LOCUS       NM_001415721            4909 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus nuclear factor of activated T-cells 1 (Nfatc1),
            transcript variant 2, mRNA.
ACCESSION   NM_001415721 XM_039096525
VERSION     NM_001415721.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4909)
  AUTHORS   Yang,T., Hei,R., Li,X., Ma,T., Shen,Y., Liu,C., He,W., Zhu,L.,
            Gu,Y., Hu,Y., Wei,W. and Shen,Y.
  TITLE     The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands
            for sebum synthesis
  JOURNAL   Cell Mol Biol Lett 28 (1), 60 (2023)
   PUBMED   37501148
  REMARK    GeneRIF: The role of NPY2R/NFATc1/DYRK1A regulatory axis in
            sebaceous glands for sebum synthesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4909)
  AUTHORS   Sun,Z.H., Liu,F., Kong,L.L., Ji,P.M., Huang,L., Zhou,H.M., Sun,R.,
            Luo,J. and Li,W.Z.
  TITLE     Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and
            VSMCs phenotypic switch in intracranial aneurysm
  JOURNAL   Biomed Pharmacother 161, 114480 (2023)
   PUBMED   37002575
  REMARK    GeneRIF: Interruption of TRPC6-NFATC1 signaling inhibits NADPH
            oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm.
REFERENCE   3  (bases 1 to 4909)
  AUTHORS   Luo,J., Li,J., Li,T., Zhang,Z., Chen,G., Li,Q., Qi,H. and Si,Z.
  TITLE     PIAS1 Alleviates Hepatic Ischemia-Reperfusion Injury in Mice
            through a Mechanism Involving NFATc1 SUMOylation
  JOURNAL   Dis Markers 2022, 4988539 (2022)
   PUBMED   36092961
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4909)
  AUTHORS   Ding,D., Yan,J., Feng,G., Zhou,Y., Ma,L. and Jin,Q.
  TITLE     Dihydroartemisinin attenuates osteoclast formation and bone
            resorption via inhibiting the NF-kappaB, MAPK and NFATc1 signaling
            pathways and alleviates osteoarthritis
  JOURNAL   Int J Mol Med 49 (1) (2022)
   PUBMED   34738623
REFERENCE   5  (bases 1 to 4909)
  AUTHORS   Shen,X., Zhang,Y., Lin,C., Weng,C., Wang,Y., Feng,S., Wang,C.,
            Shao,X., Lin,W., Li,B., Wang,H., Chen,J. and Jiang,H.
  TITLE     Calcineurin inhibitors ameliorate PAN-induced podocyte injury
            through the NFAT-Angptl4 pathway
  JOURNAL   J Pathol 252 (3), 227-238 (2020)
   PUBMED   32686149
  REMARK    GeneRIF: Calcineurin inhibitors ameliorate PAN-induced podocyte
            injury through the NFAT-Angptl4 pathway.
REFERENCE   6  (bases 1 to 4909)
  AUTHORS   Antos,C.L., McKinsey,T.A., Frey,N., Kutschke,W., McAnally,J.,
            Shelton,J.M., Richardson,J.A., Hill,J.A. and Olson,E.N.
  TITLE     Activated glycogen synthase-3 beta suppresses cardiac hypertrophy
            in vivo
  JOURNAL   Proc Natl Acad Sci U S A 99 (2), 907-912 (2002)
   PUBMED   11782539
REFERENCE   7  (bases 1 to 4909)
  AUTHORS   Kumai,M., Nishii,K., Nakamura,K., Takeda,N., Suzuki,M. and
            Shibata,Y.
  TITLE     Loss of connexin45 causes a cushion defect in early cardiogenesis
  JOURNAL   Development 127 (16), 3501-3512 (2000)
   PUBMED   10903175
REFERENCE   8  (bases 1 to 4909)
  AUTHORS   Ranger,A.M., Grusby,M.J., Hodge,M.R., Gravallese,E.M., de la
            Brousse,F.C., Hoey,T., Mickanin,C., Baldwin,H.S. and Glimcher,L.H.
  TITLE     The transcription factor NF-ATc is essential for cardiac valve
            formation
  JOURNAL   Nature 392 (6672), 186-190 (1998)
   PUBMED   9515964
REFERENCE   9  (bases 1 to 4909)
  AUTHORS   de la Pompa,J.L., Timmerman,L.A., Takimoto,H., Yoshida,H.,
            Elia,A.J., Samper,E., Potter,J., Wakeham,A., Marengere,L.,
            Langille,B.L., Crabtree,G.R. and Mak,T.W.
