LOCUS       NM_013193               4498 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus NF2, moesin-ezrin-radixin like (MERLIN) tumor
            suppressor (Nf2), mRNA.
ACCESSION   NM_013193 XM_001067432 XM_341248
VERSION     NM_013193.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4498)
  AUTHORS   Lu,J., Wang,J., Ni,H., Li,B., Yang,J., Zhu,J., Qian,J., Gao,R. and
            Xu,R.
  TITLE     Activation of the melanocortin-1 receptor attenuates neuronal
            apoptosis after traumatic brain injury by upregulating Merlin
            expression
  JOURNAL   Brain Res Bull 207, 110870 (2024)
   PUBMED   38185389
  REMARK    GeneRIF: Activation of the melanocortin-1 receptor attenuates
            neuronal apoptosis after traumatic brain injury by upregulating
            Merlin expression.
REFERENCE   2  (bases 1 to 4498)
  AUTHORS   Badhai,J., Pandey,G.K., Song,J.Y., Krijgsman,O., Bhaskaran,R.,
            Chandrasekaran,G., Kwon,M.C., Bombardelli,L., Monkhorst,K.,
            Grasso,C., Zevenhoven,J., van der Vliet,J., Cozijnsen,M.,
            Krimpenfort,P., Peeper,D., van Lohuizen,M. and Berns,A.
  TITLE     Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of
            malignant mesothelioma in mice
  JOURNAL   J Exp Med 217 (6) (2020)
   PUBMED   32271879
REFERENCE   3  (bases 1 to 4498)
  AUTHORS   Louvrier,C., Pasmant,E., Briand-Suleau,A., Cohen,J., Nitschke,P.,
            Nectoux,J., Orhant,L., Zordan,C., Goizet,C., Goutagny,S.,
            Lallemand,D., Vidaud,M., Vidaud,D., Kalamarides,M. and Parfait,B.
  TITLE     Targeted next-generation sequencing for differential diagnosis of
            neurofibromatosis type 2, schwannomatosis, and meningiomatosis
  JOURNAL   Neuro Oncol 20 (7), 917-929 (2018)
   PUBMED   29409008
REFERENCE   4  (bases 1 to 4498)
  AUTHORS   Dalal,S., Connelly,B., Singh,M. and Singh,K.
  TITLE     NF2 signaling pathway plays a pro-apoptotic role in beta-adrenergic
            receptor stimulated cardiac myocyte apoptosis
  JOURNAL   PLoS One 13 (4), e0196626 (2018)
   PUBMED   29709009
  REMARK    GeneRIF: beta-AR stimulation affects post-translational
            modifications of NF2 via the involvement beta1-AR/PKA/cAMP pathway,
            and NF2 plays a pro-apoptotic role in beta-AR-stimulated myocyte
            apoptosis via the phosphorylation (inactivation) of YAP and
            involvement of mitochondrial death pathway
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4498)
  AUTHORS   Zhang,N., Zhao,Z., Long,J., Li,H., Zhang,B., Chen,G., Li,X., Lv,T.,
            Zhang,W., Ou,X., Xu,A. and Huang,J.
  TITLE     Molecular alterations of the NF2 gene in hepatocellular carcinoma
            and intrahepatic cholangiocarcinoma
  JOURNAL   Oncol Rep 38 (6), 3650-3658 (2017)
   PUBMED   29130106
REFERENCE   6  (bases 1 to 4498)
  AUTHORS   McClatchey,A.I., Saotome,I., Ramesh,V., Gusella,J.F. and Jacks,T.
  TITLE     The Nf2 tumor suppressor gene product is essential for
            extraembryonic development immediately prior to gastrulation
  JOURNAL   Genes Dev 11 (10), 1253-1265 (1997)
   PUBMED   9171370
REFERENCE   7  (bases 1 to 4498)
  AUTHORS   Kleymenova,E.V., Bianchi,A.A., Kley,N., Pylev,L.N. and Walker,C.L.
