LOCUS       NM_139230               2682 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus nexilin (F actin binding protein) (Nexn),
            transcript variant b, mRNA.
ACCESSION   NM_139230 XM_006233483 XM_342360
VERSION     NM_139230.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2682)
  AUTHORS   Wang,C., You,X., Jiang,C., Jin,C., Meng,X. and Ding,D.
  TITLE     Hepatocyte growth factor upregulates nexilin gene expression in
            cardiomyocytes via JNK pathway
  JOURNAL   Genet Mol Res 13 (3), 4976-4982 (2014)
   PUBMED   25062485
  REMARK    GeneRIF: Hepatocyte growth factor upregulates nexilin gene
            expression in cardiomyocytes via JNK pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2682)
  AUTHORS   Lee,A., Hakuno,F., Northcott,P., Pessin,J.E. and Rozakis Adcock,M.
  TITLE     Nexilin, a cardiomyopathy-associated F-actin binding protein, binds
            and regulates IRS1 signaling in skeletal muscle cells
  JOURNAL   PLoS One 8 (1), e55634 (2013)
   PUBMED   23383252
  REMARK    GeneRIF: Nexilin, a cardiomyopathy-associated F-actin binding
            protein, binds and regulates IRS1 signaling in skeletal muscle
            cells.
REFERENCE   3  (bases 1 to 2682)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (bases 1 to 2682)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 2682)
  AUTHORS   Hassel,D., Dahme,T., Erdmann,J., Meder,B., Huge,A., Stoll,M.,
            Just,S., Hess,A., Ehlermann,P., Weichenhan,D., Grimmler,M.,
            Liptau,H., Hetzer,R., Regitz-Zagrosek,V., Fischer,C., Nurnberg,P.,
            Schunkert,H., Katus,H.A. and Rottbauer,W.
  TITLE     Nexilin mutations destabilize cardiac Z-disks and lead to dilated
            cardiomyopathy
  JOURNAL   Nat Med 15 (11), 1281-1288 (2009)
   PUBMED   19881492
REFERENCE   6  (bases 1 to 2682)
  AUTHORS   Wang,W., Zhang,W., Han,Y., Chen,J., Wang,Y., Zhang,Z. and Hui,R.
  TITLE     NELIN, a new F-actin associated protein, stimulates HeLa cell
            migration and adhesion
  JOURNAL   Biochem Biophys Res Commun 330 (4), 1127-1131 (2005)
   PUBMED   15823560
REFERENCE   7  (bases 1 to 2682)
  AUTHORS   Ohtsuka,T., Nakanishi,H., Ikeda,W., Satoh,A., Momose,Y.,
            Nishioka,H. and Takai,Y.
  TITLE     Nexilin: a novel actin filament-binding protein localized at
            cell-matrix adherens junction
  JOURNAL   J Cell Biol 143 (5), 1227-1238 (1998)
   PUBMED   9832551
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Oct 4, 2022 this sequence version replaced
            XM_006233483.4, NM_139230.1.
