatgt ttctgaaggt tcccctctcc
     3601 acctcctcca cccagaagtc aagagaacct tcttctgggt tcttgcattg actgttaagg
     3661 agctaagacc accaaaacta gtcaaaacct acaggtgttt t
//