  TITLE     Characterization of the rat neurofibromatosis 2 gene and its
            involvement in asbestos-induced mesothelioma
  JOURNAL   Mol Carcinog 18 (1), 54-60 (1997)
   PUBMED   9022813
REFERENCE   8  (bases 1 to 4498)
  AUTHORS   Claudio,J.O., Lutchman,M. and Rouleau,G.A.
  TITLE     Widespread but cell type-specific expression of the mouse
            neurofibromatosis type 2 gene
  JOURNAL   Neuroreport 6 (14), 1942-1946 (1995)
   PUBMED   8547603
REFERENCE   9  (bases 1 to 4498)
  AUTHORS   Merel,P., Hoang-Xuan,K., Sanson,M., Moreau-Aubry,A., Bijlsma,E.K.,
            Lazaro,C., Moisan,J.P., Resche,F., Nishisho,I., Estivill,X. et al.
  TITLE     Predominant occurrence of somatic mutations of the NF2 gene in
            meningiomas and schwannomas
  JOURNAL   Genes Chromosomes Cancer 13 (3), 211-216 (1995)
   PUBMED   7669741
REFERENCE   10 (bases 1 to 4498)
  AUTHORS   Gutmann,D.H., Wright,D.E., Geist,R.T. and Snider,W.D.
  TITLE     Expression of the neurofibromatosis 2 (NF2) gene isoforms during
            rat embryonic development
  JOURNAL   Hum Mol Genet 4 (3), 471-478 (1995)
   PUBMED   7795605
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CB578019.1,
            U61772.1, CB814077.1, BP499772.1, CR467414.1, CO573762.1,
            CB787451.1, CA511825.1, CK364860.1, CO387057.1, BF558742.1,
            BQ201846.1 and AA955327.1.
            
            On or before Oct 14, 2007 this sequence version replaced
            XM_341248.3, XM_001067432.1.
            
            Sequence Note: This RefSeq record was created from transcript
            sequence data from multiple strains because no single transcript
            from the same strain was available for the full length of the gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U61772.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-626               CB578019.1         1-626
            627-1334            U61772.1           221-928
            1335-1507           CB814077.1         57-229
            1508-1780           BP499772.1         85-357
            1781-2099           U61772.1           1375-1693
            2100-2148           CR467414.1         3-51                c
            2149-2202           U61772.1           1740-1793
            2203-2505           CO573762.1         50-352
            2506-2680           CB787451.1         277-451
            2681-2880           CA511825.1         158-357
            2881-3500           CK364860.1         90-709
            3501-3666           CO387057.1         185-350
            3667-3999           BF558742.1         143-475
            4000-4478           BQ201846.1         19-497              c
            4479-4498           AA955327.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..4498
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4498
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /note="NF2, moesin-ezrin-radixin like (MERLIN) tumor
                     suppressor"
                     /db_xref="GeneID:25744"
                     /db_xref="RGD:3169"
     exon            1..510
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     CDS             397..2172
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /note="schwannomin; neurofibromin-2;
                     moesin-ezrin-radixin-like protein; neurofibromatosis 2"
                     /codon_start=1
                     /product="merlin"
                     /protein_id="NP_037325.1"
                     /db_xref="GeneID:25744"
                     /db_xref="RGD:3169"
                     /translation="MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGK
                     DLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYP
