LOCUS       NM_021700               1483 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus neurogenin 3 (Neurog3), mRNA.
ACCESSION   NM_021700
VERSION     NM_021700.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1483)
  AUTHORS   Marzioni,M., Agostinelli,L., Candelaresi,C., Saccomanno,S., De
            Minicis,S., Maroni,L., Mingarelli,E., Rychlicki,C., Trozzi,L.,
            Banales,J.M., Benedetti,A. and Baroni,G.S.
  TITLE     Activation of the developmental pathway neurogenin-3/microRNA-7a
            regulates cholangiocyte proliferation in response to injury
  JOURNAL   Hepatology 60 (4), 1324-1335 (2014)
   PUBMED   24925797
  REMARK    GeneRIF: Activation of the developmental pathway
            neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in
            response to injury.
REFERENCE   2  (bases 1 to 1483)
  AUTHORS   Yang,K., Wang,Y., Du,Z. and Zhang,X.
  TITLE     Short-reactivation of neurogenin-3 and mesenchymal microenvironment
            is require for beta-cells differentiation during fetal pancreas
            development and islet regeneration
  JOURNAL   Rom J Morphol Embryol 55 (2), 305-311 (2014)
   PUBMED   24969979
  REMARK    GeneRIF: The expression of transcription factor Ngn3 and pancreatic
            mesenchymal microenvironment are important and necessary to promote
            pancreatic progenitors differentiated to islet cells regardless of
            pancreatic development or islets regeneration.
REFERENCE   3  (bases 1 to 1483)
  AUTHORS   Liang,X.D., Guo,Y.Y., Sun,M., Ding,Y., Wang,N., Yuan,L. and De,W.
  TITLE     Streptozotocin-induced expression of Ngn3 and Pax4 in neonatal rat
            pancreatic alpha-cells
  JOURNAL   World J Gastroenterol 17 (23), 2812-2820 (2011)
   PUBMED   21734788
  REMARK    GeneRIF: Data show that Ngn3 and Pax4, a transcription factor that
            lies downstream of Ngn3 and plays an important role in beta-cell
            differentiation, were expressed in the alpha-cells of STZ-treated
            rats.
REFERENCE   4  (bases 1 to 1483)
  AUTHORS   Simon-Areces,J., Dopazo,A., Dettenhofer,M., Rodriguez-Tebar,A.,
            Garcia-Segura,L.M. and Arevalo,M.A.
  TITLE     Formin1 mediates the induction of dendritogenesis and
            synaptogenesis by neurogenin3 in mouse hippocampal neurons
  JOURNAL   PLoS One 6 (7), e21825 (2011)
   PUBMED   21818269
REFERENCE   5  (bases 1 to 1483)
  AUTHORS   Piper Hanley,K., Hearn,T., Berry,A., Carvell,M.J., Patch,A.M.,
            Williams,L.J., Sugden,S.A., Wilson,D.I., Ellard,S. and Hanley,N.A.
  TITLE     In vitro expression of NGN3 identifies RAB3B as the predominant
            Ras-associated GTP-binding protein 3 family member in human islets
  JOURNAL   J Endocrinol 207 (2), 151-161 (2010)
   PUBMED   20807725
REFERENCE   6  (bases 1 to 1483)
  AUTHORS   Lee,J., Wu,Y., Qi,Y., Xue,H., Liu,Y., Scheel,D., German,M., Qiu,M.,
            Guillemot,F., Rao,M. and Gradwohl,G.
  TITLE     Neurogenin3 participates in gliogenesis in the developing
            vertebrate spinal cord
  JOURNAL   Dev Biol 253 (1), 84-98 (2003)
   PUBMED   12490199
  REMARK    GeneRIF: role in regulating glial differentiation at a
            developmental stage prior to the segregation of the oligodendrocyte
            and astrocyte lineage
            Erratum:[Dev Biol. 2003 Mar 15;255(2):440]
REFERENCE   7  (bases 1 to 1483)
  AUTHORS   Lee,C.S., Perreault,N., Brestelli,J.E. and Kaestner,K.H.
  TITLE     Neurogenin 3 is essential for the proper specification of gastric
            enteroendocrine cells and the maintenance of gastric epithelial
            cell identity
  JOURNAL   Genes Dev 16 (12), 1488-1497 (2002)
   PUBMED   12080087
REFERENCE   8  (bases 1 to 1483)
  AUTHORS   Jensen,J., Heller,R.S., Funder-Nielsen,T., Pedersen,E.E.,
            Lindsell,C., Weinmaster,G., Madsen,O.D. and Serup,P.
  TITLE     Independent development of pancreatic alpha- and beta-cells from
            neurogenin3-expressing precursors: a role for the notch pathway in
            repression of premature differentiation
  JOURNAL   Diabetes 49 (2), 163-176 (2000)
   PUBMED   10868931
REFERENCE   9  (bases 1 to 1483)
  AUTHORS   Ravassard,P., Vallin,J., Mallet,J. and Icard-Liepkalns,C.