            
            Transcript Variant: This variant (b) encodes the longer isoform
            (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.7965.1,
                                           SRR26643295.11656.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000002.1  243878097-243878152 c
            57-129              JAXUCZ010000002.1  243868275-243868347 c
            130-321             JAXUCZ010000002.1  243866779-243866970 c
            322-397             JAXUCZ010000002.1  243866088-243866163 c
            398-546             JAXUCZ010000002.1  243865697-243865845 c
            547-735             JAXUCZ010000002.1  243860723-243860911 c
            736-906             JAXUCZ010000002.1  243860476-243860646 c
            907-1095            JAXUCZ010000002.1  243858540-243858728 c
            1096-1293           JAXUCZ010000002.1  243854930-243855127 c
            1294-1515           JAXUCZ010000002.1  243853721-243853942 c
            1516-1701           JAXUCZ010000002.1  243849365-243849550 c
            1702-2059           JAXUCZ010000002.1  243847445-243847802 c
            2060-2682           JAXUCZ010000002.1  243846736-243847358 c
FEATURES             Location/Qualifiers
     source          1..2682
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     gene            1..2682
                     /gene="Nexn"
                     /note="nexilin (F actin binding protein)"
                     /db_xref="GeneID:246172"
                     /db_xref="RGD:708354"
     exon            1..56
                     /gene="Nexn"
                     /inference="alignment:Splign:2.1.0"
     exon            57..129
                     /gene="Nexn"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2073
                     /gene="Nexn"
                     /note="isoform b is encoded by transcript variant b"
                     /codon_start=1
                     /product="nexilin isoform b"
                     /protein_id="NP_631976.1"
                     /db_xref="GeneID:246172"
                     /db_xref="RGD:708354"
                     /translation="MNDVSQKAEILLSSSKPVPKSYVPKLGKGDVKDKFEAMQRAREE
                     RNQRRSRDEKQRRKEQYIREREWNRRKQEIKDMLASDEEEEPSKVEKAYVPKLTGTVK
                     GKFDEMEKHRQEEQRKRTEEERKRRIEQDLLEKRKMQRELAKRAEQEGDDSLLITVVP
                     AKSYRAAANRKDPEDLDREHRNGRVSQEEEKTRHEEECRALKEAKCLSLVMDDETEAK
                     KESRFPGKLKSTFEELERQRQENRKKQAEEEARRRLEEERRAFEEARRNMVNEEDESQ
                     DTETVFKEYRPGKLRLSFEEIERQRREEEKRKAEEEARRRMEEEKKAFAEARRSMVLD
                     DDSPEIYKAVSQESLTPGKLEINFEQLLRQKMEEERRRTEEERRQKLEMEKQEFEQLR
                     QEMGKEEEENESFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEVQKKIEEE
                     RAKRRAIDLEIKEREAENFHEDDDVDVKPAKKSESPFTHKVNMKARFEQMAKARQEEE
                     QRRIEEQKLLRMQFEQKEIDAALQKKREDDEEEEGSIVNGSTTEDEEQTRSGAPWFKK
                     PLRNTSVVDSEPVRFTVKVTGEPKPEVTWWFEGELLQDGEDYQYIERGETYCLYLPET
                     FPEDGGEYMCKAVNSKGSAASTCILTIEMDDY"
     exon            130..321
                     /gene="Nexn"
                     /inference="alignment:Splign:2.1.0"
     exon            322..397
                     /gene="Nexn"
                     /inference="alignment:Splign:2.1.0"
     exon            398..546
                     /gene="Nexn"
                     /inference="alignment:Splign:2.1.0"
     exon            547..735
                     /gene="Nexn"
                     /inference="alignment:Splign:2.1.0"
     exon            736..906
                     /gene="Nexn"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1095
                     /gene="Nexn"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1293
                     /gene="Nexn"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1515