                     ENAEEELVQEITQHLFFLQVKKQILDEKVYCPPEASVLLASYAVQAKYGDYDPSVHKR
                     GFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYG
                     VNYFTIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPL
                     DKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQM
                     ERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITE
                     EEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKE
                     ADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFDIIGDSLSFD
                     FKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHSEHS
                     DRGGTSSKHNTIKKPQAQGRRPICI"
     exon            511..636
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            637..759
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            760..843
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            844..912
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            913..995
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1071
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1206
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1281
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1395
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1518
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1736
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1842
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1970
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2136
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2181
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..4484
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcggagc ggagccggtg acagacacgc acgcgcgtgt gcgctcccaa ctactgcgcg
       61 gccccgcgac ccccgtgggt cgctgagagg cccggcgtcg gcgccactgc cgtctaggat
      121 ttctgtctaa gaggcgtccc cggcgtcccc agcccgaatc tccaagctcc gggccgcgcc
      181 cgctcttgcc ggcgtcccgt acccccagcg tcagagccag agccgggtcc tcgcggccca
      241 tgctggccgc tggggaccca ggcagcctag gtctgtctcc tgccggccag ccggccacca
      301 tggtggccct gaggcctgtg cagctactcc aggggggcta agagacccag aacgcgggcc
      361 taggggtaag ggggtcccag gccagtaccc cgcgccatgg ccggagccat cgcttcccgc
      421 atgagcttca gctcactcaa gaggaagcag cccaagacat tcacggtgcg gatcgtcacc
      481 atggatgccg agatggagtt caactgcgag atgaagtgga aagggaagga cctgtttgat
      541 ttggtatgcc ggacgctggg gcttcgggag acctggttct ttggactgca gtatacaatc
      601 aaggacacgg tggcctggct caaaatggac aagaaggtgt tggatcacga tgtttcgaag
      661 gaagaaccag ttacctttca tttcctggcc aaattttatc ctgaaaatgc tgaggaggag
      721 ctagtccagg agatcacgca gcacttattt ttcttacagg tgaagaagca gattttggat
      781 gaaaaggtct attgccctcc tgaggcgtcc gtgctcttgg cgtcatatgc tgttcaggcc
      841 aagtatggcg actatgaccc ctctgtgcac aagcgaggat ttttagccca agaggaattg
      901 cttccgaaaa gggtgataaa tctctatcag atgactccgg aaatgtggga ggagagaatt
      961 actgcttggt atgcggagca ccggggcaga gccagggatg aagctgaaat ggagtatttg
     1021 aagatagctc aggacttgga gatgtatggc gtgaactact ttacaatccg gaataaaaag
     1081 ggcacagagt tgctgcttgg agtggatgct ctgggccttc acatctacga ccctgagaac
     1141 aggctgaccc ccaagatctc cttcccgtgg aatgaaatcc gaaacatctc ctacagcgac
     1201 aaggagttta ctattaaacc actggataag aaaattgatg tctttaaatt taactcttca
     1261 aagcttcgtg ttaataagct gattcttcag ctgtgtattg ggaaccatga cctatttatg
     1321 aggagaagga aagctgactc tttagaagtt cagcagatga aagcccaggc cagggaagag
     1381 aaggcaagaa aacagatgga gcggcagcgg ctggctcgag aaaagcagat gcgggaggag
     1441 gccgagcgca cgagagatga gttagagagg aggctcctgc agatgaaaga ggaagcaacg
     1501 atggccaatg aagctctgat gcggtctgag gaaacagctg acctgttggc tgaaaaggct