  TITLE     Role of the NF-ATc transcription factor in morphogenesis of cardiac
            valves and septum
  JOURNAL   Nature 392 (6672), 182-186 (1998)
   PUBMED   9515963
REFERENCE   10 (bases 1 to 4909)
  AUTHORS   Ho,S.N., Thomas,D.J., Timmerman,L.A., Li,X., Francke,U. and
            Crabtree,G.R.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 27, 2022 this sequence version replaced XM_039096525.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.2761732.1,
                                           SRR26643296.38197.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               JAXUCZ010000018.1  76430559-76430990   c
            433-1534            JAXUCZ010000018.1  76415683-76416784   c
            1535-1694           JAXUCZ010000018.1  76399188-76399347   c
            1695-1897           JAXUCZ010000018.1  76383048-76383250   c
            1898-2070           JAXUCZ010000018.1  76381363-76381535   c
            2071-2211           JAXUCZ010000018.1  76379393-76379533   c
            2212-2267           JAXUCZ010000018.1  76368993-76369048   c
            2268-2400           JAXUCZ010000018.1  76365312-76365444   c
            2401-3075           JAXUCZ010000018.1  76351519-76352193   c
            3076-4909           JAXUCZ010000018.1  76321386-76323219   c
FEATURES             Location/Qualifiers
     source          1..4909
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..4909
                     /gene="Nfatc1"
                     /note="nuclear factor of activated T-cells 1"
                     /db_xref="GeneID:100361818"
                     /db_xref="RGD:2319357"
     exon            1..432
                     /gene="Nfatc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..3125
                     /gene="Nfatc1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nuclear factor of activated T-cells, cytoplasmic 1;
                     nuclear factor of activated T-cells, cytoplasmic,
                     calcineurin-dependent 1"
                     /codon_start=1
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     1 isoform 2"
                     /protein_id="NP_001402650.1"
                     /db_xref="GeneID:100361818"
                     /db_xref="RGD:2319357"
                     /translation="MPSTSFPVPSKFPLGPPAAVCGSGETLRPAPLAGGTMKAAEEEH
                     YSYASPSVTSTLPLPTAHSALPAACHDLQTSTPGISAVPSANHPSGYGGAVDSGPSGY
                     FLSSGNTRPNGAPTLESPRIEITSYLGLHHGSNQFFHDVEVEDVLPSCKRSPSTATLH
                     LPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTD
                     PEEGFPRSLGACHLLGSPRHSPSTSPRASVTEESWLGARGSRPTSPCNKRKYSLNGRQ
                     PSCSPHHSPTPSPHGSPRVSVTEDTWLGNTTQYTSSAIVAAINALTTDSTLDLGDGVP
                     IKSRKTALEHVPSVALKVEPAGEDLGTTPPTSDFPPEEFAFQHLRKGAFCEQYLSVPQ
                     ASYQWAKPKSLSPTSYMSPSLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRG
                     AVKASAGGHPVVQLHGYLENEPLTLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSH
                     EAILSNTKVLEIPLLPENNMRAIIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFR
                     VHIPQPSGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVIGGKKMVLSGHNFLQ
                     DSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVLEIPPFRNQRITSPVQVSFYVCNG
                     KRKRSQYQHFTYLPANVPIIKTEPTDDFEPALTCGPMSQGLSPLPRPYYSQQLTAPPD
                     PGSCLVAGFAPCSQRNTLMPTSPNASPKLHDLSSPAYAKGLANPGHSGHLGLQPPASE
                     APTMQELPRPMAVQPNSPEQPTSVRLQPQVSPHLNSSCPLGLQQVLYPNSPSSPLPPA