  TITLE     Relax promotes ectopic neuronal differentiation in Xenopus embryos
  JOURNAL   Proc Natl Acad Sci U S A 94 (16), 8602-8605 (1997)
   PUBMED   9238023
REFERENCE   10 (bases 1 to 1483)
  AUTHORS   Ravassard,P., Chatail,F., Mallet,J. and Icard-Liepkalns,C.
  TITLE     Relax, a novel rat bHLH transcriptional regulator transiently
            expressed in the ventricular proliferating zone of the developing
            central nervous system
  JOURNAL   J Neurosci Res 48 (2), 146-158 (1997)
   PUBMED   9130143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Mar 5, 2021 this sequence version replaced NM_021700.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: Y10619.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1483              JAXUCZ010000020.1  30622533-30624015
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..1483
                     /gene="Neurog3"
                     /gene_synonym="Ngn3; Relax"
                     /note="neurogenin 3"
                     /db_xref="GeneID:60329"
                     /db_xref="RGD:631350"
     exon            1..1483
                     /gene="Neurog3"
                     /gene_synonym="Ngn3; Relax"
                     /inference="alignment:Splign:2.1.0"
     CDS             451..1095
                     /gene="Neurog3"
                     /gene_synonym="Ngn3; Relax"
                     /function="transcriptional regulator"
                     /note="transcriptional regulator, Relax"
                     /codon_start=1
                     /product="neurogenin-3"
                     /protein_id="NP_067732.1"
                     /db_xref="GeneID:60329"
                     /db_xref="RGD:631350"
                     /translation="MAPHPLDAPTIQVSQETQQPFPGASDHEVLSSNSTPPSPTLVPR
                     DCSEAEAGDCRGTSRKLRARRGGRNRPKSELALSKQRRSRRKKANDRERNRMHNLNSA
                     LDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSFYGPEPPVPCGELGS
                     PGGGSSGDWGSIYSPVSQAGSLSPTASLEEFPGLQVPSSPSCLLPGTLVFSDFL"
ORIGIN      
        1 cgcgtggcgc agtccctggg cccccgttgc tgattggccc gtggcacagg cagcagcccg
       61 gcaggcacgc tcctggtccg ggcagagcag ataaagcgtg ccaggggaca cacgattagc
      121 agctcagaaa tccctctggg tctcaccact gcacagaggc cgaggacccc ctccgagctt
      181 ctttgctgcc tccagacgca atttactcca ggcgagggcg cctgcagctc agcaaaactt
      241 cgaagcgagc agaggggttc agctatccac cgctgcttga ctctgaccaa cccgcagctc
      301 tctgttcttt tgagcccgga gaactaggta acatttagga acctccaaag ggtagaagag
      361 gggagtgggt gggcgtactc tagtcccgcg tggagtgacc tctaagtcag agactgtcac
      421 accccccttc cattttttcc caacctcagg atggcgcctc atcccttgga tgcgcccacc
      481 atccaagtgt cccaagagac ccagcaaccc tttcccggag cctcggacca cgaagtgctc
      541 agttccaatt ccaccccacc tagccccact ctcgtaccga gggactgctc cgaagcagaa
      601 gcaggtgact gccgagggac atcgaggaag ctccgtgcgc ggcgcggagg gcgcaacagg
      661 cccaagagcg agttggcact gagcaagcag cgacgaagcc ggcgcaagaa ggccaacgac
      721 cgggagcgca accgcatgca caaccttaac tccgcgctgg atgcgctgcg cggtgtcctg
      781 cccaccttcc cggatgacgc caaacttaca aagatcgaga ccctgcgctt cgcccacaac
      841 tacatttggg cactgactca gacgctgcgc atagcggacc acagcttcta cggccccgag
      901 ccccctgtgc cctgtgggga gctgggaagc ccgggagggg gctccagcgg cgactggggc
      961 tctatctact ccccagtttc ccaagctggt agcctgagcc ccacagcctc attggaggag
     1021 ttccctggcc tgcaggtgcc cagctcccca tcctgtctgc tcccgggcac cctggtgttc
     1081 tcagacttct tgtgaagggc ccaaacaggc cctgggcggt gggcgctggc agaaagggag
     1141 ggagtcagag ctgtctgaaa tggaaggtag tggaggcact cgagcatctc gccccttctg
     1201 gctttcatta gtcaggtccc tgatttaacc aggattcgca cagttccttg ctgctgtgcg
     1261 tgcacaaagg acattgcagg ctgatctcct cttaaccctc ctcagtgtgg ccacctcaaa
     1321 ctcccgctcc aagcagagga gagccgtagc actaaatagt tgggagactc ccatacttcc
     1381 tggtgactcc gccctctttc aaatctgcgg gcctccaacc accgctttct ccagagtgac
     1441 ctaatccagt gttgcgtctt acctcactgg ctcttgttcc ata
//