     1561 cagatcacag aagaggaggc caagcttctg gctcaaaagg ctgcagaggc tgagcaagag
     1621 atgcagcgaa tcaaggccac agccattcgg acagaggagg agaagcgcct gatggagcag
     1681 aaggtgctgg aggctgaagt gctggcgttg aagatggctg aggagtcaga gaggagggcc
     1741 aaggaggctg atcagttaaa gcaagacttg caggaagccc gagaagcaga gcgaagagcc
     1801 aagcagaagc tcttagaaat cgccaccaag cccacatatc cacccatgaa cccaatccca
     1861 gcaccactgc ctcctgacat accgagcttc gacattattg gtgacagctt gtcattcgac
     1921 ttcaaggaca cggacatgaa gcgactttcc atggagatag agaaagagaa agtggagtac
     1981 atggagaaga gcaagcatct gcaagaacaa ctcaatgaac tcaagacaga aattgaggcc
     2041 ttgaaactca aagagaggga gacagccttg gacatcctac acagcgagca ctcagacaga
     2101 ggcggcacca gcagcaagca taacaccatc aaaaagcctc aagcccaagg cagaagacct
     2161 atctgcattt gagtcctcaa acttactctg cagagcgcca agtcccgtgt ggccttcttt
     2221 gaagaactct aggtgacccg accacctcct gccacatctg ctgctcctga caccaacggg
     2281 gtgggcctga ccccaaagga atcatcagta gagggctggc ttgtttggga actctgagta
     2341 gaaggcctga tcccctttgg gttcagttgt ttttgaactc tgaccctgca gagatttctc
     2401 aaggtgttct agttctccta gcctgcatat ctatgtctct cctccctcct ccctccccac
     2461 tccccctccc ctccctcctc cccctcactt tcctctctcc tctcagaaat atttgttgtg
     2521 tgtgggctgc cattcttcct gcaccctagg cactgtggtg taagtgtcac tgtgcgtgct
     2581 gctgactttg gtttgagaag cggctgtgag tcctgtgtgg aggctgaaat ctaccatgct
     2641 ggtgctaccc actccctgac tggggttctg ggataggcct cccctccaca gtaaggacct
     2701 gactagaagc atggactggc ttagctcaga accagcaatg ctggctcctt agccaggctc
     2761 acctgaggca gtgttatagc tgtctgactg gcaggaaaca ggcagaacag ctgtggctag
     2821 gaagagactt acgataaaag ctgctggggg acagtgtgca cgtgagtccc ttcagtctta
     2881 gccacctccc tgtggtgggc caagagcttc ctggtcacat tcccatgagt gcctgggaac
     2941 ccagctgtga ccaggacttc catccatctc ctcccactca gtatatggaa ccccagagcc
     3001 ctgctgccca tccatcatct tctagttctc tccagtacct aggccttact gtcattgtcc
     3061 tcgtcttccc ctgggggccc agagatgttc tttttgtccc tccttcccag aacctgacac
     3121 aggtatcagg ccacacatag ccagcaaact aacactactg cctgcctcca tgctgggcag
     3181 cacgtatatc ccatgtggct cgcacactcc ataggctggg cctatcttct gtgtaactgg
     3241 gctcactgct gtggccagtc agagcccatt gagtcctgac agcaggtgct atgcctcagt
     3301 ccacagacag atggacatta acttaagaca gtgaggggct gagcagtgga atggtccaca
     3361 gtaccgtttt tgagaaactg aggcacacta ccttattccc actggctggc tgttattagg
     3421 ccactttgcc ataggcagcc cgccgagtgt cacctcagca tctgtgagca cctgggatag
     3481 gactctagtc tggaacttca agttgagaag tcctcaggac ttgacacctc agcatttgcc
     3541 aagtcttctc tgacctgaaa ctcttctctg actttctttc tgtacacttg atctaacagt
     3601 ggctgtggga cacaggacag tgacgctggt tataaaaatt ataccaggcc ttgttttttt
     3661 ttttttatgc tttatatttc aaatttgaga aatgccaagt gacatagcca cacgggagcc
     3721 ctggtatttg aggagtggtg ggtgtaactt tcttaaaagg tggaacccac tcagtcagag
     3781 gtacctcagg tcccctcaag agagagaatt ggatccccag aatgtctcca gcctgctttg
     3841 agcctgtagc tgggttcttt ctggtagaca attttagagt caaagaaaga catctgaagt
     3901 ccacagtgag ctccaaccct ggctaattct agtttcagtg gttcttgcaa catgggcagg
     3961 ggtaccttgg tactgaaaca gtaagtcacc ctcagtgcag gacactgagg tcttgctgat
     4021 ggcctgtggc tggtcacata ccctgactga ggtaatatct gagccgccac agcactctga
     4081 ccccagatca ctgccgagcc tggctggaca acaccagcgg gcttacctaa cactacttca
     4141 gttactgctt tatcatcttc agacaggttt ctcacgctcc tgtactttca aaaagcccag
     4201 aggctgatac ccagcaacag taactaactg ttcttgccaa cagggccaaa gcctcaaagt
     4261 ccctagtgca agcagccttc acaggggacc cagcctcttc tgggtacctt gaggccaagc
     4321 cagggcccat gggcttccat tcctgttttc ttatcaaaca gcttttcctg ggaggcccat
     4381 tgtcgctcct gtcagggcca aaacatgaag ctgttttttg tttggggttg ggggtgatta
     4441 taatttaagt gattgtttta ataaaaactc taagctgctc tagtaaaaaa aaaaaaaa
//