                     AHEPTCLQPSALPPDVGHRQQQPQKVHRNESPSILPEVCEDSDHNLAPVPVVIKQEPE
                     ELDQLYLDDVNEIIRNDLSSTIPHS"
     exon            433..1534
                     /gene="Nfatc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1694
                     /gene="Nfatc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1897
                     /gene="Nfatc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2070
                     /gene="Nfatc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2211
                     /gene="Nfatc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2267
                     /gene="Nfatc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2400
                     /gene="Nfatc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..3075
                     /gene="Nfatc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..4909
                     /gene="Nfatc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtcagagt gagaccgaga ggctccgaac tgggcgacag agtcgcctcg cggatccgag
       61 cggcggggca cgagctcccc ggcgccgcac acacctcctc ccctggggcg agtcccgggc
      121 cgcaagcagg cctgccacgc gcgcacacac cccgcatgtc acctccccgc ggcgcgcggc
      181 gctgaacccg gcccggcgcg tgtcggcgaa ggagaggtcg gactcgggag ccggcccgga
      241 gctgctcccg gcgccagctc ccgctcctcc tcctgctgct cgccgctgcc gccaccgccg
      301 cgtggatgcc aagtaccagc tttccagtcc cttccaagtt tccactcggc cctccggccg
      361 cagtctgcgg gagcggagaa actttgcggc ccgcgccgct cgccggcggc accatgaagg
      421 cggccgagga agaacactac agttatgcgt cccctagcgt cacctcaact ctgccccttc
      481 ccacagcaca ctccgccttg ccagcggcat gccatgacct ccagacgtcc accccgggca
      541 tctcagctgt tccttcggcc aatcacccct ctggttatgg gggcgctgtg gacagtgggc
      601 cttcaggata cttcctgtcc tccggcaaca cgagacccaa tggggccccg actctcgaga
      661 gtcctcgaat cgagatcacc tcctatctgg gccttcacca cggcagcaac caatttttcc
      721 acgatgtgga ggtggaagac gtacttccta gctgcaagcg gtcaccatct acagcaaccc
      781 tgcacctgcc cagtctggaa gcctacagag acccctcctg cctgagccca gccagcagcc
      841 tgtcctccag gagctgtaac tctgaggcgt cctcctatga gtccaactat tcatacccgt
      901 acgcatcccc ccagacctct ccatggcagt caccctgtgt gtctcccaag accacggacc
      961 cagaggaggg ctttccccga agcctgggtg cctgccactt gctgggatcg ccaaggcact
     1021 ccccatccac ctctcctcgt gcaagcgtca ccgaggagag ctggctcggt gcccgtggct
     1081 cccggcccac atccccctgc aacaagcgca aatacagtct caacggcagg cagccctcct
     1141 gctcacccca ccactcgccc acaccatccc cccatggctc ccctcgggtc agcgtgacgg
     1201 aagacacctg gcttggtaac accacccagt acaccagctc tgctattgtg gcagccatca
     1261 acgccctgac cactgatagc actctggacc tgggtgacgg tgtccctatc aagtctcgaa
     1321 agacagccct ggagcacgtg ccctctgtgg ccctcaaggt agagccggct ggggaagacc
     1381 tgggcaccac accacccact tctgacttcc cacccgagga gttcgccttc cagcaccttc
     1441 ggaagggtgc cttttgtgag cagtatctgt cggtgccaca ggcctcgtat cagtgggcaa
     1501 agcccaagtc tctatcccca acgtcataca tgagcccatc cctgcctgcc cttgactggc
     1561 agctgccgtc gcactctggt ccgtatgaac tccggatcga ggtgcaaccc aagtctcacc
     1621 acagggctca ctatgagacg gaaggcagcc ggggagctgt gaaggcttct gctggaggac
     1681 accctgtcgt gcagctacat ggttacttgg aaaacgagcc tctcacgctc cagctgttca
     1741 ttgggacggc tgacgaccgc ctgctacggc cccatgcctt ctaccaggtc caccggatca
     1801 cggggaagac tgtctccacc accagccacg aggctatcct gtccaacacc aaagtcctgg
     1861 agatcccact gcttccagaa aataacatgc gagccatcat cgactgtgct gggatcctga
     1921 agctcagaaa ctctgatatc gagctgagga aaggggagac agacatcggg agaaagaaca
     1981 ccagggtgcg gctggtcttc cgagtccaca tcccccagcc cagcggccgg acgctgtctc
     2041 tccaggtggc ctcaaacccg atcgagtgct cccagcggtc ggcccaggaa ctgcccctcg