                     /gene="Nexn"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1701
                     /gene="Nexn"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..2059
                     /gene="Nexn"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2682
                     /gene="Nexn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccggac acgcagcgcg gagcgggagg agcggcgccc cggcggcggc aggcgggtac
       61 aagaatatac aaggcttcag tctgaaacca cacatagcaa acatgaatga cgtgtcacag
      121 aaggcagaga ttctgctttc ttcatctaaa cctgtcccca aatcctatgt gccaaaactc
      181 ggcaagggag atgtaaagga taaatttgaa gccatgcaga gggccaggga agaaagaaat
      241 caaaggcgat ctagagacga aaagcaaaga agaaaagaac aatatattag agaaagagaa
      301 tggaacagga gaaagcagga gattaaagac atgctcgctt ctgatgagga agaagagccg
      361 tctaaagtag aaaaggctta tgtcccaaag ctcacaggga cagttaaagg caaatttgat
      421 gaaatggaga aacacagaca ggaagaacaa aggaagagaa cagaagagga gagaaaacgc
      481 agaattgagc aggatctgtt agaaaagagg aaaatgcagc gtgaattagc aaaaagagct
      541 gagcaggaag gagatgactc actccttata acagtggtcc ctgccaaatc atacagagca
      601 gctgcaaaca ggaaggatcc tgaggacctg gacagagaac acaggaatgg aagggttagt
      661 caggaagaag aaaagacaag acatgaagaa gagtgcagag ctctcaaaga agcaaaatgc
      721 ctttcattgg tcatggatga tgaaacagag gccaaaaaag aatcacgttt tcctggaaaa
      781 ttgaaatcaa cttttgaaga actggaacga caaagacaag aaaaccgcaa gaagcaagca
      841 gaagaggaag caagacggcg cttagaagaa gagaggcgtg cctttgagga agcaaggcgg
      901 aacatggtaa acgaggagga tgaaagccaa gacacagaaa cggtttttaa agagtaccgc
      961 ccaggaaaac tccgactcag ttttgaggaa atagaaaggc aaaggagaga agaggaaaaa
     1021 cgaaaggccg aggaggaggc gcgaaggagg atggaggagg agaagaaggc atttgctgaa
     1081 gccaggagaa gcatggtatt agatgatgat tccccagaga tttataaagc agtctctcaa
     1141 gaatctctaa cgcctggaaa actggaaatt aattttgaac aattattaag acaaaaaatg
     1201 gaagaagaaa gacgacgaac agaggaagaa cggaggcaaa aactagaaat ggagaaacag
     1261 gaatttgaac aactgagaca agaaatggga aaggaagaag aagaaaatga aagctttggg
     1321 ttgagtagag aatatgaaga attaattaaa ttaaaaagga gtggttcaat tcaagccaaa
     1381 aatctaaaaa gcaagtttga aaaaattgga cagttgtctg aaaaagaagt acagaaaaag
     1441 atagaagaag agagagcaaa aaggagagca attgaccttg aaattaaaga gcgagaagca
     1501 gaaaacttcc atgaggatga tgatgttgat gtaaaacctg caaagaagag tgagtctccc
     1561 tttactcaca aagtgaacat gaaagccaga tttgaacaaa tggctaaggc aagacaagaa
     1621 gaagagcaaa ggagaattga agaacagaag ttactgcgga tgcagtttga acagaaagaa
     1681 atcgatgcag cacttcagaa aaaaagagaa gatgatgagg aagaagaagg tagcattgtt
     1741 aacggctcca ctactgaaga cgaagagcaa accagatcag gagccccatg gttcaaaaag
     1801 ccactaagaa atacctcagt tgtagacagt gagccagtga gattcactgt gaaagtgaca
     1861 ggagaaccca agccagaagt tacgtggtgg tttgaaggag aactactgca ggatggagaa
     1921 gactatcagt acatcgaaag aggagaaact tactgcctgt atttaccaga aactttcccc
     1981 gaagatggag gagaatatat gtgtaaagca gtcaacagta aaggctcagc agcgagtacc
     2041 tgtattctta ccattgaaat ggatgactac taggcttcct tctttacttg gatctcactc
     2101 tctccaactc tcttgataca tctctgagga ggggccaaaa aggagaccag aggcgccact
     2161 ctgttgactt aatcttttcc cacatcttcc aaatagctca tctaaagaac accatttcca
     2221 atgcctatca gttttattac catgctgtgc aaagtcaaaa tgcagctgac agaaaaggga
     2281 aataaatgta cacattctgc cataacctaa aacaaaagct ttatattttc cctatttata
     2341 gcatagtttg catgaataga ttttataact agccactgat tgacaattaa agtggaatga
     2401 ttagtagatt tgaaaaatgc gattttgatt taaatttcta gctttaaaaa taagtttgta
     2461 aatgtcaagt gttgtgttgc aggccttaat cccagcacac aggaggcagc aaggtctaca
     2521 gggcagccag aattacatag ttgagaccct gttaccctgg ttcctataac aacacatgtc
     2581 tgtaaataaa agcctattat gttctaatat tgggtggttt tatatttaat tttctggaaa
     2641 acgtgttgtg aaaccataat aaagttacct gtgcattaaa aa
//