     2101 tggagaagca gagcacagac agctacccgg tcattggagg gaagaagatg gtgttgtctg
     2161 gccataactt tctgcaagac tccaaggtca tcttcgtgga gaaggcccca gatggccacc
     2221 atgtctggga gatggaagcg aaaactgacc gagacctgtg caagccaaat tccctggtgc
     2281 tggagatacc acctttccgc aaccagagaa taaccagccc cgtccaagtc agcttctatg
     2341 tctgcaacgg gaagcggaag agaagccagt accagcattt cacgtacctt cctgccaatg
     2401 ttccaattat aaagacagaa cccacggacg actttgagcc agctctgacc tgtggaccaa
     2461 tgagccaggg acttagccct ctgccgaggc cttactatag ccaacaactc accgcgcctc
     2521 ctgaccctgg ctcctgcctt gtggccggct ttgccccctg ctcacagagg aacacgctga
     2581 tgcccacgtc tcccaatgca agcccaaagc tccacgacct ttcctctccc gcctacgcca
     2641 agggcctcgc caacccaggc cacagtggtc accttggact tcagccacca gcttcagagg
     2701 cccccaccat gcaggaattg ccgagaccca tggccgtcca gcccaactcg cctgagcagc
     2761 ccacatccgt caggctacag ccgcaggtga gtccacatct gaacagtagc tgtccccttg
     2821 gtctccaaca agtgctctat cccaacagcc cctcctctcc acttccacct gctgcccacg
     2881 agccaacctg cttacagccc tcagctctcc ctcctgatgt gggccaccgg cagcaacaac
     2941 cgcagaaggt tcacagaaat gaatctccgt ccatactgcc agaggtgtgt gaggacagtg
     3001 accataactt ggcccctgtt cctgtagtga tcaagcaaga gcctgaggaa ttggaccagt
     3061 tgtacctgga tgatgtaaat gagatcattc gtaacgacct ctccagcaca atcccccact
     3121 cctaattcag cacattggag ctggcagaag ccgtgaggag ctggctcagt gcagacaacc
     3181 acgcttcagc aagcgagact ttgatgagat aaactggacc cacatctggt accactcaga
     3241 aaatcccaac ttaccgaacg aatgcgggga gcttgtgtct gaagaaacag ctctccaaaa
     3301 cgacggagga gcaggagagg ggcccactgc acctctagaa agaaacacca tttcaaggaa
     3361 agagaagggc tggccagtga ggccaggggc agacactggc ccactgtgtg gcagaatgac
     3421 cccaaacctg accctcctgc ccactggatt aaaacactgg aagtgcctta tttagtccaa
     3481 ccaccacacc agggcatatg gaagtgtgca ctgaatttcc taccacgaga gtattcgtag
     3541 gagccaaagc tattaaagaa cacttccttg ggaggctctc tcctttgtac taatcgattg
     3601 gattctgacg agctgtggcc tcccgcttat ctctaacttt tctggctgtc ccacacaatt
     3661 cgcctgcgtt atccagtgcg ctctagaggc catccagcct gccaccttgg cacctctttc
     3721 atagtcagcc ccctcctctg tgtgactgaa accacaggtt tgtctgtaat agcatgctgg
     3781 ggttcttgtt cttgatccag ctgcactata gtgaaggaag ttgaacagcc caagacaggg
     3841 tcccggacag aacaaagcct gcctgcctgc gctacaggac agagcctgtg tttgcatgca
     3901 tgtacatata ggcatatatt tatgtataga tgtccaagga cggggatggt gatggccagt
     3961 ctgtgcccag cggggacttc cgtgttagca ataaccagta tccaccttga gagtgcacct
     4021 cggagtccag accctgcctt ccatcacctt ccaccagggt ccgtcacctc tggcaggcag
     4081 gtggcctttt cttgtctcgt gcagttacgg agcactctag agctgtgccc agatgcccat
     4141 cggctcccaa agggcagcat ccgaaagtgg ttatgagtaa ggagtgtaat atatctgtcc
     4201 gattatgaga tgattacttc acagcagcct tatagctctc tgcttcatct aaggaaacaa
     4261 ttaccaaaaa cggtgtttct atacgcggtc tgtggattgt gcgttttcag attagctact
     4321 ggtaacggac aggctggtgt cggcttcgtg taatcagctg cttattacag ttaactagca
     4381 gtgacctatt atttcttata accaaaataa aaaaaaaaaa aaaagcatgg tttaattaaa
     4441 acatgtttaa tgatggtgcc ttaggagtta atgccccctt atggaacaag cctgaattgc
     4501 acctgtgggt ggaagcctca agttactcac agacagacgg gggggactca acgacaggaa
     4561 aagctctccc cgcaggaaga cgcatcttca aaatgtccgt ctgtacgatg gtggcttacc
     4621 ttttccaact caccaaaaca gacaaatgtc cgaaagccat atcgaacgtt ttcacacgat
     4681 tgtgaagagc tgaggcgtgc ctgcctcgcg cgcacacaca gaacctggcc gcctgcaggc
     4741 tgcctcccac ctgcctgctt cttgtatgta ccccgtgttt ataagcatca tggagttgca
     4801 tgaaccatcc ttagtagact gtcatgtgaa agcaagcgtt tgacatttgt gtcagctatc
     4861 ttcatagtta gggaatggag ctaataaaac agtatttttt ctttctttc
//
